Th1 adjuvant N-acetyl-D-glucosamine polymer up-regulates th1 immunity but down-regulates Th2 immunity against a mycobacterial protein (MPB-59) in interleukin-10-knockout and wild-type mice

Infection and Immunity

Volumn 69, Issue 10, 2001, Pages 6123-6130

  Shibata, Y ^a   Honda, I ^a   Justice, J P ^a   Van Scott, M R ^a   Nakamura, R M ^a   Myrvik, Q N ^a  

^a EAST CAROLINA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; BCG VACCINE; CHITIN; GAMMA INTERFERON; IMMUNOGLOBULIN G1; INTERLEUKIN 10; INTERLEUKIN 4; INTERLEUKIN 5; MYCOBACTERIUM ANTIGEN; N ACETYLGLUCOSAMINE; PROSTAGLANDIN E2; PROTEIN MBP 59; UNCLASSIFIED DRUG;

ADJUVANT THERAPY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL ACTIVITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DELAYED HYPERSENSITIVITY; FEMALE; HOST RESISTANCE; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOGLOBULIN BLOOD LEVEL; KNOCKOUT MOUSE; MACROPHAGE; MOUSE; MYCOBACTERIUM BOVIS; NONHUMAN; PRIORITY JOURNAL; SPLEEN; TH1 CELL; TH2 CELL;

ACETYLGLUCOSAMINE; ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIGENS, BACTERIAL; CELLS, CULTURED; CHITIN; DINOPROSTONE; DOWN-REGULATION; FEMALE; HYPERSENSITIVITY, DELAYED; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; INTERLEUKIN-10; MACROPHAGES, ALVEOLAR; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYCOBACTERIUM BOVIS; POLYMERS; SPLEEN; TH1 CELLS; TH2 CELLS; UP-REGULATION;

EID: 0034833470     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.69.10.6123-6130.2001     Document Type: Article

References (54)

1. Effective vaccination of mice against Mycobacterium tuberculosis infection with a soluble mixture of secreted mycobacterial proteins
2. Innate pathways that control acquired immunity
3. Relationship of Bacillus Calmette-Guerin-induced suppressor cells to hematopoietic precursor cells
4. Infection with Mycobacterium avium induces production of interleukin-10 (IL-10), and administration of anti-IL-10 antibody is associated with enhanced resistance to infection in mice
5. An essential role for macrophage migration inhibitory factor in the tuberculin delayed-type hypersensitivity reaction
6. Prostaglandin E2 inhibits production of Th1 lymphokines but not of Th2 lymphokines
7. Normal bronchial epithelial cells constitutively produce the anti-inflammatory cytokine interleukin-10, which is downregulated in cystic fibrosis
8. B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells
9. Disseminated tuberculosis in interferon gamma gene-disrupted mice
10. Bacterial DNA induces NK cells to produce IFN-γ in vivo and increases the toxicity of lipopolysaccharides
11. Both innate and acquired immunity to Listeria monocytogenes infection are increased in IL-10-deficient mice
12. IL-10 neutralization augments mouse resistance to systemic Mycobacterium avium infections
13. BCG-induced macrophages as suppressor cells
14. Chronic infection due to Mycobacterium intracellulare in mice: Association with macrophage release of prostaglandin E2 and reversal by injection of indomethacin, muramyl dipeptide, or interferon-gamma
15. Infection of mice with Mycobacterium bovis-Bacillus Calmette-Guerin (BCG) suppresses allergen-induced airway eosinophilia
16. Modulation of helper T cell function by prostaglandins
17. Induction of a macrophage migration enhancement factor after desensitization of tuberculin-positive rabbits with purified protein derivative
18. Interleukin-10 is a natural suppressor of cytokine production and inflammation in a murine model of allergic bronchopulmonary aspergillosis
19. Effective isolation of MPB64 from a large volume of culture filtrate of Mycobacterium boris BCG Tokyo
20. Genetically permissive recognition of adjacent epitopes from the 19-kDa antigen of Mycobacterium tuberculosis by human and murine T cells
21. Novel insights into the genetics, biochemistry, and immunocytochemistry of the 30-kilodalton major extracellular protein of Mycobacterium tuberculosis
22. BCG infection suppresses allergic sensitization and development of increased airway reactivity in an animal model
23. Immunization of mice with mycobacterial culture filtrate proteins
24. Spleen cell cytokine secretion in Mycobacterium boris BCG-induced mice
25. IL-10 gene knockout attenuates allergen-induced airway hyperresponsiveness in C57BL/6 mice
26. Antigen provoking gamma interferon production in response to Mycobacterium bovis BCG and functional difference in T-cell responses to this antigen between viable and killed BCG-immunized mice
27. Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma
28. Interleukin-10-deficient mice develop chronic enterocolitis
29. Interleukin-10
30. Suppressor cells in mycobacterial infections
31. Cloning of a new cytokine that induces IFNγ production by T cells
32. Characteristics of protective immunity engendered by vaccination of mice with purified culture filtrate protein antigens of Mycobacterium tuberculosis
33. T-cell determinants and antibody binding sites on the major mycobacterial secretory protein MPB59 of Mycobacterium bovis
34. IFNγ modulates the early development of Th1 and Th2 responses in a murine model of cutaneous leishmaniasis
35. Adjuvant modulation of T-cell reactivity to 30-kDa secretory, protein of Mycobacterium tuberculosis H37Rv and its protective efficacy against experimental tuberculosis
36. 89Sr-treated mice with bone marrow from Corynebacterium parvum primed donors
37. Eicosanoid production by peritoneal and splenic macrophages in mice depleted of bone marrow by 89Sr
38. Alveolar macrophage priming by intravenous administration of chitin particles, polymers of N-acetyl-D-glucosamine, in mice
39. Immunoregulatory roles of IL-10 in innate immunity - IL-10 inhibits macrophage production IFN-gamma-inducing factors but enhances NK cell production of IFN-gamma
40. Chitin particle-induced cell mediated immunity is inhibited by mannan - Mannose receptor-mediated phagocytosis initiates interleukin-12 production
41. Oral administration of chitin down-regulates serum IgE levels and lung eosinophilia in the allergic mouse
42. Mapping of T cell epitopes of the 30-kDa antigen of Mycobacterium bovis strain Bacillus Calmette-Guerin in purified protein derivative (PPD)-positive individuals
43. Regulation of murine macrophage IL-12 production. Activation of macrophages in vivo, restimulation in vitro, and modulation by other cytokines
44. Interferon-γ and B cell stimulatory factor-1 reciprocally regulate 1g isotype production
45. Prostaglandin E2 differentially modulates cytokine secretion profiles of human T helper lymphocytes
46. Th1/Th2 profiles in tuberculosis, based on the proliferation and cytokine response of blood lymphocytes to mycobacterial antigens
47. Prostaglandin-E2 is a potent inhibitor of human interleukin 12 production
48. Inhibition of an established allergic response to ovalbumin in BALB/c mice by killed Mycobacterium vaccae
49. The antigen 85 complex: A major secretion product of Mycobacterium tuberculosis
50. In vitro augmentation of natural killer cell activity and production of interferon-alpha/beta and -gamma with deoxyribonucleic acid fraction from Mycobacterium bovis BCG
51. Defining protective responses to pathogens: Cytokine profiles in leprosy lesions
52. An essential role for endogenous interferon-gamma in the generation of protective T cells against Mycobacterium bovis BCG in mice
53. Heat-killed Listeria monocytogenes as an adjuvant converts established murine Th2-dominated immune responses into Th1-dominated responses
54. Total and anti-mycobacterial IgE levels in serum from patients with tuberculosis and leprosy