IL-12 is an effective adjuvant for induction of mucosal immunity

Journal of Immunology

Volumn 162, Issue 1, 1999, Pages 122-128

  Boyaka, Prosper N ^a   Marinaro, Mariarosaria ^a   Jackson, Raymond J ^a   Menon, Satish ^c   Kiyono, Hiroshi ^a,b   Jirillo, Emilio ^d   McGhee, Jerry R ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b OSAKA UNIVERSITY   (Japan)

^c MERCK RESEARCH LABORATORIES   (United States)

^d UNIVERSITY OF BARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN A; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; INTERLEUKIN 2; INTERLEUKIN 4; TETANUS TOXOID;

ACTIVE IMMUNIZATION; ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ARTICLE; HELPER CELL; IMMUNOGENICITY; IMMUNOGLOBULIN PRODUCTION; IMMUNOSTIMULATION; INTERFERON PRODUCTION; INTRANASAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ADJUVANTS, IMMUNOLOGIC; ADMINISTRATION, INTRANASAL; ANIMALS; ANTIBODIES, BACTERIAL; CD4-POSITIVE T-LYMPHOCYTES; CYTOKINES; IMMUNITY, MUCOSAL; IMMUNOGLOBULIN A, SECRETORY; INTERLEUKIN-12; INTERLEUKIN-6; MICE; MICE, INBRED C57BL; NASAL MUCOSA; TETANUS; TETANUS TOXIN; TETANUS TOXOID;

EID: 0032932272     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. + T cells. Annu. Rev. Immunol. 12:635.
2. Mosmann, T. R., and R. L. Coffman. 1989. Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7:145.
3. Manetti, R., P. Parronchi, M. G. Giudizi, M. P. Piccini, E. Maggi, G. Trinchieri, and S. Romagnani. 1993. Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells. J. Exp. Med. 177:1199.
4. + T cells. J. Exp. Med. 185:461.
5. Vajdy, M., M. H. Kosco-Vilbois, M. Kopf, G. Kohler, and N. Lycke. 1995. Impaired mucosal immune responses in interleukin 4-targeted mice. J. Exp. Med. 181:41.
6. + Th2 cells producing IL-6 and IL-10 are associated with mucosal immunoglobulin A responses. Infect. Immun. 4:1516.
7. Marinaro, M., H. F. Staats, T. Hiroi, R. J. Jackson, M. Coste, P. N. Boyaka, N. Okahashi, M. Yamamoto, H. Kiyono, H. Bluethmann, et al. 1995. Mucosal adjuvant effect of cholera toxin in mice results from induction of T helper 2 (Th2) cells and IL-4. J. Immunol. 155:4621.
8. Beagley, K. W., J. H. Eldridge, F. Lee, H. Kiyono, M. P. Everson, W. J. Koopman, T. Hirano, T. Kishimoto, and J. R. McGhee. 1989. Interleukins and IgA synthesis: human and murine interleukin 6 induce high rate IgA secretion in IgA-committed B cells. J. Exp. Med. 169:2133.
9. VanCott, J. L., H. F. Staats, D. W. Pascual, M. Roberts, S. N. Chatfield, M. Yamamoto, M. Coste, P. B. Carter, H. Kiyono, and J. R. McGhee. 1996. Regulation of mucosal and systemic antibody responses by T helper cell subsets, macrophages, and derived cytokines following oral immunization with live recombinant Salmonella. J. Immunol. 156:1504.
10. Van Ginkel, F. W., C. Liu, J. W. Simecka, J. Y. Dong, T. Greenway, R. A. Frizzell, H. Kiyono, J. R. McGhee, and D. W. Pascual. 1995. Intratracheal gene delivery with adenoviral vector induces elevated systemic IgG and mucosal IgA antibodies to adenovirus and β-galactosidase. Hum. Gene Ther. 6:895.
11. Marinaro, M., P. N. Boyaka, F. D. Finkelman, H. Kiyono, R. J. Jackson, E. Jirillo, and J. R. McGhee. 1997. Oral but not parenteral IL-12 redirects T helper 2 (Th2)-type responses to an oral vaccine without altering mucosal IgA responses. J. Exp. Med. 185:415.
12. Van Damme, J., S. Cayphas, J. Van Snick, R. Conings, W. Put, J. P. Lenaerts, R. J. Simpson, and A. Billiau. 1987. Purification and characterization of human fibroblast-derived hybridoma growth factor identical to T-cell-derived B-cell stimulatory factor-2 (interleukin-6). Eur. J. Biochem. 168:543.
13. Van Snick, J. 1990. Interleukin-6: an overview. Annu. Rev. Immunol. 8:253.
14. + precursor subpopulations. J. Immunol. 151:2895.
15. Luger, T. A., J. Krutmann, R. Kimbauer, A. Urbanski, T. Schwarz, G. Klappacher, A. Kock, M. Micksche, J. Malejczyk, E. Schauer, et al. 1989. IFN-beta 2/IL-6 augments the activity of human natural killer cells. J. Immunol. 143:1206.
16. Mule, J. J., M. C. Custer, W. D. Travis, and S. A. Rosenberg. 1992. Cellular mechanisms of the antitumor activity of recombinant IL-6 in mice. J. Immunol. 148:2622.
17. Katz, A., L. M. Shulman, A. Porgador, M. Revel, M. Feldman, and L. Eisenbach. 1993. Abrogation of B16 melanoma metastases by long-term low-dose interleukin-6 therapy. J. Immunother. 13:98.
18. Bertolini, J. N., and E. M. Benson. 1990. The role of human interleukin-6 in B-cell isotype regulation and differentiation. Cell. Immunol. 125:197.
19. Bromander, A. K., L. Ekman, M. Kopf, J. G. Nedrud, and N. Y. Lycke. 1996. IL-6-deficient mice exhibit normal mucosal IgA responses to local immunizations and Helicobacter felis infection. J. Immunol. 156:4290.
20. Ramsay, A. J., A. J. Husband, I. A. Ramshaw, S. Bao, K. I. Matthaei, G. Koehler, and M. Kopf. 1994. The role of interleukin-6 in mucosal IgA antibody responses in vivo. Science 264:561.
21. Chan, S. H., B. Perussia, J. W. Gupta, M. Kobayashi, M. Pospisil, H. A. Young, S. F. Wolf, D. Young, S. C. Clark, and G. Trinchieri. 1991. Induction of IFN-γ production by NK cell stimulatory factor (NKSF): characterization of the responder cells and synergy with other inducers. J. Exp. Med. 173:869.
22. + T cells to enhance priming for interferon γ production and diminishes interleukin 4 inhibition of such priming. Proc: Natl. Acad. Sci. USA 90:10188.
23. Trinchieri, G. 1995. Interleukin-12: a proinflammatory cytokine with immuno-regulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13:251.
24. + T cells through IL-12 produced by Listeria-induced macrophages. Science 260:547.
25. Metzger, D. W., R. M. McNutt, J. T. Collins, J. M. Buchanan, C. V. Van Cleave, and W. A. Dunnick. 1997. Interleukin-12 acts as an adjuvant for humoral immunity through interferon-γ-dependent and -independent mechanisms. Eur. J. Immunol. 27:1958.
26. Jackson, R. J., K. Fujihashi, J. Xu-Amano, H. Kiyono, C. O. Elson, and J. R. McGhee. 1993. Optimizing oral vaccines: induction of systemic and mucosal B-cell and antibody responses to tetanus toxoid by use of cholera toxin as an adjuvant. Infect. Immun. 61:4272.
27. Xu-Amano, J., H. Kiyono, R. J. Jackson, H. F. Staats, K. Fujihashi, P. D. Burrows, C. O. Elson, S. Pillai, and J. R. McGhee. 1993. Helper T cell subsets for immunoglobulin A responses: oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues. J. Exp. Med. 178:1309.
28. Costelloe, K. E., S. H. Smith, and R. E. Callard. 1993. Interleukin 6 is not required for antigen-specific antibody responses by human B cells. Eur. J. Immunol. 23:984.
29. Takatsuki, F., A. Okano, C. Suzuki, R. Chieda, Y. Takahara, T. Hirano, T. Kishimoto, J. Hamuro, and Y. Akiyama. 1988. Human recombinant IL-6/B cell stimulatory factor 2 augments murine antigen-specific antibody responses in vitro and in vivo. J. Immunol. 141:3072.
30. Baqar, S., N. D. Pacheco, and F. M. Rollwagen. 1993. Modulation of mucosal immunity against Campylobacter jejuni by orally administered cytokines. Antimicrob. Agents Chemother. 37:2688.
31. Ulevitch, R. J., and P. S. Tobias. 1995. Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin. Annu. Rev. Immunol. 13:437.
32. Li, L., D. Young, S. F. Wolf, and Y. S. Choi. 1996. Interleukin-12 stimulates B cell growth by inducing IFN-gamma. Cell. Immunol. 168-133.
33. Aralanandam, B. P., and D. W. Metzger. 1998. Modulation of mucosal and systemic immunity by intranasal interleukin 12 delivery. Vaccine. In Press.
34. Finkelman, F. D., J. Holmes, I. M. Katona, J. F. Urban, M. P. Beckman, L. S. Park, K. A. Schooley, R. L. Coffman, T. R. Mosmann, and W. E. Paul. 1990. Lymphokine control of in vivo immunoglobulin isotype selection. Annu. Rev. Immunol. 8:303.
35. Finkelman, F. D., I. M. Katona, J. F. Urban Jr., J. Holmes, J. O'Hara, A. S. Tung, J. V. Sample, and W. E. Paul. 1988. IL-4 is required to generate and sustain in vivo IgE responses. J. Immunol. 141:2335.
36. + T helper cell 1 development in interleukin 6-deficient mice infected with Candida albicans. J. Exp. Med. 183:1345.
37. Wynn, T. A., D. Jankovic, S. Hieny, K. Zioncheck, P. Jardieu, A. W. Cheever, A. Sher. 1995. IL-12 exacerbates rather than suppresses T helper 2-dependent pathology in the absence of endogenous IFN-γ. J. Immunol. 154:3999.
38. Germann, T., M. Bongartz, H. Dlugonska, H. Hess, E. Schmitt, L. Kolbe, E. Kolsch, F. J. Podlaski, M. K. Gately, and E. Rude. 1995. Interleukin-12 profoundly up-regulates the synthesis of antigen-specific complement-fixing IgG2a, IgG2b and IgG3 antibody subclasses in vivo. Eur. J. Immunol. 25:823.
39. Finkelman, F. D., K. B. Madden, A. W. Cheveer, I. M. Katona, S. C. Morris, M. K. Gately, B. R. Hubbard, W. C. Gause, and J. F. Urban, Jr. 1994. Effects of Interleukin 12 on immune responses and host protection in mice infected with intestinal nematode parasites. J. Exp. Med. 179:1563.
40. Marinaro, M., P. N. Boyaka, R. J. Jackson, F. D. Finkelman, H. Kiyono, E. Jirillo, and J. R. McGhee. 1998. Use of intranasal IL-12 to target predominantly Th1 responses to nasal and Th2 responses to oral vaccines given with cholera toxin. J. Immunol. 162:114.