Integrated Genomic Characterization Reveals Novel, Therapeutically Relevant Drug Targets in FGFR and EGFR Pathways in Sporadic Intrahepatic Cholangiocarcinoma

PLoS Genetics

Volumn 10, Issue 2, 2014, Pages

  Borad, Mitesh J ^a,b   Champion, Mia D ^a,b   Egan, Jan B ^b   Liang, Winnie S ^c   Fonseca, Rafael ^a,b   Bryce, Alan H ^a,b   McCullough, Ann E ^a   Barrett, Michael T ^a,c   Hunt, Katherine ^a   Patel, Maitray D ^a   Young, Scott W ^a   Collins, Joseph M ^a   Silva, Alvin C ^a   Condjella, Rachel M ^a   Block, Matthew ^b,d   McWilliams, Robert R ^b,d   Lazaridis, Konstantinos N ^b   Klee, Eric W ^a,b   Bible, Keith C ^d   Harris, Pamela ^e   Oliver, Gavin R ^a,b   Bhavsar, Jaysheel D ^a,b   Nair, Asha A ^a,b   Middha, Sumit ^a,b   Asmann, Yan ^a,b   Kocher, Jean Pierre ^a,b   Schahl, Kimberly ^b   Kipp, Benjamin R ^b   Barr Fritcher, Emily G ^b   Baker, Angela ^c   Aldrich, Jessica ^c   Kurdoglu, Ahmet ^c   Izatt, Tyler ^c   Christoforides, Alexis ^c   Cherni, Irene ^c   Nasser, Sara ^c   Reiman, Rebecca ^c   Phillips, Lori ^c   McDonald, Jackie ^c   Adkins, Jonathan ^c   Mastrian, Stephen D ^c   Placek, Pamela ^c   Watanabe, Aprill T ^c   LoBello, Janine ^c   Han, Haiyong ^c   Von Hoff, Daniel ^a,c   Craig, David W ^c   Stewart, A Keith ^a,b   Carpten, John D ^c   more..

^a MAYO CLINIC   (United States)

^b MAYO CLINIC   (United States)

^c TRANSLATIONAL GENOMICS RESEARCH INSTITUTE   (United States)

^d MAYO CLINIC CANCER CENTER   (United States)

^e NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; FIBROBLAST GROWTH FACTOR RECEPTOR 2; PAZOPANIB; PONATINIB; TRANSCRIPTOME; EGFR PROTEIN, HUMAN; FGFR2 PROTEIN, HUMAN; IMIDAZOLE DERIVATIVE; PROTEIN KINASE INHIBITOR; PYRIDAZINE DERIVATIVE; PYRIMIDINE DERIVATIVE; QUINAZOLINE DERIVATIVE; SULFONAMIDE;

ADULT; ADVANCED CANCER; AGED; ALLELE; ARTICLE; BILE DUCT CARCINOMA; CANCER REGRESSION; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG RESPONSE; ERRFI1 GENE; EXOME; FEMALE; FGFR2 GENE; GENE; GENE FUSION; GENE LOCUS; GENOME ANALYSIS; HUMAN; HUMAN TISSUE; MALE; MGEA5 GENE; MIDDLE AGED; NONSENSE MUTATION; PERSONALIZED MEDICINE; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; SOMATIC MUTATION; TACC3 GENE; ANTAGONISTS AND INHIBITORS; BILE DUCT NEOPLASMS; CHOLANGIOCARCINOMA; GENETICS; HUMAN GENOME; INTRAHEPATIC BILE DUCT; METABOLISM; MOLECULARLY TARGETED THERAPY; MUTATION; PATHOLOGY; PROGNOSIS; TUMOR CELL LINE;

BILE DUCT NEOPLASMS; BILE DUCTS, INTRAHEPATIC; CELL LINE, TUMOR; CHOLANGIOCARCINOMA; GENOME, HUMAN; HUMANS; IMIDAZOLES; MOLECULAR TARGETED THERAPY; MUTATION; PROGNOSIS; PROTEIN KINASE INHIBITORS; PYRIDAZINES; PYRIMIDINES; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 2; SIGNAL TRANSDUCTION; SULFONAMIDES; TRANSCRIPTOME;

EID: 84901742112     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1004135     Document Type: Article

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