Induction of high antitoxin titers against tetanus toxoid in rabbits by intranasal immunization with dextran microspheres

International Journal of Pharmaceutics

Volumn 360, Issue 1-2, 2008, Pages 12-17

  Sajadi Tabassi, S Abolghasem ^a,c   Tafaghodi, Mohsen ^a,b   Jaafari, Mahmoud Reza ^a  

^a MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Antitoxin titers; Dextran microsphere; Nasal immunization; Tetanus toxoid

Indexed keywords

ANTITOXIN; CPG OLIGODEOXYNUCLEOTIDE; DEXTRAN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; MICROSPHERE; SEPHADEX; TETANUS TOXOID;

ANIMAL EXPERIMENT; ANTIBODY DETECTION; ANTIBODY TITER; ANTIGENICITY; ARTICLE; BIOASSAY; BURNING SENSATION; CLINICAL ARTICLE; CONTROLLED STUDY; COUGHING; ENZYME LINKED IMMUNOSORBENT ASSAY; HEMOLYSIS; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; LUNG LAVAGE; NONHUMAN; NORMAL HUMAN; NOSE IRRITATION; PRIORITY JOURNAL; RABBIT; SIDE EFFECT; SNEEZING;

ADMINISTRATION, INTRANASAL; ANIMALS; ANTITOXINS; DEXTRANS; DRUG COMPOUNDING; ERYTHROCYTES; EXCIPIENTS; HEMOLYSIS; IMMUNOGLOBULIN G; IRRITANTS; MICROSPHERES; NEUTRALIZATION TESTS; PARTICLE SIZE; RABBITS; SOLUBILITY; TETANUS TOXOID;

EID: 47149107389     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2008.03.036     Document Type: Article

References (39)

1. Bjork E., and Edman P. Characterization of degradable starch microspheres as a nasal delivery system for drugs. Int. J. Pharm. 62 (1990) 187-192
2. Bjork E., Bjurstrom S., and Edman P. Morphologic examination of rabbit nasal mucosa after nasal administration of degradable starch microspheres. Int. J. Pharm. 75 (1991) 73-79
3. Chandler S.G., Ilium L., and Thomas N.W. Nasal absorption in rats. II. Effect of enhancers on insulin absorption and nasal histology. Int. J. Pharm. 76 (1991) 61-70
4. Cornaz A.-L., De Ascentis A., Colombo P., and Buri P. In vitro characteristics of nicotine microspheres for transnasal delivery. Int. J. Pharm. 129 (1996) 175-183
5. Degling L., and Stjarnkvist P. Biodegradable microspheres. XVIII. The adjuvant effect of polyacryl starch microparticles with conjugated human serum albumin. Vaccine 13 (1995) 629-636
6. Diwan M., Misra A., Khar R.K., and Talwar G.P. Long-term high immune response to diphtheria toxoid in rodents with diphtheria toxoid conjugated to dextran as a single contact point delivery system. Vaccine 15 (1997) 1867-1871
7. Diwan M., Khar R.K., and Talwar G.P. Tetanus toxoid loaded 'preformed microspheres' of cross-linked dextran. Vaccine 19 (2001) 3853-3859
8. Diwan M., Tafaghodi M., and Samuel J. Enhancement of immune responses by co-delivery of a CpG oligodeoxynucleotide and tetanus toxoid in biodegradable nanospheres. J. Control. Release 85 (2002) 247-262
9. Dokmetjian J., Della Valle C., Lavigne V., de Lujan C.M., and Manghi M.A. A possible explanation for the discrepancy between ELISA and neutralising antibodies to tetanus toxin. Vaccine 18 (2000) 2698-2703
10. Eldridge J.H., Staas J.K., Meulbroek J.A., McGhee J.R., Tice T.R., and Gilley R.M. Biodegradable microspheres as a vaccine delivery system. Mol. Immunol. 28 (1991) 287-294
11. Florence A.T. The oral absorption of micro- and nanoparticles: neither exceptional nor unusual. Pharm. Res. 14 (1997) 259-266
12. Fujihashi K., Koga T., van Ginkel F.W., Hagiwara Y., and McGhee J.R. A dilemma for mucosal vaccination: efficacy versus toxicity using enterotoxin-based adjuvants. Vaccine 20 (2002) 2431-2438
13. Gill I.J., Fisher A.N., Farraj N., Pitt C.G., Davis S.S., and Illum L. Intranasal absorption of granulocyte-colony stimulating factor (G-CSF) from powder formulations, in sheep. Eur. J. Pharm. Sci. 6 (1998) 1-10
14. Illum L., Jorgensen H., Bisgaard H., Krogsgaard O., and Rossing N. Bioadhesive microspheres as a potential nasal drug delivery system. Int. J. Pharm. 39 (1987) 189-199
15. Illum L., Farraj N.F., Davis S.S., Johansen B.R., and O'Hagan D.T. Investigation of the nasal absorption of biosynthetic human growth hormone in sheep-use of a bioadhesive microsphere delivery system. Int. J. Pharm. 63 (1990) 207-211
16. Illum L., Fisher A.N., Jabbal-Gill I., and Davis S.S. Bioadhesive starch microspheres and absorption enhancing agents act synergistically to enhance the nasal absorption of polypeptides. Int. J. Pharm. 222 (2001) 109-119
17. Jepson M.A., Clark M.A., and Hirst B.H. M cell targeting by lectins: a strategy for mucosal vaccination and drug delivery. Adv. Drug Deliv. Rev. 56 (2004) 511-525
18. O'Hagan D.T., Rafferty D., Wharton S., and Illum L. Intravaginal immunization in sheep using a bioadhesive microsphere antigen delivery system. Vaccine 11 (1993) 660-664
19. O'Hagan D.T. The intestinal uptake of particles and the implications for drug and antigen delivery. J. Anat. 189 (1996) 477-482
20. Oechslein C.R., Fricker G., and Kissel T. Nasal delivery of octreotide: absorption enhancement by particulate carrier systems. Int. J. Pharm. 139 (1996) 25-32
21. Pereswetoff-Morath L., and Edman P. Dextran microspheres as a potential nasal drug delivery system for insulin-in vitro and in vivo properties. Int. J. Pharm. 124 (1995) 37-44
22. Pereswetoff-Morath L., Bjurstrom S., Khan R., Dahlin M., and Edman P. Toxicological aspects of the use of dextran microspheres and thermogelling ethyl(hydroxyethyl) cellulose (EHEC) as nasal drug delivery systems. Int. J. Pharm. 128 (1996) 9-21
23. Pereswetoff-Morath L., and Edman P. Immunological consequences of nasal drug delivery in dextran microspheres and ethyl(hydroxyethyl)cellulose in rats. Int. J. Pharm. 128 (1996) 23-28
24. Pereswetoff-Morath L. Microspheres as nasal drug delivery systems. Adv. Drug Deliv. Rev. 29 (1998) 185-194
25. Rydell N., and Sjoholm I. Oral vaccination against diphtheria using polyacryl starch microparticles as adjuvant. Vaccine 22 (2004) 1265-1274
26. Rydell N., and Sjoholm I. Mucosal vaccination against diphtheria using starch microparticles as adjuvant for cross-reacting material (CRM197) of diphtheria toxin. Vaccine 23 (2005) 2775-2783
27. Ryden L., and Edman P. Effect of polymers and microspheres on the nasal absorption of insulin in rats. Int. J. Pharm. 83 (1982) 1-10
28. Stenekes R.J.H., Loebis A.E., Fernandes C.M., Crommelin D.J.A., and Hennink W.E. Degradable dextran microspheres for the controlled release of liposomes. Int. J. Pharm. 214 (2001) 17-20
29. Stertman L., Strindelius L., and Sjoholm I. Starch microparticles as an adjuvant in immunization: effect of route of administration on the immune response in mice. Vaccine 22 (2004) 2863-2872
30. Stertman L., Lundgren E., and Sjoholm I. Starch microparticles as a vaccine adjuvant: only uptake in Peyer's patches decides the profile of the immune response. Vaccine 24 (2006) 3661-3668
31. Tafaghodi M., Sajadi Tabassi S.A., Jaafari M.R., Zakavi S.R., and Momen Nejad M. Evaluation of the clearance characteristics of various microspheres in the human nose by gamma-scintigraphy. Int. J. Pharm. 280 (2004) 125-135
32. Tafaghodi M., Jaafari M.R., and Sajadi Tabasi S.A. Nasal immunization studies by liposomes encapsulated with tetanus toxoid and CpG-ODN. Eur. J. Pharm. Biopharm. 64 (2006) 138-145
33. Tafaghodi M., Sajadi Tabasi S.A., and Jaafari M.R. Induction of systemic and mucosal immune responses by intranasal administration of alginate microspheres encapsulated with tetanus toxoid and CpG-ODN. Int. J. Pharm. 319 (2006) 37-43
34. Tafaghodi M., Sajadi Tabasi S.A., and Jaafari M.R. Nasal immunization study by PLGA nanospheres encapsulated with tetanus toxoid and CpG-ODN. Iranian J. Pharm. Res. 6 (2007) 151-158
35. Tafaghodi M., Jaafari M.R., and Sajadi Tabasi S.A. Nasal immunization studies by cationic, fusogenic and cationic-fusogenic liposomes encapsulated with tetanus toxoid. Curr. Drug Deliv. 5 (2008) 108-113
36. van der Lubben I.M., Verhoef J.C., Borchard G., and Junginger H.E. Chitosan for mucosal vaccination. Adv. Drug Deliv. Rev. 52 (2001) 139-144
37. Voet D., and Voet J.G. Biochemistry (1990), John Wiley & Sons, USA
38. Walker R.I. New strategies for using mucosal vaccination to achieve more effective immunization. Vaccine 12 (1994) 387-400
39. Wassilak S.G.F., Orenstein W.A., and Sutter R.W. Tetanus toxoid. In: Plotkinand Mortimer (Ed). Vaccines vols. 57-90 (1994)