Oral vaccination with immune stimulating complexes

Immunology Letters

Volumn 65, Issue 1-2, 1999, Pages 133-140

  McI Mowat, Allan ^a   Smith, Rosemary E ^a   Donachie, Anne M ^a   Furrie, Elizabeth ^b   Grdic, Dubravka ^c   Lycke, Nils ^c  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b NINEWELLS HOSPITAL   (United Kingdom)

^c UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Innate immunity; ISCOMS; Oral vaccine; Saponin

Indexed keywords

INTERLEUKIN 4; INTERLEUKIN 5; NITRIC OXIDE; OVALBUMIN; QUIL A; VACCINE;

ANIMAL EXPERIMENT; ANTIGEN ANTIBODY COMPLEX; CONFERENCE PAPER; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; IMMUNOGENICITY; IMMUNOSTIMULATION; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; VACCINATION; VACCINE PRODUCTION;

ADJUVANTS, IMMUNOLOGIC; ADMINISTRATION, ORAL; ANIMALS; IMMUNITY, NATURAL; INFLAMMATION MEDIATORS; INTESTINES; ISCOMS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; OVALBUMIN; SAPONINS; VACCINATION;

EID: 0344958650     PISSN: 01652478     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-2478(98)00136-9     Document Type: Conference Paper

References (33)

1. WHO, The World Health Report, WHO (1996).
2. Bloom B.R. Vaccines for the Third World. Nature. 342:1989;115-116.
3. McGhee J.R., Mestecky J., Dertzbaugh M.T., Eldridge J.H., Hirasawa M., Kiyono H. The mucosal immune system: from fundamental concepts to vaccine development. Vaccine. 10:1992;75-88.
4. Strobel S., Mowat A.M. Immune responses to dietary antigens: oral tolerance. Immunol. Today. 19:1998;173-181.
5. Mowat A.M. The regulation of immune responses to dietary protein antigens. Immunol. Today. 8:1987;93-98.
6. C.O. Elson, M.T. Derztbaugh, Mucosal adjuvants, in: P.L. Ogra, J. Mestecky, M.E. Lamm, W. Strober, J. R. McGhee, J. Bienenstocl (Eds.), Handbook of Mucosal Immunology, Academic Press, San Diego CA, 1994, pp. 391-402.
7. Morein B., Lövgren K., Rönnberg B., Sjölander A., Villacres-Erikeson M. Immunostimulating complexes: clinical potential in vaccine development. Clin. Immunother. 3:1995;461-475.
8. Morein B., Fossum C., Lovgren K., Hoglund S. The ISCOM-a modern approach to vaccines. Semin. Virol. 1:1990;49.
9. Varsanyi T.M., Morein B., Love A., Norrby E. Protection against lethal Measles virus infection in mice by immune-stimulating complexes containing the hemagglutinin or fusion protein. J. Virol. 61:1987;3896-3901.
10. Ertürk M., Jennings R., Hockley D., Potter C.W. Antibody responses and protection in mice immunised with herpes simplex type 1 antigen immune-stimulating complex preparation. J. Gen. Virol. 70:1989;2149-2155.
11. J. Cox, a. 1Coulter, R. Macfarlan, L. Beezum, J. Bates, T.-Y. Wong, D. Drane, Development of an influenza-ISCOM™ vaccine, in: G. Gregoriadis, B. McCormack, A.C. Allison (Eds.), Vaccine Design: the Role of Cytokine Networks, vol. 293, Plenum Press, New York, 1997, pp. 33-49.
12. Mowat A.M., Maloy K.J., Donachie A.M. Immune stimulating complexes as adjuvants for inducing local and systemic immunity after oral immunisation with protein antigens. Immunology. 80:1993;527-534.
13. Mowat A.M., Donachie A.M., Reid G., Jarrett O. Immune stimulating complexes containing Quil A and protein antigen prime Class I MHC-restricted T lymphocytes in vivo and are active by the oral route. Immunology. 72:1991;317-322.
14. A.M. Mowat, K.J. Maloy, Immune stimulating complexes as vectors for oral immunisation, in: D.T. O'Hagan (Ed.), Novel delivery systems for oral vaccines, CRC Press, Boca Raton FL, 1994, pp. 207-223.
15. + T-cell responses by oral or parenteral immunization with ISCOMS. Eur. J. Immunol. 25:1995;2835-2841.
16. + cytotoxic T-cells by immunisation with purified HIV-1 envelope protein in ISCOMS. Nature. 344:1990;873-875.
17. Heeg K., Kuon W., Wagner H. Vaccination of Class I major histocompatibility complex (MHC)-restricted murine CD8+cytotoxic T lymphocytes toward soluble antigen: immuno stimulating complexes enter the Class I MHC-restricted antigen pathway and allow sensitization against the immunodominant peptide. Eur. J. Immunol. 21:1991;1523-1527.
18. A.M. Mowat, G. Reid, The preparation of immune stimulating complexes (ISCOMS) as adjuvants for local and systemic immunisation with protein antigens, in: J.E. Coligan, A.M. Kruisbeek, D. Margulies, E. Shevach, W. Strober, (Eds.), Current Protocols in Immunology, John Wiley and Sons, New York, 1994, pp. 2.11.1-12.
19. Garside P., Steel M., Worthey E.A., Satoskar A., Alexander J., Bluethmann H., Liew F.Y., Mowat A.M. Th2 cells are subject to high dose oral tolerance and are not essential for its induction. J. Immunol. 154:1995;5649-5655.
20. Peng H.-J., Turner M.W., Strobel S. The generation of a 'tolerogen' after the ingestion of ovalbumin is time-dependent and unrelated to serum levels of immunoreactive antigen. Clin. Exp. Immunol. 81:1990;510-515.
21. Furrie E., Turner M.W., Strobel S. Failure of scid mice to generate an oral tolerogen after a feed of ovalbumin: a role for a functioning gut-associated lymhpoid system. Immunology. 83:1994;562-567.
22. Smith R.E., Donachie A.M., McLaren F.H., Mowat A.M. Preservation of mucosal and systemic adjuvant properties of ISCOMS in the absence of functional interleukin 4 or γinterferon. Immunology. 93:1998;556-562.
23. T. Kato, R.L. Owen, Structure and function of intestinal mucosal epithelium, in: P.L. Ogra, J. Mestecky, M.E. Lamm, W. Strober, J.R. McGhee, J. Bienenstock, Handbook of Mucosal Immunology, Academic Press, San Diego, 1994, pp. 11-26.
24. Mowat A.M., Viney J.L. The anatomical basis of mucosal immune responses. Immunol. Rev. 156:1997;145-166.
25. Claassen I., Osterhaus A., Boersma W., Schellekens M., Claassen E. Fluorescent labelling of virus, bacteria, and iscoms: in vivo systemic and mucosal localisation patterns. Adv. Exp. Med. Biol. 371B:1995;1485-1489.
26. Lazorova L., Artursson P., Engstrom A., Sjolander A. Transport of an influenza virus vaccine formulation (iscom) in Caco-2 cells. Am. J. Physiol. 270:1996;G554-G564.
27. Fearon D.T., Locksley R.M. The instructive role of innate immunity in the acquired immune response. Science. 272:1996;50-54.
28. Watson D.L., Watson N.A., Fossum C., Lövgren K. Interactions between immune-stimulating complexes (ISCOMs) and peritoneal mononuclear leucocytes. Microbiol. Immunol. 36:1992;199-203.
29. Claassen I.J.T.M., Osterhaus A.D.M.E., Claassen E. Antigen detection in vivo after immunization with different presentation forms of rabies virus antigen: involvement of marginal metallophilic macrophages in the uptake of immune-stimulating complexes. Eur. J. Immunol. 25:1995;1446-1452.
30. Banchereau J., Stelman R.L. Dendritic cells and the control of immunity. Nature. 392:1998;245-252.
31. J. Magram, S.R. Connaughton, R.R. Warriar, D.M. Carvajal, C.-Y. Wu, J. Ferrante, C. Stewart, V. Sarmiento, D.A. Faherty, M.R. Gately, IL-12 defieient mice are defective in IFN-g production and type 1 cytokie responses, Immunity (1996) In Press.
32. Piccotti J.R., Li K., Chan S.Y., Ferrante J., Magram J., Eichwald E.J., Bishop D.K. Allocation reactive the development in IL-12-deficient mice. J. Immunol. 160:1998;1132-1138.
33. Vajdy M., Kosco-Vilbols M.H., Kopf M., Kohler G., Lycke N. Impaired mucosal immune responses in Interleukin 4-targeted mice. J. Exp. Med. 181:1995;41-53.