메뉴 건너뛰기




Volumn 83, Issue 2, 2005, Pages 119-128

ISCOM™-based vaccines: The second decade

Author keywords

Adjuvant; Immune response; Immunotherapy; ISCOM; ISCOMATRIX

Indexed keywords

ADJUVANT; ISCOM; ISCOMATRIX; VACCINE; ANTIGEN; CHOLESTEROL; PHOSPHOLIPID; SAPONIN;

EID: 16344393356     PISSN: 08189641     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1711.2005.01319.x     Document Type: Review
Times cited : (161)

References (84)
  • 1
    • 0021255985 scopus 로고
    • Iscom, a novel structure for antigenic presentation of membrane proteins from enveloped viruses
    • Morein B, Sundquist B, Hoglund S, Dalsgaard K, Osterhaus A. Iscom, a novel structure for antigenic presentation of membrane proteins from enveloped viruses. Nature 1984; 308: 457-60.
    • (1984) Nature , vol.308 , pp. 457-460
    • Morein, B.1    Sundquist, B.2    Hoglund, S.3    Dalsgaard, K.4    Osterhaus, A.5
  • 2
    • 0035925595 scopus 로고    scopus 로고
    • Immune responses to ISCOM formulations in animal and primate models
    • Sjolander A, Drane D, Maraskovsky E et al. Immune responses to ISCOM formulations in animal and primate models. Vaccine 2001; 19: 2661-5.
    • (2001) Vaccine , vol.19 , pp. 2661-2665
    • Sjolander, A.1    Drane, D.2    Maraskovsky, E.3
  • 3
    • 0033136324 scopus 로고    scopus 로고
    • Immune-stimulating complexes induce an IL-12-dependent cascade of innate immune responses
    • Smith RE, Donachie AM, Grdic D, Lycke N, Mowat AM. Immune-stimulating complexes induce an IL-12-dependent cascade of innate immune responses. J. Immunol. 1999; 162: 5536-46.
    • (1999) J. Immunol. , vol.162 , pp. 5536-5546
    • Smith, R.E.1    Donachie, A.M.2    Grdic, D.3    Lycke, N.4    Mowat, A.M.5
  • 4
    • 0037789399 scopus 로고    scopus 로고
    • Dendritic cell maturation enhances CD8+ T-cell responses to exogenous antigen via a proteasome-independent mechanism of major histocompatibility complex class I loading
    • Robson NC, Beacock-Sharp H, Donachie AM, Mowat AM. Dendritic cell maturation enhances CD8+ T-cell responses to exogenous antigen via a proteasome-independent mechanism of major histocompatibility complex class I loading. Immunology 2003; 109: 374-83.
    • (2003) Immunology , vol.109 , pp. 374-383
    • Robson, N.C.1    Beacock-Sharp, H.2    Donachie, A.M.3    Mowat, A.M.4
  • 5
    • 0034668208 scopus 로고    scopus 로고
    • Induction of lymphocyte recruitment in the absence of a detectable immune response
    • Windon RG, Chaplin PJ, Beezum L et al. Induction of lymphocyte recruitment in the absence of a detectable immune response. Vaccine 2000; 19: 572-8.
    • (2000) Vaccine , vol.19 , pp. 572-578
    • Windon, R.G.1    Chaplin, P.J.2    Beezum, L.3
  • 6
    • 0029002567 scopus 로고
    • Antigen detection in vivo after immunization with different presentation forms of rabies virus antigen: Involvement of marginal metallophilic macrophages in the uptake of immune-stimulating complexes
    • Claassen IJ, Osterhaus AD, Claassen E. Antigen detection in vivo after immunization with different presentation forms of rabies virus antigen: involvement of marginal metallophilic macrophages in the uptake of immune-stimulating complexes. Eur. J. Immunol. 1995; 25: 1446-52.
    • (1995) Eur. J. Immunol. , vol.25 , pp. 1446-1452
    • Claassen, I.J.1    Osterhaus, A.D.2    Claassen, E.3
  • 8
    • 17344366042 scopus 로고    scopus 로고
    • Heterotypic protection against influenza by immunostimulating complexes is associated with the induction of cross-reactive cytotoxic T lymphocytes
    • Sambhara S, Woods S, Arpino R et al. Heterotypic protection against influenza by immunostimulating complexes is associated with the induction of cross-reactive cytotoxic T lymphocytes. J. Infect. Dis. 1998; 177: 1266-74.
    • (1998) J. Infect. Dis. , vol.177 , pp. 1266-1274
    • Sambhara, S.1    Woods, S.2    Arpino, R.3
  • 9
    • 0035898928 scopus 로고    scopus 로고
    • Intranasal immunisation with influenza-ISCOM induces strong mucosal as well as systemic antibody and cytotoxic T-lymphocyte responses
    • Sjotander S, Drane D, Davis R, Beezum L, Pearse M, Cox J. Intranasal immunisation with influenza-ISCOM induces strong mucosal as well as systemic antibody and cytotoxic T-lymphocyte responses. Vaccine 2001; 19: 4072-80.
    • (2001) Vaccine , vol.19 , pp. 4072-4080
    • Sjotander, S.1    Drane, D.2    Davis, R.3    Beezum, L.4    Pearse, M.5    Cox, J.6
  • 10
    • 0034663498 scopus 로고    scopus 로고
    • Induction of antibody and T-cell responses by immunization with ISCOMS containing the 38-kilodalton protein of Mycobacterium tuberculosis
    • da Fonseca DP, Frerichs J, Singh M, Snippe H, Verheul AF. Induction of antibody and T-cell responses by immunization with ISCOMS containing the 38-kilodalton protein of Mycobacterium tuberculosis. Vaccine 2001; 19: 122-31.
    • (2001) Vaccine , vol.19 , pp. 122-131
    • Da Fonseca, D.P.1    Frerichs, J.2    Singh, M.3    Snippe, H.4    Verheul, A.F.5
  • 11
    • 0032912036 scopus 로고    scopus 로고
    • Induction of antibody responses in the common mucosal immune system by respiratory syncytical virus immunostimulating complexes
    • Hu KF, Ekstrom J, Merza M, Lovgren-Bengtsson K, Morein B. Induction of antibody responses in the common mucosal immune system by respiratory syncytical virus immunostimulating complexes. Med. Microbiol. Immunol. 1999; 187: 191-8.
    • (1999) Med. Microbiol. Immunol. , vol.187 , pp. 191-198
    • Hu, K.F.1    Ekstrom, J.2    Merza, M.3    Lovgren-Bengtsson, K.4    Morein, B.5
  • 12
    • 0031902954 scopus 로고    scopus 로고
    • The immunostimulating complex (ISCOM) is an efficient mucosal delivery system for respiratory syncytial virus (RSV) envelope antigens inducing high local and systemic antibody responses
    • Hu KF, Elvander M, Merza M, Akerblom L, Brandenburg A, Morein B. The immunostimulating complex (ISCOM) is an efficient mucosal delivery system for respiratory syncytial virus (RSV) envelope antigens inducing high local and systemic antibody responses. Clin. Exp. Immunol. 1998; 113: 235-43.
    • (1998) Clin. Exp. Immunol. , vol.113 , pp. 235-243
    • Hu, K.F.1    Elvander, M.2    Merza, M.3    Akerblom, L.4    Brandenburg, A.5    Morein, B.6
  • 13
    • 0033522821 scopus 로고    scopus 로고
    • Immunogenicity of various presentation forms of PorA outer membrane protein of Neisseria meningitidis in mice
    • Peeters CC, Claassen IJ, Schuller M, Kersten GF, van der Voort EM, Poolman JT. Immunogenicity of various presentation forms of PorA outer membrane protein of Neisseria meningitidis in mice. Vaccine 1999; 17: 2702-712.
    • (1999) Vaccine , vol.17 , pp. 2702-2712
    • Peeters, C.C.1    Claassen, I.J.2    Schuller, M.3    Kersten, G.F.4    Van Der Voort, E.M.5    Poolman, J.T.6
  • 14
    • 0029996188 scopus 로고    scopus 로고
    • Priming in vivo and quantification in vitro of class I MHC-restricted cytotoxic T cells to human papilloma virus type 11 early proteins (E6 and E7) using immunostimulating complexes (ISCOMs)
    • Tarpey I, Stacey SN, McIndoe A, Davies DH. Priming in vivo and quantification in vitro of class I MHC-restricted cytotoxic T cells to human papilloma virus type 11 early proteins (E6 and E7) using immunostimulating complexes (ISCOMs). Vaccine 1996; 14: 230-36.
    • (1996) Vaccine , vol.14 , pp. 230-236
    • Tarpey, I.1    Stacey, S.N.2    McIndoe, A.3    Davies, D.H.4
  • 15
    • 0030426068 scopus 로고    scopus 로고
    • Immunogenicity of immunostimulating complexes of Japanese encephalitis virus in experimental animals
    • Yeolekar LR, Banerjee K. Immunogenicity of immunostimulating complexes of Japanese encephalitis virus in experimental animals. Acta Virol. 1996; 40: 245-50.
    • (1996) Acta Virol. , vol.40 , pp. 245-250
    • Yeolekar, L.R.1    Banerjee, K.2
  • 16
    • 0032855158 scopus 로고    scopus 로고
    • Effect of oral rotavirus/iscom vaccines on immune responses in gnotobiotic lambs
    • van Pinxteren LA, Bruce MG, Campbell I et al. Effect of oral rotavirus/iscom vaccines on immune responses in gnotobiotic lambs. Vet. Immunol. Immunopathol. 1999; 71: 53-67.
    • (1999) Vet. Immunol. Immunopathol. , vol.71 , pp. 53-67
    • Van Pinxteren, L.A.1    Bruce, M.G.2    Campbell, I.3
  • 17
    • 0344197071 scopus 로고    scopus 로고
    • The major Epstein-Barr virus (EBV) envelope glycoprotein gp340 when incorporated into Iscoms primes cytotoxic T-cell responses directed against EBV lymphoblastoid cell lines
    • Wilson AD, Lovgren-Bengtsson K, Villacres-Ericsson M, Morein B, Morgan AJ. The major Epstein-Barr virus (EBV) envelope glycoprotein gp340 when incorporated into Iscoms primes cytotoxic T-cell responses directed against EBV lymphoblastoid cell lines. Vaccine 1999; 17: 1282-90.
    • (1999) Vaccine , vol.17 , pp. 1282-1290
    • Wilson, A.D.1    Lovgren-Bengtsson, K.2    Villacres-Ericsson, M.3    Morein, B.4    Morgan, A.J.5
  • 18
    • 0035284757 scopus 로고    scopus 로고
    • Characterization of hepatitis C virus core-specific immune responses primed in rhesus macaques by a nonclassical ISCOM vaccine
    • Polakos NK, Drane D, Cox J et al. Characterization of hepatitis C virus core-specific immune responses primed in rhesus macaques by a nonclassical ISCOM vaccine. J. Immunol. 2001; 166: 3589-98.
    • (2001) J. Immunol. , vol.166 , pp. 3589-3598
    • Polakos, N.K.1    Drane, D.2    Cox, J.3
  • 19
    • 0032978729 scopus 로고    scopus 로고
    • Comparison of immunity generated by nucleic acid-, MF59-, and ISCOM-formulated human immunodeficiency virus type 1 vaccines in Rhesus macaques: Evidence for viral clearance
    • Verschoor EJ, Mooij P, Oostermeijer H et al. Comparison of immunity generated by nucleic acid-, MF59-, and ISCOM-formulated human immunodeficiency virus type 1 vaccines in Rhesus macaques: evidence for viral clearance. J. Virol. 1999; 73: 3292-300.
    • (1999) J. Virol. , vol.73 , pp. 3292-3300
    • Verschoor, E.J.1    Mooij, P.2    Oostermeijer, H.3
  • 20
    • 0031730080 scopus 로고    scopus 로고
    • ISCOMs: An adjuvant with multiple functions
    • Sjolander A, Cox JC, Barr IG. ISCOMs: an adjuvant with multiple functions. J. Leukoc. Biol. 1998; 64: 713-23.
    • (1998) J. Leukoc. Biol. , vol.64 , pp. 713-723
    • Sjolander, A.1    Cox, J.C.2    Barr, I.G.3
  • 21
    • 0031562670 scopus 로고    scopus 로고
    • Iscoms containing purified Quillaja saponins upregulate both Th1-like and Th2-like immune responses
    • Sjolander A, van't Land B, Lovgren-Bengtsson K. Iscoms containing purified Quillaja saponins upregulate both Th1-like and Th2-like immune responses. Cell Immunol. 1997; 177: 69-76.
    • (1997) Cell Immunol. , vol.177 , pp. 69-76
    • Sjolander, A.1    Van't Land, B.2    Lovgren-Bengtsson, K.3
  • 22
    • 0018612959 scopus 로고
    • Activation of mouse complement by different classes of mouse antibody
    • Klaus GG, Pepys MB, Kitajima K, Askonas BA. Activation of mouse complement by different classes of mouse antibody. Immunology 1979; 38: 687-95.
    • (1979) Immunology , vol.38 , pp. 687-695
    • Klaus, G.G.1    Pepys, M.B.2    Kitajima, K.3    Askonas, B.A.4
  • 25
    • 0021967361 scopus 로고
    • Importance of immunogtobutin isotype in human antibody-dependent, cell-mediated cytotoxicity directed by murine monoclonal antibodies
    • Kipps TJ, Parham P, Punt J, Herzenberg LA. Importance of immunogtobutin isotype in human antibody-dependent, cell-mediated cytotoxicity directed by murine monoclonal antibodies. J. Exp. Med. 1985; 161: 1-17.
    • (1985) J. Exp. Med. , vol.161 , pp. 1-17
    • Kipps, T.J.1    Parham, P.2    Punt, J.3    Herzenberg, L.A.4
  • 26
    • 0025310910 scopus 로고
    • Induction of CD8+ cytotoxic T cells by immunization with purified HIV-1 envelope protein in ISCOMs
    • Takahashi H, Takeshita T, Morein B, Putney S, Germain RN, Berzofsky JA. Induction of CD8+ cytotoxic T cells by immunization with purified HIV-1 envelope protein in ISCOMs. Nature 1990; 344: 873-5.
    • (1990) Nature , vol.344 , pp. 873-875
    • Takahashi, H.1    Takeshita, T.2    Morein, B.3    Putney, S.4    Germain, R.N.5    Berzofsky, J.A.6
  • 27
    • 0036232477 scopus 로고    scopus 로고
    • Construction and characterization of an experimental ISCOMS-based hepatitis B polypeptide vaccine
    • Guan XJ, Wu YZ, Jia ZC, Shi TD, Tang Y. Construction and characterization of an experimental ISCOMS-based hepatitis B polypeptide vaccine. World J. Gastroenterol. 2002; 8: 294-7.
    • (2002) World J. Gastroenterol. , vol.8 , pp. 294-297
    • Guan, X.J.1    Wu, Y.Z.2    Jia, Z.C.3    Shi, T.D.4    Tang, Y.5
  • 28
    • 0035860585 scopus 로고    scopus 로고
    • Cytotoxic T cell polyepitope vaccines delivered by ISCOMs
    • Le TT, Drane D, Malliaros J et al. Cytotoxic T cell polyepitope vaccines delivered by ISCOMs. Vaccine 2001; 19: 4669-75.
    • (2001) Vaccine , vol.19 , pp. 4669-4675
    • Le, T.T.1    Drane, D.2    Malliaros, J.3
  • 29
    • 11144356454 scopus 로고    scopus 로고
    • NY-ESO-1 protein formulated in ISCOMATRIX adjuvant is a potent anticancer vaccine inducing both humoral and CD8+ T-cell-mediated immunity and protection against NY-ESO-1+ tumors
    • Maraskovsky E, Sjolander S, Drane DP et al. NY-ESO-1 protein formulated in ISCOMATRIX adjuvant is a potent anticancer vaccine inducing both humoral and CD8+ T-cell-mediated immunity and protection against NY-ESO-1+ tumors. Clin. Cancer Res. 2004; 10: 2879-90.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 2879-2890
    • Maraskovsky, E.1    Sjolander, S.2    Drane, D.P.3
  • 31
    • 0032147238 scopus 로고    scopus 로고
    • Vaccine strategies to overcome maternal antibody mediated inhibition of measles vaccine
    • Osterhaus A, van Amerongen G, van Binnendijk R. Vaccine strategies to overcome maternal antibody mediated inhibition of measles vaccine. Vaccine 1998; 16: 1479-81.
    • (1998) Vaccine , vol.16 , pp. 1479-1481
    • Osterhaus, A.1    Van Amerongen, G.2    Van Binnendijk, R.3
  • 32
    • 4444307198 scopus 로고    scopus 로고
    • ISCOM based vaccines for cancer immunotherapy
    • Lenarczyk A, Le TT, Drane D et al. ISCOM based vaccines for cancer immunotherapy. Vaccine 2004; 22: 963-74.
    • (2004) Vaccine , vol.22 , pp. 963-974
    • Lenarczyk, A.1    Le, T.T.2    Drane, D.3
  • 33
    • 0342635461 scopus 로고    scopus 로고
    • Priming with Chlamydia trachomatis major outer membrane protein (MOMP) DNA followed by MOMP ISCOM boosting enhances protection and is associated with increased immunolobulin A and Th1 cellular immune responses
    • Dong-Ji Z, Yang X, Shen C, Lu H, Murdin A, Brunham RC. Priming with Chlamydia trachomatis major outer membrane protein (MOMP) DNA followed by MOMP ISCOM boosting enhances protection and is associated with increased immunolobulin A and Th1 cellular immune responses. Infect. Immun. 2000; 68: 3074-8.
    • (2000) Infect. Immun. , vol.68 , pp. 3074-3078
    • Dong-Ji, Z.1    Yang, X.2    Shen, C.3    Lu, H.4    Murdin, A.5    Brunham, R.C.6
  • 34
    • 0034445180 scopus 로고    scopus 로고
    • Induction of protective immunity against Chlamydia trachomatis genital infection by a vaccine based on major outer membrane protein-lipophilic immune response-stimulating complexes
    • Igietseme JU, Murdin A. Induction of protective immunity against Chlamydia trachomatis genital infection by a vaccine based on major outer membrane protein-lipophilic immune response-stimulating complexes. Infect. Immun. 2000; 68: 6798-806.
    • (2000) Infect. Immun. , vol.68 , pp. 6798-6806
    • Igietseme, J.U.1    Murdin, A.2
  • 35
    • 0034014199 scopus 로고    scopus 로고
    • Antibody responses, cytokine levels and protection of mice immunised with HSV-2 antigens formulated into NISV or ISCOM delivery systems
    • Mohamedi SA, Brewer JM, Alexander J, Heath AW, Jennings R. Antibody responses, cytokine levels and protection of mice immunised with HSV-2 antigens formulated into NISV or ISCOM delivery systems. Vaccine 2000; 18: 2083-94.
    • (2000) Vaccine , vol.18 , pp. 2083-2094
    • Mohamedi, S.A.1    Brewer, J.M.2    Alexander, J.3    Heath, A.W.4    Jennings, R.5
  • 36
    • 0032374269 scopus 로고    scopus 로고
    • Immunopotentiation of humoral and cellular responses to inactivated influenza vaccines by two different adjuvants with potential for human use
    • Deliyannis G, Jackson DC, Dyer W et al. Immunopotentiation of humoral and cellular responses to inactivated influenza vaccines by two different adjuvants with potential for human use. Vaccine 1998; 16: 2058-68.
    • (1998) Vaccine , vol.16 , pp. 2058-2068
    • Deliyannis, G.1    Jackson, D.C.2    Dyer, W.3
  • 38
    • 0028923840 scopus 로고
    • Adjuvanticity of ISCOMs incorporating a T cell-reactive lipoprotein of the facultative intracellular pathogen Francisella tularensis
    • Golovliov I, Ericsson M, Akerblom L, Sandstrom G, Tarnvik A, Sjostedt A. Adjuvanticity of ISCOMs incorporating a T cell-reactive lipoprotein of the facultative intracellular pathogen Francisella tularensis. Vaccine 1995; 13: 261-7.
    • (1995) Vaccine , vol.13 , pp. 261-267
    • Golovliov, I.1    Ericsson, M.2    Akerblom, L.3    Sandstrom, G.4    Tarnvik, A.5    Sjostedt, A.6
  • 39
    • 0023872566 scopus 로고
    • Measles virus fusion protein presented in an immune-stimulating complex (iscom) induces haemolysis-inhibiting and fusion-inhibiting antibodies, virus-specific T cells and protection in mice
    • de Vries P, van Binnendijk RS, van der Marel P et al. Measles virus fusion protein presented in an immune-stimulating complex (iscom) induces haemolysis-inhibiting and fusion-inhibiting antibodies, virus-specific T cells and protection in mice. J. Gen. Virol. 1988; 69: 549-59.
    • (1988) J. Gen. Virol. , vol.69 , pp. 549-559
    • De Vries, P.1    Van Binnendijk, R.S.2    Van Der Marel, P.3
  • 40
    • 0023472908 scopus 로고
    • Protection against lethal measles virus infection in mice by immune-stimulating complexes containing the hemagglutinin or fusion protein
    • Varsanyi TM, Morein B, Love A, Norrby E. Protection against lethal measles virus infection in mice by immune-stimulating complexes containing the hemagglutinin or fusion protein. J. Virol. 1987; 61: 3896-901.
    • (1987) J. Virol. , vol.61 , pp. 3896-3901
    • Varsanyi, T.M.1    Morein, B.2    Love, A.3    Norrby, E.4
  • 42
    • 0034022518 scopus 로고    scopus 로고
    • Use of herpes simplex virus (HSV) type 1 ISCOMS 703 vaccine for prophylactic and therapeutic treatment of primary and recurrent HSV-2 infection in guinea pigs
    • Simms JR, Heath AW, Jennings R. Use of herpes simplex virus (HSV) type 1 ISCOMS 703 vaccine for prophylactic and therapeutic treatment of primary and recurrent HSV-2 infection in guinea pigs. J. Infect. Dis. 2000; 181: 1240-48.
    • (2000) J. Infect. Dis. , vol.181 , pp. 1240-1248
    • Simms, J.R.1    Heath, A.W.2    Jennings, R.3
  • 43
    • 0033577349 scopus 로고    scopus 로고
    • ISCOM vaccine induced protection against a lethal challenge with a human H5N1 influenza virus
    • Rimmelzwaan GF, Claas EC, van Amerongen G, de Jong JC. Osterhaus AD. ISCOM vaccine induced protection against a lethal challenge with a human H5N1 influenza virus. Vaccine 1999; 17: 1355-8.
    • (1999) Vaccine , vol.17 , pp. 1355-1358
    • Rimmelzwaan, G.F.1    Claas, E.C.2    Van Amerongen, G.3    De Jong, J.C.4    Osterhaus, A.D.5
  • 44
    • 0037086488 scopus 로고    scopus 로고
    • Systemic and intestinal antibody secreting cell responses and protection in gnotobiotic pigs immunized orally with attenuated Wa human rotavirus and Wa 2/6-rotavirus-like-particles associated with immunostimulating complexes
    • Iosef C, Van Nguyen T, Jeong K et al. Systemic and intestinal antibody secreting cell responses and protection in gnotobiotic pigs immunized orally with attenuated Wa human rotavirus and Wa 2/6-rotavirus-like-particles associated with immunostimulating complexes. Vaccine 2002; 20: 1741-53.
    • (2002) Vaccine , vol.20 , pp. 1741-1753
    • Iosef, C.1    Van Nguyen, T.2    Jeong, K.3
  • 45
    • 10744228649 scopus 로고    scopus 로고
    • Antibody responses to human rotavirus (HRV) in gnotobiotic pigs following a new prime/boost vaccine strategy using oral attenuated HRV priming and intranasal VP2/6 rotavirus-like particle (VLP) boosting with ISCOM
    • Gonzalez AM, Nguyen TV, Azevedo MS et al. Antibody responses to human rotavirus (HRV) in gnotobiotic pigs following a new prime/boost vaccine strategy using oral attenuated HRV priming and intranasal VP2/6 rotavirus-like particle (VLP) boosting with ISCOM. Clin. Exp. Immunol. 2004; 135: 361-72.
    • (2004) Clin. Exp. Immunol. , vol.135 , pp. 361-372
    • Gonzalez, A.M.1    Nguyen, T.V.2    Azevedo, M.S.3
  • 46
    • 0028151401 scopus 로고
    • Protection of rhesus macaques from SIV infection by immunization with different experimental SIV vaccines
    • de Vries P, Heeney JL, Boes J et al. Protection of rhesus macaques from SIV infection by immunization with different experimental SIV vaccines. Vaccine 1994; 12: 1443-52.
    • (1994) Vaccine , vol.12 , pp. 1443-1452
    • De Vries, P.1    Heeney, J.L.2    Boes, J.3
  • 47
    • 0030932065 scopus 로고    scopus 로고
    • Induction of protective immunity against influenza virus in a macaque model: Comparison of conventional and iscom vaccines
    • Rimmelzwaan GF, Baars M, van Beek R et al. Induction of protective immunity against influenza virus in a macaque model: comparison of conventional and iscom vaccines. J. Gen. Virol. 1997; 78: 757-65.
    • (1997) J. Gen. Virol. , vol.78 , pp. 757-765
    • Rimmelzwaan, G.F.1    Baars, M.2    Van Beek, R.3
  • 48
    • 0031027893 scopus 로고    scopus 로고
    • Protective immunity in macaques vaccinated with live attenuated, recombinant, and subunit measles vaccines in the presence of passively acquired antibodies
    • van Binnendijk RS, Poelen MC, van Amerongen G, de Vries P, Osterhaus AD. Protective immunity in macaques vaccinated with live attenuated, recombinant, and subunit measles vaccines in the presence of passively acquired antibodies. J. Infect. Dis. 1997; 175: 524-32.
    • (1997) J. Infect. Dis. , vol.175 , pp. 524-532
    • Van Binnendijk, R.S.1    Poelen, M.C.2    Van Amerongen, G.3    De Vries, P.4    Osterhaus, A.D.5
  • 49
    • 0028175476 scopus 로고
    • Long-standing protection of macaques against cell-free HIV-2 with a HIV-2 iscom vaccine
    • Putkonen P, Bjorling E, Akerblom L et al. Long-standing protection of macaques against cell-free HIV-2 with a HIV-2 iscom vaccine. J. Acquir. Immune Defic. Syndr. 1994; 7: 551-9.
    • (1994) J. Acquir. Immune Defic. Syndr. , vol.7 , pp. 551-559
    • Putkonen, P.1    Bjorling, E.2    Akerblom, L.3
  • 50
    • 0032036524 scopus 로고    scopus 로고
    • The role of type-1 and type-2 T-helper immune responses in HIV-1 vaccine protection
    • Heeney JL, van Gils ME, van der Meide P et al. The role of type-1 and type-2 T-helper immune responses in HIV-1 vaccine protection. J. Med. Primatol. 1998; 27: 50-58.
    • (1998) J. Med. Primatol. , vol.27 , pp. 50-58
    • Heeney, J.L.1    Van Gils, M.E.2    Van Der Meide, P.3
  • 51
    • 13144255687 scopus 로고    scopus 로고
    • beta-chemokines and neutralizing antibody titers correlate with sterilizing immunity generated in HIV-1 vaccinated macaques
    • Heeney JL, Teeuwsen VJ, van Gils M et al. beta-Chemokines and neutralizing antibody titers correlate with sterilizing immunity generated in HIV-1 vaccinated macaques. Proc. Natl Acad. Sci. USA 1998; 95: 10803-808.
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 10803-10808
    • Heeney, J.L.1    Teeuwsen, V.J.2    Van Gils, M.3
  • 52
    • 0033019064 scopus 로고    scopus 로고
    • HIV-1 vaccine-induced immune responses which correlate with protection from SHIV infection: Compiled preclinical efficacy data from trials with ten different HIV-1 vaccine candidates
    • Heeney J, Akerblom L, Barnett S et al. HIV-1 vaccine-induced immune responses which correlate with protection from SHIV infection: compiled preclinical efficacy data from trials with ten different HIV-1 vaccine candidates. Immunol. Lett. 1999; 66: 189-95.
    • (1999) Immunol. Lett. , vol.66 , pp. 189-195
    • Heeney, J.1    Akerblom, L.2    Barnett, S.3
  • 53
    • 0027487487 scopus 로고
    • HIV experimental vaccines based on the iscom technology using envelope and GAG gene products
    • Akerblom L, Nara P, Dunlop N, Putney S, Morein B. HIV experimental vaccines based on the iscom technology using envelope and GAG gene products. Biotechnol. Ther. 1993; 4: 145-61.
    • (1993) Biotechnol. Ther. , vol.4 , pp. 145-161
    • Akerblom, L.1    Nara, P.2    Dunlop, N.3    Putney, S.4    Morein, B.5
  • 54
    • 0025762026 scopus 로고
    • Vaccination of class I major histocompatibility complex (MHC)-restricted murine CD8+ cytotoxic T lymphocytes towards soluble antigens: Immunostimulating-ovalbumin complexes enter the class 1 MHC-restricted antigen pathway and allow sensitization against the immunodominant peptide
    • Heeg K, Kuon W, Wagner H. Vaccination of class I major histocompatibility complex (MHC)-restricted murine CD8+ cytotoxic T lymphocytes towards soluble antigens: immunostimulating-ovalbumin complexes enter the class 1 MHC-restricted antigen pathway and allow sensitization against the immunodominant peptide. Eur. J. Immunol. 1991; 21: 1523-7.
    • (1991) Eur. J. Immunol. , vol.21 , pp. 1523-1527
    • Heeg, K.1    Kuon, W.2    Wagner, H.3
  • 55
    • 0024454657 scopus 로고
    • Immune response to immunostimulatory complexes (ISCOMs) prepared from human immunodeficiency virus type 1 (HIV-1) or the HIV-1 external envelope glycoprotein (gp120)
    • Pyle SW, Morein B, Bess JW Jr et al. Immune response to immunostimulatory complexes (ISCOMs) prepared from human immunodeficiency virus type 1 (HIV-1) or the HIV-1 external envelope glycoprotein (gp120). Vaccine 1989; 7: 465-73.
    • (1989) Vaccine , vol.7 , pp. 465-473
    • Pyle, S.W.1    Morein, B.2    Bess Jr., J.W.3
  • 56
    • 0025373282 scopus 로고
    • Increased immunogenicity of a non-amphipathic protein (BSA) after inclusion into iscoms
    • Morein B, Ekstrom J, Lovgren K. Increased immunogenicity of a non-amphipathic protein (BSA) after inclusion into iscoms. J. Immunol. Methods 1990; 128: 177-81.
    • (1990) J. Immunol. Methods , vol.128 , pp. 177-181
    • Morein, B.1    Ekstrom, J.2    Lovgren, K.3
  • 57
    • 0025162786 scopus 로고
    • Immunogenic properties of ISCOM prepared with influenza virus nucleoprotein
    • Weiss HP, Stitz L, Becht H. Immunogenic properties of ISCOM prepared with influenza virus nucleoprotein. Arch. Virol. 1990; 114: 109-20.
    • (1990) Arch. Virol. , vol.114 , pp. 109-120
    • Weiss, H.P.1    Stitz, L.2    Becht, H.3
  • 58
    • 0026697004 scopus 로고
    • Soluble proteins incorporate into ISCOMs after covalent attachment of fatty acid
    • Reid G. Soluble proteins incorporate into ISCOMs after covalent attachment of fatty acid. Vaccine 1992; 10: 597-602.
    • (1992) Vaccine , vol.10 , pp. 597-602
    • Reid, G.1
  • 59
    • 0026721872 scopus 로고
    • Iscom immunization with synthetic peptides representing measles virus hemagglutinin
    • Pedersen IR, Bog-Hansen TC, Dalsgaard K, Heegaard PM. Iscom immunization with synthetic peptides representing measles virus hemagglutinin. Virus Res. 1992; 24: 145-59.
    • (1992) Virus Res. , vol.24 , pp. 145-159
    • Pedersen, I.R.1    Bog-Hansen, T.C.2    Dalsgaard, K.3    Heegaard, P.M.4
  • 60
    • 0028243439 scopus 로고
    • Immune responses and protective effect in mice vaccinated orally with surface sporozoite protein of Eimeria falciformis in ISCOMs
    • Kazanji M, Laurent F, Pery P. Immune responses and protective effect in mice vaccinated orally with surface sporozoite protein of Eimeria falciformis in ISCOMs. Vaccine 1994; 12: 798-804.
    • (1994) Vaccine , vol.12 , pp. 798-804
    • Kazanji, M.1    Laurent, F.2    Pery, P.3
  • 61
    • 0026689113 scopus 로고
    • Incorporation of soluble antigens into ISCOMs: HIV gp120 ISCOMs induce virus neutralizing antibodies
    • Browning M, Reid G, Osborne R, Jarrett O. Incorporation of soluble antigens into ISCOMs: HIV gp120 ISCOMs induce virus neutralizing antibodies. Vaccine 1992; 10: 585-90.
    • (1992) Vaccine , vol.10 , pp. 585-590
    • Browning, M.1    Reid, G.2    Osborne, R.3    Jarrett, O.4
  • 62
    • 0025806703 scopus 로고
    • Immune-stimulating complexes containing Quil A and protein antigen prime class I MHC-restricted T lymphocytes in vivo and are immunogenic by the oral route
    • Mowat AM, Donachie AM, Reid G, Jarrett O. Immune-stimulating complexes containing Quil A and protein antigen prime class I MHC-restricted T lymphocytes in vivo and are immunogenic by the oral route. Immunology 1991; 72: 317-22.
    • (1991) Immunology , vol.72 , pp. 317-322
    • Mowat, A.M.1    Donachie, A.M.2    Reid, G.3    Jarrett, O.4
  • 63
    • 0030581353 scopus 로고    scopus 로고
    • Linkage of a fusion peptide to a CTL epitope from the nucleoprotein of measles virus enables incorporation into ISCOMs and induction of CTL responses following intranasal immunization
    • Hsu SC, Schadeck EB, Delmas A, Shaw M, Steward MW. Linkage of a fusion peptide to a CTL epitope from the nucleoprotein of measles virus enables incorporation into ISCOMs and induction of CTL responses following intranasal immunization. Vaccine 1996; 14: 1159-66.
    • (1996) Vaccine , vol.14 , pp. 1159-1166
    • Hsu, S.C.1    Schadeck, E.B.2    Delmas, A.3    Shaw, M.4    Steward, M.W.5
  • 64
    • 4243138178 scopus 로고    scopus 로고
    • Generating neutralizing antibodies, Th1 response and MHC non restricted immunogenicity of HIV-I env and gag peptides in liposomes and ISCOMs with in-built adjuvanticity
    • Agrawal L, Haq W, Hanson CV, Rao DN. Generating neutralizing antibodies, Th1 response and MHC non restricted immunogenicity of HIV-I env and gag peptides in liposomes and ISCOMs with in-built adjuvanticity. J. Immune Based Ther. Vaccines 2003; 1: 5.
    • (2003) J. Immune Based Ther. Vaccines , vol.1 , pp. 5
    • Agrawal, L.1    Haq, W.2    Hanson, C.V.3    Rao, D.N.4
  • 65
    • 0034668219 scopus 로고    scopus 로고
    • Introduction of the haemagglutinin transmembrane region in the influenza virus matrix protein facilitates its incorporation into ISCOM and activation of specific CD8 (+) cytotoxic T lymphocytes
    • Voeten JT, Rimmelzwaan GF, Nieuwkoop NJ, Lovgren-Bengtsson K, Osterhaus AD. Introduction of the haemagglutinin transmembrane region in the influenza virus matrix protein facilitates its incorporation into ISCOM and activation of specific CD8 (+) cytotoxic T lymphocytes. Vaccine 2000; 19: 514-22.
    • (2000) Vaccine , vol.19 , pp. 514-522
    • Voeten, J.T.1    Rimmelzwaan, G.F.2    Nieuwkoop, N.J.3    Lovgren-Bengtsson, K.4    Osterhaus, A.D.5
  • 66
    • 0032929051 scopus 로고    scopus 로고
    • General expression vectors for production of hydrophobically tagged immunogens for direct iscom incorporation
    • Andersson C, Sandberg L, Murby M, Sjolander A, Lovgren-Bengtsson K, Stahl S. General expression vectors for production of hydrophobically tagged immunogens for direct iscom incorporation. J. Immunol. Methods 1999; 222: 171-82.
    • (1999) J. Immunol. Methods , vol.222 , pp. 171-182
    • Andersson, C.1    Sandberg, L.2    Murby, M.3    Sjolander, A.4    Lovgren-Bengtsson, K.5    Stahl, S.6
  • 67
    • 4444256586 scopus 로고    scopus 로고
    • Association of antigens to ISCOMATRIX adjuvant using metal chelation leads to improved CTL responses
    • Malliaros J, Quinn C, Arnold FH et al. Association of antigens to ISCOMATRIX adjuvant using metal chelation leads to improved CTL responses. Vaccine 2004; 22: 3968-75.
    • (2004) Vaccine , vol.22 , pp. 3968-3975
    • Malliaros, J.1    Quinn, C.2    Arnold, F.H.3
  • 68
    • 0034327167 scopus 로고    scopus 로고
    • Cutting edge: The mucosal adjuvant cholera toxin redirects vaccine proteins into olfactory tissues
    • van Ginkel FW, Jackson RJ, Yuki Y, McGhee JR. Cutting edge: the mucosal adjuvant cholera toxin redirects vaccine proteins into olfactory tissues. J. Immunol. 2000; 165: 4778-82.
    • (2000) J. Immunol. , vol.165 , pp. 4778-4782
    • Van Ginkel, F.W.1    Jackson, R.J.2    Yuki, Y.3    McGhee, J.R.4
  • 69
    • 0037035853 scopus 로고    scopus 로고
    • A dilemma for mucosal vaccination: Efficacy versus toxicity using enterotoxin-based adjuvants
    • Fujihashi K, Koga T, van Ginkel FW, Hagiwara Y, McGhee JR. A dilemma for mucosal vaccination: efficacy versus toxicity using enterotoxin-based adjuvants. Vaccine 2002; 20: 2431-8.
    • (2002) Vaccine , vol.20 , pp. 2431-2438
    • Fujihashi, K.1    Koga, T.2    Van Ginkel, F.W.3    Hagiwara, Y.4    McGhee, J.R.5
  • 71
    • 0343658179 scopus 로고    scopus 로고
    • Uptake and adjuvant activity of orally delivered saponin and ISCOM vaccines
    • Sjolander A, Cox JC. Uptake and adjuvant activity of orally delivered saponin and ISCOM vaccines. Adv. Drug Deliv. Rev. 1998; 34: 321-38.
    • (1998) Adv. Drug Deliv. Rev. , vol.34 , pp. 321-338
    • Sjolander, A.1    Cox, J.C.2
  • 72
    • 0037435982 scopus 로고    scopus 로고
    • Intranasal vaccination with ISCOMATRIX adjuvanted influenza vaccine
    • Coulter A, Harris R, Davis R et al. Intranasal vaccination with ISCOMATRIX adjuvanted influenza vaccine. Vaccine 2003; 21: 946-9.
    • (2003) Vaccine , vol.21 , pp. 946-949
    • Coulter, A.1    Harris, R.2    Davis, R.3
  • 73
    • 0031917995 scopus 로고    scopus 로고
    • Intranasal immunization of mice with herpes simplex virus type 2 recombinant gD2: The effect of adjuvants on mucosal and serum antibody responses
    • Ugozzoli M, O'Hagan DT, Ott GS. Intranasal immunization of mice with herpes simplex virus type 2 recombinant gD2: the effect of adjuvants on mucosal and serum antibody responses. Immunology 1998; 93: 563-71.
    • (1998) Immunology , vol.93 , pp. 563-571
    • Ugozzoli, M.1    O'Hagan, D.T.2    Ott, G.S.3
  • 74
    • 0032537946 scopus 로고    scopus 로고
    • A mucosal IgA response, but no systemic antibody response, is evoked by intranasal immunisation of dogs with Echinococcus granulosus surface antigens iscoms
    • Carol H, Nieto A. A mucosal IgA response, but no systemic antibody response, is evoked by intranasal immunisation of dogs with Echinococcus granulosus surface antigens iscoms. Vet. Immunol. Immunopathol. 1998; 65: 29-41.
    • (1998) Vet. Immunol. Immunopathol. , vol.65 , pp. 29-41
    • Carol, H.1    Nieto, A.2
  • 75
    • 0029935568 scopus 로고    scopus 로고
    • Acceleration of influenza virus clearance by Th1 cells in the nasal site of mice immunized intranasally with adjuvant-combined recombinant nucleoprotein
    • Tamura S, Miyata K, Matsuo K et al. Acceleration of influenza virus clearance by Th1 cells in the nasal site of mice immunized intranasally with adjuvant-combined recombinant nucleoprotein. J. Immunol. 1996; 156: 3892-900.
    • (1996) J. Immunol. , vol.156 , pp. 3892-3900
    • Tamura, S.1    Miyata, K.2    Matsuo, K.3
  • 76
    • 0028806066 scopus 로고
    • Intranasal immunization of mice against influenza with synthetic peptides anchored to proteosomes
    • Levi R, Aboud-Pirak E, Leclerc C, Lowell GH, Arnon R. Intranasal immunization of mice against influenza with synthetic peptides anchored to proteosomes. Vaccine 1995; 13: 1353-9.
    • (1995) Vaccine , vol.13 , pp. 1353-1359
    • Levi, R.1    Aboud-Pirak, E.2    Leclerc, C.3    Lowell, G.H.4    Arnon, R.5
  • 77
    • 0021255985 scopus 로고
    • Iscom, a novel structure for antigenic presentation of membrane proteins from enveloped viruses
    • Morein B, Sundquist B, Hoglund S, Dalsgaard K, Osterhaus A. Iscom, a novel structure for antigenic presentation of membrane proteins from enveloped viruses. Nature 1984; 308: 457-60.
    • (1984) Nature , vol.308 , pp. 457-460
    • Morein, B.1    Sundquist, B.2    Hoglund, S.3    Dalsgaard, K.4    Osterhaus, A.5
  • 78
    • 8644252813 scopus 로고    scopus 로고
    • Phase 1 study of HPV16-specific immunotherapy with E6E7 fusion protein and ISCOMATRIX™ adjuvant in women with cervical intraepithelial neoplasia
    • Frazer IH, Quinn M, Nicklin JL et al. Phase 1 study of HPV16-specific immunotherapy with E6E7 fusion protein and ISCOMATRIX™ adjuvant in women with cervical intraepithelial neoplasia. Vaccine 2004; 23: 172-81.
    • (2004) Vaccine , vol.23 , pp. 172-181
    • Frazer, I.H.1    Quinn, M.2    Nicklin, J.L.3
  • 79
    • 3242658810 scopus 로고    scopus 로고
    • Recombinant NY-ESO-1 protein with ISCOMATRIX adjuvant induces broad integrated antibody and CD4 (+) and CD8 (+) T cell responses in humans
    • Davis ID, Chen W, Jackson H et al. Recombinant NY-ESO-1 protein with ISCOMATRIX adjuvant induces broad integrated antibody and CD4 (+) and CD8 (+) T cell responses in humans. Proc. Natl Acad. Sci. USA 2004; 101: 10 697-702.
    • (2004) Proc. Natl Acad. Sci. USA , vol.101
    • Davis, I.D.1    Chen, W.2    Jackson, H.3
  • 80
    • 0033526828 scopus 로고    scopus 로고
    • Augmentation of human influenza A virus-specific cytotoxic T lymphocyte memory by influenza vaccine and adjuvanted carriers (ISCOMS)
    • Ennis FA, Cruz J, Jameson J, Klein M, Burt D, Thipphawong J. Augmentation of human influenza A virus-specific cytotoxic T lymphocyte memory by influenza vaccine and adjuvanted carriers (ISCOMS). Virology 1999; 259: 256-61.
    • (1999) Virology , vol.259 , pp. 256-261
    • Ennis, F.A.1    Cruz, J.2    Jameson, J.3    Klein, M.4    Burt, D.5    Thipphawong, J.6
  • 81
    • 0034623979 scopus 로고    scopus 로고
    • A randomized, double blind study in young healthy adults comparing cell mediated and humoral immune responses induced by influenza ISCOM vaccines and conventional vaccines
    • Rimmelzwaan GF, Nieuwkoop N, Brandenburg A et al. A randomized, double blind study in young healthy adults comparing cell mediated and humoral immune responses induced by influenza ISCOM vaccines and conventional vaccines. Vaccine 2001; 19: 1180-87.
    • (2001) Vaccine , vol.19 , pp. 1180-1187
    • Rimmelzwaan, G.F.1    Nieuwkoop, N.2    Brandenburg, A.3
  • 82
    • 0035414579 scopus 로고    scopus 로고
    • Heterosubtypic immunity against human influenza A viruses, including recently emerged avian H5 and H9 viruses, induced by FLU-ISCOM vaccine in mice requires both cytotoxic T-lymphocyte and macrophage function
    • Sambhara S, Kurichh A, Miranda R et al. Heterosubtypic immunity against human influenza A viruses, including recently emerged avian H5 and H9 viruses, induced by FLU-ISCOM vaccine in mice requires both cytotoxic T-lymphocyte and macrophage function. Cell Immunol. 2001; 211: 143-53.
    • (2001) Cell Immunol. , vol.211 , pp. 143-153
    • Sambhara, S.1    Kurichh, A.2    Miranda, R.3
  • 83
    • 0022880259 scopus 로고
    • Antigenic determinants of influenza virus hemagglutinin. XII. The epitopes of a synthetic peptide representing the C-terminus of HA1
    • Jackson DC, Tang XL, Brown LE, Murray JM, White DO, Tregear GW. Antigenic determinants of influenza virus hemagglutinin. XII. The epitopes of a synthetic peptide representing the C-terminus of HA1. Virology 1986; 155: 625-32.
    • (1986) Virology , vol.155 , pp. 625-632
    • Jackson, D.C.1    Tang, X.L.2    Brown, L.E.3    Murray, J.M.4    White, D.O.5    Tregear, G.W.6
  • 84
    • 0036229655 scopus 로고    scopus 로고
    • Induction of long-term memory CD8 (+) T cells for recall of viral clearing responses against influenza virus
    • Deliyannis G, Jackson DC, Ede NJ et al. Induction of long-term memory CD8 (+) T cells for recall of viral clearing responses against influenza virus. J. Virol. 2002; 76: 4212-21.
    • (2002) J. Virol. , vol.76 , pp. 4212-4221
    • Deliyannis, G.1    Jackson, D.C.2    Ede, N.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.