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Volumn 260, Issue 2, 2003, Pages 273-282

Immune response after oral administration of the encapsulated malaria synthetic peptide SPf66

Author keywords

Malaria; Microparticle; Oral administration; Poly D,L lactide co glycolide; SPf66; Vaccination

Indexed keywords

ANTIGEN; IMMUNOGLOBULIN G ANTIBODY; MALARIA SYNTHETIC PEPTIDE; MALARIA VACCINE; POLYGLACTIN; RESOMER; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG;

EID: 0038121685     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(03)00266-7     Document Type: Article
Times cited : (43)

References (55)
  • 1
    • 0032054674 scopus 로고    scopus 로고
    • Mucosal immunogenicity elicited in mice by oral vaccination with phosphorilcholine encapsulated in poly(D,L-lactide-co-glycolide) microspheres
    • Allaoui-Attarki K., Fattal E., Pecquet S., Trollé S., Chachaty E., Couvreur P., Andremont A. Mucosal immunogenicity elicited in mice by oral vaccination with phosphorilcholine encapsulated in poly(D,L-lactide-co-glycolide) microspheres. Vaccine. 16:1998;685-691.
    • (1998) Vaccine , vol.16 , pp. 685-691
    • Allaoui-Attarki, K.1    Fattal, E.2    Pecquet, S.3    Trollé, S.4    Chachaty, E.5    Couvreur, P.6    Andremont, A.7
  • 2
    • 0027984492 scopus 로고
    • Randomised trial of efficacy of SPf66 vaccine against Plasmodium falciparum malaria in children in southern Tanzania
    • Alonso P.L., Smith T., Schellenberg J.R., Masanja H., Mwankusye S., Urassa H. Randomised trial of efficacy of SPf66 vaccine against Plasmodium falciparum malaria in children in southern Tanzania. Lancet. 344:1994;1175-1181.
    • (1994) Lancet , vol.344 , pp. 1175-1181
    • Alonso, P.L.1    Smith, T.2    Schellenberg, J.R.3    Masanja, H.4    Mwankusye, S.5    Urassa, H.6
  • 3
    • 0031952788 scopus 로고    scopus 로고
    • Oral immunization with poly(lactide-co-glycolide) microparticles containing an entrapped recombinant glycoprotein (gD2) from herpes simplex type 2 virus
    • Barackman J.D., Singh M., Ugozzoli M., Ott G.S., O'Hagan D.T. Oral immunization with poly(lactide-co-glycolide) microparticles containing an entrapped recombinant glycoprotein (gD2) from herpes simplex type 2 virus. S.T.P. Pharm. Sci. 8:1998;41-46.
    • (1998) S.T.P. Pharm. Sci. , vol.8 , pp. 41-46
    • Barackman, J.D.1    Singh, M.2    Ugozzoli, M.3    Ott, G.S.4    O'Hagan, D.T.5
  • 4
    • 0024856330 scopus 로고
    • Vaccines for the third world
    • Bloom B.R. Vaccines for the third world. Nature. 342:1989;115-120.
    • (1989) Nature , vol.342 , pp. 115-120
    • Bloom, B.R.1
  • 5
    • 0027988506 scopus 로고
    • Comparative efficacy of biodegradable liposomes and microspheres as carriers for delivery of Vibrio cholerae antigens in the intestine
    • Chandrashekhar U., Sinha S., Bhagat H.R., Srivastava B.S. Comparative efficacy of biodegradable liposomes and microspheres as carriers for delivery of Vibrio cholerae antigens in the intestine. Vaccine. 12:1994;1384-1388.
    • (1994) Vaccine , vol.12 , pp. 1384-1388
    • Chandrashekhar, U.1    Sinha, S.2    Bhagat, H.R.3    Srivastava, B.S.4
  • 6
    • 0032995755 scopus 로고    scopus 로고
    • Biodegradable microparticles of influenza viral vaccine: Comparison of the effects of routes of administration on the in vivo immune response in mice
    • Chattaraj S.C., Rathinavelu A., Das S.K. Biodegradable microparticles of influenza viral vaccine: comparison of the effects of routes of administration on the in vivo immune response in mice. J. Control. Rel. 58:1999;223-232.
    • (1999) J. Control. Rel. , vol.58 , pp. 223-232
    • Chattaraj, S.C.1    Rathinavelu, A.2    Das, S.K.3
  • 7
    • 0035961506 scopus 로고    scopus 로고
    • Protection against Bordetella pertussis infection following parenteral or oral immunization with antigens entrapped in biodegradable particles: Effect of formulation and route of immunization on induction of Th1 and Th2 cells
    • Conway M.A., Madrigal-Estebas L., McClean S., Brayden D.J., Mills K.H.G. Protection against Bordetella pertussis infection following parenteral or oral immunization with antigens entrapped in biodegradable particles: effect of formulation and route of immunization on induction of Th1 and Th2 cells. Vaccine. 19:2001;1940-1950.
    • (2001) Vaccine , vol.19 , pp. 1940-1950
    • Conway, M.A.1    Madrigal-Estebas, L.2    McClean, S.3    Brayden, D.J.4    Mills, K.H.G.5
  • 8
    • 0030445728 scopus 로고    scopus 로고
    • Single dose, polymeric, microparticle-based vaccines: The influence of formulation conditions on the magnitude and duration of the immune response to a protein antigen
    • Coombes A.G.A., Lavelle E.C., Jenkins P.G., Davis S.S. Single dose, polymeric, microparticle-based vaccines: the influence of formulation conditions on the magnitude and duration of the immune response to a protein antigen. Vaccine. 14:1996;1429-1438.
    • (1996) Vaccine , vol.14 , pp. 1429-1438
    • Coombes, A.G.A.1    Lavelle, E.C.2    Jenkins, P.G.3    Davis, S.S.4
  • 9
    • 0030471901 scopus 로고    scopus 로고
    • Gastrointestinal uptake of biodegradable microparticles: Effect of particle size
    • Desai M.P., Labhasetwar V., Amidon G.L., Levy R.J. Gastrointestinal uptake of biodegradable microparticles: effect of particle size. Pharm. Res. 13:1996;1838-1845.
    • (1996) Pharm. Res. , vol.13 , pp. 1838-1845
    • Desai, M.P.1    Labhasetwar, V.2    Amidon, G.L.3    Levy, R.J.4
  • 10
    • 17344377596 scopus 로고    scopus 로고
    • A phase I safety and immunogenicity trial with the candidate malaria vaccine RTS, S/SBAS2 in semi-immune adults in the Gambia
    • Doherty J.F., Pinder M., Tornieporth N., Carton C., Vigneron L., Milligan P. A phase I safety and immunogenicity trial with the candidate malaria vaccine RTS, S/SBAS2 in semi-immune adults in the Gambia. Am. J. Trop. Med. Hyg. 61:1999;865-868.
    • (1999) Am. J. Trop. Med. Hyg. , vol.61 , pp. 865-868
    • Doherty, J.F.1    Pinder, M.2    Tornieporth, N.3    Carton, C.4    Vigneron, L.5    Milligan, P.6
  • 11
    • 0036263333 scopus 로고    scopus 로고
    • Oral vaccination with subunit vaccines protects animals against aerosol infection with Mycobacterium tuberculosis
    • Doherty T.M., Olsen A.W., Pinxteren L., Andersen P. Oral vaccination with subunit vaccines protects animals against aerosol infection with Mycobacterium tuberculosis. Infect. Immun. 70:2002;3111-3121.
    • (2002) Infect. Immun. , vol.70 , pp. 3111-3121
    • Doherty, T.M.1    Olsen, A.W.2    Pinxteren, L.3    Andersen, P.4
  • 13
    • 0034703807 scopus 로고    scopus 로고
    • Microencapsulated enterotoxigenic Escherichia coli and detached fimbriae for peroral vaccination in pigs
    • Felder Ch.B., Vorlaender N., Gander B., Merkle H.P., Bertschinger H.U. Microencapsulated enterotoxigenic Escherichia coli and detached fimbriae for peroral vaccination in pigs. Vaccine. 19:2001;706-715.
    • (2001) Vaccine , vol.19 , pp. 706-715
    • Felder, Ch.B.1    Vorlaender, N.2    Gander, B.3    Merkle, H.P.4    Bertschinger, H.U.5
  • 14
    • 0029926181 scopus 로고
    • Breaking of oral tolerance by encapsulated antigen
    • Flanagan M., Jain S., Michael J.G. Breaking of oral tolerance by encapsulated antigen. Ann. N.Y. Acad. Sci. 778:1994;373-375.
    • (1994) Ann. N.Y. Acad. Sci. , vol.778 , pp. 373-375
    • Flanagan, M.1    Jain, S.2    Michael, J.G.3
  • 15
    • 0028358048 scopus 로고
    • Induction of anergy or active suppression following oral tolerance is determined by antigen dosage
    • Friedman A., Weiner H.L. Induction of anergy or active suppression following oral tolerance is determined by antigen dosage. Proc. Natl. Acad. Sci. U.S.A. 91:1994;6688-6692.
    • (1994) Proc. Natl. Acad. Sci. U.S.A. , vol.91 , pp. 6688-6692
    • Friedman, A.1    Weiner, H.L.2
  • 18
    • 0032490610 scopus 로고    scopus 로고
    • Aluminum compounds as vaccine adjuvants
    • Gupta R.K. Aluminum compounds as vaccine adjuvants. Adv. Drug Del. Rev. 32:1998;155-172.
    • (1998) Adv. Drug Del. Rev. , vol.32 , pp. 155-172
    • Gupta, R.K.1
  • 19
    • 0037159628 scopus 로고    scopus 로고
    • Size-dependant immune responses after subcutaneous, oral and intranasal administration of BSA loaded nanospheres
    • Gutierro I., Hernández R.M., Igartua M., Gascón A.R., Pedraz J.L. Size-dependant immune responses after subcutaneous, oral and intranasal administration of BSA loaded nanospheres. Vaccine. 21:2002;67-77.
    • (2002) Vaccine , vol.21 , pp. 67-77
    • Gutierro, I.1    Hernández, R.M.2    Igartua, M.3    Gascón, A.R.4    Pedraz, J.L.5
  • 21
    • 0034950338 scopus 로고    scopus 로고
    • Tetanus toxoid loaded nanoparticles from sulfobutylated poly(vinylalcohol)-graft-poly-(lactide-co-glycolide): Evaluation of antibody response after oral and nasal application in mice
    • Jung T., Kamm W., Breitenbach A., Hungerer K.-D., Hundt E., Kissel T. Tetanus toxoid loaded nanoparticles from sulfobutylated poly(vinylalcohol)-graft-poly-(lactide-co-glycolide): evaluation of antibody response after oral and nasal application in mice. Pharm. Res. 18:2001;352-360.
    • (2001) Pharm. Res. , vol.18 , pp. 352-360
    • Jung, T.1    Kamm, W.2    Breitenbach, A.3    Hungerer, K.-D.4    Hundt, E.5    Kissel, T.6
  • 23
    • 0037154847 scopus 로고    scopus 로고
    • Oral immunization of mice with ricin toxoid vaccine encapsulated in polymeric microspheres against aerosol challenge
    • Kende M., Yan C., Hewetson J., Frick M.A., Rill W.L., Tammariello R. Oral immunization of mice with ricin toxoid vaccine encapsulated in polymeric microspheres against aerosol challenge. Vaccine. 20:2002;1681-1691.
    • (2002) Vaccine , vol.20 , pp. 1681-1691
    • Kende, M.1    Yan, C.2    Hewetson, J.3    Frick, M.A.4    Rill, W.L.5    Tammariello, R.6
  • 24
    • 0035972026 scopus 로고    scopus 로고
    • A Phase I safety and immunogenicity trial of UBI® microparticulate monovalent HIV-1 MN oral peptide immunogen with parenteral boost in HIV-1 seronegative human subjects
    • Lambert J.S., Keefer M., Mulligan M.J., Schwartz D., Mestecku J., Weinhold K., Smith C., Hsieh R., Moldoveanu Z., Fast P., Forrest B., Koff W. A Phase I safety and immunogenicity trial of UBI® microparticulate monovalent HIV-1 MN oral peptide immunogen with parenteral boost in HIV-1 seronegative human subjects. Vaccine. 19:2001;3033-3042.
    • (2001) Vaccine , vol.19 , pp. 3033-3042
    • Lambert, J.S.1    Keefer, M.2    Mulligan, M.J.3    Schwartz, D.4    Mestecku, J.5    Weinhold, K.6    Smith, C.7    Hsieh, R.8    Moldoveanu, Z.9    Fast, P.10    Forrest, B.11    Koff, W.12
  • 25
    • 0028049676 scopus 로고
    • Induction of mucosal and systemic responses by immunization with ovalbumin entrapped in poly(lactide-co-glycolide) microparticles
    • Maloy K.J., Donachie A.M., O'Hagan D.T., Mowat A.McI. Induction of mucosal and systemic responses by immunization with ovalbumin entrapped in poly(lactide-co-glycolide) microparticles. Immunology. 81:1994;661-667.
    • (1994) Immunology , vol.81 , pp. 661-667
    • Maloy, K.J.1    Donachie, A.M.2    O'Hagan, D.T.3    Mowat, A.McI.4
  • 27
    • 0034668188 scopus 로고    scopus 로고
    • Oral immunization with size-purified microsphere beads as a vehicle selectively induces systemic tolerance and sensitization
    • Matsunaga Y., Wakatsuki Y., Tabata Y., Kawasaki H., Usui T., Yoshida M.et al. Oral immunization with size-purified microsphere beads as a vehicle selectively induces systemic tolerance and sensitization. Vaccine. 19:2001;579-588.
    • (2001) Vaccine , vol.19 , pp. 579-588
    • Matsunaga, Y.1    Wakatsuki, Y.2    Tabata, Y.3    Kawasaki, H.4    Usui, T.5    Yoshida, M.6
  • 28
    • 0030883026 scopus 로고    scopus 로고
    • Induction of a cytotoxic T lymphocyte response by immunization with a malaria specific CTL peptide entrapped in biodegradable polymer microspheres
    • Men Y., Tamber H., Audran R., Gander B., Corradin G. Induction of a cytotoxic T lymphocyte response by immunization with a malaria specific CTL peptide entrapped in biodegradable polymer microspheres. Vaccine. 15:1997;1405-1412.
    • (1997) Vaccine , vol.15 , pp. 1405-1412
    • Men, Y.1    Tamber, H.2    Audran, R.3    Gander, B.4    Corradin, G.5
  • 29
    • 20744456789 scopus 로고
    • Solid-phase peptide synthesis. Part I. The synthesis of a tetrapeptide
    • Merrifield R.B. Solid-phase peptide synthesis. Part I. The synthesis of a tetrapeptide. J. Am. Chem. Soc. 85:1963;2149-2154.
    • (1963) J. Am. Chem. Soc. , vol.85 , pp. 2149-2154
    • Merrifield, R.B.1
  • 31
    • 0027400796 scopus 로고
    • T cell responses to pre-erythrocytic stages of malaria: Role in protection and vaccine development against pre-erythrocytic stages
    • Nardin E.H., Nussenzweig R.S. T cell responses to pre-erythrocytic stages of malaria: role in protection and vaccine development against pre-erythrocytic stages. Annu. Rev. Immunol. 11:1993;687-727.
    • (1993) Annu. Rev. Immunol. , vol.11 , pp. 687-727
    • Nardin, E.H.1    Nussenzweig, R.S.2
  • 32
    • 0031765186 scopus 로고    scopus 로고
    • Delivery of MUC1 mucin peptide by poly(D,L-lactic-co-glycolic acid) microspheres induces type 1 T helper immune responses
    • Newman K.D., Sosnowski D.L., Kwon G.S., Samuel J. Delivery of MUC1 mucin peptide by poly(D,L-lactic-co-glycolic acid) microspheres induces type 1 T helper immune responses. J. Pharm. Sci. 87:1998;1421-1427.
    • (1998) J. Pharm. Sci. , vol.87 , pp. 1421-1427
    • Newman, K.D.1    Sosnowski, D.L.2    Kwon, G.S.3    Samuel, J.4
  • 34
    • 0028229570 scopus 로고
    • A population-based clinical trial with the SPf66 synthetic Plasmodium falciparum malaria vaccine in Venezuela
    • Noya O., Gabaldón Y., Alarcón B., Borges R., Zerpa N., Urbáez J.D. A population-based clinical trial with the SPf66 synthetic Plasmodium falciparum malaria vaccine in Venezuela. J. Infect. Dis. 170:1994;396-402.
    • (1994) J. Infect. Dis. , vol.170 , pp. 396-402
    • Noya, O.1    Gabaldón, Y.2    Alarcón, B.3    Borges, R.4    Zerpa, N.5    Urbáez, J.D.6
  • 35
    • 0000507687 scopus 로고
    • Microparticles as oral vaccines
    • O'Hagan, D.T. (Ed.). CRC Press, Boca Raton, FL
    • O'Hagan, D.T., 1994. Microparticles as oral vaccines. In: O'Hagan, D.T. (Ed.), Novel Delivery Systems for Oral Vaccines. CRC Press, Boca Raton, FL, pp. 175-205.
    • (1994) Novel Delivery Systems for Oral Vaccines , pp. 175-205
    • O'Hagan, D.T.1
  • 36
    • 0032832125 scopus 로고    scopus 로고
    • Induction of cytotoxic T-cell responses following oral immunization with synthetic peptides encapsulated in PLG microparticles
    • Partidos C.D., Vohra P., Jones D.H., Farrar G., Steward M.W. Induction of cytotoxic T-cell responses following oral immunization with synthetic peptides encapsulated in PLG microparticles. J. Control. Rel. 62:1999;325-332.
    • (1999) J. Control. Rel. , vol.62 , pp. 325-332
    • Partidos, C.D.1    Vohra, P.2    Jones, D.H.3    Farrar, G.4    Steward, M.W.5
  • 37
    • 0023278942 scopus 로고
    • Induction of protective immunity against experimental infection with malaria using synthetic peptides
    • Patarroyo M.E., Romero P., Torres M.L., Clavijo P., Moreno A., Martínez A. Induction of protective immunity against experimental infection with malaria using synthetic peptides. Nature. 328:1987;629-632.
    • (1987) Nature , vol.328 , pp. 629-632
    • Patarroyo, M.E.1    Romero, P.2    Torres, M.L.3    Clavijo, P.4    Moreno, A.5    Martínez, A.6
  • 38
    • 0033988615 scopus 로고    scopus 로고
    • Oral tolerance elicited in mice by β-lactoglobulin entrapped in biodegradable microspheres
    • Pecqet S., Leo E., Fritsché R., Pfeifer A., Couvreur P., Fattal E. Oral tolerance elicited in mice by β-lactoglobulin entrapped in biodegradable microspheres. Vaccine. 18:2000;1196-1202.
    • (2000) Vaccine , vol.18 , pp. 1196-1202
    • Pecqet, S.1    Leo, E.2    Fritsché, R.3    Pfeifer, A.4    Couvreur, P.5    Fattal, E.6
  • 39
    • 0029813303 scopus 로고    scopus 로고
    • Influenza virus nucleoprotein-specific immunoglobulin G subclass and cytokine responses elicited by DNA vaccination are dependent on the route of vector DNA delivery
    • Pertmer T.M., Roberts T.R., Haynes J.R. Influenza virus nucleoprotein-specific immunoglobulin G subclass and cytokine responses elicited by DNA vaccination are dependent on the route of vector DNA delivery. J. Virol. 70:1996;6119-6125.
    • (1996) J. Virol. , vol.70 , pp. 6119-6125
    • Pertmer, T.M.1    Roberts, T.R.2    Haynes, J.R.3
  • 40
    • 0037033980 scopus 로고    scopus 로고
    • Progress and challenges for malaria vaccines
    • Richie T.L., Saul A. Progress and challenges for malaria vaccines. Nature. 415:2002;694-700.
    • (2002) Nature , vol.415 , pp. 694-700
    • Richie, T.L.1    Saul, A.2
  • 42
    • 0037086636 scopus 로고    scopus 로고
    • Remarkably high antibody levels and protection against P. falciparum malaria in Aotus monkeys after one single immunization of SPf66 encapsulated in PLGA microspheres
    • Rosas J.E., Pedraz J.L., Hernández R.M., Gascón A.R., Igartua M., Guzmán F., Rodríguez R., Cortés J., Patarroyo M.E. Remarkably high antibody levels and protection against P. falciparum malaria in Aotus monkeys after one single immunization of SPf66 encapsulated in PLGA microspheres. Vaccine. 20:2002;1707-1710.
    • (2002) Vaccine , vol.20 , pp. 1707-1710
    • Rosas, J.E.1    Pedraz, J.L.2    Hernández, R.M.3    Gascón, A.R.4    Igartua, M.5    Guzmán, F.6    Rodríguez, R.7    Cortés, J.8    Patarroyo, M.E.9
  • 43
    • 0025729844 scopus 로고
    • Studies on the humoral immune response to a synthetic vaccine against Plasmodium falciparum malaria
    • Salcedo M., Barreto L., Rojas M., Moya R., Cote J., Patarroyo M.E. Studies on the humoral immune response to a synthetic vaccine against Plasmodium falciparum malaria. Clin. Exp. Immunol. 84:1991;122-128.
    • (1991) Clin. Exp. Immunol. , vol.84 , pp. 122-128
    • Salcedo, M.1    Barreto, L.2    Rojas, M.3    Moya, R.4    Cote, J.5    Patarroyo, M.E.6
  • 44
    • 0029046307 scopus 로고
    • Uptake of microparticle-adsorbed protein antigen by bone marrow-derived dendritic cells results in up-regulation of interleukin-1a and interleukin-12 p40/p35 and triggers prolonged, efficient antigen presentation
    • Scheicher C., Mehlig M., Dienes H.-P., Reske K. Uptake of microparticle-adsorbed protein antigen by bone marrow-derived dendritic cells results in up-regulation of interleukin-1a and interleukin-12 p40/p35 and triggers prolonged, efficient antigen presentation. Eur. J. Immunol. 25:1995;1566-1572.
    • (1995) Eur. J. Immunol. , vol.25 , pp. 1566-1572
    • Scheicher, C.1    Mehlig, M.2    Dienes, H.-P.3    Reske, K.4
  • 45
    • 0036176042 scopus 로고    scopus 로고
    • Cross-protective immunity of mice induced by oral immunization with pneumococcal surface adhesin A encapsulated in microspheres
    • Seo J.-Y., Seong S.Y., Ahn B.-Y., Kwon I.C., Chung H., Jeong S.Y. Cross-protective immunity of mice induced by oral immunization with pneumococcal surface adhesin A encapsulated in microspheres. Infect. Immun. 70:2002;1143-1149.
    • (2002) Infect. Immun. , vol.70 , pp. 1143-1149
    • Seo, J.-Y.1    Seong, S.Y.2    Ahn, B.-Y.3    Kwon, I.C.4    Chung, H.5    Jeong, S.Y.6
  • 47
    • 0034100399 scopus 로고    scopus 로고
    • Induction of secretory immunity with bioadhesive poly(D,L-lactide-co-glycolide) microparticles containing Streptococcus sobrinus glucosyltransferase
    • Smith D.J., Trantolo D.J., King W.F., Gusek E.J., Fackler P.H., Gresser J.D., De Souza V.L., Wise D.L. Induction of secretory immunity with bioadhesive poly(D,L-lactide-co-glycolide) microparticles containing Streptococcus sobrinus glucosyltransferase. Oral Microbiol. Immunol. 15:2000;124-130.
    • (2000) Oral Microbiol. Immunol. , vol.15 , pp. 124-130
    • Smith, D.J.1    Trantolo, D.J.2    King, W.F.3    Gusek, E.J.4    Fackler, P.H.5    Gresser, J.D.6    De Souza, V.L.7    Wise, D.L.8
  • 48
    • 0035115020 scopus 로고    scopus 로고
    • Efficacy of two alternate vaccines based on Plasmodium falciparum merozoite surface protein 1 in an Aotus challenge trial
    • Stowers A.W., Cioce V., Shimp R.L., Lawson M., Hui G., Muratova O. Efficacy of two alternate vaccines based on Plasmodium falciparum merozoite surface protein 1 in an Aotus challenge trial. Infect. Immun. 69:2001;1536-1546.
    • (2001) Infect. Immun. , vol.69 , pp. 1536-1546
    • Stowers, A.W.1    Cioce, V.2    Shimp, R.L.3    Lawson, M.4    Hui, G.5    Muratova, O.6
  • 49
    • 0030470545 scopus 로고    scopus 로고
    • Size effect on systemic and mucosal immune responses induced by oral administration of biodegradable microspheres
    • Tabata Y., Inoue Y., Ikada Y. Size effect on systemic and mucosal immune responses induced by oral administration of biodegradable microspheres. Vaccine. 14:1996;1677-1685.
    • (1996) Vaccine , vol.14 , pp. 1677-1685
    • Tabata, Y.1    Inoue, Y.2    Ikada, Y.3
  • 50
    • 0035652273 scopus 로고    scopus 로고
    • Peptide-based subunit vaccines against pre-erythrocytic stages of malaria parasites
    • Tsuji M., Zavala F. Peptide-based subunit vaccines against pre-erythrocytic stages of malaria parasites. Mol. Immunol. 38:2001;433-442.
    • (2001) Mol. Immunol. , vol.38 , pp. 433-442
    • Tsuji, M.1    Zavala, F.2
  • 51
    • 0028876363 scopus 로고
    • Synthetic delivery system for tuberculosis vaccines: Immunological evaluation of the M. tuberculosis 38 kDa protein entrapped in biodegradable PLG microparticles
    • Vordermeier H.M., Coombes A.G.A., Jenkins P., McGee J.P., O'Hagan D.T., Davis S.S., Singh M. Synthetic delivery system for tuberculosis vaccines: immunological evaluation of the M. tuberculosis 38 kDa protein entrapped in biodegradable PLG microparticles. Vaccine. 13:1995;1576-1582.
    • (1995) Vaccine , vol.13 , pp. 1576-1582
    • Vordermeier, H.M.1    Coombes, A.G.A.2    Jenkins, P.3    McGee, J.P.4    O'Hagan, D.T.5    Davis, S.S.6    Singh, M.7
  • 52
    • 85031160875 scopus 로고    scopus 로고
    • W.H.O., 2003. http://www.who.int/health-topics/malaria.htm
    • (2003)
  • 53
    • 0032538597 scopus 로고    scopus 로고
    • Induction of antigen-specific cytotoxic T lymphocytes in human by a malaria DNA vaccine
    • Wang R., Doolan D.L., Le T.P., Hedstrom R.C., Coonan K.M., Charoenvit Y. Induction of antigen-specific cytotoxic T lymphocytes in human by a malaria DNA vaccine. Science. 282:1998;476-480.
    • (1998) Science , vol.282 , pp. 476-480
    • Wang, R.1    Doolan, D.L.2    Le, T.P.3    Hedstrom, R.C.4    Coonan, K.M.5    Charoenvit, Y.6
  • 54
    • 0033635054 scopus 로고    scopus 로고
    • Protein instability in poly(lactic-co-glycolic acid) microparticles
    • van de Weert M., Hennink W.E., Jiskoot W. Protein instability in poly(lactic-co-glycolic acid) microparticles. Pharm. Res. 17:2000;1159-1167.
    • (2000) Pharm. Res. , vol.17 , pp. 1159-1167
    • Van de Weert, M.1    Hennink, W.E.2    Jiskoot, W.3
  • 55
    • 0037151317 scopus 로고    scopus 로고
    • Oral immunogenicity of the inactivated Vibrio cholerae whole-cell vaccine encapsulated in biodegradable microparticles
    • Yeh M.-K., Liu Y.T., Chen J.-L., Chiang C.-H. Oral immunogenicity of the inactivated Vibrio cholerae whole-cell vaccine encapsulated in biodegradable microparticles. J. Control. Rel. 82:2002;237-247.
    • (2002) J. Control. Rel. , vol.82 , pp. 237-247
    • Yeh, M.-K.1    Liu, Y.T.2    Chen, J.-L.3    Chiang, C.-H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.