Oligonucleotide containing CpG motifs enhances immune response to mucosally or systemically administered tetanus toxoid

Vaccine

Volumn 19, Issue 13-14, 2001, Pages 1636-1642

  Eastcott, Jean W ^a   Holmberg, Cynthia J ^a   Dewhirst, Floyd E ^a   Esch, Thomas R ^a   Smith, Daniel J ^a   Taubman, Martin A ^a  

^a FORSYTH INSTITUTE   (United States)

Author keywords

CpG motifs; Mucosal immunity; Oligodeoxynucleotide

Indexed keywords

ALUMINUM HYDROXIDE; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; OLIGODEOXYNUCLEOTIDE; TETANUS TOXOID;

ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; CELL PROLIFERATION; CONTROLLED STUDY; CPG ISLAND; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNIZATION; IMMUNOGLOBULIN BLOOD LEVEL; MALE; MUCOSAL IMMUNITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; SALIVA LEVEL; SALIVARY GLAND; STOMACH INTUBATION; TETANUS;

ADJUVANTS, IMMUNOLOGIC; ALUMINUM HYDROXIDE; ANIMALS; BASE SEQUENCE; CPG ISLANDS; DNA METHYLATION; IMMUNITY, MUCOSAL; IMMUNIZATION; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; INJECTIONS, INTRAVENOUS; INTUBATION, GASTROINTESTINAL; KINETICS; LYMPH NODES; MALE; OLIGODEOXYRIBONUCLEOTIDES; RATS; RATS, INBRED STRAINS; SALIVA; SALIVARY GLANDS; SPLEEN; STOMACH; TETANUS TOXOID; TITRIMETRY;

EID: 0035825599     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(00)00422-9     Document Type: Article

References (30)

1. Lymphocyte activation by CpG dinucleotide motifs in prokaryotic DNA
2. CpG motifs in bacterial DNA trigger direct B-cell activation
3. Bacterial DNA-induced NK cell IFN-gamma production is dependent on macrophage secretion of IL-12
4. Bacterial DNA induces NK cells to produce IFN-gamma in vivo and increases the toxicity of lipopolysaccharides
5. Macrophages ingest and are activated by bacterial DNA
6. Immune activation by bacterial DNA: A new genetic code
7. CpG DNA is a potent enhancer of systemic and mucosal immune responses against hepatitis B surface antigen with intranasal administration to mice
8. CpG DNA, a novel immune enhancer for systemic and mucosal immunization with influenza virus
9. CpG oligonucleotides trigger protective and curative Th1 responses in lethal murine leishmaniasis
10. CpG oligonucleotides act as adjuvants that switch on T helper 1 (Th1) immunity
11. Synthetic oligonucleotides containing CpG motifs enhance immunogenicity of a peptide malaria vaccine in Aotus monkeys
12. Adjuvant properties of aluminum and calcium compounds
13. Epithelial M cells: Gateways for mucosal infection and immunization
14. Coimmunization with complementary glucosyltransferase peptides results in enhanced immunogenicity and protection against dental caries
15. Secretory gamma A antibodies induced by local immunization
16. Dental caries in congenitally athymic rats
17. CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma
18. Suppression of tumor growth and induction of specific tumor immunity by intradermal inoculation of a mixture of living tumor cells and live Mycobacterium bovis in syngeneic mice
19. Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity
20. Synthetic oligonucleotides with particular base sequences from the cDNA encoding proteins of Mycobacterium bovis BCG induce interferons and activate natural killer cells
21. Ability of oligonucleotides with certain palindromes to induce interferon production and augment natural killer cell activity is associated with their base length
22. Bacterial DNA induces murine interferon-gamma production by stimulation of interleukin-12 and tumor necrosis factor-alpha
23. Stage-specific oligonucleotide uptake in murine bone marrow B-cell precursors
24. Lipofection of synthetic oligodeoxyribonucleotide having a palindromic sequence of AACGTT to murine splenocytes enhances interferon production and natural killer activity
25. CpG motifs in bacterial DNA activate leukocytes through the pH-dependent generation of reactive oxygen species
26. Nonspecific suppression of [3H] thymidine incorporation by 'control' oligonucleotides
27. DNA as an adjuvant: Capacity of insect DNA and synthetic oligodeoxynucleotides to augment T cell responses to specific antigen
28. CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen
29. Antibody responses to non-immunogenic synthetic peptides induced by co-immunization with immunogenic peptides
30. Mechanism and function of a newly identified CpG DNA motif in human primary B cells