Quillaja saponaria extract as mucosal adjuvant with chitosan functionalized gold nanoparticles for mucosal vaccine delivery: Stability and immunoefficiency studies

International Journal of Pharmaceutics

Volumn 441, Issue 1-2, 2013, Pages 636-642

  Barhate, Ganesh ^a   Gautam, Manish ^b   Gairola, Sunil ^b   Jadhav, Suresh ^b   Pokharkar, Varsha ^a  

^a BHARATI VIDYAPEETH DEEMED UNIVERSITY   (India)

^b Serum Institute of India Ltd   (India)

Author keywords

Adjuvant synergy; Formulation stability; Gold nanoparticle; Mucosal vaccine

Indexed keywords

CHITOSAN; GOLD NANOPARTICLE; PLANT EXTRACT; QUILLAJA SAPONARIA EXTRACT; TETANUS TOXOID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN SPECIFICITY; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG STABILITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE; FOURIER TRANSFORM INFRARED PHOTOACOUSTIC SPECTROSCOPY; HYDROLYSIS; IMMUNE RESPONSE; IN VITRO STUDY; MOUSE; NONHUMAN; PH; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SPECTROSCOPY; ZETA POTENTIAL;

ADJUVANTS, IMMUNOLOGIC; ADMINISTRATION, ORAL; ANIMALS; CHITOSAN; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; DRUG STABILITY; ENZYME-LINKED IMMUNOSORBENT ASSAY; GOLD; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; METAL NANOPARTICLES; MICE; MICE, INBRED BALB C; MUCOUS MEMBRANE; PARTICLE SIZE; PLANT EXTRACTS; QUILLAJA; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TETANUS TOXOID; VACCINES;

EID: 84872810738     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.10.033     Document Type: Article

References (39)

1. M. Amidi, E. Mastrobattista, W. Jiskoot, and W.E. Hennink Chitosan-based delivery systems for protein therapeutics and antigens Adv. Drug Deliv. Rev. 62 2010 59 82
2. A. Bendelac, and R. Medzhitov Adjuvants of immunity: harnessing innate immunity to promote adaptive immunity J. Exp. Med. 195 2002 F19 F23
3. D.R. Bhumkar, H.M. Joshi, M. Sastry, and V.B. Pokharkar Chitosan reduced gold nanoparticles as novel carriers for transmucosal delivery of insulin Pharm. Res. 24 2007 1415 1426
4. S.C. Boca, M. Potara, F. Toderas, O. Stephan, P.L. Baldeck, and S. Astilean Uptake and biological effects of chitosan-capped gold nanoparticles on Chinese hamster ovary cells Mater. Sci. Eng. C 3 2011 1184 1189
5. O. Borges, F. Lebre, D. Bento, G. Borchard, and H.E. Junginger Mucosal vaccines: recent progress in understanding the natural barriers Pharm. Res. 27 2010 211 223
6. P.N. Boyaka, M. Marinaro, R.J. Jackson, F.W. van Ginkel, E.C. Boyaka, K.L. Kirk, C.R. Kensil, and J.R. McGhee Oral QS-21 requires early IL-4 help for induction of mucosal and systemic immunity J. Immunol. 166 2001 2283 2290
7. M. Carbonaro, and A. Nucara Secondary structure of food proteins by Fourier transform spectroscopy in the mid-infrared region Amino Acids 38 2010 679 690
8. A.M. Carcaboso, R.M. Hernández, M. Igartua, J.E. Rosas, M.E. Patarroyo, and J.L. Pedraz Potent, long lasting systemic antibody levels and mixed Th1/Th2 immune response after nasal immunization with malaria antigen loaded PLGA microparticles Vaccine 22 2004 1423 1432
9. CD Pro, 2012. http://lamar.colostate.edu/∼sreeram/CDPro/main.html (accessed 03.05.2012).
10. D.H.A. Corrêa, and C.H.I. Ramos The use of circular dichroism spectroscopy to study protein folding, form and function Afr. J. Biochem. Res. 3 2009 164 173
11. S.C. Diesner, X.Y. Wang, E.J. Jarolim, E. Untersmayr, and F. Gabor Use of lectin-functionalized particles for oral immunotherapy Ther. Deliv. 3 2012 277 290
12. T. Fifis, A. Gamvrellis, B.C. Irwin, G.A. Pietersz, J. Li, P.L. Mottram, I.F.C. McKenzie, and M. Plebanski Size-dependent immunogenicity: therapeutic and protective properties of nano-vaccines against tumors J. Immunol. 173 2004 3148 3154
13. N. Garçon, and M. Van Mechelen Recent clinical experience with vaccines using MPL- and QS-21-containing adjuvant systems Expert Rev. Vaccine 10 2011 471 486
14. P. Garidel, M. Hegyi, S. Bassarab, and M. Weichel A rapid, sensitive and economical assessment of monoclonal antibody conformational stability by intrinsic tryptophan fluorescence spectroscopy Biotechnol. J. 3 2008 1201 1211
15. P. Ghosh, G. Han, M. De, C.K. Kim, and V.M. Rotello Gold nanoparticles in delivery applications Adv. Drug Deliv. Rev. 60 2008 1307 1315
16. N.K. Gupta, P. Tomar, V. Sharma, and V.K. Dixit Development and characterization of chitosan coated poly-(ε-caprolactone) nanoparticulate system for effective immunization against influenza Vaccine 29 2011 9026 9037
17. M. Iosin, F. Toderas, P.L. Baldeck, and S. Astilean Study of protein-gold nanoparticle conjugates by fluorescence and surface-enhanced Raman scattering J. Mol. Struct. 924-926 2009 196 200
18. P. Johansen, H.P. Merkle, and B. Gander Physico-chemical and antigenic properties of tetanus and diphtheria toxoids and steps towards improved stability Biochim. Biophys. Acta 1425 1998 425 436
19. C.G. Kumar, S.K. Mamidyala, B. Sreedhar, and B.V. Reddy Synthesis and characterization of gold glyconanoparticles functionalized with sugars of sweet Sorghum syrup Biotechnol. Prog. 27 2011 1455 1463
20. J.M. Langle A nasally administered proteosome-adjuvanted inactivated trivalent influenza vaccine: evidence in adults to date 5th WHO Meeting on Influenza Vaccines that Induce Broad Spectrum and Long-lasting Immune Responses 2011
21. M. Liang, I.C. Lin, M.R. Whittaker, R.F. Minchin, M.J. Monteiro, and I. Toth Cellular uptake of densely packed polymer coatings on gold nanoparticles ACS Nano 4 2010 403 413
22. I.C. Lin, M. Liang, T.Y. Liu, M.J. Monteiro, and I. Toth Cellular transport pathways of polymer coated gold nanoparticles Nanomed. Nanotechnol. 8 2012 8 11
23. P.O. Livingston, and G. Ragupathi Cancer vaccines targeting carbohydrate antigens Hum. Vaccin. 2 2006 137 143
24. O.H. Lowry, N.J. Rosebrough, A.L. Farr, and R.J. Randall Protein measurement with the Folin phenol reagent J. Biol. Chem. 193 1951 265 275
25. I. Lubben, J.C. Verhoef, G. Borchard, and H.E. Junginger Chitosan for mucosal vaccination Adv. Drug Deliv. Rev. 52 2001 139 144
26. K. Matsuda, A.A. Chaudhari, and J.H. Lee Evaluation of safety and protection efficacy on cpxR and lon deleted mutant of Salmonella Gallinarum as a live vaccine candidate for fowl typhoid Vaccine 29 2011 668 674
27. K.H.G. Mills, C. Cosgrove, E.A. McNeela, A. Sexton, R. Giemza, I.J. Gill, A. Church, W. Lin, L. Illum, A. Podda, R. Rappuoli, M. Pizza, G.E. Griffin, and D.J.M. Lewis Protective levels of diphtheria-neutralizing antibody induced in healthy volunteers by unilateral priming-boosting intranasal immunization associated with restricted ipsilateral mucosal secretory immunoglobulin A Infect. Immun. 71 2003 726 732
28. N. Mishra, S. Tiwari, B. Vaidya, G.P. Agrawal, and S.P. Vyas Lectin anchored PLGA nanoparticles for oral mucosal immunization against hepatitis B J. Drug Target. 19 2011 67 78
29. M.R. Neutra, and P.A. Kozlowski Mucosal vaccines: the promise and the challenge Nat. Rev. Immunol. 6 2006 148 158
30. C.M. O'Neal, S.E. Crawford, M.K. Estes, and M.E. Conner Rotavirus VLPs administered mucosally induce protective immunity J. Virol. 71 1997 8707 8717
31. S. Parween, P.K. Gupta, and V.S. Chauhan Induction of humoral immune response against PfMSP-119 and PvMSP-119 using gold nanoparticles along with alum Vaccine 29 2011 2451 2460
32. J.T. Pelton, and L.R. McLean Spectroscopic methods for analysis of protein secondary structure Anal. Biochem. 277 2000 167 176
33. V. Pokharkar, D. Bhumkar, K. Suresh, Y. Shinde, S. Gairola, and S.S. Jadhav Gold nanoparticles as a potential carrier for transmucosal vaccine delivery J. Biomed. Nanotechnol. 7 2011 57 59
34. M.R. Roner, K.I. Tam, and M.K. Barrager Prevention of rotavirus infections in vitro with aqueous extracts of Quillaja Saponaria Molina Future Med. Chem. 2 2010 1883 1897
35. G. Ragupathi, J.R. Gardner, P.O. Livingston, and D.Y. Gin Natural and synthetic saponin adjuvant QS-21 for vaccines against cancer Expert Rev. Vaccine 10 2011 463 470
36. H.X. Sun, Y. Xie, and Y.P. Ye Advances in saponin-based adjuvants Vaccine 27 2009 1787 1796
37. US FDA, 2012. http://www.fda.gov/iceci/inspections/inspectionguides/ ucm074935.htm (accessed 01.07.2012).
38. H. Yamamoto, Y. Kuno, S. Sugimoto, H. Takeuchi, and Y. Kawashima Surface-modified PLGA nanosphere with chitosan improved pulmonary delivery of calcitonin by mucoadhesion and opening of the intercellular tight junctions J. Control. Release 102 2005 373 381
39. H.Y. Zhou, X.G. Chen, and W.F. Zhang In vitro and in vivo evaluation of mucoadhesiveness of chitosan/cellulose acetate multimicrospheres J. Biomed. Mater. Res. A 83 2007 1146 1153