Antigen presentation in vaccine development

Comparative Immunology, Microbiology and Infectious Diseases

Volumn 26, Issue 5-6, 2003, Pages 309-328

  Takahashi, Hidemi ^a  

^a NIPPON MEDICAL SCHOOL   (Japan)

Author keywords

Acquired adaptive immunity; Antigen processing and presentation; Cross presentation; Cytotoxic T lymphocytes; Dendritic cells; Innate immunity; Vaccine development

Indexed keywords

CD1 ANTIGEN; CYTOKINE; IMMUNOGLOBULIN RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; TOLL LIKE RECEPTOR; VACCINE;

ANTIBODY PRODUCTION; ANTIGEN PRESENTATION; ANTIGEN RECOGNITION; B LYMPHOCYTE; CELL TYPE; CELLULAR IMMUNITY; CYTOKINE RELEASE; DENDRITIC CELL; DRUG DESIGN; HUMAN; HUMORAL IMMUNITY; IMMUNE RESPONSE; PATTERN RECOGNITION; REVIEW; T LYMPHOCYTE;

EID: 0141717938     PISSN: 01479571     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0147-9571(03)00017-1     Document Type: Article

References (107)

1. Rescigno M, Urbano M, Valzasina B, et al. Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria. Nat Immunol 2001;2(4):361-7.
2. 4+ T cell depletion and viral replication in SIV infection. Science 1998;280(5362): 427-31.
3. Wilson LA, Murphey-Corb M, Martin LN, et al. Identification of SIV env-specific CTL in the jejunal mucosa in vaginally exposed, seronegative rhesus macaques (Macaca mulatta). J Med Primatol 2000;29(3-4):173-81.
4. Spira AI, Marx PA, Patterson BK, et al. Cellular targets of infection and route of viral dissemination after an intravaginal inoculation of simian immunodeficiency virus into rhesus macaques. J Exp Med 1996;183(1):215-25.
5. Miller CJ, Hu J. T cell-tropic simian immunodeficiency virus (SIV) and simian-human immunodeficiency viruses are readily transmitted by vaginal inoculation of rhesus macaques, and Langerhans' cells of the female genital tract are infected with SIV. J Infect Dis 1999; 179(3):S413-7.
6. Lohman BL, Miller CJ, McChesney MB. Antiviral cytotoxic T lymphocytes in vaginal mucosa of simian immunodeficiency virus-infected rhesus macaques. J Immunol 1995; 155(12):5855-60.
7. Mowat AM, Viney JL. The anatomical basis of intestinal immunity. Immunol Rev 1997;156: 145-66.
8. Kelsall BL, Strober W. Distinct populations of dendritic cells are present in the subepithelial dome and T cell regions of the murine Peyer's patch. J Exp Med 1996;183(1):237-47.
9. Kraehenbuhl JP, Neutra MR. Epithelial M cells: differentiation and function. Annu Rev Cell Dev Biol 2000;16:301-32.
10. Medzhitov R, Janeway Jr. C. The toll receptor family and microbial recognition. Trends Microbiol 2000;8(10):452-6.
11. Akira S, Takeda K, Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol 2001;2(8):675-80.
12. Aliprantis AO, Yang RB, Mark MR, et al. Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2. Science 1999;285(5428):736-9.
13. Takeuchi O, Hoshino K, Kawai T, et al. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 1999;11(4): 443-51.
14. Underhill DM, Ozinsky A, Smith KD, et al. Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages. Proc Natl Acad Sci USA 1999;96(25): 14459-63.
15. Poltorak A, He X, Smirnova I, et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 1998;282(5396):2085-8.
16. Hayashi F, Smith KD, Ozinsky A, et al. The innate immune response to bacterial flagellin is mediated by toll-like receptor 5. Nature 2001;410(6832):1099-103.
17. Hemmi H, Takeuchi O, Kawai T, et al. A toll-like receptor recognizes bacterial DNA. Nature 2000;408(6813):740-5.
18. Alexopoulou L, Holt AC, Medzhitov R, et al. Recognition of double-stranded RNA and activation of NF-kappaB by toll-like receptor 3. Nature 2001;413(6857):732-8.
19. Moller G. One non-specific signal triggers B lymphocytes. Transplant Rev 1975;23:126-37.
20. Geijtenbeek TB, Torensma R, van Vliet SJ, et al. Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses. Cell 2000;100(5): 575-85.
21. Geijtenbeek TB, Kwon DS, Torensma R, et al. DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells. Cell 2000;100(5):587-97.
22. Pohlmann S, Baribaud F, Lee B, et al. DC-SIGN interactions with human immunodeficiency virus type 1 and 2 and simian immunodeficiency virus. J Virol 2001; 75(10):4664-72.
23. Heath SL, Tew JG, Szakal AK, et al. Follicular dendritic cells and human immunodeficiency virus infectivity. Nature 1995;377(6551):740-4.
24. Kwon DS, Gregorio G, Bitton N, et al. DC-SIGN-mediated internalization of HIV is required for trans-enhancement of T cell infection. Immunity 2002;16(1):135-44.
25. Sol-Foulon N, Moris A, Nobile C, et al. HIV-1 nef-induced upregulation of DC-SIGN in dendritic cells promotes lymphocyte clustering and viral spread. Immunity 2002;16(1): 145-55.
26. Takahashi H. Antigen processing and presentation. Microbiol Immunol 1993;37(1):1-9.
27. Moody DB, Porcelli SA. CD1 trafficking: invariant chain gives a new twist to the tale. Immunity 2001;15(6):861-5.
28. Goldberg AL, Rock KL. Proteolysis, proteasomes and antigen presentation. Nature 1992; 357(6377):375-9.
29. Cresswell P, Bangia N, Dick T, et al. The nature of the MHC class I peptide loading complex. Immunol Rev 1999;172:21-8.
30. Kozlowski S, Takeshita T, Boehncke WH, et al. Excess beta 2 microglobulin promoting functional peptide association with purified soluble class I MHC molecules. Nature 1991; 349(6304):74-7.
31. Nakagawa Y, Takeshita T, Berzofsky JA, et al. Analysis of the mechanism for extracellular processing in the presentation of human immunodeficiency virus-1 envelope protein-derived peptide to epitope-specific cytotoxic T lymphocytes. Immunology 2000; 101(1):76-82.
32. Takahashi H, Cease KB, Berzofsky JA. Identification of proteases that process distinct epitopes on the same protein. J Immunol 1989;142(7):2221-9.
33. Collins DS, Unanue ER, Harding CV. Reduction of disulfide bonds within lysosomes is a key step in antigen processing. J Immunol 1991;147(12):4054-9.
34. Nijman HW, Kleijmeer MJ, Ossevoort MA, et al. Antigen capture and major histocompatibility class II compartments of freshly isolated and cultured human blood dendritic cells. J Exp Med 1995;182(1):163-74.
35. Kleijmeer MJ, Ossevoort MA, van Veen CJ, et al. MHC class II compartments and the kinetics of antigen presentation in activated mouse spleen dendritic cells. J Immunol 1995; 154(11):5715-24.
36. Shi GP, Villadangos JA, Dranoff G, et al. Cathepsin S required for normal MHC class II peptide loading and germinal center development. Immunity 1999;10(2):197-206.
37. Nakagawa TY, Brissette WH, Lira PD, et al. Impaired invariant chain degradation and antigen presentation and diminished collagen-induced arthritis in cathepsin S null mice. Immunity 1999;10(2):207-17.
38. Driessen C, Bryant RA, Lennon-Dumenil AM, et al. Cathepsin S controls the trafficking and maturation of MHC class II molecules in dendritic cell. J Cell Biol 1999;147(4): 775-90.
39. Pierre P, Mellman I. Developmental regulation of invariant chain proteolysis controls MHC class II trafficking in mouse dendritic cells. Cell 1998;93(7):1135-45.
40. Alfonso C, Karlsson L. Nonclassical MHC class II molecules. Annu Rev Immunol 2000;18: 113-42.
41. Burdin N, Kronenberg M. CD1-mediated immune responses to glycolipids. Curr Opin Immunol 1999;11(3):326-31.
42. Gumperz JE, Brenner MB. CD1-specific T cells in microbial immunity. Curr Opin Immunol 2001;13(4):471-8.
43. Angenieux C, Salamero J, Fricker D, et al. Characterization of CD1e, a third type of CD1 molecule expressed in dendritic cells. J Biol Chem 2000;275(48):37757-64.
44. Sieling PA, Chatterjee D, Porcelli SA, et al. CD1-restricted T cell recognition of microbial lipoglycan antigens. Science 1995;269(5221):227-30.
45. Moody DB, Reinhold BB, Guy MR, et al. Structural requirements for glycolipid antigen recognition by CD1b-restricted T cells. Science 1997;278(5336):283-6.
46. Beckman EM, Porcelli SA, Morita CT, et al. Recognition of a lipid antigen by CD1-restricted alpha beta + T cells. Nature 1994;372(6507):691-4.
47. Moody DB, Ulrichs T, Muhlecker W, et al. CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection. Nature 2000;404(6780):884-8.
48. Joyce S, Woods AS, Yewdell JW, et al. Natural ligand of mouse CD1d1: cellular- glycosylphosphatidylinositol. Science 1998;279(5356):1541-4.
49. Kawano T, Cui J, Koezuka Y, et al. CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides. Science 1997;278(5343):1626-9.
50. 8-T cells. J Exp Med 1997;186(1):109-20.
51. 1+T lymphocytes. Science 1995;268(5212):863-5.
52. Jayawardena-Wolf J, Bendelac A. CD1 and lipid antigens: intracellular pathways for antigen presentation. Curr Opin Immunol 2001;13(1):109-13.
53. Sugita M, Grant EP, van Donselaar E, et al. Separate pathways for antigen presentation by CD1 molecules. Immunity 1999;11(6):743-52.
54. Shamshiev A, Donda A, Prigozy TI, et al. The alphabeta T cell response to self-glycolipids shows a novel mechanism of CD1b loading and a requirement for complex oligosaccharides. Immunity 2000;13(2):255-64.
55. Briken V, Jackman RM, Watts GF, et al. Human CD1b and CD1c isoforms survey different intracellular compartments for the presentation of microbial lipid antigens. J Exp Med 2000; 192(2):281-8.
56. Jayawardena-Wolf J, Benlagha K, Chiu YH, et al. CD1d endosomal trafficking is independently regulated by an intrinsic CD1d-encoded tyrosine motif and by the invariant chain. Immunity 2001;15(6):897-908.
57. Riese RJ, Shi GP, Villadangos J, et al. Regulation of CD1 function and NK1.1(+) T cell selection and maturation by cathepsin S. Immunity 2001;15(6):909-19.
58. Rowland-Jones S, Sutton J, Ariyoshi K, et al. HIV-specific cytotoxic T-cells in HIV-exposed but uninfected Gambian women. Nat Med 1995;1(1):59-64.
59. Mazzoli S, Lopalco L, Salvi A, et al. Human immunodeficiency virus (HIV)-specific IgA and HIV neutralizing activity in the serum of exposed seronegative partners of HIV-seropositive persons. J Infect Dis 1999;180(3):871-5.
60. Schwartz RH. T-lymphocyte recognition of antigen in association with gene products of the major histocompatibility complex. Annu Rev Immunol 1985;32:37-61.
61. Germain RN. Immunology. The ins and outs of antigen processing and presentation. Nature 1986;322(6081):687-9.
62. Berzofsky JA, Brett SJ, Streicher HZ, et al. Antigen processing for presentation to T lymphocytes: function, mechanisms, and implications for the T-cell repertoire. Immunol Rev 1988;106:5-31.
63. 8+ cytotoxic T cells by immunization with purified HIV-1 envelope protein in ISCOMs. Nature 1990;344(6269): 873-5.
64. Wu JY, Gardner BH, Murphy CI, et al. Saponin adjuvant enhancement of antigen-specificimmune responses to an experimental HIV-1 vaccine. J Immunol 1992;148(5): 1519-25.
65. Zhou F, Huang L. Monophosphoryl lipid A enhances specific CTL induction by a soluble protein antigen entrapped in liposomes. Vaccine 1993;11(11):1139-44.
66. Pfeifer JD, Wick MJ, Roberts RL, et al. Phagocytic processing of bacterial antigens for class I MHC presentation to T cells. Nature 1993;361(6410):359-62.
67. Gromme M, Uytdehaag FG, Janssen H, et al. Recycling MHC class I molecules and endosomal peptide loading. Proc Natl Acad Sci USA 1999;96(18):10326-31.
68. MacAry PA, Lindsay M, Scott MA, et al. Mobilization of MHC class I molecules from late endosomes to the cell surface following activation of CD34-derived human Langerhans cells. Proc Natl Acad Sci USA 2001;98(7):3982-7.
69. Rodriguez A, Regnault A, Kleijmeer M, et al. Selective transport of internalized antigens to the cytosol for MHC class I presentation in dendritic cells. Nat Cell Biol 1999;1(6): 362-8.
70. Kovacsovics-Bankowski M, Rock KL. A phagosome-to-cytosol pathway for exogenous antigens presented on MHC class I molecules. Science 1995;267(5195):243-6.
71. Bevan MJ. Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay. J Exp Med 1976;143(5): 280- 1283-8.
72. Norbury CC, Chambers BJ, Prescott AR, et al. Constitutive macropinocytosis allows TAP-dependent major histocompatibility complex class I presentation of exogenous soluble antigen by bone marrow-derived dendritic cells. Eur J Immunol 1997;27(1): 280-8.
73. 8+ cytotoxic T lymphocytes by immunization with syngeneic irradiated HIV-1 envelope derived peptide-pulsed dendritic cells. Int Immunol 1993;5(8):849-57.
74. Takahashi H, Cohen J, Hosmalin A, et al. An immunodominant epitope of the human immunodeficiency virus envelope glycoprotein gp160 recognized by class I major histocompatibility complex molecule-restricted murine cytotoxic T lymphocytes. Proc Natl Acad Sci USA 1988;85(9):3105-9.
75. Takeshita T, Takahashi H, Kozlowski S, et al. Molecular analysis of the same HIV peptide functionally binding to both a class I and a class II MHC molecule. J Immunol 1995;154(4): 1973-86.
76. Albert ML, Sauter B, Bhardwaj N. Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. Nature 1998;392(6671):86-9.
77. Berard F, Blanco P, Davoust J, et al. Cross-priming of naive CD8 T cells against melanoma antigens using dendritic cells loaded with killed allogeneic melanoma cells. J Exp Med 2000; 192(11):1535-44.
78. Fields RC, Shimizu K, Mule JJ. Murine dendritic cells pulsed with whole tumor lysates mediate potent antitumor immune responses in vitro and in vivo. Proc Natl Acad Sci USA 1998;95(16):9482-7.
79. Wolfers J, Lozier A, Raposo G, et al. Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming. Nat Med 2001;7(3):297-303.
80. Hirota K, Nagata K, Norose Y, et al. Identification of an antigenic epitope in Helicobacter pylori urease that induces neutralizing antibody production. Infect Immun 2001;69(11): 6597-603.
81. Bittle JL, Houghten RA, Alexander H, et al. Protection against foot-and-mouth disease by immunization with a chemically synthesized peptide predicted from the viral nucleotide sequence. Nature 1982;298(5869):30-3.
82. Westhof E, Altschuh D, Moras D, et al. Correlation between segmental mobility and the location of antigenic determinants in proteins. Nature 1984;311(5982):123-6.
83. Nishiyama Y, Hamada H, Nonaka S, et al. Homeostatic regulation of intestinal villous epithelia by B lymphocytes. J Immunol 2002;168(6):2626-33.
84. Allen PM, Babbitt BP, Unanue ER. T-cell recognition of lysozyme: the biochemical basis of presentation. Immunol Rev 1987;98:171-87.
85. Brown JH, Jardetzky TS, Gorga JC, et al. Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1. Nature 1993;364(6432):33-9.
86. Bjorkman PJ, Saper MA, Samraoui B, et al. The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens. Nature 1987;329(6139): 512-8.
87. Takeda A, Tuazon CU, Ennis FA. Antibody-enhanced infection by HIV-1 via Fc receptor-mediated entry. Science 1988;242(4878):580-3.
88. Robinson Jr. WE, Montefiori DC, Mitchell WM, et al. Antibody-dependent enhancement of human immunodeficiency virus type 1 (HIV-1) infection in vitro by serum from HIV-1-infected and passively immunized chimpanzees. Proc Natl Acad Sci USA 1989;86(12): 4710-4.
89. Chicz RM, Urban RG, Lane WS, et al. Predominant naturally processed peptides bound to HLA-DR1 are derived from MHC-related molecules and are heterogeneous in size. Nature 1992;358(6389):764-8.
90. Pamer EG, Harty JT, Bevan MJ. Precise prediction of a dominant class I MHC-restricted epitope of Listeria monocytogenes. Nature 1991;353(6347):852-5.
91. DeLisi C, Berzofsky JA. T-cell antigenic sites tend to be amphipathic structures. Proc Natl Acad Sci USA 1985;82(20):7048-52.
92. Rothbard JB, Taylor WR. A sequence pattern common to T cell epitopes. Embo J 1988;7(1): 93-100.
93. Ahlers JD, Takeshita T, Pendleton CD, et al. Enhanced immunogenicity of HIV-1 vaccine construct by modification of the native peptide sequence. Proc Natl Acad Sci USA 1997; 94(20):10856-61.
94. Takahashi H, Houghten R, Putney SD, et al. Structural requirements for class I MHC molecule-mediated antigen presentation and cytotoxic T cell recognition of an immunodominant determinant of the human immunodeficiency virus envelope protein. J Exp Med 1989; 170(6):2023-35.
95. Takahashi H, Merli S, Putney SD, et al. A single amino acid interchange yields reciprocal CTL specificities for HIV-1 gp160. Science 1989;246(4926):118-21.
96. Takahashi H, Nakagawa Y, Pendleton CD, et al. Induction of broadly cross-reactive cytotoxic T cells recognizing an HIV-1 envelope determinant. Science 1992;255(5042): 333-6.
97. Klenerman P, Zinkernagel RM. Original antigenic sin impairs cytotoxic T lymphocyte responses to viruses bearing variant epitopes. Nature 1998;394(6692):482-5.
98. 8+ cytotoxic T lymphocytes by free antigenic peptide: a self-veto mechanism? J Exp Med 1996;183(3):879-89.
99. 8+ cytotoxic T lymphocytes by free antigenic peptide. Int Immunol 2001;13(1):43-51.
100. 8+ HIV-1 envelope-specific murine CTLs by short exposure to antigenic peptide. J Immunol 2002; 169(11 ):6588-6593.
101. 2 T cell receptors. Immunity 2001;14(3):331-44.
102. Tanaka Y, Morita CT, Nieves E, et al. Natural and synthetic non-peptide antigens recognized by human gamma delta T cells. Nature 1995;375(6527):155-8.
103. Bukowski JF, Morita CT, Brenner MB. Human gamma delta T cells recognize alkylamines derived from microbes, edible plants, and tea: implications for innate immunity. Immunity 1999;11(1):57-65.
104. Allison TJ, Winter CC, Fournie JJ, et al. Structure of a human gammadelta T-cell antigen receptor. Nature 2001;411(6839):820-4.
105. Enose Y, Ui M, Miyake A, et al. Protection by intranasal immunization of a nef-deleted, nonpathogenic SHIV against intravaginal challenge with a heterilogous pathogenic SHIV. Virology 2002;298(2):306-316.
106. Yamamoto S, Kiyono H, Yamamoto M, et al. A nontoxic mutant of cholera toxin elicits Th2-type responses for enhanced mucosal immunity. Proc Natl Acad Sci USA 1997;94(10): 5267-72.
107. Haregewoin A, Soman G, Hom RC, et al. Human gamma delta+ T cells respond to mycobacterial heat-shock protein. Nature 1989;340(6231):309-12.