Curcumin effectively inhibits oncogenic NF-κB signaling and restrains stemness features in liver cancer

Journal of Hepatology

Volumn 63, Issue 3, 2015, Pages 661-669

  Marquardt, Jens U ^a,b   Gomez Quiroz, Luis ^c   Arreguin Camacho, Lucrecia O ^b   Pinna, Federico ^d   Lee, Yun Han ^a   Kitade, Mitsuteru ^a   Domínguez, Mayrel Palestino ^c   Castven, Darko ^b   Breuhahn, Kai ^d   Conner, Elizabeth A ^a   Galle, Peter R ^b   Andersen, Jesper B ^e   Factor, Valentina M ^a   Thorgeirsson, Snorri S ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

^c DEPARTAMENTO DE QUÍMICA   (Mexico)

^d UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^e UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Cancer stem cells; Hepatocarcinogenesis; Histone deacetylases; Liver cancer; NF B

Indexed keywords

B RAF KINASE; BMI1 PROTEIN; CD133 ANTIGEN; CREBBP PROTEIN; CURCUMIN; CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYTOCHROME P450 1A1; EPITHELIAL CELL ADHESION MOLECULE; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIG3 PROTEIN; MYC PROTEIN; PKMYT1 PROTEIN; POLO LIKE KINASE 1; PROTEIN; SMALL INTERFERING RNA; SN 50; STAT3 PROTEIN; STEM CELL FACTOR; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOTAGMIN I; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TP53BP1 PROTEIN; TRANSCRIPTION FACTOR E2F3; TRANSCRIPTION FACTOR JUNB; TRANSCRIPTION FACTOR NANOG; TRICHOSTATIN A; TRICHOSTATINE A; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UNINDEXED DRUG; ANTINEOPLASTIC AGENT; HYDROXAMIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER GROWTH; CANCER PROGNOSIS; CANCER STEM CELL; CARCINOGENICITY; CELL CYCLE REGULATION; CELL DEATH; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; GLOBAL GENE EXPRESSION MICROARRAY; HEPATOMA CELL; HUMAN; HUMAN CELL; LIVER CANCER; LIVER CANCER CELL LINE; LIVER CELL CARCINOMA; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; ONCOLOGICAL PARAMETERS; PRIORITY JOURNAL; PROGNOSIS; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SPHERE FORMATION; TUMOR GROWTH; TUMOR INITIATING CELL; UPREGULATION; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; LIVER NEOPLASMS; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CURCUMIN; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; LIVER NEOPLASMS; MICE; NEOPLASTIC STEM CELLS; NF-KAPPA B; SIGNAL TRANSDUCTION;

EID: 84939270207     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2015.04.018     Document Type: Article

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