메뉴 건너뛰기




Volumn 6, Issue 7, 2015, Pages 480-503

Intranasal and oral vaccination with protein-based antigens: Advantages, challenges and formulation strategies

Author keywords

Adjuvant; Immunostimulant; Mucosal vaccine; Protein antigen; Vaccine delivery system

Indexed keywords

ALPHA GALACTOSYLCERAMIDE; ALPHA TOCOPHEROL; ALUMINUM POTASSIUM SULFATE; ANTIGEN; BACTERIAL DNA; BACTERIAL TOXIN; CHITOSAN; COMPOUND 48-80; CYTOKINE; DEXTRAN; DOUBLE STRANDED RNA; EUDRAGIT; GLYCOLIPID; GOLD NANOPARTICLE; HYALURONIC ACID; IMIDAZOQUINOLINE DERIVATIVE; IMMUNOSTIMULATING AGENT; LIPID; LIPOSOME; NIOSOME; PEPTIDOGLYCAN; POLYGLUTAMIC ACID; SAPONIN; STARCH; VIROSOME; VIRUS LIKE PARTICLE VACCINE; IMMUNOLOGICAL ADJUVANT; PROTEIN;

EID: 84943359553     PISSN: 1674800X     EISSN: 16748018     Source Type: Journal    
DOI: 10.1007/s13238-015-0164-2     Document Type: Review
Times cited : (120)

References (247)
  • 1
    • 0032972467 scopus 로고    scopus 로고
    • Iscom is an efficient mucosal delivery system for Mycoplasma mycoides subsp. Mycoides (MmmSC) antigens inducing high mucosal and systemic antibody responses
    • Abusugra I, Morein B (1999) Iscom is an efficient mucosal delivery system for Mycoplasma mycoides subsp. mycoides (MmmSC) antigens inducing high mucosal and systemic antibody responses. FEMS Immunol Med Microbiol 23:5–12
    • (1999) FEMS Immunol Med Microbiol , vol.23 , pp. 5-12
    • Abusugra, I.1    Morein, B.2
  • 2
    • 84872311271 scopus 로고    scopus 로고
    • Multiple antigen peptide consisting of B- and T-cell epitopes of F1 antigen of Y. Pestis showed enhanced humoral and mucosal immune response in different strains of mice
    • Ali R, Kumar S, Naqvi RA, Sheikh IA, Rao DN (2013) Multiple antigen peptide consisting of B- and T-cell epitopes of F1 antigen of Y. pestis showed enhanced humoral and mucosal immune response in different strains of mice. Int Immunopharmacol 15:97–105
    • (2013) Int Immunopharmacol , vol.15 , pp. 97-105
    • Ali, R.1    Kumar, S.2    Naqvi, R.A.3    Sheikh, I.A.4    Rao, D.N.5
  • 3
  • 5
    • 78049288264 scopus 로고    scopus 로고
    • Vaccine delivery: A matter of size, geometry, kinetics and molecular patterns
    • Bachmann MF, Jennings GT (2010) Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns. Nat Rev Immunol 10:787–796
    • (2010) Nat Rev Immunol , vol.10 , pp. 787-796
    • Bachmann, M.F.1    Jennings, G.T.2
  • 6
    • 84856282033 scopus 로고    scopus 로고
    • Adjuvanted, antigen loaded N-trimethyl chitosan nanoparticles for nasal and intradermal vaccination: Adjuvant- and site-dependent immunogenicity in mice
    • Bal SM, Slutter B, Verheul R, Bouwstra JA, Jiskoot W (2012) Adjuvanted, antigen loaded N-trimethyl chitosan nanoparticles for nasal and intradermal vaccination: adjuvant- and site-dependent immunogenicity in mice. Eur J Pharm Sci 45:475–481
    • (2012) Eur J Pharm Sci , vol.45 , pp. 475-481
    • Bal, S.M.1    Slutter, B.2    Verheul, R.3    Bouwstra, J.A.4    Jiskoot, W.5
  • 7
    • 0031906229 scopus 로고    scopus 로고
    • Oral immunization with recombinant Norwalk virus-like particles induces a systemic and mucosal immune response in mice
    • Ball JM, Hardy ME, Atmar RL, Conner ME, Estes MK (1998) Oral immunization with recombinant Norwalk virus-like particles induces a systemic and mucosal immune response in mice. J Virol 72:1345–1353
    • (1998) J Virol , vol.72 , pp. 1345-1353
    • Ball, J.M.1    Hardy, M.E.2    Atmar, R.L.3    Conner, M.E.4    Estes, M.K.5
  • 8
    • 0032546352 scopus 로고    scopus 로고
    • Dendritic cells and the control of immunity
    • Banchereau J, Steinman RM (1998) Dendritic cells and the control of immunity. Nature 392:245–252
    • (1998) Nature , vol.392 , pp. 245-252
    • Banchereau, J.1    Steinman, R.M.2
  • 9
    • 84872810738 scopus 로고    scopus 로고
    • Quillaja saponaria extract as mucosal adjuvant with chitosan functionalized gold nanoparticles for mucosal vaccine delivery: Stability and immunoefficiency studies
    • Barhate G, Gautam M, Gairola S, Jadhav S, Pokharkar V (2013) Quillaja saponaria extract as mucosal adjuvant with chitosan functionalized gold nanoparticles for mucosal vaccine delivery: stability and immunoefficiency studies. Int J Pharm 441:636–642
    • (2013) Int J Pharm , vol.441 , pp. 636-642
    • Barhate, G.1    Gautam, M.2    Gairola, S.3    Jadhav, S.4    Pokharkar, V.5
  • 10
    • 78149463086 scopus 로고    scopus 로고
    • Bioadhesive delivery systems for mucosal vaccine delivery
    • Baudner BC, O’Hagan DT (2010) Bioadhesive delivery systems for mucosal vaccine delivery. J Drug Target 18:752–770
    • (2010) J Drug Target , vol.18 , pp. 752-770
    • Baudner, B.C.1    O’hagan, D.T.2
  • 11
    • 0033551132 scopus 로고    scopus 로고
    • Mucosal vaccination overcomes the barrier to recombinant vaccinia immunization caused by preexisting poxvirus immunity
    • Belyakov IM, Moss B, Strober W, Berzofsky JA (1999) Mucosal vaccination overcomes the barrier to recombinant vaccinia immunization caused by preexisting poxvirus immunity. Proc Natl Acad Sci USA 96:4512–4517
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 4512-4517
    • Belyakov, I.M.1    Moss, B.2    Strober, W.3    Berzofsky, J.A.4
  • 12
    • 35748974510 scopus 로고    scopus 로고
    • Evaluation of the immune response following a short oral vaccination schedule with hepatitis B antigen encapsulated into alginate-coated chitosan nanoparticles
    • Borges O, Tavares J, de Sousa A, Borchard G, Junginger HE, Cordeiro-da-Silva A (2007) Evaluation of the immune response following a short oral vaccination schedule with hepatitis B antigen encapsulated into alginate-coated chitosan nanoparticles. Eur J Pharm Sci 32:278–290
    • (2007) Eur J Pharm Sci , vol.32 , pp. 278-290
    • Borges, O.1    Tavares, J.2    De Sousa, A.3    Borchard, G.4    Junginger, H.E.5    Cordeiro-Da-Silva, A.6
  • 13
    • 43249088985 scopus 로고    scopus 로고
    • Immune response by nasal delivery of hepatitis B surface antigen and codelivery of a CpG ODN in alginate coated chitosan nanoparticles
    • Borges O, Cordeiro-da-Silva A, Tavares J, Santarem N, de Sousa A, Borchard G, Junginger HE (2008) Immune response by nasal delivery of hepatitis B surface antigen and codelivery of a CpG ODN in alginate coated chitosan nanoparticles. Eur J Pharm Biopharm 69:405–416
    • (2008) Eur J Pharm Biopharm , vol.69 , pp. 405-416
    • Borges, O.1    Cordeiro-Da-Silva, A.2    Tavares, J.3    Santarem, N.4    De Sousa, A.5    Borchard, G.6    Junginger, H.E.7
  • 16
    • 74649084593 scopus 로고    scopus 로고
    • The ABC of clinical and experimental adjuvants–a brief overview
    • Brunner R, Jensen-Jarolim E, Pali-Scholl I (2010) The ABC of clinical and experimental adjuvants–a brief overview. Immunol Lett 128:29–35
    • (2010) Immunol Lett , vol.128 , pp. 29-35
    • Brunner, R.1    Jensen-Jarolim, E.2    Pali-Scholl, I.3
  • 17
    • 84871269972 scopus 로고    scopus 로고
    • Evaluation of TLR agonists as potential mucosal adjuvants for HIV gp140 and tetanus toxoid in mice
    • Buffa V, Klein K, Fischetti L, Shattock RJ (2012) Evaluation of TLR agonists as potential mucosal adjuvants for HIV gp140 and tetanus toxoid in mice. Plos One 7:e50529
    • (2012) Plos One , vol.7
    • Buffa, V.1    Klein, K.2    Fischetti, L.3    Shattock, R.J.4
  • 19
    • 0030891509 scopus 로고    scopus 로고
    • Humoral, mucosal, and cellular immunity in response to a human immunodeficiency virus type 1 immunogen expressed by a Venezuelan equine encephalitis virus vaccine vector
    • Caley IJ, Betts MR, Irlbeck DM, Davis NL, Swanstrom R, Frelinger JA, Johnston RE (1997) Humoral, mucosal, and cellular immunity in response to a human immunodeficiency virus type 1 immunogen expressed by a Venezuelan equine encephalitis virus vaccine vector. J Virol 71:3031–3038
    • (1997) J Virol , vol.71 , pp. 3031-3038
    • Caley, I.J.1    Betts, M.R.2    Irlbeck, D.M.3    Davis, N.L.4    Swanstrom, R.5    Frelinger, J.A.6    Johnston, R.E.7
  • 21
    • 0026654831 scopus 로고
    • Enhanced secretory IgA and systemic IgG antibody responses after oral immunization with biodegradable microparticles containing antigen
    • Challacombe SJ, Rahman D, Jeffery H, Davis SS, O’Hagan DT (1992) Enhanced secretory IgA and systemic IgG antibody responses after oral immunization with biodegradable microparticles containing antigen. Immunology 76:164–168
    • (1992) Immunology , vol.76 , pp. 164-168
    • Challacombe, S.J.1    Rahman, D.2    Jeffery, H.3    Davis, S.S.4    O’hagan, D.T.5
  • 22
    • 77951461235 scopus 로고    scopus 로고
    • Assessment of gold nanoparticles as a size-dependent vaccine carrier for enhancing the antibody response against synthetic foot-and-mouth disease virus peptide
    • Chen YS, Hung YC, Lin WH, Huang GS (2010) Assessment of gold nanoparticles as a size-dependent vaccine carrier for enhancing the antibody response against synthetic foot-and-mouth disease virus peptide. Nanotechnology 21:195101
    • (2010) Nanotechnology , vol.21
    • Chen, Y.S.1    Hung, Y.C.2    Lin, W.H.3    Huang, G.S.4
  • 23
    • 79251471424 scopus 로고    scopus 로고
    • Improved antigen cross-presentation by polyethyleneiminebased nanoparticles
    • Chen J, Li Z, Huang H, Yang Y, Ding Q, Mai J, Guo W, Xu Y (2011) Improved antigen cross-presentation by polyethyleneiminebased nanoparticles. Int J Nanomed 6:77–84
    • (2011) Int J Nanomed , vol.6 , pp. 77-84
    • Chen, J.1    Li, Z.2    Huang, H.3    Yang, Y.4    Ding, Q.5    Mai, J.6    Guo, W.7    Xu, Y.8
  • 24
    • 0035851035 scopus 로고    scopus 로고
    • Targeting polymerised liposome vaccine carriers to intestinal M cells
    • Clark MA, Blair H, Liang L, Brey RN, Brayden D, Hirst BH (2001) Targeting polymerised liposome vaccine carriers to intestinal M cells. Vaccine 20:208–217
    • (2001) Vaccine , vol.20 , pp. 208-217
    • Clark, M.A.1    Blair, H.2    Liang, L.3    Brey, R.N.4    Brayden, D.5    Hirst, B.H.6
  • 25
  • 26
    • 67349170777 scopus 로고    scopus 로고
    • Alpha-galactosylceramide is an effective mucosal adjuvant for repeated intranasal or oral delivery of HIV peptide antigens
    • Courtney AN, Nehete PN, Nehete BR, Thapa P, Zhou DP, Sastry KJ (2009) Alpha-galactosylceramide is an effective mucosal adjuvant for repeated intranasal or oral delivery of HIV peptide antigens. Vaccine 27:3335–3341
    • (2009) Vaccine , vol.27 , pp. 3335-3341
    • Courtney, A.N.1    Nehete, P.N.2    Nehete, B.R.3    Thapa, P.4    Zhou, D.P.5    Sastry, K.J.6
  • 27
    • 33646541417 scopus 로고    scopus 로고
    • Adjuvants modulating mucosal immune responses or directing systemic responses towards the mucosa
    • Cox E, Verdonck F, Vanrompay D, Goddeeris B (2006) Adjuvants modulating mucosal immune responses or directing systemic responses towards the mucosa. Vet Res 37:511–539
    • (2006) Vet Res , vol.37 , pp. 511-539
    • Cox, E.1    Verdonck, F.2    Vanrompay, D.3    Goddeeris, B.4
  • 29
  • 31
    • 84903381095 scopus 로고    scopus 로고
    • From empiricism to rational design: A personal perspective of the evolution of vaccine development
    • De Gregorio E, Rappuoli R (2014) From empiricism to rational design: a personal perspective of the evolution of vaccine development. Nat Rev Immunol 14:505–514
    • (2014) Nat Rev Immunol , vol.14 , pp. 505-514
    • De Gregorio, E.1    Rappuoli, R.2
  • 32
    • 33846138309 scopus 로고    scopus 로고
    • Controlled delivery of peptides and proteins
    • Degim IT, Celebi N (2007) Controlled delivery of peptides and proteins. Curr Pharm Des 13:99–117
    • (2007) Curr Pharm Des , vol.13 , pp. 99-117
    • Degim, I.T.1    Celebi, N.2
  • 33
    • 79956114010 scopus 로고    scopus 로고
    • Pathogen-associated molecular patterns on biomaterials: A paradigm for engineering new vaccines
    • Demento SL, Siefert AL, Bandyopadhyay A, Sharp FA, Fahmy TM (2011) Pathogen-associated molecular patterns on biomaterials: a paradigm for engineering new vaccines. Trends Biotechnol 29:294–306
    • (2011) Trends Biotechnol , vol.29 , pp. 294-306
    • Demento, S.L.1    Siefert, A.L.2    Bandyopadhyay, A.3    Sharp, F.A.4    Fahmy, T.M.5
  • 34
    • 77953710988 scopus 로고    scopus 로고
    • Molecular and structural characterization of the L1 virus-like particles that are used as vaccine antigens in Cervarix (TM), the AS04-adjuvanted HPV-16 and-18 cervical cancer vaccine
    • Deschuyteneer M, Elouahabi A, Plainchamp D, Plisnier M, Soete D, Corazza Y, Lockman L, Giannini S, Deschamps M (2010) Molecular and structural characterization of the L1 virus-like particles that are used as vaccine antigens in Cervarix (TM), the AS04-adjuvanted HPV-16 and-18 cervical cancer vaccine. Hum Vaccines 6:407–419
    • (2010) Hum Vaccines , vol.6 , pp. 407-419
    • Deschuyteneer, M.1    Elouahabi, A.2    Plainchamp, D.3    Plisnier, M.4    Soete, D.5    Corazza, Y.6    Lockman, L.7    Giannini, S.8    Deschamps, M.9
  • 35
    • 84861990084 scopus 로고    scopus 로고
    • Crossing the barrier: Targeting epithelial receptors for enhanced oral vaccine delivery
    • Devriendt B, De Geest BG, Goddeeris BM, Cox E (2012) Crossing the barrier: targeting epithelial receptors for enhanced oral vaccine delivery. J Control Release 160:431–439
    • (2012) J Control Release , vol.160 , pp. 431-439
    • Devriendt, B.1    De Geest, B.G.2    Goddeeris, B.M.3    Cox, E.4
  • 37
    • 33947189535 scopus 로고    scopus 로고
    • Receptor-binding domain of SARS-CoV spike protein induces long-term protective immunity in an animal model
    • Du L, Zhao G, He Y, Guo Y, Zheng BJ, Jiang S, Zhou Y (2007) Receptor-binding domain of SARS-CoV spike protein induces long-term protective immunity in an animal model. Vaccine 25:2832–2838
    • (2007) Vaccine , vol.25 , pp. 2832-2838
    • Du, L.1    Zhao, G.2    He, Y.3    Guo, Y.4    Zheng, B.J.5    Jiang, S.6    Zhou, Y.7
  • 38
    • 84891885053 scopus 로고    scopus 로고
    • A truncated receptor-binding domain of MERS-CoV spike protein potently inhibits MERS-CoV infection and induces strong neutralizing antibody responses: Implication for developing therapeutics and vaccines
    • Du L, Kou Z, Ma C, Tao X, Wang L, Zhao G, Chen Y, Yu F, Tseng CT, Zhou Y et al (2013a) A truncated receptor-binding domain of MERS-CoV spike protein potently inhibits MERS-CoV infection and induces strong neutralizing antibody responses: implication for developing therapeutics and vaccines. PLoS One 8:e81587
    • (2013) Plos One , vol.8
    • Du, L.1    Kou, Z.2    Ma, C.3    Tao, X.4    Wang, L.5    Zhao, G.6    Chen, Y.7    Yu, F.8    Tseng, C.T.9    Zhou, Y.10
  • 39
    • 84883286587 scopus 로고    scopus 로고
    • Identification of a receptorbinding domain in the S protein of the novel human coronavirus Middle East respiratory syndrome coronavirus as an essential target for vaccine development
    • Du L, Zhao G, Kou Z, Ma C, Sun S, Poon VK, Lu L, Wang L, Debnath AK, Zheng BJ et al (2013b) Identification of a receptorbinding domain in the S protein of the novel human coronavirus Middle East respiratory syndrome coronavirus as an essential target for vaccine development. J Virol 87:9939–9942
    • (2013) J Virol , vol.87 , pp. 9939-9942
    • Du, L.1    Zhao, G.2    Kou, Z.3    Ma, C.4    Sun, S.5    Poon, V.K.6    Lu, L.7    Wang, L.8    Debnath, A.K.9    Zheng, B.J.10
  • 40
    • 0035825599 scopus 로고    scopus 로고
    • Oligonucleotide containing CpG motifs enhances immune response to mucosally or systemically administered tetanus toxoid
    • Eastcott JW, Holmberg CJ, Dewhirst FE, Esch TR, Smith DJ, Taubman MA (2001) Oligonucleotide containing CpG motifs enhances immune response to mucosally or systemically administered tetanus toxoid. Vaccine 19:1636–1642
    • (2001) Vaccine , vol.19 , pp. 1636-1642
    • Eastcott, J.W.1    Holmberg, C.J.2    Dewhirst, F.E.3    Esch, T.R.4    Smith, D.J.5    Taubman, M.A.6
  • 41
    • 34948813217 scopus 로고    scopus 로고
    • The bacterial second messenger cdiGMP exhibits promising activity as a mucosal adjuvant
    • Ebensen T, Schulze K, Riese P, Morr M, Guzman CA (2007) The bacterial second messenger cdiGMP exhibits promising activity as a mucosal adjuvant. Clin Vaccine Immunol 14:952–958
    • (2007) Clin Vaccine Immunol , vol.14 , pp. 952-958
    • Ebensen, T.1    Schulze, K.2    Riese, P.3    Morr, M.4    Guzman, C.A.5
  • 42
    • 79960291542 scopus 로고    scopus 로고
    • Bis-(3’,5’)-cyclic dimeric adenosine monophosphate: Strong Th1/Th2/Th17 promoting mucosal adjuvant
    • Ebensen T, Libanova R, Schulze K, Yevsa T, Morr M, Guzman CA (2011) Bis-(3’,5’)-cyclic dimeric adenosine monophosphate: strong Th1/Th2/Th17 promoting mucosal adjuvant. Vaccine 29:5210–5220
    • (2011) Vaccine , vol.29 , pp. 5210-5220
    • Ebensen, T.1    Libanova, R.2    Schulze, K.3    Yevsa, T.4    Morr, M.5    Guzman, C.A.6
  • 43
    • 34247569871 scopus 로고    scopus 로고
    • Pathogen-mimicking nanoparticles for vaccine delivery to dendritic cells
    • Elamanchili P, Lutsiak CM, Hamdy S, Diwan M, Samuel J (2007) “Pathogen-mimicking” nanoparticles for vaccine delivery to dendritic cells. J Immunother 30:378–395
    • (2007) J Immunother , vol.30 , pp. 378-395
    • Elamanchili, P.1    Lutsiak, C.M.2    Hamdy, S.3    Diwan, M.4    Samuel, J.5
  • 44
    • 15544389510 scopus 로고    scopus 로고
    • Efficacy of a saponin-adjuvanted inactivated respiratory syncytial virus vaccine in calves
    • Ellis JA, West KH, Waldner C, Rhodes C (2005) Efficacy of a saponin-adjuvanted inactivated respiratory syncytial virus vaccine in calves. Can Vet J 46:155–162
    • (2005) Can Vet J , vol.46 , pp. 155-162
    • Ellis, J.A.1    West, K.H.2    Waldner, C.3    Rhodes, C.4
  • 45
    • 0032054624 scopus 로고    scopus 로고
    • Intra nasal administration of poly-lactic acid microsphere co-encapsulated Yersinia pestis subunits confers protection from pneumonic plague in the mouse
    • Eyles JE, Sharp GJ, Williamson ED, Spiers ID, Alpar HO (1998) Intra nasal administration of poly-lactic acid microsphere co-encapsulated Yersinia pestis subunits confers protection from pneumonic plague in the mouse. Vaccine 16:698–707
    • (1998) Vaccine , vol.16 , pp. 698-707
    • Eyles, J.E.1    Sharp, G.J.2    Williamson, E.D.3    Spiers, I.D.4    Alpar, H.O.5
  • 46
    • 0033971133 scopus 로고    scopus 로고
    • Generation of protective immune responses to plague by mucosal administration of microsphere coencapsulated recombinant subunits
    • Eyles JE, Williamson ED, Spiers ID, Stagg AJ, Jones SM, Alpar HO (2000) Generation of protective immune responses to plague by mucosal administration of microsphere coencapsulated recombinant subunits. J Control Release 63:191–200
    • (2000) J Control Release , vol.63 , pp. 191-200
    • Eyles, J.E.1    Williamson, E.D.2    Spiers, I.D.3    Stagg, A.J.4    Jones, S.M.5    Alpar, H.O.6
  • 47
    • 57549114032 scopus 로고    scopus 로고
    • The enhancement of the immune response against S. Equi antigens through the intranasal administration of poly-epsiloncaprolactone- based nanoparticles
    • Florindo HF, Pandit S, Lacerda L, Goncalves LMD, Alpar HO, Almeida AJ (2009) The enhancement of the immune response against S. equi antigens through the intranasal administration of poly-epsiloncaprolactone- based nanoparticles. Biomaterials 30:879–891
    • (2009) Biomaterials , vol.30 , pp. 879-891
    • Florindo, H.F.1    Pandit, S.2    Lacerda, L.3    Goncalves, L.4    Alpar, H.O.5    Almeida, A.J.6
  • 48
    • 80052028524 scopus 로고    scopus 로고
    • Current status of multiple antigenpresenting peptide vaccine systems: Application of organic and inorganic nanoparticles
    • Fujita Y, Taguchi H (2011) Current status of multiple antigenpresenting peptide vaccine systems: application of organic and inorganic nanoparticles. Chem Cent J 5:48
    • (2011) Chem Cent J , vol.5
    • Fujita, Y.1    Taguchi, H.2
  • 49
    • 84895506447 scopus 로고    scopus 로고
    • An overview of adjuvant formulations and delivery systems
    • Garcia A, De Sanctis JB (2014) An overview of adjuvant formulations and delivery systems. APMIS 122:257–267
    • (2014) APMIS , vol.122 , pp. 257-267
    • Garcia, A.1    De Sanctis, J.B.2
  • 50
    • 84862646294 scopus 로고    scopus 로고
    • Chitosan-based drug nanocarriers: Where do we stand?
    • Garcia-Fuentes M, Alonso MJ (2012) Chitosan-based drug nanocarriers: where do we stand? J Control Release 161:496–504
    • (2012) J Control Release , vol.161 , pp. 496-504
    • Garcia-Fuentes, M.1    Alonso, M.J.2
  • 52
    • 27644592654 scopus 로고    scopus 로고
    • Recombinant poxviruses as mucosal vaccine vectors
    • Gherardi MM, Esteban M (2005) Recombinant poxviruses as mucosal vaccine vectors. J Gen Virol 86:2925–2936
    • (2005) J Gen Virol , vol.86 , pp. 2925-2936
    • Gherardi, M.M.1    Esteban, M.2
  • 53
    • 69549119855 scopus 로고    scopus 로고
    • Fc receptortargeted mucosal vaccination as a novel strategy for the generation of enhanced immunity against mucosal and nonmucosal pathogens
    • Gosselin EJ, Bitsaktsis C, Li Y, Iglesias BV (2009) Fc receptortargeted mucosal vaccination as a novel strategy for the generation of enhanced immunity against mucosal and nonmucosal pathogens. Arch Immunol Ther Exp (Warsz) 57:311–323
    • (2009) Arch Immunol Ther Exp (Warsz) , vol.57 , pp. 311-323
    • Gosselin, E.J.1    Bitsaktsis, C.2    Li, Y.3    Iglesias, B.V.4
  • 54
    • 84888011629 scopus 로고    scopus 로고
    • A decade after SARS: Strategies for controlling emerging coronaviruses
    • Graham RL, Donaldson EF, Baric RS (2013) A decade after SARS: strategies for controlling emerging coronaviruses. Nat Rev Microbiol 11:836–848
    • (2013) Nat Rev Microbiol , vol.11 , pp. 836-848
    • Graham, R.L.1    Donaldson, E.F.2    Baric, R.S.3
  • 55
    • 33748794562 scopus 로고    scopus 로고
    • Virus-like particles: Passport to immune recognition
    • Grgacic EV, Anderson DA (2006) Virus-like particles: passport to immune recognition. Methods 40:60–65
    • (2006) Methods , vol.40 , pp. 60-65
    • Grgacic, E.V.1    Erson, D.A.2
  • 56
    • 0034802009 scopus 로고    scopus 로고
    • Recombinant Norwalk virus-like particles administered intranasally to mice induce systemic and mucosal (Fecal and vaginal) immune responses
    • Guerrero RA, Ball JM, Krater SS, Pacheco SE, Clements JD, Estes MK (2001) Recombinant Norwalk virus-like particles administered intranasally to mice induce systemic and mucosal (fecal and vaginal) immune responses. J Virol 75:9713–9722
    • (2001) J Virol , vol.75 , pp. 9713-9722
    • Guerrero, R.A.1    Ball, J.M.2    Krater, S.S.3    Pacheco, S.E.4    Clements, J.D.5    Estes, M.K.6
  • 57
    • 36749076604 scopus 로고    scopus 로고
    • M-cell targeted biodegradable PLGA nanoparticles for oral immunization against hepatitis B
    • Gupta PN, Khatri K, Goyal AK, Mishra N, Vyas SP (2007) M-cell targeted biodegradable PLGA nanoparticles for oral immunization against hepatitis B. J Drug Target 15:701–713
    • (2007) J Drug Target , vol.15 , pp. 701-713
    • Gupta, P.N.1    Khatri, K.2    Goyal, A.K.3    Mishra, N.4    Vyas, S.P.5
  • 58
    • 80052270541 scopus 로고    scopus 로고
    • Targeting dendritic cells with nano-particulate PLGA cancer vaccine formulations
    • Hamdy S, Haddadi A, Hung RW, Lavasanifar A (2011) Targeting dendritic cells with nano-particulate PLGA cancer vaccine formulations. Adv Drug Deliv Rev 63:943–955
    • (2011) Adv Drug Deliv Rev , vol.63 , pp. 943-955
    • Hamdy, S.1    Haddadi, A.2    Hung, R.W.3    Lavasanifar, A.4
  • 59
    • 0035889935 scopus 로고    scopus 로고
    • HIV mucosal vaccine: Nasal immunization with rBCG-V3J1 induces a long term V3J1 peptide-specific neutralizing immunity in Th1- and Th2-deficient conditions
    • Hiroi T, Goto H, Someya K, Yanagita M, Honda M, Yamanaka N, Kiyono H (2001) HIV mucosal vaccine: nasal immunization with rBCG-V3J1 induces a long term V3J1 peptide-specific neutralizing immunity in Th1- and Th2-deficient conditions. J Immunol 167:5862–5867
    • (2001) J Immunol , vol.167 , pp. 5862-5867
    • Hiroi, T.1    Goto, H.2    Someya, K.3    Yanagita, M.4    Honda, M.5    Yamanaka, N.6    Kiyono, H.7
  • 60
    • 17644371966 scopus 로고    scopus 로고
    • Mucosal immunity and vaccines
    • Holmgren J, Czerkinsky C (2005) Mucosal immunity and vaccines. Nat Med 11:S45–53
    • (2005) Nat Med , vol.11
    • Holmgren, J.1    Czerkinsky, C.2
  • 61
    • 0031902954 scopus 로고    scopus 로고
    • The immunostimulating complex (ISCOM) is an efficient mucosal delivery system for respiratory syncytial virus (RSV) envelope antigens inducing high local and systemic antibody responses
    • Hu KF, Elvander M, Merza M, Akerblom L, Brandenburg A, Morein B (1998) The immunostimulating complex (ISCOM) is an efficient mucosal delivery system for respiratory syncytial virus (RSV) envelope antigens inducing high local and systemic antibody responses. Clin Exp Immunol 113:235–243
    • (1998) Clin Exp Immunol , vol.113 , pp. 235-243
    • Hu, K.F.1    Elvander, M.2    Merza, M.3    Akerblom, L.4    Brandenburg, A.5    Morein, B.6
  • 62
    • 0035940308 scopus 로고    scopus 로고
    • Immunostimulating complexes (ISCOMs) for nasal vaccination
    • Hu KF, Lovgren-Bengtsson K, Morein B (2001) Immunostimulating complexes (ISCOMs) for nasal vaccination. Adv Drug Deliv Rev 51:149–159
    • (2001) Adv Drug Deliv Rev , vol.51 , pp. 149-159
    • Hu, K.F.1    Lovgren-Bengtsson, K.2    Morein, B.3
  • 63
    • 58449100288 scopus 로고    scopus 로고
    • A novel replication-competent vaccinia vector MVTT is superior to MVA for inducing high levels of neutralizing antibody via mucosal vaccination
    • Huang X, Lu B, Yu W, Fang Q, Liu L, Zhuang K, Shen T, Wang H, Tian P, Zhang L et al (2009) A novel replication-competent vaccinia vector MVTT is superior to MVA for inducing high levels of neutralizing antibody via mucosal vaccination. PLoS One 4: e4180
    • (2009) Plos One , vol.4
    • Huang, X.1    Lu, B.2    Yu, W.3    Fang, Q.4    Liu, L.5    Zhuang, K.6    Shen, T.7    Wang, H.8    Tian, P.9    Zhang, L.10
  • 69
    • 77949269003 scopus 로고    scopus 로고
    • Mucosal adjuvant activity of oligomannosecoated liposomes for nasal immunization
    • Ishii M, Kojima N (2010) Mucosal adjuvant activity of oligomannosecoated liposomes for nasal immunization. Glycoconj J 27:115–123
    • (2010) Glycoconj J , vol.27 , pp. 115-123
    • Ishii, M.1    Kojima, N.2
  • 70
    • 70349943834 scopus 로고    scopus 로고
    • STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
    • Ishikawa H, Ma Z, Barber GN (2009) STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity. Nature 461:788–792
    • (2009) Nature , vol.461 , pp. 788-792
    • Ishikawa, H.1    Ma, Z.2    Barber, G.N.3
  • 71
    • 33646139149 scopus 로고    scopus 로고
    • Strong systemic and mucosal immune responses to surface-modified PLGA microspheres containing recombinant hepatitis B antigen administered intranasally
    • Jaganathan KS, Vyas SP (2006) Strong systemic and mucosal immune responses to surface-modified PLGA microspheres containing recombinant hepatitis B antigen administered intranasally. Vaccine 24:4201–4211
    • (2006) Vaccine , vol.24 , pp. 4201-4211
    • Jaganathan, K.S.1    Vyas, S.P.2
  • 72
    • 16244384193 scopus 로고    scopus 로고
    • Development of a single dose tetanus toxoid formulation based on polymeric microspheres: A comparative study of poly(D, L-lactic-co-glycolic acid) versus chitosan microspheres
    • Jaganathan KS, Rao YU, Singh P, Prabakaran D, Gupta S, Jain A, Vyas SP (2005) Development of a single dose tetanus toxoid formulation based on polymeric microspheres: a comparative study of poly(D, L-lactic-co-glycolic acid) versus chitosan microspheres. Int J Pharm 294:23–32
    • (2005) Int J Pharm , vol.294 , pp. 23-32
    • Jaganathan, K.S.1    Rao, Y.U.2    Singh, P.3    Prabakaran, D.4    Gupta, S.5    Jain, A.6    Vyas, S.P.7
  • 73
    • 77649180085 scopus 로고    scopus 로고
    • PEG-PLA-PEG block copolymeric nanoparticles for oral immunization against hepatitis B
    • Jain AK, Goyal AK, Mishra N, Vaidya B, Mangal S, Vyas SP (2010) PEG-PLA-PEG block copolymeric nanoparticles for oral immunization against hepatitis B. Int J Pharm 387:253–262
    • (2010) Int J Pharm , vol.387 , pp. 253-262
    • Jain, A.K.1    Goyal, A.K.2    Mishra, N.3    Vaidya, B.4    Mangal, S.5    Vyas, S.P.6
  • 74
    • 84895068018 scopus 로고    scopus 로고
    • Improved stability and immunological potential of tetanus toxoid containing surface engineered bilosomes following oral administration
    • Jain S, Harde H, Indulkar A, Agrawal AK (2014) Improved stability and immunological potential of tetanus toxoid containing surface engineered bilosomes following oral administration. Nanomedicine 10:431–440
    • (2014) Nanomedicine , vol.10 , pp. 431-440
    • Jain, S.1    Harde, H.2    Indulkar, A.3    Agrawal, A.K.4
  • 76
    • 84891373866 scopus 로고    scopus 로고
    • Targeted oral delivery of BmpB vaccine using porous PLGA microparticles coated with M cell homing peptide-coupled chitosan
    • Jiang T, Singh B, Li HS, Kim YK, Kang SK, Nah JW, Choi YJ, Cho CS (2014) Targeted oral delivery of BmpB vaccine using porous PLGA microparticles coated with M cell homing peptide-coupled chitosan. Biomaterials 35:2365–2373
    • (2014) Biomaterials , vol.35 , pp. 2365-2373
    • Jiang, T.1    Singh, B.2    Li, H.S.3    Kim, Y.K.4    Kang, S.K.5    Nah, J.W.6    Choi, Y.J.7    Cho, C.S.8
  • 78
    • 4444381770 scopus 로고    scopus 로고
    • Intranasal immunization with inactivated influenza virus enhances immune responses to coadministered simian-human immunodeficiency virus-like particle antigens
    • Kang SM, Guo L, Yao Q, Skountzou I, Compans RW (2004) Intranasal immunization with inactivated influenza virus enhances immune responses to coadministered simian-human immunodeficiency virus-like particle antigens. J Virol 78:9624–9632
    • (2004) J Virol , vol.78 , pp. 9624-9632
    • Kang, S.M.1    Guo, L.2    Yao, Q.3    Skountzou, I.4    Compans, R.W.5
  • 79
    • 34249677845 scopus 로고    scopus 로고
    • Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists
    • Kanzler H, Barrat FJ, Hessel EM, Coffman RL (2007) Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists. Nat Med 13:552–559
    • (2007) Nat Med , vol.13 , pp. 552-559
    • Kanzler, H.1    Barrat, F.J.2    Hessel, E.M.3    Coffman, R.L.4
  • 80
    • 0348078301 scopus 로고    scopus 로고
    • Antigen-specific IgA and IgG responses in calves inoculated intranasally with ovalbumin encapsulated in poly(DL-lactide-coglycolide) microspheres
    • Kavanagh OV, Earley B, Murray M, Foster CJ, Adair BM (2003) Antigen-specific IgA and IgG responses in calves inoculated intranasally with ovalbumin encapsulated in poly(DL-lactide-coglycolide) microspheres. Vaccine 21:4472–4480
    • (2003) Vaccine , vol.21 , pp. 4472-4480
    • Kavanagh, O.V.1    Earley, B.2    Murray, M.3    Foster, C.J.4    Adair, B.M.5
  • 81
    • 84876147378 scopus 로고    scopus 로고
    • Local and systemic immune responses in mice to intranasal delivery of peptides representing bovine respiratory syncytial virus epitopes encapsulated in poly (DL-lactide-co-glycolide) microparticles
    • Kavanagh OV, Adair BM, Welsh MD, Earley B (2013) Local and systemic immune responses in mice to intranasal delivery of peptides representing bovine respiratory syncytial virus epitopes encapsulated in poly (DL-lactide-co-glycolide) microparticles. Res Vet Sci 94:809–812
    • (2013) Res Vet Sci , vol.94 , pp. 809-812
    • Kavanagh, O.V.1    Adair, B.M.2    Welsh, M.D.3    Earley, B.4
  • 86
    • 69249145293 scopus 로고    scopus 로고
    • Th17 cells at the crossroads of innate and adaptive immunity against infectious diseases at the mucosa
    • Khader SA, Gaffen SL, Kolls JK (2009) Th17 cells at the crossroads of innate and adaptive immunity against infectious diseases at the mucosa. Mucosal Immunol 2:403–411
    • (2009) Mucosal Immunol , vol.2 , pp. 403-411
    • Khader, S.A.1    Gaffen, S.L.2    Kolls, J.K.3
  • 87
    • 33646569394 scopus 로고    scopus 로고
    • Identification of a peptide enhancing mucosal and systemic immune responses against EGFP after oral administration in mice
    • Kim SH, Lee KY, Kim J, Park SM, Park BK, Jang YS (2006) Identification of a peptide enhancing mucosal and systemic immune responses against EGFP after oral administration in mice. Mol Cells 21:244–250
    • (2006) Mol Cells , vol.21 , pp. 244-250
    • Kim, S.H.1    Lee, K.Y.2    Kim, J.3    Park, S.M.4    Park, B.K.5    Jang, Y.S.6
  • 88
    • 78650662147 scopus 로고    scopus 로고
    • The M celltargeting ligand promotes antigen delivery and induces antigenspecific immune responses in mucosal vaccination
    • Kim SH, Seo KW, Kim J, Lee KY, Jang YS (2010) The M celltargeting ligand promotes antigen delivery and induces antigenspecific immune responses in mucosal vaccination. J Immunol 185:5787–5795
    • (2010) J Immunol , vol.185 , pp. 5787-5795
    • Kim, S.H.1    Seo, K.W.2    Kim, J.3    Lee, K.Y.4    Jang, Y.S.5
  • 89
  • 90
    • 77955270464 scopus 로고    scopus 로고
    • Nanotechnology-based manipulation of dendritic cells for enhanced immunotherapy strategies
    • Klippstein R, Pozo D (2010) Nanotechnology-based manipulation of dendritic cells for enhanced immunotherapy strategies. Nanomedicine 6:523–529
    • (2010) Nanomedicine , vol.6 , pp. 523-529
    • Klippstein, R.1    Pozo, D.2
  • 95
    • 0020080103 scopus 로고
    • The newly licensed hepatitis B vaccine. Characteristics and indications for use
    • Krugman S (1982) The newly licensed hepatitis B vaccine. Characteristics and indications for use. JAMA 247:2012–2015
    • (1982) JAMA , vol.247 , pp. 2012-2015
    • Krugman, S.1
  • 96
    • 1942510862 scopus 로고    scopus 로고
    • A corn-based delivery system for animal vaccines: An oral transmissible gastroenteritis virus vaccine boosts lactogenic immunity in swine
    • Lamphear BJ, Jilka JM, Kesl L, Welter M, Howard JA, Streatfield SJ (2004) A corn-based delivery system for animal vaccines: an oral transmissible gastroenteritis virus vaccine boosts lactogenic immunity in swine. Vaccine 22:2420–2424
    • (2004) Vaccine , vol.22 , pp. 2420-2424
    • Lamphear, B.J.1    Jilka, J.M.2    Kesl, L.3    Welter, M.4    Howard, J.A.5    Streatfield, S.J.6
  • 97
    • 79957725162 scopus 로고    scopus 로고
    • Defending the mucosa: Adjuvant and carrier formulations for mucosal immunity
    • Lawson LB, Norton EB, Clements JD (2011) Defending the mucosa: adjuvant and carrier formulations for mucosal immunity. Curr Opin Immunol 23:414–420
    • (2011) Curr Opin Immunol , vol.23 , pp. 414-420
    • Lawson, L.B.1    Norton, E.B.2    Clements, J.D.3
  • 99
    • 34247484942 scopus 로고    scopus 로고
    • Long-lasting protection against canine visceral leishmaniasis using the LiESAp-MDP vaccine in endemic areas of France: Double-blind randomised efficacy field trial
    • Lemesre JL, Holzmuller P, Goncalves RB, Bourdoiseau G, Hugnet C, Cavaleyra M, Papierok G (2007) Long-lasting protection against canine visceral leishmaniasis using the LiESAp-MDP vaccine in endemic areas of France: double-blind randomised efficacy field trial. Vaccine 25:4223–4234
    • (2007) Vaccine , vol.25 , pp. 4223-4234
    • Lemesre, J.L.1    Holzmuller, P.2    Goncalves, R.B.3    Bourdoiseau, G.4    Hugnet, C.5    Cavaleyra, M.6    Papierok, G.7
  • 100
    • 70349621646 scopus 로고    scopus 로고
    • Transient facial nerve paralysis (Bell’s palsy) following intranasal delivery of a genetically detoxified mutant of Escherichia coli heat labile toxin
    • Lewis DJ, Huo Z, Barnett S, Kromann I, Giemza R, Galiza E, Woodrow M, Thierry-Carstensen B, Andersen P, Novicki D et al (2009) Transient facial nerve paralysis (Bell’s palsy) following intranasal delivery of a genetically detoxified mutant of Escherichia coli heat labile toxin. PLoS One 4:e6999
    • (2009) Plos One , vol.4
    • Lewis, D.J.1    Huo, Z.2    Barnett, S.3    Kromann, I.4    Giemza, R.5    Galiza, E.6    Woodrow, M.7    Thierry-Carstensen, B.8    Ersen, P.9    Novicki, D.10
  • 101
    • 84864297173 scopus 로고    scopus 로고
    • Microparticle surface modifications targeting dendritic cells for non-activating applications
    • Lewis JS, Zaveri TD, Crooks CP 2nd, Keselowsky BG (2012) Microparticle surface modifications targeting dendritic cells for non-activating applications. Biomaterials 33:7221–7232
    • (2012) Biomaterials , vol.33 , pp. 7221-7232
    • Lewis, J.S.1    Zaveri, T.D.2    Crooks, C.P.3    Keselowsky, B.G.4
  • 102
    • 0035858098 scopus 로고    scopus 로고
    • Oral administration of hepatitis E virus-like particles induces a systemic and mucosal immune response in mice
    • Li T, Takeda N, Miyamura T (2001) Oral administration of hepatitis E virus-like particles induces a systemic and mucosal immune response in mice. Vaccine 19:3476–3484
    • (2001) Vaccine , vol.19 , pp. 3476-3484
    • Li, T.1    Takeda, N.2    Miyamura, T.3
  • 104
    • 83655197404 scopus 로고    scopus 로고
    • Preparation and investigation of Ulex europaeus agglutinin I-conjugated liposomes as potential oral vaccine carriers
    • Li K, Chen D, Zhao X, Hu H, Yang C, Pang D (2011a) Preparation and investigation of Ulex europaeus agglutinin I-conjugated liposomes as potential oral vaccine carriers. Arch Pharm Res 34:1899–1907
    • (2011) Arch Pharm Res , vol.34 , pp. 1899-1907
    • Li, K.1    Chen, D.2    Zhao, X.3    Hu, H.4    Yang, C.5    Pang, D.6
  • 105
    • 79955613203 scopus 로고    scopus 로고
    • Application of Ulex europaeus agglutinin I-modified liposomes for oral vaccine: Ex Vivo bioadhesion and in Vivo immunity
    • Li K, Zhao X, Xu S, Pang D, Yang C, Chen D (2011b) Application of Ulex europaeus agglutinin I-modified liposomes for oral vaccine: Ex Vivo bioadhesion and in Vivo immunity. Chem Pharm Bull (Tokyo) 59:618–623
    • (2011) Chem Pharm Bull (Tokyo) , vol.59 , pp. 618-623
    • Li, K.1    Zhao, X.2    Xu, S.3    Pang, D.4    Yang, C.5    Chen, D.6
  • 106
    • 77950689915 scopus 로고    scopus 로고
    • The member of the cyclic dinucleotide family bis-(3′,5′)-cyclic dimeric inosine monophosphate exerts potent activity as mucosal adjuvant (vol 28, pg 2249, 2010)
    • Libanova R, Ebensen T, Schulze K, Bruhn D, Norder M, Yevsa T, Morr M, Guzman CA (2010) The member of the cyclic dinucleotide family bis-(3′,5′)-cyclic dimeric inosine monophosphate exerts potent activity as mucosal adjuvant (vol 28, pg 2249, 2010). Vaccine 28:3625–3625
    • (2010) Vaccine , vol.28
    • Libanova, R.1    Ebensen, T.2    Schulze, K.3    Bruhn, D.4    Norder, M.5    Yevsa, T.6    Morr, M.7    Guzman, C.A.8
  • 107
    • 0344009671 scopus 로고    scopus 로고
    • Oral colon-specific drug delivery for bee venom peptide: Development of a coated calcium alginate gel beads-entrapped liposome
    • Liu X, Chen DW, Xie LP, Zhang RQ (2003) Oral colon-specific drug delivery for bee venom peptide: development of a coated calcium alginate gel beads-entrapped liposome. J Control Release 93:293–300
    • (2003) J Control Release , vol.93 , pp. 293-300
    • Liu, X.1    Chen, D.W.2    Xie, L.P.3    Zhang, R.Q.4
  • 108
    • 79952831478 scopus 로고    scopus 로고
    • Epithelial cells lining salivary gland ducts are early target cells of severe acute respiratory syndrome coronavirus infection in the upper respiratory tracts of rhesus macaques
    • Liu L, Wei Q, Alvarez X, Wang H, Du Y, Zhu H, Jiang H, Zhou J, Lam P, Zhang L et al (2011) Epithelial cells lining salivary gland ducts are early target cells of severe acute respiratory syndrome coronavirus infection in the upper respiratory tracts of rhesus macaques. J Virol 85:4025–4030
    • (2011) J Virol , vol.85 , pp. 4025-4030
    • Liu, L.1    Wei, Q.2    Alvarez, X.3    Wang, H.4    Du, Y.5    Zhu, H.6    Jiang, H.7    Zhou, J.8    Lam, P.9    Zhang, L.10
  • 109
    • 84881479703 scopus 로고    scopus 로고
    • Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26
    • Lu G, Hu Y, Wang Q, Qi J, Gao F, Li Y, Zhang Y, Zhang W, Yuan Y, Bao J et al (2013) Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26. Nature 500:227–231
    • (2013) Nature , vol.500 , pp. 227-231
    • Lu, G.1    Hu, Y.2    Wang, Q.3    Qi, J.4    Gao, F.5    Li, Y.6    Zhang, Y.7    Zhang, W.8    Yuan, Y.9    Bao, J.10
  • 110
    • 84864338756 scopus 로고    scopus 로고
    • Recent progress in mucosal vaccine development: Potential and limitations
    • Lycke N (2012) Recent progress in mucosal vaccine development: potential and limitations. Nat Rev Immunol 12:592–605
    • (2012) Nat Rev Immunol , vol.12 , pp. 592-605
    • Lycke, N.1
  • 111
    • 84896545485 scopus 로고    scopus 로고
    • Intranasal vaccination with recombinant receptor-binding domain of MERS-CoV spike protein induces much stronger local mucosal immune responses than subcutaneous immunization: Implication for designing novel mucosal MERS vaccines
    • Ma C, Li Y, Wang L, Zhao G, Tao X, Tseng CT, Zhou Y, Du L, Jiang S (2014a) Intranasal vaccination with recombinant receptor-binding domain of MERS-CoV spike protein induces much stronger local mucosal immune responses than subcutaneous immunization: Implication for designing novel mucosal MERS vaccines. Vaccine 32:2100–2108
    • (2014) Vaccine , vol.32 , pp. 2100-2108
    • Ma, C.1    Li, Y.2    Wang, L.3    Zhao, G.4    Tao, X.5    Tseng, C.T.6    Zhou, Y.7    Du, L.8    Jiang, S.9
  • 112
    • 84905003150 scopus 로고    scopus 로고
    • M-cell targeted polymeric lipid nanoparticles containing a toll-like receptor agonist to boost oral immunity
    • Ma T, Wang L, Yang T, Ma G, Wang S (2014b) M-cell targeted polymeric lipid nanoparticles containing a toll-like receptor agonist to boost oral immunity. Int J Pharm 473:296–303
    • (2014) Int J Pharm , vol.473 , pp. 296-303
    • Ma, T.1    Wang, L.2    Yang, T.3    Ma, G.4    Wang, S.5
  • 114
    • 83155183262 scopus 로고    scopus 로고
    • Microfold-cell targeted surface engineered polymeric nanoparticles for oral immunization
    • Malik B, Goyal AK, Markandeywar TS, Rath G, Zakir F, Vyas SP (2012) Microfold-cell targeted surface engineered polymeric nanoparticles for oral immunization. J Drug Target 20:76–84
    • (2012) J Drug Target , vol.20 , pp. 76-84
    • Malik, B.1    Goyal, A.K.2    Markandeywar, T.S.3    Rath, G.4    Zakir, F.5    Vyas, S.P.6
  • 115
    • 0028049676 scopus 로고
    • Induction of mucosal and systemic immune responses by immunization with ovalbumin entrapped in poly(Lactide-co-glycolide) microparticles
    • Maloy KJ, Donachie AM, O’Hagan DT, Mowat AM (1994) Induction of mucosal and systemic immune responses by immunization with ovalbumin entrapped in poly(lactide-co-glycolide) microparticles. Immunology 81:661–667
    • (1994) Immunology , vol.81 , pp. 661-667
    • Maloy, K.J.1    Donachie, A.M.2    O’hagan, D.T.3    Mowat, A.M.4
  • 116
    • 31544434900 scopus 로고    scopus 로고
    • Oral delivery of tetanus toxoid using vesicles containing bile salts (Bilosomes) induces significant systemic and mucosal immunity
    • Mann JFS, Scales HE, Shakir E, Alexander J, Carter KC, Mullen AB, Ferro VA (2006) Oral delivery of tetanus toxoid using vesicles containing bile salts (bilosomes) induces significant systemic and mucosal immunity. Methods 38:90–95
    • (2006) Methods , vol.38 , pp. 90-95
    • Mann, J.1    Scales, H.E.2    Shakir, E.3    Alexander, J.4    Carter, K.C.5    Mullen, A.B.6    Ferro, V.A.7
  • 117
    • 67349098411 scopus 로고    scopus 로고
    • Lipid vesicle size of an oral influenza vaccine delivery vehicle influences the Th1/Th2 bias in the immune response and protection against infection
    • Mann JF, Shakir E, Carter KC, Mullen AB, Alexander J, Ferro VA (2009) Lipid vesicle size of an oral influenza vaccine delivery vehicle influences the Th1/Th2 bias in the immune response and protection against infection. Vaccine 27:3643–3649
    • (2009) Vaccine , vol.27 , pp. 3643-3649
    • Mann, J.F.1    Shakir, E.2    Carter, K.C.3    Mullen, A.B.4    Alexander, J.5    Ferro, V.A.6
  • 119
    • 84899907322 scopus 로고    scopus 로고
    • Intranasal delivery of nanoparticles encapsulating BPI3V proteins induces an early humoral immune response in mice
    • Mansoor F, Earley B, Cassidy JP, Markey B, Foster C, Doherty S, Welsh MD (2014) Intranasal delivery of nanoparticles encapsulating BPI3V proteins induces an early humoral immune response in mice. Res Vet Sci 96:551–557
    • (2014) Res Vet Sci , vol.96 , pp. 551-557
    • Mansoor, F.1    Earley, B.2    Cassidy, J.P.3    Markey, B.4    Foster, C.5    Doherty, S.6    Welsh, M.D.7
  • 121
    • 0141889064 scopus 로고    scopus 로고
    • Vaccine adjuvants: Role and mechanisms of action in vaccine immunogenicity
    • Marciani DJ (2003) Vaccine adjuvants: role and mechanisms of action in vaccine immunogenicity. Drug Discov Today 8:934–943
    • (2003) Drug Discov Today , vol.8 , pp. 934-943
    • Marciani, D.J.1
  • 122
    • 63149126030 scopus 로고    scopus 로고
    • Towards an understanding of the adjuvant action of aluminium
    • Marrack P, McKee AS, Munks MW (2009) Towards an understanding of the adjuvant action of aluminium. Nat Rev Immunol 9:287–293
    • (2009) Nat Rev Immunol , vol.9 , pp. 287-293
    • Marrack, P.1    McKee, A.S.2    Munks, M.W.3
  • 123
    • 0029891823 scopus 로고    scopus 로고
    • Expression of Norwalk virus capsid protein in transgenic tobacco and potato and its oral immunogenicity in mice
    • Mason HS, Ball JM, Shi JJ, Jiang X, Estes MK, Arntzen CJ (1996) Expression of Norwalk virus capsid protein in transgenic tobacco and potato and its oral immunogenicity in mice. Proc Natl Acad Sci USA 93:5335–5340
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 5335-5340
    • Mason, H.S.1    Ball, J.M.2    Shi, J.J.3    Jiang, X.4    Estes, M.K.5    Arntzen, C.J.6
  • 125
    • 84902374211 scopus 로고    scopus 로고
    • Characterization of protein-adjuvant coencapsulation in microparticles for vaccine delivery
    • Mathew S, Lendlein A, Wischke C (2014) Characterization of protein-adjuvant coencapsulation in microparticles for vaccine delivery. Eur J Pharm Biopharm 87:403–407
    • (2014) Eur J Pharm Biopharm , vol.87 , pp. 403-407
    • Mathew, S.1    Lendlein, A.2    Wischke, C.3
  • 126
    • 79958245618 scopus 로고    scopus 로고
    • Intranasal immunization with poly(Gammaglutamic acid) nanoparticles entrapping antigenic proteins can induce potent tumor immunity
    • Matsuo K, Koizumi H, Akashi M, Nakagawa S, Fujita T, Yamamoto A, Okada N (2011) Intranasal immunization with poly(gammaglutamic acid) nanoparticles entrapping antigenic proteins can induce potent tumor immunity. J Control Release 152:310–316
    • (2011) J Control Release , vol.152 , pp. 310-316
    • Matsuo, K.1    Koizumi, H.2    Akashi, M.3    Nakagawa, S.4    Fujita, T.5    Yamamoto, A.6    Okada, N.7
  • 128
    • 0032209286 scopus 로고    scopus 로고
    • Cutting edge: CpG DNA is a potent enhancer of systemic and mucosal immune responses against hepatitis B surface antigen with intranasal administration to mice
    • McCluskie MJ, Davis HL (1998) Cutting edge: CpG DNA is a potent enhancer of systemic and mucosal immune responses against hepatitis B surface antigen with intranasal administration to mice. J Immunol 161:4463–4466
    • (1998) J Immunol , vol.161 , pp. 4463-4466
    • McCluskie, M.J.1    Davis, H.L.2
  • 129
    • 0034703827 scopus 로고    scopus 로고
    • CpG DNA is an effective oral adjuvant to protein antigens in mice
    • McCluskie MJ, Weeratna RD, Krieg AM, Davis HL (2000) CpG DNA is an effective oral adjuvant to protein antigens in mice. Vaccine 19:950–957
    • (2000) Vaccine , vol.19 , pp. 950-957
    • McCluskie, M.J.1    Weeratna, R.D.2    Krieg, A.M.3    Davis, H.L.4
  • 131
    • 79956312742 scopus 로고    scopus 로고
    • Intranasal immunization with recombinant HA and mast cell activator C48/80 elicits protective immunity against 2009 pandemic H1N1 influenza in mice
    • Meng S, Liu Z, Xu L, Li L, Mei S, Bao L, Deng W, Li L, Lei R, Xie L et al (2011) Intranasal immunization with recombinant HA and mast cell activator C48/80 elicits protective immunity against 2009 pandemic H1N1 influenza in mice. PLoS One 6:e19863
    • (2011) Plos One , vol.6
    • Meng, S.1    Liu, Z.2    Xu, L.3    Li, L.4    Mei, S.5    Bao, L.6    Deng, W.7    Li, L.8    Lei, R.9    Xie, L.10
  • 132
    • 0242500998 scopus 로고    scopus 로고
    • Application of polyethyleneglycol (PEG)-modified liposomes for oral vaccine: Effect of lipid dose on systemic and mucosal immunity
    • Minato S, Iwanaga K, Kakemi M, Yamashita S, Oku N (2003) Application of polyethyleneglycol (PEG)-modified liposomes for oral vaccine: effect of lipid dose on systemic and mucosal immunity. J Control Release 89:189–197
    • (2003) J Control Release , vol.89 , pp. 189-197
    • Minato, S.1    Iwanaga, K.2    Kakemi, M.3    Yamashita, S.4    Oku, N.5
  • 133
    • 0030431989 scopus 로고    scopus 로고
    • Stimulating role of toxoids-laden liposomes in oral immunization against diphtheria and tetanus infections
    • Mirchamsy H, Manhouri H, Hamedi M, Ahourai P, Fateh G, Hamzeloo Z (1996) Stimulating role of toxoids-laden liposomes in oral immunization against diphtheria and tetanus infections. Biologicals 24:343–350
    • (1996) Biologicals , vol.24 , pp. 343-350
    • Mirchamsy, H.1    Manhouri, H.2    Hamedi, M.3    Ahourai, P.4    Fateh, G.5    Hamzeloo, Z.6
  • 134
    • 0021255985 scopus 로고
    • Iscom, a novel structure for antigenic presentation of membrane proteins from enveloped viruses
    • Morein B, Sundquist B, Hoglund S, Dalsgaard K, Osterhaus A (1984) Iscom, a novel structure for antigenic presentation of membrane proteins from enveloped viruses. Nature 308:457–460
    • (1984) Nature , vol.308 , pp. 457-460
    • Morein, B.1    Sundquist, B.2    Hoglund, S.3    Dalsgaard, K.4    Osterhaus, A.5
  • 135
    • 0033997662 scopus 로고    scopus 로고
    • Effectiveness of intranasal immunization with HIV-gp160 and an HIV-1 env CTL epitope peptide (E7) in combination with the mucosal adjuvant LT(R192G)
    • Morris CB, Cheng E, Thanawastien A, Cardenas-Freytag L, Clements JD (2000) Effectiveness of intranasal immunization with HIV-gp160 and an HIV-1 env CTL epitope peptide (E7) in combination with the mucosal adjuvant LT(R192G). Vaccine 18:1944–1951
    • (2000) Vaccine , vol.18 , pp. 1944-1951
    • Morris, C.B.1    Cheng, E.2    Thanawastien, A.3    Cardenas-Freytag, L.4    Clements, J.D.5
  • 139
    • 18244402390 scopus 로고    scopus 로고
    • Immunologic roles of hyaluronan
    • Mummert ME (2005) Immunologic roles of hyaluronan. Immunol Res 31:189–206
    • (2005) Immunol Res , vol.31 , pp. 189-206
    • Mummert, M.E.1
  • 140
    • 1342268100 scopus 로고    scopus 로고
    • Use of the inactivated intranasal influenza vaccine and the risk of Bell’s palsy in Switzerland
    • Mutsch M, Zhou W, Rhodes P, Bopp M, Chen RT, Linder T, Spyr C, Steffen R (2004) Use of the inactivated intranasal influenza vaccine and the risk of Bell’s palsy in Switzerland. N Engl J Med 350:896–903
    • (2004) N Engl J Med , vol.350 , pp. 896-903
    • Mutsch, M.1    Zhou, W.2    Rhodes, P.3    Bopp, M.4    Chen, R.T.5    Linder, T.6    Spyr, C.7    Steffen, R.8
  • 141
    • 77649198518 scopus 로고    scopus 로고
    • Chitins and chitosans as immunoadjuvants and non-allergenic drug carriers
    • Muzzarelli RA (2010) Chitins and chitosans as immunoadjuvants and non-allergenic drug carriers. Mar Drugs 8:292–312
    • (2010) Mar Drugs , vol.8 , pp. 292-312
    • Muzzarelli, R.A.1
  • 142
    • 84876918345 scopus 로고    scopus 로고
    • Recent advances in claudin-targeting technology
    • Nagase S, Doyama R, Yagi K, Kondoh M (2013) Recent advances in claudin-targeting technology. Biol Pharm Bull 36:708–714
    • (2013) Biol Pharm Bull , vol.36 , pp. 708-714
    • Nagase, S.1    Doyama, R.2    Yagi, K.3    Kondoh, M.4
  • 143
    • 0032874490 scopus 로고    scopus 로고
    • A universal influenza A vaccine based on the extracellular domain of the M2 protein
    • Neirynck S, Deroo T, Saelens X, Vanlandschoot P, Jou WM, Fiers W (1999) A universal influenza A vaccine based on the extracellular domain of the M2 protein. Nat Med 5:1157–1163
    • (1999) Nat Med , vol.5 , pp. 1157-1163
    • Neirynck, S.1    Deroo, T.2    Saelens, X.3    Vanlandschoot, P.4    Jou, W.M.5    Fiers, W.6
  • 144
    • 33644836224 scopus 로고    scopus 로고
    • Mucosal vaccines: The promise and the challenge
    • Neutra MR, Kozlowski PA (2006) Mucosal vaccines: the promise and the challenge. Nat Rev Immunol 6:148–158
    • (2006) Nat Rev Immunol , vol.6 , pp. 148-158
    • Neutra, M.R.1    Kozlowski, P.A.2
  • 145
    • 0030576516 scopus 로고    scopus 로고
    • Epithelial M cells: Gateways for mucosal infection and immunization
    • Neutra MR, Frey A, Kraehenbuhl JP (1996) Epithelial M cells: gateways for mucosal infection and immunization. Cell 86:345–348
    • (1996) Cell , vol.86 , pp. 345-348
    • Neutra, M.R.1    Frey, A.2    Kraehenbuhl, J.P.3
  • 147
    • 37549036732 scopus 로고    scopus 로고
    • Fcgamma receptors as regulators of immune responses
    • Nimmerjahn F, Ravetch JV (2008) Fcgamma receptors as regulators of immune responses. Nat Rev Immunol 8:34–47
    • (2008) Nat Rev Immunol , vol.8 , pp. 34-47
    • Nimmerjahn, F.1    Ravetch, J.V.2
  • 150
    • 84870751323 scopus 로고    scopus 로고
    • A new strategy based on SmRho protein loaded chitosan nanoparticles as a candidate oral vaccine against schistosomiasis
    • Oliveira CR, Rezende CM, Silva MR, Pego AP, Borges O, Goes AM (2012) A new strategy based on SmRho protein loaded chitosan nanoparticles as a candidate oral vaccine against schistosomiasis. PLoS Negl Trop Dis 6:e1894
    • (2012) Plos Negl Trop Dis , vol.6
    • Oliveira, C.R.1    Rezende, C.M.2    Silva, M.R.3    Pego, A.P.4    Borges, O.5    Goes, A.M.6
  • 151
    • 0035940315 scopus 로고    scopus 로고
    • Nasal delivery of epitope based vaccines
    • Olszewska W, Steward MW (2001) Nasal delivery of epitope based vaccines. Adv Drug Deliv Rev 51:161–171
    • (2001) Adv Drug Deliv Rev , vol.51 , pp. 161-171
    • Olszewska, W.1    Steward, M.W.2
  • 152
    • 77951128917 scopus 로고    scopus 로고
    • Evaluation of ISCOM vaccines for mucosal immunization against hepatitis B
    • Pandey RS, Dixit VK (2010) Evaluation of ISCOM vaccines for mucosal immunization against hepatitis B. J Drug Target 18:282–291
    • (2010) J Drug Target , vol.18 , pp. 282-291
    • Pandey, R.S.1    Dixit, V.K.2
  • 153
    • 84977980216 scopus 로고    scopus 로고
    • Vaccine strategies utilizing C-type lectin receptors on dendritic cells in vivo
    • Park CG (2014) Vaccine strategies utilizing C-type lectin receptors on dendritic cells in vivo. Clin Exp Vaccine Res 3:149–154
    • (2014) Clin Exp Vaccine Res , vol.3 , pp. 149-154
    • Park, C.G.1
  • 155
    • 17644416719 scopus 로고    scopus 로고
    • Targeting the innate immune response with improved vaccine adjuvants
    • Pashine A, Valiante NM, Ulmer JB (2005) Targeting the innate immune response with improved vaccine adjuvants. Nat Med 11: S63–68
    • (2005) Nat Med , vol.11
    • Pashine, A.1    Valiante, N.M.2    Ulmer, J.B.3
  • 156
    • 77950613459 scopus 로고    scopus 로고
    • Archaeal lipid mucosal vaccine adjuvant and delivery system
    • Patel GB, Chen W (2010) Archaeal lipid mucosal vaccine adjuvant and delivery system. Expert Rev Vaccines 9:431–440
    • (2010) Expert Rev Vaccines , vol.9 , pp. 431-440
    • Patel, G.B.1    Chen, W.2
  • 157
    • 36549047962 scopus 로고    scopus 로고
    • Mucosal and systemic immune responses by intranasal immunization using archaeal lipid-adjuvanted vaccines
    • Patel GB, Zhou HY, Ponce A, Chen WX (2007) Mucosal and systemic immune responses by intranasal immunization using archaeal lipid-adjuvanted vaccines. Vaccine 25:8622–8636
    • (2007) Vaccine , vol.25 , pp. 8622-8636
    • Patel, G.B.1    Zhou, H.Y.2    Ponce, A.3    Chen, W.X.4
  • 158
    • 52949114226 scopus 로고    scopus 로고
    • Safety of intranasally administered archaeal lipid mucosal vaccine adjuvant and delivery (AMVAD) vaccine in mice
    • Patel GB, Ponce A, Zhou H, Chen W (2008) Safety of intranasally administered archaeal lipid mucosal vaccine adjuvant and delivery (AMVAD) vaccine in mice. Int J Toxicol 27:329–339
    • (2008) Int J Toxicol , vol.27 , pp. 329-339
    • Patel, G.B.1    Ponce, A.2    Zhou, H.3    Chen, W.4
  • 159
    • 84858256662 scopus 로고    scopus 로고
    • Evaluation of the sublingual route for administration of influenza H5N1 virosomes in combination with the bacterial second messenger c-di-GMP
    • Pedersen GK, Ebensen T, Gjeraker IH, Svindland S, Bredholt G, Guzman CA, Cox RJ (2011) Evaluation of the sublingual route for administration of influenza H5N1 virosomes in combination with the bacterial second messenger c-di-GMP. PLoS One 6:e26973
    • (2011) Plos One , vol.6
    • Pedersen, G.K.1    Ebensen, T.2    Gjeraker, I.H.3    Svindland, S.4    Bredholt, G.5    Guzman, C.A.6    Cox, R.J.7
  • 160
    • 77956402347 scopus 로고    scopus 로고
    • The Eurocine (R) L3 adjuvants with subunit influenza antigens induce protective immunity in mice after intranasal vaccination
    • Petersson P, Hedenskog M, Alves D, Brytting M, Schroder U, Linde A, Lundkvist A (2010) The Eurocine (R) L3 adjuvants with subunit influenza antigens induce protective immunity in mice after intranasal vaccination. Vaccine 28:6491–6497
    • (2010) Vaccine , vol.28 , pp. 6491-6497
    • Petersson, P.1    Hedenskog, M.2    Alves, D.3    Brytting, M.4    Schroder, U.5    Linde, A.6    Lundkvist, A.7
  • 162
    • 22144431850 scopus 로고    scopus 로고
    • Local and systemic activity of the polysaccharide chitosan at lymphoid tissues after oral administration
    • Porporatto C, Bianco ID, Correa SG (2005) Local and systemic activity of the polysaccharide chitosan at lymphoid tissues after oral administration. J Leukoc Biol 78:62–69
    • (2005) J Leukoc Biol , vol.78 , pp. 62-69
    • Porporatto, C.1    Bianco, I.D.2    Correa, S.G.3
  • 164
    • 61649116885 scopus 로고    scopus 로고
    • Intranasal administration of peptide antigens of HIV with mucosal adjuvant CpG ODN coentrapped in microparticles enhances the mucosal and systemic immune responses
    • Pun PB, Bhat AA, Mohan T, Kulkarni S, Paranjape R, Rao DN (2009) Intranasal administration of peptide antigens of HIV with mucosal adjuvant CpG ODN coentrapped in microparticles enhances the mucosal and systemic immune responses. Int Immunopharmacol 9:468–477
    • (2009) Int Immunopharmacol , vol.9 , pp. 468-477
    • Pun, P.B.1    Bhat, A.A.2    Mohan, T.3    Kulkarni, S.4    Paranjape, R.5    Rao, D.N.6
  • 165
    • 0036889760 scopus 로고    scopus 로고
    • Targeted drug delivery via the transferrin receptor-mediated endocytosis pathway
    • Qian ZM, Li H, Sun H, Ho K (2002) Targeted drug delivery via the transferrin receptor-mediated endocytosis pathway. Pharmacol Rev 54:561–587
    • (2002) Pharmacol Rev , vol.54 , pp. 561-587
    • Qian, Z.M.1    Li, H.2    Sun, H.3    Ho, K.4
  • 166
    • 79957627493 scopus 로고    scopus 로고
    • A 2020 vision for vaccines against HIV, tuberculosis and malaria
    • Rappuoli R, Aderem A (2011) A 2020 vision for vaccines against HIV, tuberculosis and malaria. Nature 473:463–469
    • (2011) Nature , vol.473 , pp. 463-469
    • Rappuoli, R.1    Aderem, A.2
  • 167
    • 0034810961 scopus 로고    scopus 로고
    • Induction of systemic and mucosal immune response in cattle by intranasal administration of pig serum albumin in alginate microparticles
    • Rebelatto MC, Guimond P, Bowersock TL, HogenEsch H (2001) Induction of systemic and mucosal immune response in cattle by intranasal administration of pig serum albumin in alginate microparticles. Vet Immunol Immunopathol 83:93–105
    • (2001) Vet Immunol Immunopathol , vol.83 , pp. 93-105
    • Rebelatto, M.C.1    Guimond, P.2    Bowersock, T.L.3    Hogenesch, H.4
  • 169
    • 84882754914 scopus 로고    scopus 로고
    • Unique insights into the intestinal absorption, transit, and subsequent biodistribution of polymer-derived microspheres
    • Reineke JJ, Cho DY, Dingle YT, Morello AP 3rd, Jacob J, Thanos CG, Mathiowitz E (2013) Unique insights into the intestinal absorption, transit, and subsequent biodistribution of polymer-derived microspheres. Proc Natl Acad Sci USA 110:13803–13808
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 13803-13808
    • Reineke, J.J.1    Cho, D.Y.2    Dingle, Y.T.3    Morello, A.P.4    Jacob, J.5    Thanos, C.G.6    Mathiowitz, E.7
  • 170
    • 3242765120 scopus 로고    scopus 로고
    • Role of IgA versus IgG in the control of influenza viral infection in the murine respiratory tract
    • Renegar KB, Small PA Jr, Boykins LG, Wright PF (2004) Role of IgA versus IgG in the control of influenza viral infection in the murine respiratory tract. J Immunol 173:1978–1986
    • (2004) J Immunol , vol.173 , pp. 1978-1986
    • Renegar, K.B.1    Small, P.A.2    Boykins, L.G.3    Wright, P.F.4
  • 172
    • 84862508744 scopus 로고    scopus 로고
    • Mucosal immunity and nasal influenza vaccination
    • Rose MA, Zielen S, Baumann U (2012) Mucosal immunity and nasal influenza vaccination. Expert Rev Vaccines 11:595–607
    • (2012) Expert Rev Vaccines , vol.11 , pp. 595-607
    • Rose, M.A.1    Zielen, S.2    Baumann, U.3
  • 173
    • 1542301029 scopus 로고    scopus 로고
    • Oral vaccination against diphtheria using polyacryl starch microparticles as adjuvant
    • Rydell N, Sjoholm I (2004) Oral vaccination against diphtheria using polyacryl starch microparticles as adjuvant. Vaccine 22:1265–1274
    • (2004) Vaccine , vol.22 , pp. 1265-1274
    • Rydell, N.1    Sjoholm, I.2
  • 174
    • 15044351347 scopus 로고    scopus 로고
    • Mucosal vaccination against diphtheria using starch microparticles as adjuvant for cross-reacting material (CRM197) of diphtheria toxin
    • Rydell N, Sjoholm I (2005) Mucosal vaccination against diphtheria using starch microparticles as adjuvant for cross-reacting material (CRM197) of diphtheria toxin. Vaccine 23:2775–2783
    • (2005) Vaccine , vol.23 , pp. 2775-2783
    • Rydell, N.1    Sjoholm, I.2
  • 176
    • 84931060402 scopus 로고    scopus 로고
    • Biomaterials for nanoparticle vaccine delivery systems
    • Sahdev P, Ochyl LJ, Moon JJ (2014) Biomaterials for nanoparticle vaccine delivery systems. Pharm Res 31:2563–2582
    • (2014) Pharm Res , vol.31 , pp. 2563-2582
    • Sahdev, P.1    Ochyl, L.J.2    Moon, J.J.3
  • 177
    • 47149107389 scopus 로고    scopus 로고
    • Induction of high antitoxin titers against tetanus toxoid in rabbits by intranasal immunization with dextran microspheres
    • Sajadi Tabassi SA, Tafaghodi M, Jaafari MR (2008) Induction of high antitoxin titers against tetanus toxoid in rabbits by intranasal immunization with dextran microspheres. Int J Pharm 360:12–17
    • (2008) Int J Pharm , vol.360 , pp. 12-17
    • Sajadi Tabassi, S.A.1    Tafaghodi, M.2    Jaafari, M.R.3
  • 178
    • 84925807864 scopus 로고    scopus 로고
    • Intranasal delivery of influenza rNP adjuvanted with c-di-AMP induces strong humoral and cellular immune responses and provides protection against virus challenge
    • Sanchez MV, Ebensen T, Schulze K, Cargnelutti D, Blazejewska P, Scodeller EA, Guzman CA (2014) Intranasal delivery of influenza rNP adjuvanted with c-di-AMP induces strong humoral and cellular immune responses and provides protection against virus challenge. PLoS One 9:e104824
    • (2014) Plos One , vol.9
    • Sanchez, M.V.1    Ebensen, T.2    Schulze, K.3    Cargnelutti, D.4    Blazejewska, P.5    Scodeller, E.A.6    Guzman, C.A.7
  • 180
    • 40849140609 scopus 로고    scopus 로고
    • An efficient plant viral expression system generating orally immunogenic Norwalk virus-like particles
    • Santi L, Batchelor L, Huang Z, Hjelm B, Kilbourne J, Arntzen CJ, Chen Q, Mason HS (2008) An efficient plant viral expression system generating orally immunogenic Norwalk virus-like particles. Vaccine 26:1846–1854
    • (2008) Vaccine , vol.26 , pp. 1846-1854
    • Santi, L.1    Batchelor, L.2    Huang, Z.3    Hjelm, B.4    Kilbourne, J.5    Arntzen, C.J.6    Chen, Q.7    Mason, H.S.8
  • 181
    • 28444432664 scopus 로고    scopus 로고
    • Lipid microparticles for mucosal immunization against hepatitis B
    • Saraf S, Mishra D, Asthana A, Jain R, Singh S, Jain NK (2006) Lipid microparticles for mucosal immunization against hepatitis B. Vaccine 24:45–56
    • (2006) Vaccine , vol.24 , pp. 45-56
    • Saraf, S.1    Mishra, D.2    Asthana, A.3    Jain, R.4    Singh, S.5    Jain, N.K.6
  • 183
    • 70349998153 scopus 로고    scopus 로고
    • TMC-MCC (N-trimethyl chitosan-mono-N-carboxymethyl chitosan) nanocomplexes for mucosal delivery of vaccines
    • Sayin B, Somavarapu S, Li XW, Sesardic D, Senel S, Alpar OH (2009) TMC-MCC (N-trimethyl chitosan-mono-N-carboxymethyl chitosan) nanocomplexes for mucosal delivery of vaccines. Eur J Pharm Sci 38:362–369
    • (2009) Eur J Pharm Sci , vol.38 , pp. 362-369
    • Sayin, B.1    Somavarapu, S.2    Li, X.W.3    Sesardic, D.4    Senel, S.5    Alpar, O.H.6
  • 185
    • 84944660452 scopus 로고
    • Clinical evaluation in healthy adults of a hepatitis B vaccine made by recombinant DNA
    • Scolnick EM, McLean AA, West DJ, McAleer WJ, Miller WJ, Buynak EB (1984) Clinical evaluation in healthy adults of a hepatitis B vaccine made by recombinant DNA. JAMA 251:2812–2815
    • (1984) JAMA , vol.251 , pp. 2812-2815
    • Scolnick, E.M.1    McLean, A.A.2    West, D.J.3    McAleer, W.J.4    Miller, W.J.5    Buynak, E.B.6
  • 186
    • 0034680182 scopus 로고    scopus 로고
    • Vaccines against intracellular infections requiring cellular immunity
    • Seder RA, Hill AV (2000) Vaccines against intracellular infections requiring cellular immunity. Nature 406:793–798
    • (2000) Nature , vol.406 , pp. 793-798
    • Seder, R.A.1    Hill, A.V.2
  • 187
    • 84890307437 scopus 로고    scopus 로고
    • Development of oligomannose-coated liposome-based nasal vaccine against human parainfluenza virus type 3
    • Senchi K, Matsunaga S, Hasegawa H, Kimura H, Ryo A (2013) Development of oligomannose-coated liposome-based nasal vaccine against human parainfluenza virus type 3. Front Microbiol 4:346
    • (2013) Front Microbiol , vol.4
    • Senchi, K.1    Matsunaga, S.2    Hasegawa, H.3    Kimura, H.4    Ryo, A.5
  • 188
    • 33748766757 scopus 로고    scopus 로고
    • Correlation between mouse potency and in vitro relative potency for human papillomavirus Type 16 virus-like particles and gardasil (R) vaccine samples
    • Shank-Retzlaff M, Wang F, Morley T, Anderson C, Hamm M, Brown M, Rowland K, Pancari G, Zorman J, Lowe R et al (2005) Correlation between mouse potency and in vitro relative potency for human papillomavirus Type 16 virus-like particles and gardasil (R) vaccine samples. Hum Vaccines 1:191–197
    • (2005) Hum Vaccines , vol.1 , pp. 191-197
    • Shank-Retzlaff, M.1    Wang, F.2    Morley, T.3    Erson, C.4    Hamm, M.5    Brown, M.6    Rowland, K.7    Pancari, G.8    Zorman, J.9    Lowe, R.10
  • 189
    • 62849109927 scopus 로고    scopus 로고
    • Pharmaceutical aspects of intranasal delivery of vaccines using particulate systems
    • Sharma S, Mukkur TK, Benson HA, Chen Y (2009) Pharmaceutical aspects of intranasal delivery of vaccines using particulate systems. J Pharm Sci 98:812–843
    • (2009) J Pharm Sci , vol.98 , pp. 812-843
    • Sharma, S.1    Mukkur, T.K.2    Benson, H.A.3    Chen, Y.4
  • 190
    • 84874825627 scopus 로고    scopus 로고
    • Binding of bacterial secondary messenger molecule c di-GMP is a STING operation
    • Shaw N, Ouyang SY, Liu ZJ (2013) Binding of bacterial secondary messenger molecule c di-GMP is a STING operation. Protein Cell 4:117–129
    • (2013) Protein Cell , vol.4 , pp. 117-129
    • Shaw, N.1    Ouyang, S.Y.2    Liu, Z.J.3
  • 192
    • 0034833470 scopus 로고    scopus 로고
    • Th1 adjuvant N-acetyl-D-glucosamine polymer upregulates Th1 immunity but down-regulates Th2 immunity against a mycobacterial protein (MPB-59) in interleukin-10-knockout and wild-type mice
    • Shibata Y, Honda I, Justice JP, Van Scott MR, Nakamura RM, Myrvik QN (2001) Th1 adjuvant N-acetyl-D-glucosamine polymer upregulates Th1 immunity but down-regulates Th2 immunity against a mycobacterial protein (MPB-59) in interleukin-10-knockout and wild-type mice. Infect Immun 69:6123–6130
    • (2001) Infect Immun , vol.69 , pp. 6123-6130
    • Shibata, Y.1    Honda, I.2    Justice, J.P.3    Van Scott, M.R.4    Nakamura, R.M.5    Myrvik, Q.N.6
  • 193
  • 194
    • 72449211710 scopus 로고    scopus 로고
    • M-cell targeted delivery of recombinant hepatitis B surface antigen using cholera toxin B subunit conjugated bilosomes
    • Shukla A, Katare OP, Singh B, Vyas SP (2010) M-cell targeted delivery of recombinant hepatitis B surface antigen using cholera toxin B subunit conjugated bilosomes. Int J Pharm 385:47–52
    • (2010) Int J Pharm , vol.385 , pp. 47-52
    • Shukla, A.1    Katare, O.P.2    Singh, B.3    Vyas, S.P.4
  • 195
    • 80052238985 scopus 로고    scopus 로고
    • Significant systemic and mucosal immune response induced on oral delivery of diphtheria toxoid using nano-bilosomes
    • Shukla A, Singh B, Katare OP (2011) Significant systemic and mucosal immune response induced on oral delivery of diphtheria toxoid using nano-bilosomes. Br J Pharmacol 164:820–827
    • (2011) Br J Pharmacol , vol.164 , pp. 820-827
    • Shukla, A.1    Singh, B.2    Katare, O.P.3
  • 196
    • 0032402214 scopus 로고    scopus 로고
    • The preparation and characterization of polymeric antigen delivery systems for oral administration
    • Singh M, O’Hagan D (1998) The preparation and characterization of polymeric antigen delivery systems for oral administration. Adv Drug Deliv Rev 34:285–304
    • (1998) Adv Drug Deliv Rev , vol.34 , pp. 285-304
    • Singh, M.1    O’hagan, D.2
  • 197
    • 0035936976 scopus 로고    scopus 로고
    • A novel bioadhesive intranasal delivery system for inactivated influenza vaccines
    • Singh M, Briones M, O’Hagan DT (2001) A novel bioadhesive intranasal delivery system for inactivated influenza vaccines. J Control Release 70:267–276
    • (2001) J Control Release , vol.70 , pp. 267-276
    • Singh, M.1    Briones, M.2    O’hagan, D.T.3
  • 198
    • 31544467293 scopus 로고    scopus 로고
    • Diphtheria toxoid loaded poly-(Epsilon-caprolactone) nanoparticles as mucosal vaccine delivery systems
    • Singh J, Pandit S, Bramwell VW, Alpar HO (2006) Diphtheria toxoid loaded poly-(epsilon-caprolactone) nanoparticles as mucosal vaccine delivery systems. Methods 38:96–105
    • (2006) Methods , vol.38 , pp. 96-105
    • Singh, J.1    Pandit, S.2    Bramwell, V.W.3    Alpar, H.O.4
  • 199
    • 33748795114 scopus 로고    scopus 로고
    • Saponin-adjuvanted particulate vaccines for clinical use
    • Skene CD, Sutton P (2006) Saponin-adjuvanted particulate vaccines for clinical use. Methods 40:53–59
    • (2006) Methods , vol.40 , pp. 53-59
    • Skene, C.D.1    Sutton, P.2
  • 200
    • 33846503219 scopus 로고    scopus 로고
    • Incorporation of glycosylphosphatidylinositol-anchored granulocyte- macrophage colony-stimulating factor or CD40 ligand enhances immunogenicity of chimeric simian immunodeficiency virus-like particles
    • Skountzou I, Quan FS, Gangadhara S, Ye L, Vzorov A, Selvaraj P, Jacob J, Compans RW, Kang SM (2007) Incorporation of glycosylphosphatidylinositol-anchored granulocyte- macrophage colony-stimulating factor or CD40 ligand enhances immunogenicity of chimeric simian immunodeficiency virus-like particles. J Virol 81:1083–1094
    • (2007) J Virol , vol.81 , pp. 1083-1094
    • Skountzou, I.1    Quan, F.S.2    Gangadhara, S.3    Ye, L.4    Vzorov, A.5    Selvaraj, P.6    Jacob, J.7    Compans, R.W.8    Kang, S.M.9
  • 201
    • 84880877024 scopus 로고    scopus 로고
    • Applications of nanotechnology for immunology
    • Smith DM, Simon JK, Baker JR Jr (2013) Applications of nanotechnology for immunology. Nat Rev Immunol 13:592–605
    • (2013) Nat Rev Immunol , vol.13 , pp. 592-605
    • Smith, D.M.1    Simon, J.K.2    Baker, J.R.3
  • 202
    • 79961079794 scopus 로고    scopus 로고
    • Intracellular targeting of PLGA nanoparticles encapsulating antigenic peptide to the endoplasmic reticulum of dendritic cells and its effect on antigen cross-presentation in vitro
    • Sneh-Edri H, Likhtenshtein D, Stepensky D (2011) Intracellular targeting of PLGA nanoparticles encapsulating antigenic peptide to the endoplasmic reticulum of dendritic cells and its effect on antigen cross-presentation in vitro. Mol Pharm 8:1266–1275
    • (2011) Mol Pharm , vol.8 , pp. 1266-1275
    • Sneh-Edri, H.1    Likhtenshtein, D.2    Stepensky, D.3
  • 203
    • 21344448183 scopus 로고    scopus 로고
    • Effect of vitamin E TPGS on immune response to nasally delivered diphtheria toxoid loaded poly(Caprolactone) microparticles
    • Somavarapu S, Pandit S, Gradassi G, Bandera M, Ravichandran E, Alpar OH (2005) Effect of vitamin E TPGS on immune response to nasally delivered diphtheria toxoid loaded poly(caprolactone) microparticles. Int J Pharm 298:344–347
    • (2005) Int J Pharm , vol.298 , pp. 344-347
    • Somavarapu, S.1    Pandit, S.2    Gradassi, G.3    Bandera, M.4    Ravichandran, E.5    Alpar, O.H.6
  • 205
    • 79551554495 scopus 로고    scopus 로고
    • Mucosal targeting of a BoNT/A subunit vaccine adjuvanted with a mast cell activator enhances induction of BoNT/A neutralizing antibodies in rabbits
    • Staats HF, Fielhauer JR, Thompson AL, Tripp AA, Sobel AE, Maddaloni M, Abraham SN, Pascual DW (2011) Mucosal targeting of a BoNT/A subunit vaccine adjuvanted with a mast cell activator enhances induction of BoNT/A neutralizing antibodies in rabbits. PLoS One 6:e16532
    • (2011) Plos One , vol.6
    • Staats, H.F.1    Fielhauer, J.R.2    Thompson, A.L.3    Tripp, A.A.4    Sobel, A.E.5    Maddaloni, M.6    Abraham, S.N.7    Pascual, D.W.8
  • 206
    • 33646447036 scopus 로고    scopus 로고
    • Phase I evaluation of intranasal trivalent inactivated influenza vaccine with nontoxigenic Escherichia coli enterotoxin and novel biovector as mucosal adjuvants, using adult volunteers
    • Stephenson I, Zambon MC, Rudin A, Colegate A, Podda A, Bugarini R, Del Giudice G, Minutello A, Bonnington S, Holmgren J et al (2006) Phase I evaluation of intranasal trivalent inactivated influenza vaccine with nontoxigenic Escherichia coli enterotoxin and novel biovector as mucosal adjuvants, using adult volunteers. J Virol 80:4962–4970
    • (2006) J Virol , vol.80 , pp. 4962-4970
    • Stephenson, I.1    Zambon, M.C.2    Rudin, A.3    Colegate, A.4    Podda, A.5    Bugarini, R.6    Del Giudice, G.7    Minutello, A.8    Bonnington, S.9    Holmgren, J.10
  • 207
    • 78249285928 scopus 로고    scopus 로고
    • Cross-protection against influenza virus infection by intranasal administration of M1-based vaccine with chitosan as an adjuvant
    • Sui ZW, Chen QJ, Fang F, Zheng M, Chen Z (2010) Cross-protection against influenza virus infection by intranasal administration of M1-based vaccine with chitosan as an adjuvant. Vaccine 28:7690–7698
    • (2010) Vaccine , vol.28 , pp. 7690-7698
    • Sui, Z.W.1    Chen, Q.J.2    Fang, F.3    Zheng, M.4    Chen, Z.5
  • 208
    • 61349084783 scopus 로고    scopus 로고
    • Advances in saponin-based adjuvants
    • Sun HX, Xie Y, Ye YP (2009a) Advances in saponin-based adjuvants. Vaccine 27:1787–1796
    • (2009) Vaccine , vol.27 , pp. 1787-1796
    • Sun, H.X.1    Xie, Y.2    Ye, Y.P.3
  • 209
    • 67649336398 scopus 로고    scopus 로고
    • ISCOMs and ISCOMATRIX
    • Sun HX, Xie Y, Ye YP (2009b) ISCOMs and ISCOMATRIX. Vaccine 27:4388–4401
    • (2009) Vaccine , vol.27 , pp. 4388-4401
    • Sun, H.X.1    Xie, Y.2    Ye, Y.P.3
  • 211
    • 77949415982 scopus 로고    scopus 로고
    • Preparation and in vivo study of dry powder microspheres for nasal immunization
    • Tafaghodi M, Rastegar S (2010) Preparation and in vivo study of dry powder microspheres for nasal immunization. J Drug Target 18:235–242
    • (2010) J Drug Target , vol.18 , pp. 235-242
    • Tafaghodi, M.1    Rastegar, S.2
  • 212
    • 0141717938 scopus 로고    scopus 로고
    • Antigen presentation in vaccine development
    • Takahashi H (2003) Antigen presentation in vaccine development. Comp Immunol Microbiol Infect Dis 26:309–328
    • (2003) Comp Immunol Microbiol Infect Dis , vol.26 , pp. 309-328
    • Takahashi, H.1
  • 213
    • 0001331728 scopus 로고
    • Synthetic peptide vaccine design: Synthesis and properties of a high-density multiple antigenic peptide system
    • Tam JP (1988) Synthetic peptide vaccine design: synthesis and properties of a high-density multiple antigenic peptide system. Proc Natl Acad Sci USA 85:5409–5413
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 5409-5413
    • Tam, J.P.1
  • 214
    • 13844313860 scopus 로고    scopus 로고
    • Defense mechanisms against influenza virus infection in the respiratory tract mucosa
    • Tamura S, Kurata T (2004) Defense mechanisms against influenza virus infection in the respiratory tract mucosa. Jpn J Infect Dis 57:236–247
    • (2004) Jpn J Infect Dis , vol.57 , pp. 236-247
    • Tamura, S.1    Kurata, T.2
  • 215
    • 84896732608 scopus 로고    scopus 로고
    • Gold nanoparticle-M2e conjugate coformulated with CpG induces protective immunity against influenza A virus
    • Tao W, Ziemer KS, Gill HS (2014) Gold nanoparticle-M2e conjugate coformulated with CpG induces protective immunity against influenza A virus. Nanomedicine (Lond) 9:237–251
    • (2014) Nanomedicine (Lond) , vol.9 , pp. 237-251
    • Tao, W.1    Ziemer, K.S.2    Gill, H.S.3
  • 216
    • 68649083210 scopus 로고    scopus 로고
    • Influence of surface charge of PLGA particles of recombinant hepatitis B surface antigen in enhancing systemic and mucosal immune responses
    • Thomas C, Gupta V, Ahsan F (2009) Influence of surface charge of PLGA particles of recombinant hepatitis B surface antigen in enhancing systemic and mucosal immune responses. Int J Pharm 379:41–50
    • (2009) Int J Pharm , vol.379 , pp. 41-50
    • Thomas, C.1    Gupta, V.2    Ahsan, F.3
  • 217
    • 78650544598 scopus 로고    scopus 로고
    • Molecular basis of the mucosal immune system: From fundamental concepts to advances in liposome-based vaccines
    • Tiwari S, Agrawal GP, Vyas SP (2010) Molecular basis of the mucosal immune system: from fundamental concepts to advances in liposome-based vaccines. Nanomedicine (Lond) 5:1617–1640
    • (2010) Nanomedicine (Lond) , vol.5 , pp. 1617-1640
    • Tiwari, S.1    Agrawal, G.P.2    Vyas, S.P.3
  • 219
    • 79958012662 scopus 로고    scopus 로고
    • Viral protein complexed liposomes for intranasal delivery of hepatitis B surface antigen
    • Tiwari S, Verma SK, Agrawal GP, Vyas SP (2011b) Viral protein complexed liposomes for intranasal delivery of hepatitis B surface antigen. Int J Pharm 413:211–219
    • (2011) Int J Pharm , vol.413 , pp. 211-219
    • Tiwari, S.1    Verma, S.K.2    Agrawal, G.P.3    Vyas, S.P.4
  • 220
    • 0031918253 scopus 로고    scopus 로고
    • Stealth PLA-PEG nanoparticles as protein carriers for nasal administration
    • Tobio M, Gref R, Sanchez A, Langer R, Alonso MJ (1998) Stealth PLA-PEG nanoparticles as protein carriers for nasal administration. Pharm Res 15:270–275
    • (1998) Pharm Res , vol.15 , pp. 270-275
    • Tobio, M.1    Gref, R.2    Sanchez, A.3    Langer, R.4    Alonso, M.J.5
  • 221
    • 14144250911 scopus 로고    scopus 로고
    • Recent advances with liposomes as pharmaceutical carriers
    • Torchilin VP (2005) Recent advances with liposomes as pharmaceutical carriers. Nat Rev Drug Discov 4:145–160
    • (2005) Nat Rev Drug Discov , vol.4 , pp. 145-160
    • Torchilin, V.P.1
  • 222
    • 0028970060 scopus 로고
    • Interleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity
    • Trinchieri G (1995) Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu Rev Immunol 13:251–276
    • (1995) Annu Rev Immunol , vol.13 , pp. 251-276
    • Trinchieri, G.1
  • 223
    • 33645046626 scopus 로고    scopus 로고
    • Inducing systemic and mucosal immune responses to B-T construct of F1 antigen of Yersinia pestis in microsphere delivery
    • Tripathi V, Chitralekha KT, Bakshi AR, Tomar D, Deshmukh RA, Baig MA, Rao DN (2006) Inducing systemic and mucosal immune responses to B-T construct of F1 antigen of Yersinia pestis in microsphere delivery. Vaccine 24:3279–3289
    • (2006) Vaccine , vol.24 , pp. 3279-3289
    • Tripathi, V.1    Chitralekha, K.T.2    Bakshi, A.R.3    Tomar, D.4    Deshmukh, R.A.5    Baig, M.A.6    Rao, D.N.7
  • 225
    • 84886032264 scopus 로고    scopus 로고
    • A novel influenza virus hemagglutinin-respiratory syncytial virus (RSV) fusion protein subunit vaccine against influenza and RSV
    • Turner TM, Jones LP, Tompkins SM, Tripp RA (2013) A novel influenza virus hemagglutinin-respiratory syncytial virus (RSV) fusion protein subunit vaccine against influenza and RSV. J Virol 87:10792–10804
    • (2013) J Virol , vol.87 , pp. 10792-10804
    • Turner, T.M.1    Jones, L.P.2    Tompkins, S.M.3    Tripp, R.A.4
  • 226
    • 79952285914 scopus 로고    scopus 로고
    • Design of a protective single-dose intranasal nanoparticle-based vaccine platform for respiratory infectious diseases
    • Ulery BD, Kumar D, Ramer-Tait AE, Metzger DW, Wannemuehler MJ, Narasimhan B (2011) Design of a protective single-dose intranasal nanoparticle-based vaccine platform for respiratory infectious diseases. PLoS One 6:e17642
    • (2011) Plos One , vol.6
    • Ulery, B.D.1    Kumar, D.2    Ramer-Tait, A.E.3    Metzger, D.W.4    Wannemuehler, M.J.5    Narasimhan, B.6
  • 228
    • 0034327167 scopus 로고    scopus 로고
    • Cutting edge: The mucosal adjuvant cholera toxin redirects vaccine proteins into olfactory tissues
    • van Ginkel FW, Jackson RJ, Yuki Y, McGhee JR (2000) Cutting edge: The mucosal adjuvant cholera toxin redirects vaccine proteins into olfactory tissues. J Immunol 165:4778–4782
    • (2000) J Immunol , vol.165 , pp. 4778-4782
    • Van Ginkel, F.W.1    Jackson, R.J.2    Yuki, Y.3    McGhee, J.R.4
  • 229
    • 84905993471 scopus 로고    scopus 로고
    • Combatting infectious diseases; nanotechnology as a platform for rational vaccine design
    • van Riet E, Ainai A, Suzuki T, Kersten G, Hasegawa H (2014) Combatting infectious diseases; nanotechnology as a platform for rational vaccine design. Adv Drug Deliv Rev 74:28–34
    • (2014) Adv Drug Deliv Rev , vol.74 , pp. 28-34
    • Van Riet, E.1    Ainai, A.2    Suzuki, T.3    Kersten, G.4    Hasegawa, H.5
  • 231
  • 233
    • 13844267658 scopus 로고    scopus 로고
    • PLA-PEG particles as nasal protein carriers: The influence of the particle size
    • Vila A, Sanchez A, Evora C, Soriano I, McCallion O, Alonso MJ (2005) PLA-PEG particles as nasal protein carriers: the influence of the particle size. Int J Pharm 292:43–52
    • (2005) Int J Pharm , vol.292 , pp. 43-52
    • Vila, A.1    Sanchez, A.2    Evora, C.3    Soriano, I.4    McCallion, O.5    Alonso, M.J.6
  • 234
    • 85017798345 scopus 로고    scopus 로고
    • Innate endogenous adjuvants prime to desirable immune responses via mucosal routes
    • Wang X, Meng D (2014) Innate endogenous adjuvants prime to desirable immune responses via mucosal routes, Protein Cell, 1–15
    • (2014) Protein Cell , pp. 1-15
    • Wang, X.1    Meng, D.2
  • 237
    • 0037056036 scopus 로고    scopus 로고
    • Polyacryl starch microparticles as adjuvant in oral immunisation, inducing mucosal and systemic immune responses in mice
    • Wikingsson LD, Sjoholm I (2002) Polyacryl starch microparticles as adjuvant in oral immunisation, inducing mucosal and systemic immune responses in mice. Vaccine 20:3355–3363
    • (2002) Vaccine , vol.20 , pp. 3355-3363
    • Wikingsson, L.D.1    Sjoholm, I.2
  • 238
    • 84874984038 scopus 로고    scopus 로고
    • Protecting against plague: Towards a next-generation vaccine
    • Williamson ED, Oyston PC (2013) Protecting against plague: towards a next-generation vaccine. Clin Exp Immunol 172:1–8
    • (2013) Clin Exp Immunol , vol.172 , pp. 1-8
    • Williamson, E.D.1    Oyston, P.C.2
  • 239
    • 0942298133 scopus 로고    scopus 로고
    • A 193-amino acid fragment of the SARS coronavirus S protein efficiently binds angiotensin-converting enzyme 2
    • Wong SK, Li W, Moore MJ, Choe H, Farzan M (2004) A 193-amino acid fragment of the SARS coronavirus S protein efficiently binds angiotensin-converting enzyme 2. J Biol Chem 279:3197–3201
    • (2004) J Biol Chem , vol.279 , pp. 3197-3201
    • Wong, S.K.1    Li, W.2    Moore, M.J.3    Choe, H.4    Farzan, M.5
  • 241
    • 77955772258 scopus 로고    scopus 로고
    • Targeted delivery of chitosan nanoparticles to Peyer’s patch using M cell-homing peptide selected by phage display technique
    • Yoo MK, Kang SK, Choi JH, Park IK, Na HS, Lee HC, Kim EB, Lee NK, Nah JW, Choi YJ et al (2010) Targeted delivery of chitosan nanoparticles to Peyer’s patch using M cell-homing peptide selected by phage display technique. Biomaterials 31:7738–7747
    • (2010) Biomaterials , vol.31 , pp. 7738-7747
    • Yoo, M.K.1    Kang, S.K.2    Choi, J.H.3    Park, I.K.4    Na, H.S.5    Lee, H.C.6    Kim, E.B.7    Lee, N.K.8    Nah, J.W.9    Choi, Y.J.10
  • 242
    • 0037159627 scopus 로고    scopus 로고
    • Antibody responses and protection against influenza virus infection in different congenic strains of mice immunized intranasally with adjuvant-combined A/Beijing/262/95 (H1N1) virus hemagglutinin or neuraminidase
    • Yoshikawa T, Suzuki Y, Nomoto A, Sata T, Kurata T, Tamura S (2002) Antibody responses and protection against influenza virus infection in different congenic strains of mice immunized intranasally with adjuvant-combined A/Beijing/262/95 (H1N1) virus hemagglutinin or neuraminidase. Vaccine 21:60–66
    • (2002) Vaccine , vol.21 , pp. 60-66
    • Yoshikawa, T.1    Suzuki, Y.2    Nomoto, A.3    Sata, T.4    Kurata, T.5    Tamura, S.6
  • 243
    • 0347448152 scopus 로고    scopus 로고
    • Effectiveness of the quillaja saponin semisynthetic analog GPI-0100 in potentiating mucosal and systemic responses to recombinant HagB from Porphyromonas gingivalis
    • Zhang P, Yang QB, Marciani DJ, Martin M, Clements JD, Michalek SM, Katz J (2003) Effectiveness of the quillaja saponin semisynthetic analog GPI-0100 in potentiating mucosal and systemic responses to recombinant HagB from Porphyromonas gingivalis. Vaccine 21:4459–4471
    • (2003) Vaccine , vol.21 , pp. 4459-4471
    • Zhang, P.1    Yang, Q.B.2    Marciani, D.J.3    Martin, M.4    Clements, J.D.5    Michalek, S.M.6    Katz, J.7
  • 244
    • 84901003129 scopus 로고    scopus 로고
    • Current advancements and potential strategies in the development of MERS-CoV vaccines
    • Zhang N, Jiang S, Du L (2014) Current advancements and potential strategies in the development of MERS-CoV vaccines. Expert Rev Vaccines 13:761–774
    • (2014) Expert Rev Vaccines , vol.13 , pp. 761-774
    • Zhang, N.1    Jiang, S.2    Du, L.3
  • 245
    • 84886091627 scopus 로고    scopus 로고
    • Virus-like particle-based human vaccines: Quality assessment based on structural and functional properties
    • Zhao Q, Li S, Yu H, Xia N, Modis Y (2013) Virus-like particle-based human vaccines: quality assessment based on structural and functional properties. Trends Biotechnol 31:654–663
    • (2013) Trends Biotechnol , vol.31 , pp. 654-663
    • Zhao, Q.1    Li, S.2    Yu, H.3    Xia, N.4    Modis, Y.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.