Multiple antigen peptide consisting of B- and T-cell epitopes of F1 antigen of Y. pestis showed enhanced humoral and mucosal immune response in different strains of mice

International Immunopharmacology

Volumn 15, Issue 1, 2013, Pages 97-105

  Ali, Riyasat ^a   Kumar, Sudhir ^a   Naqvi, Raza Ali ^a   Sheikh, Ishfaq Ahmed ^b   Rao, D N ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^b KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

Author keywords

Antibody titer; CpG; F1 antigen; Multiple antigen peptide; Y. pestis

Indexed keywords

B LYMPHOCYTE ANTIGEN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G2B; MURABUTIDE; POLYGLACTIN; SECRETORY IMMUNOGLOBULIN; T LYMPHOCYTE ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY TITER; ARTICLE; B LYMPHOCYTE; BACTERIAL STRAIN; CONTROLLED STUDY; CPG ISLAND; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMORAL IMMUNITY; IMMUNOBLOTTING; IMMUNOREACTIVITY; MOUSE; MUCOSAL IMMUNITY; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; T LYMPHOCYTE; YERSINIA PESTIS;

ACETYLMURAMYL-ALANYL-ISOGLUTAMINE; ADJUVANTS, IMMUNOLOGIC; ADMINISTRATION, INTRANASAL; ANIMALS; ANTIGENS; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; EPITOPES, B-LYMPHOCYTE; EPITOPES, T-LYMPHOCYTE; FEMALE; IMMUNITY, HUMORAL; IMMUNITY, MUCOSAL; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; LACTIC ACID; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICROSPHERES; OLIGODEOXYRIBONUCLEOTIDES; PEPTIDES; POLYGLYCOLIC ACID; VACCINES, SUBUNIT;

EID: 84872311271     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2012.10.029     Document Type: Article

References (36)

1. R.D. Perry, and J.D. Fetherston Yersinia pestis-etiologic agent of plague Clin Microbiol Rev 10 1997 35 66
2. T.V. Inglesby, D.T. Dennis, D.A. Henderson, J.G. Bartlett, M.S. Ascher, and E. Eitzen Plague as a biological weapon: medical and public health management. Working Group on Civilian Biodefense JAMA 283 2000 2281 2290
3. K.F. Meyer Effectiveness of live or killed plague vaccines in man Bull World Health Organ 42 1970 653 666
4. Y. Du, R. Rosqvist, and A. Forsberg Role of fraction 1 antigen of Yersinia pestis in inhibition of phagocytosis Infect Immun 70 2002 1453 1460
5. G.P. Andrews, D.G. Heath, G.W. Anderson, S.L. Welkos, and A.M. Friedlander Fraction 1 capsular antigen (F1) purification from Yersinia pestis CO92 and from an Escherichia coli recombinant strain and efficacy against lethal plague challenge Infect Immun 64 1996 2180 2187
6. K.F. Meyer, J.A. Hightower, and F.R. McCrumb Plague immunization. VI. Vaccination with the fraction I antigen of Yersinia pestis J Infect Dis 129 1974 S41 S45 [Suppl.]
7. D.N. Posnett, H. McGrath, and J.P. Tam A novel method for producing antipeptide antibodies. Production of site-specific antibodies to the T cell antigen receptor beta-chain J Biol Chem 263 1988 1719 1725
8. C.Y. Wang, D.J. Looney, M.L. Li, A.M. Walfield, J. Ye, and B. Hosein Long-term high-titer neutralizing activity induced by octameric synthetic HIV-1 antigen Science 254 1991 285 288
9. T.C. VanCott, R.W. Kaminski, J.R. Mascola, V.S. Kalyanaraman, N.M. Wassef, and C.R. Alving HIV-1 neutralizing antibodies in the genital and respiratory tracts of mice intranasally immunized with oligomeric gp160 J Immunol 160 1998 2000 2012
10. R.W. Titball, and E.D. Williamson Vaccination against bubonic and pneumonic plague Vaccine 19 2001 4175 4184
11. F. Patricia Protection in mice passively immunized with serum from cynomolgus macaques and humans vaccinated with recombinant plague vaccine (rF1V) Vaccine 28 2010 7748 7756
12. L. Sabhnani, and D.N. Rao Developing subunit immunogens using B and T cell epitopes and their constructs derived from the F1 antigen of Yersinia pestis using novel delivery vehicles FEMS Immunol Med Microbiol 38 2003 215 229
13. G. Gupta, A.A. Khan, and D.N. Rao Cell-mediated immune response and Th1/Th2 cytokine profile of B-T constructs of F1 and V antigen of Yersinia pestis Scand J Immunol 71 2010 186 198
14. V. Tripathi, K.T. Chitralekha, A.R. Bakshi, D. Tomar, R.A. Deshmukh, and M.A. Baig Inducing systemic and mucosal immune responses to B-T construct of F1 antigen of Yersinia pestis in microsphere delivery Vaccine 24 2006 3279 3289
15. C. Partidos, C. Stanley, and M. Steward The influence of orientation and number of copies of T and B cell epitopes on the specificity and affinity of antibodies induced by chimeric peptides Eur J Immunol 22 1992 2675 2680
16. J.P. Tam Synthetic peptide vaccine design: synthesis and properties of a high-density multiple antigenic peptide system Proc Natl Acad Sci U S A 85 1988 5409 5413
17. S.B. Uppada, A.A. Bhat, A. Sah, and D.N. Rao Enhanced humoral and mucosal immune responses after intranasal immunization with chimeric multiple antigen peptide of LcrV antigen epitopes of Yersinia pestis coupled to palmitate in mice Vaccine 29 2011 9352 9360
18. A.A. Khan, J.P. Babu, G. Gupta, and D.N. Rao Identifying B and T cell epitopes and studying humoral, mucosal and cellular immune responses of peptides derived from V antigen of Yersinia pestis Vaccine 26 2008 316 332
19. J. Hill, J.E. Eyles, S.J. Elvin, G.D. Healey, R.A. Lukaszewski, and R.W. Titball Administration of antibody to the lung protects mice against pneumonic plague Infect Immun 74 2006 3068 3070
20. S.J. Elvin, J.E. Eyles, K.A. Howard, E. Ravichandran, S. Somavarappu, and H.O. Alpar Protection against bubonic and pneumonic plague with a single dose microencapsulated sub-unit vaccine Vaccine 24 2006 4433 4439
21. G.W. Anderson Jr., D.G. Heath, C.R. Bolt, S.L. Welkos, and A.M. Friedlander Short- and long-term efficacy of single-dose subunit vaccines against Yersinia pestis in mice Am J Trop Med Hyg 58 1998 793 799
22. D.G. Heath, G.W. Anderson, J.M. Mauro Jr., S.L. Welkos, G.P. Andrews, and J. Adamovicz Protection against experimental bubonic and pneumonic plague by a recombinant capsular F1-V antigen fusion protein vaccine Vaccine 16 1998 1131 1137
23. G.W. Anderson, S.E. Leary Jr., E.D. Williamson, R.W. Titball, S.L. Welkos, and P.L. Worsham Recombinant V antigen protects mice against pneumonic and bubonic plague caused by F1-capsule-positive and -negative strains of Yersinia pestis Infect Immun 64 1996 4580 4585
24. M.J. McCluskie, and H.L. Davis CpG DNA is a potent enhancer of systemic and mucosal immune responses against hepatitis B surface antigen with intranasal administration to mice J Immunol 161 1998 4463 4469
25. D.M. Klinman Immunotherapeutic uses of CpG oligodeoxynucleotides Nat Rev Immunol 4 2004 249 258
26. D.M. Klinman, H. Xie, S.F. Little, D. Currie, and B.E. Ivins CpG oligonucleotides improve the protective immune response induced by the anthrax vaccination of rhesus macaques Vaccine 22 2004 2881 2886
27. A.A. Bhat, R.K. Seth, B. Jayaprakash, S. Biswas, and D.N. Rao Induction of mucosal and systemic humoral immune responses in murine system byintranasal immunization with peptide antigens of P. vivax and CpG oligodeoxynucleotide (ODN) in microparticle delivery Int Immunopharmacol 9 2009 1197 1208
28. E.D. Williamson, P.M. Vesey, K.J. Gillhespy, S.M. Eley, M. Green, and R.W. Titball An IgG1 titre to the F1 and V antigens correlates with protection against plague in the mouse model Clin Exp Immunol 116 1999 107 114
29. K.S. Rupesh, R. Ali, J.P. Babu, and D.N. Rao Cell-mediated immune response to epitopic MAP (Multiple antigen peptide) construct of LcrV antigen of Yersinia pestis in murine model Cell Immunol 278 2012 55 62
30. G.N. Mihai, and F. Gerben Nucleotide-binding oligomerization domain-2 modulates specific TLR pathways for the induction of cytokine release J Immunol 174 2005 6518 6523
31. S.E. Girardin, I.G. Boneca, J. Viala, M. Chamaillard, A. Labigne, and G. Thomas Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection J Biol Chem 278 2003 8869 8872
32. T. Watanabe, N. Asano, P.J. Murray, K. Ozato, P. Tailor, and I.J. Fuss Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis J Clin Invest 118 2008 545 559
33. W. Stober, A. Kitani, I. Fuss, N. Asano, and T. Watanabe The molecular basis of NOD2 susceptibility mutations in Crohn's disease Mucosal Immunol 1 Suppl. 1 2008 S5 S9
34. C.S. Kaetzel The polymeric immunoglobulin receptor: bridging innate and adaptive immune responses at mucosal surfaces Immunol Rev 206 2005 83 99
35. J.R. McGhee, J. Mestecky, and H. Kiyono The mucosal immune system: from fundamental concepts to vaccine development Vaccine 10 1992 75 88
36. J.P. Tam, and Y.A. Lu Vaccine engineering: enhancement of immunogenicity of synthetic peptide vaccines related to hepatitis in chemically defined models consisting of T- and B-cell epitopes Proc Natl Acad Sci U S A 86 1989 9084 9088