A 193-Amino Acid Fragment of the SARS Coronavirus S Protein Efficiently Binds Angiotensin-converting Enzyme 2

Journal of Biological Chemistry

Volumn 279, Issue 5, 2004, Pages 3197-3201

  Wong, Swee Kee ^a   Li, Wenhui ^a   Moore, Michael J ^a   Choe, Hyeryun ^b   Farzan, Michael ^a,c  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c Partners AIDS Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ANTIBODIES; CELLS; ENZYMES; MUTAGENESIS;

SEVERE ACUTE RESPIRATORY SYNDROME (SARS);

BIOCHEMISTRY;

ACE2 ENZYME; ALANINE; AMINO ACID; ASPARTIC ACID; CARBOXYPEPTIDASE; CELL ADHESION MOLECULE; CYSTEINE; DIPEPTIDYL CARBOXYPEPTIDASE; GLUTAMIC ACID; MEMBRANE PROTEIN; RECEPTOR SUBUNIT; SPIKE GLYCOPROTEIN, CORONAVIRUS; VIRUS ENVELOPE PROTEIN; VIRUS PROTEIN; VITRONECTIN;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL LINE; CHEMISTRY; DOSE RESPONSE; FLOW CYTOMETRY; GENETIC TRANSFECTION; HOST CELL; HUMAN; IC 50; METABOLISM; MUTATION; NONHUMAN; POINT MUTATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN TERTIARY STRUCTURE; RECEPTOR BINDING; SARS CORONAVIRUS; SEVERE ACUTE RESPIRATORY SYNDROME; TARGET CELL;

ALANINE; CARBOXYPEPTIDASES; CELL LINE; CYSTEINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FLOW CYTOMETRY; GLUTAMIC ACID; HUMANS; INHIBITORY CONCENTRATION 50; MEMBRANE GLYCOPROTEINS; MUTATION; PEPTIDYL-DIPEPTIDASE A; POINT MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SARS VIRUS; TRANSFECTION; VIRAL ENVELOPE PROTEINS;

ANIMALIA; CORONAVIRUS; SARS CORONAVIRUS; SARS COV;

EID: 0942298133     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.C300520200     Document Type: Article

References (18)

1. Ksiazek, T. G., Erdman, D., Goldsmith, C. S., Zaki, S. R., Peret, T., Emery, S., Tong, S., Urbani, C., Comer, J. A., Lim, W., Rollin, P. E., Dowell, S. F., Ling, A. E., Humphrey, C. D., Shieh, W. J., Guarner, J., Paddock, C. D., Rota, P., Fields, B., DeRisi, J., Yang, J. Y., Cox, N., Hughes, J. M., LeDuc, J. W., Bellini, W. J., and Anderson, L. J. (2003) N. Engl. J. Med. 348, 1953-1966
2. Drosten, C., Gunther, S., Preiser, W., van der Werf, S., Brodt, H. R., Becker, S., Rabenau, H., Panning, M., Kolesnikova, L., Fouchier, R. A., Berger, A., Burguiere, A. M., Cinatl, J., Eickmann, M., Escriou, N., Grywna, K., Kramme, S., Manuguerra, J. C., Muller, S., Rickerts, V., Sturmer, M., Vieth, S., Klenk, H. D., Osterhaus, A. D., Schmitz, H., and Doerr, H. W. (2003) N. Engl. J. Med. 348, 1967-1976
3. Kuiken, T., Fouchier, R. A., Schutten, M., Rimmelzwaan, G. F., van Amerongen, G., van Riel, D., Laman, J. D., de Jong, T., van Doornum, G., Lim, W., Ling, A. E., Chan, P. K., Tam, J. S., Zambon, M. C., Gopal, R., Drosten, C., van der Werf, S., Escriou, N., Manuguerra, J. C., Stohr, K., Peiris, J. S., and Osterhaus, A. D. (2003) Lancet. 362, 263-270
4. Fouchier, R. A., Kuiken, T., Schutten, M., van Amerongen, G., van Doornum, G. J., van den Hoogen, B. G., Peiris, M., Lim, W., Stohr, K., and Osterhaus, A. D. (2003) Nature 423, 240
5. Marra, M. A., Jones, S. J., Astell, C. R., Holt, R. A., Brooks-Wilson, A., Butterfield, Y. S., Khattra, J., Asano, J. K., Barber, S. A., Chan, S. Y., Cloutier, A., Coughlin, S. M., Freeman, D., Girn, N., Griffith, O. L., Leach, S. R., Mayo, M., McDonald, H., Montgomery, S. B., Pandoh, P. K., Petrescu, A. S., Robertson, A. G., Schein, J. E., Siddiqui, A., Smailus, D. E., Stott, J. M., Yang, G. S., Plummer, F., Andonov, A., Artsob, H., Bastien, N., Bernard, K., Booth, T. F., Bowness, D., Czub, M., Drebot, M., Fernando, L., Flick, R., Garbutt, M., Gray, M., Grolla, A., Jones, S., Feldmann, H., Meyers, A., Kabani, A., Li, Y., Normand, S., Stroher, U., Tipples, G. A., Tyler, S., Vogrig, R., Ward, D., Watson, B., Brunham, R. C., Krajden, M., Petric, M., Skowronski, D. M., Upton, C., and Roper, R. L. (2003) Science 300, 1399-1404
6. Rota, P. A., Oberste, M. S., Monroe, S. S., Nix, W. A., Campagnoli, R., Icenogle, J. P., Penaranda, S., Bankamp, B., Maher, K., Chen, M. H., Tong, S., Tamin, A., Lowe, L., Frace, M., DeRisi, J. L., Chen, Q., Wang, D., Erdman, D. D., Peret, T. C., Burns, C., Ksiazek, T. G., Rollin, P. E., Sanchez, A., Liffick, S., Holloway, B., Limor, J., McCaustland, K., Olsen-Rasmussen, M., Fouchier, R., Gunther, S., Osterhaus, A. D., Drosten, C., Pallansch, M. A., Anderson, L. J., and Bellini, W. J. (2003) Science 300, 1394-1399
7. Li, W., Moore, M. J., Vasilieva, N., Sui, J., Wong, S. K., Berne, M. A., Somasundaran, M., Sullivan, J. L., Luzeriaga, C., Greenough, T. C., Choe, H., and Farzan, M. (2003) Nature 426, 450-454
8. Sturman, L. S., and Holmes, K. V. (1984) Adv. Exp. Med. Biol. 173, 25-35
9. Jackwood, M. W., Hilt, D. A., Callison, S. A., Lee, C. W., Plaza, H., and Wade, E. (2001) Avian Dis. 45, 366-372
10. Gallagher, T. M., and Buchmeier, M. J. (2001) Virology 279, 371-374
11. Bonavia, A., Zelus, B. D., Wentworth, D. E., Talbot, P. J., and Holmes, K. V. (2003) J. Virol. 77, 2530-2538
12. Breslin, J. J., Mork, I., Smith, M. K., Vogel, L. K., Hemmila, E. M., Bonavia, A., Talbot, P. J., Sjostrom, H., Noren, O., and Holmes, K. V. (2003) J. Virol. 77, 4435-4438
13. Kubo, H., Yamada, Y. K., and Taguchi, F. (1994) J. Virol. 68, 5403-5410
14. Dveksler, G. S., Pensiero, M. N., Cardellichio, C. B., Williams, R. K., Jiang, G. S., Holmes, K. V., and Dieffenbach, C. W. (1991) J. Virol. 65, 6881-6891
15. Dveksler, G. S., Dieffenbach, C. W., Cardellichio, C. B., McCuaig, K., Pensiero, M. N., Jiang, G. S., Beauchemin, N., and Holmes, K. V. (1993) J. Virol. 67, 1-8
16. Yeager, C. L., Ashmun, R. A., Williams, R. K., Cardellichio, C. B., Shapiro, L. H., Look, A. T., and Holmes, K. V. (1992) Nature 357, 420-422
17. Farzan, M., Mirzabekov, T., Kolchinsky, P., Wyatt, R., Cayabyab, M., Gerard, N. P., Gerard, C., Sodroski, J., and Choe, H. (1999) Cell 96, 667-676
18. Bannert, N., Schenten, D., Craig, S., and Sodroski, J. (2000) J. Virol. 74, 10984-10993