Stealth PLA-PEG nanoparticles as protein carriers for nasal administration

Pharmaceutical Research

Volumn 15, Issue 2, 1998, Pages 270-275

  Tobio M ^a   Gref, R ^b   Sanchez A ^a   Langer, R ^c   Alonso, M J ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^b LAB DE CHIM PHYS MACROMOLECULAIRE   (France)

^c Massachusetts Institute of Technology Cambridge   (United States)

Author keywords

Nasal administration; Poly(lactic acid) polyethylene glycol; Protein delivery; Protein mucosal transport; Stealth nanoparticles; Vaccine delivery

Indexed keywords

GELATIN; IODINE 125; MACROGOL; NANOPARTICLE; POLYLACTIC ACID; POLYMER; TETANUS TOXOID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; ENCAPSULATION; FEMALE; HYDROPHOBICITY; NONHUMAN; NOSE MUCOSA; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN TRANSPORT; RADIOACTIVITY; TISSUE DISTRIBUTION;

ADMINISTRATION, INTRANASAL; ANIMALS; DRUG CARRIERS; LACTATES; MICROSCOPY, ELECTRON; PARTICLE SIZE; POLYETHYLENE GLYCOLS; RATS; TETANUS TOXOID; TISSUE DISTRIBUTION;

EID: 0031918253     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011922819926     Document Type: Article

References (24)

1. A. T. Florence. Pharm. Res. 14:259-266 (1997).
2. H. O. Alpar, J. C. Bowen, and M. R. W. Brown. Int. J. Pharm. 88:335-344 (1992).
3. D. T. O'Hagan. Clin. Pharmacokinet. 22:335-344 (1992).
4. P. Wüthrich and P. Buri. Pharm. Acta Helvetiae 64:322-331 (1989).
5. A. E. Pontirolli. J. Control. Rel. 13:247-251 (1990).
6. A. J. Almeida and H. O. Alpar. J. Drug Targ. 3:455-467 (1996).
7. C. F. Kuper, P. J. Koornstra, D. M. H. Hameleers, J. Biewenga, B. J. Spit, A. M. Duijvestijn, P. J. C. van Bedra, and T. Smimia. Immunol. Today 13:219-224 (1992).
8. E. Abraham. Vaccine 10:461-468 (1992).
9. J. C. Bowen, O. Alpar, R. Phillpots, I. S. Roberts, and M. R. W. Brown. J. Lipos. Res. 5:193-214 (1995).
10. A. J. Almeida, H. O. Alpar, and M. R. W. Brown. J. Pharm. Pharmacol. 45:198-203 (1993).
11. J. H. Eldridge, C. J. Hammond, J. A. Meulbroek, J. K. Staas, R. M. Gilley, and T. R. Tice. J. Control. Rel. 11:205-214 (1990).
12. R. Gref., Y. Minimitake, M. T. Perracchia, V. Trubetskoy, V. Torchilin, and R. Langer. Science 263:1600-1603 (1994).
13. M. T. Peracchia, R. Gref, Y. Minimitake, A. Domb, N. Lotan, and R. Langer. J. Control. Rel. 46:223-231 (1997).
14. Y. Minimitake, R. Gref, J. S. Hrkach, M. T. Peracchia, A. Domb, and R. Langer. Macromolecules (Submitted).
15. M. D. Blanco and M. J. Alonso. Eur. J. Pharm. Biopharm. 43:287-294 (1997).
16. H. Carstensen, B. W. Muller, and R. H. Muller. Int. J. Pharm. 67:29-37 (1991).
17. M. J. Alonso, S. Cohen, T. G. Park, R. K. Gupta, G. Siber, and R. Langer. Pharm. Res. 10:945-953 (1993).
18. A. E. Hawley, L. Illum, and S. S. Davis. Pharm. Res. 14:657-203 (1997).
19. M. J. Alonso, B. Villamayor, M. Tobío, S. Schwendeman, R. K. Gupta, G. Siber, and R. Langer. Proceed. Intern. Symp. Rel. Bioact. Mater. 23:825-826 (1996).
20. M. Tobío and M. J. Alonso. Proceed. Intern. Symp. Rel. Bioact. Mater. 24:425-426 (1997).
21. D. Bazile, C. Prud'homme, M. T. Bassoulet, M. Marlard, G. Spenlehauer, and M. Veillard. J. Pharm. Sci. 84:493-498 (1995).
22. S. Stolnik, S. E. Dunn, M. C. Garnett, M. C. Davis, A. G. A. Coombes, D. C. Taylor, M. P. Irving, S. C. Purkiss, T. F. Tadros, S. S. Davis, and L. Illum. Pharm. Res. 11:1800-1808 (1994).
23. A. T. Florence and P. U. Jani. Pharmaceutical Particulate Carriers, Marcel Dekker, New York, 1993, pp. 65-108.
24. H. O. Alpar, A. J. Almeida, and M. R. W. Brown. J. Drug Targeting 2:147-149 (1994).