메뉴 건너뛰기




Volumn 33, Issue 16, 2015, Pages 1745-1753

Immune therapy in GI malignancies: A review

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BEVACIZUMAB; BMS 936559; CD3 ANTIGEN; CETUXIMAB; CHIMERIC ANTIGEN RECEPTOR; CP 870893; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; GEMCITABINE; IPILIMUMAB; MGD 007; NIVOLUMAB; PANITUMUMAB; PEMBROLIZUMAB; PROGRAMMED DEATH 1 RECEPTOR; RAMUCIRUMAB; TRASTUZUMAB; TUMOR VACCINE; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 2; ANTIBODY; AUTACOID; CANCER VACCINE;

EID: 84937112293     PISSN: 0732183X     EISSN: 15277755     Source Type: Journal    
DOI: 10.1200/JCO.2015.60.7879     Document Type: Review
Times cited : (39)

References (65)
  • 2
    • 42149188994 scopus 로고    scopus 로고
    • Immunotherapy for gastrointestinal cancer: Current status and strategies for improving efficacy
    • Elkord E, Hawkins RE, Stern PL: Immunotherapy for gastrointestinal cancer: Current status and strategies for improving efficacy. Expert Opin Biol Ther 8:385-395, 2008
    • (2008) Expert Opin Biol Ther , vol.8 , pp. 385-395
    • Elkord, E.1    Hawkins, R.E.2    Stern, P.L.3
  • 3
    • 33845644023 scopus 로고    scopus 로고
    • New strategies to improve the efficacy of colorectal cancer vaccines: From bench to bedside
    • Mocellin S: New strategies to improve the efficacy of colorectal cancer vaccines: From bench to bedside. Curr Opin Investig Drugs 7:1052-1061, 2006
    • (2006) Curr Opin Investig Drugs , vol.7 , pp. 1052-1061
    • Mocellin, S.1
  • 4
    • 84888638819 scopus 로고    scopus 로고
    • The microbiome and cancer
    • Schwabe RF, Jobin C: The microbiome and cancer. Nat Rev Cancer 13:800-812, 2013
    • (2013) Nat Rev Cancer , vol.13 , pp. 800-812
    • Schwabe, R.F.1    Jobin, C.2
  • 5
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA: Hallmarks of cancer: The next generation. Cell 144:646-674, 2011
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 6
    • 9144266295 scopus 로고    scopus 로고
    • Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
    • Hingorani SR, Petricoin EF, Maitra A, et al: Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell 4:437-450, 2003
    • (2003) Cancer Cell , vol.4 , pp. 437-450
    • Hingorani, S.R.1    Petricoin, E.F.2    Maitra, A.3
  • 7
    • 19344362405 scopus 로고    scopus 로고
    • Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice
    • Hingorani SR, Wang L, Multani AS, et al: Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell 7:469-483, 2005
    • (2005) Cancer Cell , vol.7 , pp. 469-483
    • Hingorani, S.R.1    Wang, L.2    Multani, A.S.3
  • 8
    • 34247532726 scopus 로고    scopus 로고
    • Clinical significance and therapeutic potential of the programmed death-1 ligand/programmed death-1 pathway in human pancreatic cancer
    • Nomi T, Sho M, Akahori T, et al: Clinical significance and therapeutic potential of the programmed death-1 ligand/programmed death-1 pathway in human pancreatic cancer. Clin Cancer Res 13:2151-2157, 2007
    • (2007) Clin Cancer Res , vol.13 , pp. 2151-2157
    • Nomi, T.1    Sho, M.2    Akahori, T.3
  • 9
    • 61549122071 scopus 로고    scopus 로고
    • Overexpression of PD-L1 significantly associates with tumor aggressiveness and postoperative recurrence in human hepatocellular carcinoma
    • Gao Q, Wang XY, Qiu SJ, et al: Overexpression of PD-L1 significantly associates with tumor aggressiveness and postoperative recurrence in human hepatocellular carcinoma. Clin Cancer Res 15: 971-979, 2009
    • (2009) Clin Cancer Res , vol.15 , pp. 971-979
    • Gao, Q.1    Wang, X.Y.2    Qiu, S.J.3
  • 10
    • 84903955050 scopus 로고    scopus 로고
    • Galectin-1 drives pancreatic carcinogenesis through stroma remodeling and Hedge-hog signaling activation
    • Martínez-Bosch N, Fernández-Barrena MG, Moreno M, et al: Galectin-1 drives pancreatic carcinogenesis through stroma remodeling and Hedge-hog signaling activation. Cancer Res 74:3512-3524, 2014
    • (2014) Cancer Res , vol.74 , pp. 3512-3524
    • Martínez-Bosch, N.1    Fernández-Barrena, M.G.2    Moreno, M.3
  • 11
    • 78049353635 scopus 로고    scopus 로고
    • FOXP3+ regulatory T cells and tumoral indoleamine 2,3-dioxygenase expression predicts the carcinogenesis of intraductal papillary mucinous neoplasms of the pancreas
    • Kobayashi N, Kubota K, Kato S, et al: FOXP3+ regulatory T cells and tumoral indoleamine 2,3-dioxygenase expression predicts the carcinogenesis of intraductal papillary mucinous neoplasms of the pancreas. Pancreatology 10:631-640, 2010
    • (2010) Pancreatology , vol.10 , pp. 631-640
    • Kobayashi, N.1    Kubota, K.2    Kato, S.3
  • 12
    • 33644775726 scopus 로고    scopus 로고
    • Prognostic value of indoleamine 2,3-dioxygenase expression in colorectal cancer: Effect on tumor-infiltrating T cells
    • Brandacher G, Perathoner A, Ladurner R, et al: Prognostic value of indoleamine 2,3-dioxygenase expression in colorectal cancer: Effect on tumor-infiltrating T cells. Clin Cancer Res 12:1144-1151, 2006
    • (2006) Clin Cancer Res , vol.12 , pp. 1144-1151
    • Brandacher, G.1    Perathoner, A.2    Ladurner, R.3
  • 14
    • 84890281217 scopus 로고    scopus 로고
    • Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer
    • Feig C, Jones JO, Kraman M, et al: Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer. Proc Natl Acad Sci U S A 110:20212-20217, 2013
    • (2013) Proc Natl Acad Sci u S a , vol.110 , pp. 20212-20217
    • Feig, C.1    Jones, J.O.2    Kraman, M.3
  • 16
    • 0037180757 scopus 로고    scopus 로고
    • Inflammation and cancer
    • Coussens LM, Werb Z: Inflammation and cancer. Nature 420:860-867, 2002
    • (2002) Nature , vol.420 , pp. 860-867
    • Coussens, L.M.1    Werb, Z.2
  • 17
    • 26844464792 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor-beta-dependent manner
    • Ghiringhelli F, Ménard C, Terme M, et al: CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor-beta-dependent manner. J Exp Med 202:1075-1085, 2005
    • (2005) J Exp Med , vol.202 , pp. 1075-1085
    • Ghiringhelli, F.1    Ménard, C.2    Terme, M.3
  • 19
    • 84907449220 scopus 로고    scopus 로고
    • Pancreatic stellate cells and pancreas cancer: Current perspectives and future strategies
    • Haqq J, Howells LM, Garcea G, et al: Pancreatic stellate cells and pancreas cancer: Current perspectives and future strategies. Eur J Cancer 50:2570-2582, 2014
    • (2014) Eur J Cancer , vol.50 , pp. 2570-2582
    • Haqq, J.1    Howells, L.M.2    Garcea, G.3
  • 20
    • 67149143399 scopus 로고    scopus 로고
    • Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
    • Olive KP, Jacobetz MA, Davidson CJ, et al: Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 324:1457-1461, 2009
    • (2009) Science , vol.324 , pp. 1457-1461
    • Olive, K.P.1    Jacobetz, M.A.2    Davidson, C.J.3
  • 21
    • 28844444157 scopus 로고    scopus 로고
    • Exploring the tumour environment: Cancer-associated fibroblasts as targets in cancer therapy
    • Micke P, Ostman A: Exploring the tumour environment: Cancer-associated fibroblasts as targets in cancer therapy. Expert Opin Ther Targets 9:1217-1233, 2005
    • (2005) Expert Opin Ther Targets , vol.9 , pp. 1217-1233
    • Micke, P.1    Ostman, A.2
  • 22
    • 84865080615 scopus 로고    scopus 로고
    • The pancreas cancer microenvironment
    • Feig C, Gopinathan A, Neesse A, et al: The pancreas cancer microenvironment. Clin Cancer Res 18:4266-4276, 2012
    • (2012) Clin Cancer Res , vol.18 , pp. 4266-4276
    • Feig, C.1    Gopinathan, A.2    Neesse, A.3
  • 23
    • 79953151458 scopus 로고    scopus 로고
    • Cancer immunoediting: Integrating immunity's roles in cancer suppression and promotion
    • Schreiber RD, Old LJ, Smyth MJ: Cancer immunoediting: Integrating immunity's roles in cancer suppression and promotion. Science 331:1565-1570, 2011
    • (2011) Science , vol.331 , pp. 1565-1570
    • Schreiber, R.D.1    Old, L.J.2    Smyth, M.J.3
  • 24
    • 84877052290 scopus 로고    scopus 로고
    • Inflammatory networks and immune surveillance of pancreatic carcinoma
    • Vonderheide RH, Bayne LJ: Inflammatory networks and immune surveillance of pancreatic carcinoma. Curr Opin Immunol 25:200-205, 2013
    • (2013) Curr Opin Immunol , vol.25 , pp. 200-205
    • Vonderheide, R.H.1    Bayne, L.J.2
  • 25
    • 84896702241 scopus 로고    scopus 로고
    • Role of the immune system in pancreatic cancer progression and immune modulating treatment strategies
    • Sideras K, Braat H, Kwekkeboom J, et al: Role of the immune system in pancreatic cancer progression and immune modulating treatment strategies. Cancer Treat Rev 40:513-522, 2014
    • (2014) Cancer Treat Rev , vol.40 , pp. 513-522
    • Sideras, K.1    Braat, H.2    Kwekkeboom, J.3
  • 26
    • 57749093121 scopus 로고    scopus 로고
    • Inflammation and stem cells in gastrointestinal carcinogenesis
    • Quante M, Wang TC: Inflammation and stem cells in gastrointestinal carcinogenesis. Physiology (Bethesda) 23:350-359, 2008
    • (2008) Physiology (Bethesda) , vol.23 , pp. 350-359
    • Quante, M.1    Wang, T.C.2
  • 27
    • 84859158384 scopus 로고    scopus 로고
    • Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity
    • Topalian SL, Drake CG, Pardoll DM: Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity. Curr Opin Immunol 24:207-212, 2012
    • (2012) Curr Opin Immunol , vol.24 , pp. 207-212
    • Topalian, S.L.1    Drake, C.G.2    Pardoll, D.M.3
  • 28
    • 84879599112 scopus 로고    scopus 로고
    • At the bedside: CTLA-4- and PD-1-blocking antibodies in cancer immunotherapy
    • Callahan MK, Wolchok JD: At the bedside: CTLA-4- and PD-1-blocking antibodies in cancer immunotherapy. J Leukoc Biol 94:41-53, 2013
    • (2013) J Leukoc Biol , vol.94 , pp. 41-53
    • Callahan, M.K.1    Wolchok, J.D.2
  • 29
    • 13744253833 scopus 로고    scopus 로고
    • Interaction of PD-L1 on tumor cells with PD-1 on tumorspecific T cells as a mechanism of immune evasion: Implications for tumor immunotherapy
    • Blank C, Gajewski TF, Mackensen A: Interaction of PD-L1 on tumor cells with PD-1 on tumorspecific T cells as a mechanism of immune evasion: Implications for tumor immunotherapy. Cancer Immunol Immunother 54:307-314, 2005
    • (2005) Cancer Immunol Immunother , vol.54 , pp. 307-314
    • Blank, C.1    Gajewski, T.F.2    Mackensen, A.3
  • 31
  • 33
    • 84859108137 scopus 로고    scopus 로고
    • Circulating CD4+CD25+ regulatory T cells in patients with pancreatic cancer
    • Yamamoto T, Yanagimoto H, Satoi S, et al: Circulating CD4+CD25+ regulatory T cells in patients with pancreatic cancer. Pancreas 41:409-415, 2012
    • (2012) Pancreas , vol.41 , pp. 409-415
    • Yamamoto, T.1    Yanagimoto, H.2    Satoi, S.3
  • 34
    • 80054102628 scopus 로고    scopus 로고
    • Elevated myeloid-derived suppressor cells in pancreatic, esophageal and gastric cancer are an independent prognostic factor and are associated with significant elevation of the Th2 cytokine interleukin-13
    • Gabitass RF, Annels NE, Stocken DD, et al: Elevated myeloid-derived suppressor cells in pancreatic, esophageal and gastric cancer are an independent prognostic factor and are associated with significant elevation of the Th2 cytokine interleukin-13. Cancer Immunol Immunother 60:1419-1430, 2011
    • (2011) Cancer Immunol Immunother , vol.60 , pp. 1419-1430
    • Gabitass, R.F.1    Annels, N.E.2    Stocken, D.D.3
  • 35
    • 35148814410 scopus 로고    scopus 로고
    • Dynamics of the immune reaction to pancreatic cancer from inception to invasion
    • Clark CE, Hingorani SR, Mick R, et al: Dynamics of the immune reaction to pancreatic cancer from inception to invasion. Cancer Res 67:9518-9527, 2007
    • (2007) Cancer Res , vol.67 , pp. 9518-9527
    • Clark, C.E.1    Hingorani, S.R.2    Mick, R.3
  • 36
    • 20044364936 scopus 로고    scopus 로고
    • Phase I study of sequential vaccinations with fowlpox-CEA(6D)-TRICOM alone and sequentially with vaccinia-CEA(6D)-TRICOM, with and without granulocyte-macrophage colony-stimulating factor, in patients with carcinoembryonic antigen-expressing carcinomas
    • Marshall JL, Gulley JL, Arlen PM, et al: Phase I study of sequential vaccinations with fowlpox-CEA(6D)-TRICOM alone and sequentially with vaccinia-CEA(6D)-TRICOM, with and without granulocyte-macrophage colony-stimulating factor, in patients with carcinoembryonic antigen-expressing carcinomas. J Clin Oncol 23:720-731, 2005
    • (2005) J Clin Oncol , vol.23 , pp. 720-731
    • Marshall, J.L.1    Gulley, J.L.2    Arlen, P.M.3
  • 37
    • 84888130428 scopus 로고    scopus 로고
    • A randomized phase II study of immunization with dendritic cells modified with poxvectors encoding CEA and MUC1 compared with the same poxvectors plus GM-CSF for resected metastatic colorectal cancer
    • Morse MA, Niedzwiecki D, Marshall JL, et al: A randomized phase II study of immunization with dendritic cells modified with poxvectors encoding CEA and MUC1 compared with the same poxvectors plus GM-CSF for resected metastatic colorectal cancer. Ann Surg 258:879-886, 2013
    • (2013) Ann Surg , vol.258 , pp. 879-886
    • Morse, M.A.1    Niedzwiecki, D.2    Marshall, J.L.3
  • 38
    • 84883207410 scopus 로고    scopus 로고
    • Evaluation of ipilimumab in combination with allogeneic pancreatic tumor cells transfected with a GM-CSF gene in previously treated pancreatic cancer
    • Le DT, Lutz E, Uram JN, et al: Evaluation of ipilimumab in combination with allogeneic pancreatic tumor cells transfected with a GM-CSF gene in previously treated pancreatic cancer. J Immunother 36:382-389, 2013
    • (2013) J Immunother , vol.36 , pp. 382-389
    • Le, D.T.1    Lutz, E.2    Uram, J.N.3
  • 39
    • 84856519280 scopus 로고    scopus 로고
    • A live-attenuated Listeria vaccine (ANZ-100) and a live-attenuated Listeria vaccine expressing mesothelin (CRS-207) for advanced cancers: Phase I studies of safety and immune induction
    • Le DT, Brockstedt DG, Nir-Paz R, et al: A live-attenuated Listeria vaccine (ANZ-100) and a live-attenuated Listeria vaccine expressing mesothelin (CRS-207) for advanced cancers: Phase I studies of safety and immune induction. Clin Cancer Res 18:858-868, 2012
    • (2012) Clin Cancer Res , vol.18 , pp. 858-868
    • Le, D.T.1    Brockstedt, D.G.2    Nir-Paz, R.3
  • 40
    • 84929431322 scopus 로고    scopus 로고
    • Safety and survival with GVAX pancreas prime and Listeria monocytogenes-expressing mesothelin (CRS-207) boost vaccines for metastatic pancreatic cancer
    • Le DT, Wang-Gilliam A, Picozzi V, et al: Safety and survival with GVAX pancreas prime and Listeria monocytogenes-expressing mesothelin (CRS-207) boost vaccines for metastatic pancreatic cancer. J Clin Oncol 33:1325-1333, 2015
    • (2015) J Clin Oncol , vol.33 , pp. 1325-1333
    • Le, D.T.1    Wang-Gilliam, A.2    Picozzi, V.3
  • 41
    • 84871991189 scopus 로고    scopus 로고
    • Addition of algenpantucel-L immunotherapy to standard adjuvant therapy for pancreatic cancer: A phase 2 study
    • Hardacre JM, Mulcahy M, Small W, et al: Addition of algenpantucel-L immunotherapy to standard adjuvant therapy for pancreatic cancer: A phase 2 study. J Gastrointest Surg 17:94-100, 2013
    • (2013) J Gastrointest Surg , vol.17 , pp. 94-100
    • Hardacre, J.M.1    Mulcahy, M.2    Small, W.3
  • 42
    • 84888086049 scopus 로고    scopus 로고
    • A phase I study of an agonist CD40 monoclonal antibody (CP-870,893) in combination with gemcitabine in patients with advanced pancreatic ductal adenocarcinoma
    • Beatty GL, Torigian DA, Chiorean EG, et al: A phase I study of an agonist CD40 monoclonal antibody (CP-870,893) in combination with gemcitabine in patients with advanced pancreatic ductal adenocarcinoma. Clin Cancer Res 19:6286-6295, 2013
    • (2013) Clin Cancer Res , vol.19 , pp. 6286-6295
    • Beatty, G.L.1    Torigian, D.A.2    Chiorean, E.G.3
  • 43
    • 77958050577 scopus 로고    scopus 로고
    • Phase 2 trial of single agent ipilimumab (anti-CTLA-4) for locally advanced or metastatic pancreatic adenocarcinoma
    • Royal RE, Levy C, Turner K, et al: Phase 2 trial of single agent ipilimumab (anti-CTLA-4) for locally advanced or metastatic pancreatic adenocarcinoma. J Immunother 33:828-833, 2010
    • (2010) J Immunother , vol.33 , pp. 828-833
    • Royal, R.E.1    Levy, C.2    Turner, K.3
  • 44
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
    • Brahmer JR, Tykodi SS, Chow LQ, et al: Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med 366:2455-2465, 2012
    • (2012) N Engl J Med , vol.366 , pp. 2455-2465
    • Brahmer, J.R.1    Tykodi, S.S.2    Chow, L.Q.3
  • 46
    • 84900301377 scopus 로고    scopus 로고
    • Cancer immunotherapy based on mutation-specific CD4+ T cells in a patient with epithelial cancer
    • Tran E, Turcotte S, Gros A, et al: Cancer immunotherapy based on mutation-specific CD4+ T cells in a patient with epithelial cancer. Science 344:641-645, 2014
    • (2014) Science , vol.344 , pp. 641-645
    • Tran, E.1    Turcotte, S.2    Gros, A.3
  • 47
    • 84903710545 scopus 로고    scopus 로고
    • A critical review of HER2-positive gastric cancer evaluation and treatment: From trastuzumab, and beyond
    • Gomez-Martín C, Lopez-Rios F, Aparicio J, et al: A critical review of HER2-positive gastric cancer evaluation and treatment: From trastuzumab, and beyond. Cancer Lett 351:30-40, 2014
    • (2014) Cancer Lett , vol.351 , pp. 30-40
    • Gomez-Martín, C.1    Lopez-Rios, F.2    Aparicio, J.3
  • 48
    • 84894483952 scopus 로고    scopus 로고
    • Phase I trial of a recombinant yeast-CEA vaccine (GI-6207) in adults with metastatic CEA-expressing carcinoma
    • Bilusic M, Heery CR, Arlen PM, et al: Phase I trial of a recombinant yeast-CEA vaccine (GI-6207) in adults with metastatic CEA-expressing carcinoma. Cancer Immunol Immunother 63:225-234, 2014
    • (2014) Cancer Immunol Immunother , vol.63 , pp. 225-234
    • Bilusic, M.1    Heery, C.R.2    Arlen, P.M.3
  • 49
    • 77956262693 scopus 로고    scopus 로고
    • Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): A phase 3, open-label, randomised controlled trial
    • Bang YJ, Van Cutsem E, Feyereislova A, et al: Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): A phase 3, open-label, randomised controlled trial. Lancet 376:687-697, 2010
    • (2010) Lancet , vol.376 , pp. 687-697
    • Bang, Y.J.1    Van Cutsem, E.2    Feyereislova, A.3
  • 50
    • 0035152718 scopus 로고    scopus 로고
    • Novel allogeneic granulocyte-macrophage colony-stimulating factor-secreting tumor vaccine for pancreatic cancer: A phase I trial of safety and immune activation
    • Jaffee EM, Hruban RH, Biedrzycki B, et al: Novel allogeneic granulocyte-macrophage colony-stimulating factor-secreting tumor vaccine for pancreatic cancer: A phase I trial of safety and immune activation. J Clin Oncol 19:145-156, 2001
    • (2001) J Clin Oncol , vol.19 , pp. 145-156
    • Jaffee, E.M.1    Hruban, R.H.2    Biedrzycki, B.3
  • 51
    • 79151486551 scopus 로고    scopus 로고
    • A lethally irradiated allogeneic granulocyte-macrophage colony stimulating factor-secreting tumor vaccine for pancreatic adenocarcinoma: A phase II trial of safety, efficacy, and immune activation
    • Lutz E, Yeo CJ, Lillemoe KD, et al: A lethally irradiated allogeneic granulocyte-macrophage colony stimulating factor-secreting tumor vaccine for pancreatic adenocarcinoma: A phase II trial of safety, efficacy, and immune activation. Ann Surg 253:328-335, 2011
    • (2011) Ann Surg , vol.253 , pp. 328-335
    • Lutz, E.1    Yeo, C.J.2    Lillemoe, K.D.3
  • 52
    • 40949157885 scopus 로고    scopus 로고
    • Allogeneic granulocyte macrophage colony-stimulating factor-secreting tumor immunotherapy alone or in sequence with cyclophosphamide for metastatic pancreatic cancer: A pilot study of safety, feasibility, and immune activation
    • Laheru D, Lutz E, Burke J, et al: Allogeneic granulocyte macrophage colony-stimulating factor-secreting tumor immunotherapy alone or in sequence with cyclophosphamide for metastatic pancreatic cancer: A pilot study of safety, feasibility, and immune activation. Clin Cancer Res 14:1455-1463, 2008
    • (2008) Clin Cancer Res , vol.14 , pp. 1455-1463
    • Laheru, D.1    Lutz, E.2    Burke, J.3
  • 53
    • 3543060047 scopus 로고    scopus 로고
    • Mesothelin-specific CD8(+) T cell responses provide evidence of in vivo cross-priming by antigen-presenting cells in vaccinated pancreatic cancer patients
    • Thomas AM, Santarsiero LM, Lutz ER, et al: Mesothelin-specific CD8(+) T cell responses provide evidence of in vivo cross-priming by antigen-presenting cells in vaccinated pancreatic cancer patients. J Exp Med 200:297-306, 2004
    • (2004) J Exp Med , vol.200 , pp. 297-306
    • Thomas, A.M.1    Santarsiero, L.M.2    Lutz, E.R.3
  • 54
    • 84902124061 scopus 로고    scopus 로고
    • Discovery of mesothelin and exploiting it as a target for immunotherapy
    • Pastan I, Hassan R: Discovery of mesothelin and exploiting it as a target for immunotherapy. Cancer Res 74:2907-2912, 2014
    • (2014) Cancer Res , vol.74 , pp. 2907-2912
    • Pastan, I.1    Hassan, R.2
  • 55
    • 84862150896 scopus 로고    scopus 로고
    • Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer
    • Bayne LJ, Beatty GL, Jhala N, et al: Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer. Cancer Cell 21:822-835, 2012
    • (2012) Cancer Cell , vol.21 , pp. 822-835
    • Bayne, L.J.1    Beatty, G.L.2    Jhala, N.3
  • 56
    • 84862147254 scopus 로고    scopus 로고
    • Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia
    • Pylayeva-Gupta Y, Lee KE, Hajdu CH, et al: Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia. Cancer Cell 21:836-847, 2012
    • (2012) Cancer Cell , vol.21 , pp. 836-847
    • Pylayeva-Gupta, Y.1    Lee, K.E.2    Hajdu, C.H.3
  • 57
    • 84964314430 scopus 로고    scopus 로고
    • Immunotherapy converts nonimmunogenic pancreatic tumors into immunogenic foci of immune regulation
    • Lutz ER, Wu AA, Bigelow E, et al: Immunotherapy converts nonimmunogenic pancreatic tumors into immunogenic foci of immune regulation. Cancer Immunol Res 2:616-631, 2014
    • (2014) Cancer Immunol Res , vol.2 , pp. 616-631
    • Lutz, E.R.1    Wu, A.A.2    Bigelow, E.3
  • 58
    • 33947506186 scopus 로고    scopus 로고
    • Clinical activity and immune modulation in cancer patients treated with CP-870,893, a novel CD40 agonist monoclonal antibody
    • Vonderheide RH, Flaherty KT, Khalil M, et al: Clinical activity and immune modulation in cancer patients treated with CP-870,893, a novel CD40 agonist monoclonal antibody. J Clin Oncol 25:876-883, 2007
    • (2007) J Clin Oncol , vol.25 , pp. 876-883
    • Vonderheide, R.H.1    Flaherty, K.T.2    Khalil, M.3
  • 59
    • 33847407907 scopus 로고    scopus 로고
    • A pilot study of CTLA-4 blockade after cancer vaccine failure in patients with advanced malignancy
    • O'Mahony D, Morris JC, Quinn C, et al: A pilot study of CTLA-4 blockade after cancer vaccine failure in patients with advanced malignancy. Clin Cancer Res 13:958-964, 2007
    • (2007) Clin Cancer Res , vol.13 , pp. 958-964
    • O'Mahony, D.1    Morris, J.C.2    Quinn, C.3
  • 60
    • 84879876002 scopus 로고    scopus 로고
    • Identification and selective degradation of neopeptide-containing truncated mutant proteins in the tumors with high microsatellite instability
    • Kim WK, Park M, Kim YJ, et al: Identification and selective degradation of neopeptide-containing truncated mutant proteins in the tumors with high microsatellite instability. Clin Cancer Res 19:3369-3382, 2013
    • (2013) Clin Cancer Res , vol.19 , pp. 3369-3382
    • Kim, W.K.1    Park, M.2    Kim, Y.J.3
  • 61
    • 84887943622 scopus 로고    scopus 로고
    • The analysis of microsatellite instability in extracolonic gastrointestinal malignancy
    • Williams AS, Huang WY: The analysis of microsatellite instability in extracolonic gastrointestinal malignancy. Pathology 45:540-552, 2013
    • (2013) Pathology , vol.45 , pp. 540-552
    • Williams, A.S.1    Huang, W.Y.2
  • 62
    • 70350225838 scopus 로고    scopus 로고
    • Lymphocytic reaction to colorectal cancer is associated with longer survival, independent of lymph node count, microsatellite instability, and CpG island methylator phenotype
    • Ogino S, Nosho K, Irahara N, et al: Lymphocytic reaction to colorectal cancer is associated with longer survival, independent of lymph node count, microsatellite instability, and CpG island methylator phenotype. Clin Cancer Res 15:6412-6420, 2009
    • (2009) Clin Cancer Res , vol.15 , pp. 6412-6420
    • Ogino, S.1    Nosho, K.2    Irahara, N.3
  • 63
    • 78349277576 scopus 로고    scopus 로고
    • Tumour-infiltrating T-cell subsets, molecular changes in colorectal cancer, and prognosis: Cohort study and literature review
    • Nosho K, Baba Y, Tanaka N, et al: Tumour-infiltrating T-cell subsets, molecular changes in colorectal cancer, and prognosis: Cohort study and literature review. J Pathol 222:350-366, 2010
    • (2010) J Pathol , vol.222 , pp. 350-366
    • Nosho, K.1    Baba, Y.2    Tanaka, N.3
  • 64
    • 84899631361 scopus 로고    scopus 로고
    • Antibody-modified T cells: CARs take the front seat for hematologic malignancies
    • Maus MV, Grupp SA, Porter DL, et al: Antibody-modified T cells: CARs take the front seat for hematologic malignancies. Blood 123:2625-2635, 2014
    • (2014) Blood , vol.123 , pp. 2625-2635
    • Maus, M.V.1    Grupp, S.A.2    Porter, D.L.3
  • 65
    • 77950475517 scopus 로고    scopus 로고
    • Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2
    • Morgan RA, Yang JC, Kitano M, et al: Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2. Mol Ther 18:843-851, 2010
    • (2010) Mol Ther , vol.18 , pp. 843-851
    • Morgan, R.A.1    Yang, J.C.2    Kitano, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.