메뉴 건너뛰기




Volumn 106, Issue , 2015, Pages 256-271

Quercetin: A flavonol with multifaceted therapeutic applications?

Author keywords

Dietary sources; Drug interactions; Metabolism; Quercetin; Therapeutic applications; Toxicity

Indexed keywords

QUERCETIN; ANTIOXIDANT; GLYCOSIDE;

EID: 84942509629     PISSN: 0367326X     EISSN: 18736971     Source Type: Journal    
DOI: 10.1016/j.fitote.2015.09.018     Document Type: Review
Times cited : (619)

References (209)
  • 1
    • 0027291905 scopus 로고
    • Intake of potentially anticarcinogenic flavonoids and their determinants in adults in the Netherlands
    • M.G. Hertog, P.C. Hollman, M.B. Katan, and D. Kromhout Intake of potentially anticarcinogenic flavonoids and their determinants in adults in The Netherlands Nutr. Cancer 20 1993 21 29
    • (1993) Nutr. Cancer , vol.20 , pp. 21-29
    • Hertog, M.G.1    Hollman, P.C.2    Katan, M.B.3    Kromhout, D.4
  • 2
    • 0029610477 scopus 로고
    • Review of the biology of quercetin and related bioflavonoids
    • J.V. Formica, and W. Regelson Review of the biology of quercetin and related bioflavonoids Food Chem. Toxicol. 33 1995 1061 1080
    • (1995) Food Chem. Toxicol. , vol.33 , pp. 1061-1080
    • Formica, J.V.1    Regelson, W.2
  • 4
    • 0031471298 scopus 로고    scopus 로고
    • Flavonoidzufuhr erwachsener in einem bayrischen teilkollektiv der nationalen verzehrsstudie
    • J. Linseisen, J. Radtke, and G. Wolfram Flavonoidzufuhr erwachsener in einem bayrischen teilkollektiv der nationalen verzehrsstudie Z. Ernahrungswiss. 36 1997 403 412
    • (1997) Z. Ernahrungswiss. , vol.36 , pp. 403-412
    • Linseisen, J.1    Radtke, J.2    Wolfram, G.3
  • 5
    • 54749157343 scopus 로고    scopus 로고
    • Flavonols, flavone and anthocyanins as natural antioxidants of food and their possible role in the prevention of chronic diseases
    • H. Böhm, H. Boeing, J. Hempel, B. Raab, and A. Kroke Flavonols, flavone and anthocyanins as natural antioxidants of food and their possible role in the prevention of chronic diseases Z. Ernahrungswiss. 37 1998 147 163
    • (1998) Z. Ernahrungswiss. , vol.37 , pp. 147-163
    • Böhm, H.1    Boeing, H.2    Hempel, J.3    Raab, B.4    Kroke, A.5
  • 6
    • 34548812546 scopus 로고    scopus 로고
    • A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties
    • M. Harwood, B. Danielewska-Nikiel, J.F. Borzelleca, G.W. Flamm, G.M. Williams, and T.C. Lines A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties Food Chem. Toxicol. 45 2007 2179 2205
    • (2007) Food Chem. Toxicol. , vol.45 , pp. 2179-2205
    • Harwood, M.1    Danielewska-Nikiel, B.2    Borzelleca, J.F.3    Flamm, G.W.4    Williams, G.M.5    Lines, T.C.6
  • 7
    • 0028153276 scopus 로고
    • Flavonoid antioxidants: Rate constants for reactions with oxygen radicals
    • W. Bors, C. Michel, and M. Saran Flavonoid antioxidants: rate constants for reactions with oxygen radicals Methods Enzymol. 234 1994 420 429
    • (1994) Methods Enzymol. , vol.234 , pp. 420-429
    • Bors, W.1    Michel, C.2    Saran, M.3
  • 8
    • 0035865879 scopus 로고    scopus 로고
    • Peroxidative metabolism of apigenin and naringenin versus luteolin and quercetin: Glutathione oxidation and conjugation
    • G. Galati, M.Y. Moridani, T.S. Chan, and P.J. O'Brien Peroxidative metabolism of apigenin and naringenin versus luteolin and quercetin: glutathione oxidation and conjugation Free Radic. Biol. Med. 30 2001 370 382
    • (2001) Free Radic. Biol. Med. , vol.30 , pp. 370-382
    • Galati, G.1    Moridani, M.Y.2    Chan, T.S.3    O'Brien, P.J.4
  • 9
    • 0036131064 scopus 로고    scopus 로고
    • The regioselectivity of glutathione adduct formation with flavonoid quinone/quinone methides is pH-dependent
    • H.M. Awad, M.G. Boersma, S. Boeren, P.J. van Bladeren, J. Vervoort, and I.M. Rietjens The regioselectivity of glutathione adduct formation with flavonoid quinone/quinone methides is pH-dependent Chem. Res. Toxicol. 15 2002 343 351
    • (2002) Chem. Res. Toxicol. , vol.15 , pp. 343-351
    • Awad, H.M.1    Boersma, M.G.2    Boeren, S.3    Van Bladeren, P.J.4    Vervoort, J.5    Rietjens, I.M.6
  • 10
    • 0025083565 scopus 로고
    • Metabolic activation of quercetin mutagenicity
    • R. Vrijsen, Y. Michotte, and A. Boeye Metabolic activation of quercetin mutagenicity Mutat. Res. 232 1990 243 248
    • (1990) Mutat. Res. , vol.232 , pp. 243-248
    • Vrijsen, R.1    Michotte, Y.2    Boeye, A.3
  • 11
    • 0025874589 scopus 로고
    • Study on the mutagenic activity of 13 bioflavonoids with the Salmonella Ara test
    • J. Jurado, E. Alejandre-Duran, A. Alonso-Moraga, and C. Pueyo Study on the mutagenic activity of 13 bioflavonoids with the Salmonella Ara test Mutagenesis 6 1991 289 295
    • (1991) Mutagenesis , vol.6 , pp. 289-295
    • Jurado, J.1    Alejandre-Duran, E.2    Alonso-Moraga, A.3    Pueyo, C.4
  • 12
    • 0029118098 scopus 로고
    • Structural requirements for mutagenicity of flavonoids upon nitrosation. A structure-activity study
    • J. Rueff, J. Gaspar, and A. Laires Structural requirements for mutagenicity of flavonoids upon nitrosation. A structure-activity study Mutagenesis 10 1995 325 328
    • (1995) Mutagenesis , vol.10 , pp. 325-328
    • Rueff, J.1    Gaspar, J.2    Laires, A.3
  • 13
    • 0033990797 scopus 로고    scopus 로고
    • Chemical features offlavonols affecting their genotoxicity. Potential implications in their use as therapeutical agents
    • I.D. Silva, J. Gaspar, G.G. da Costa, A.S. Rodrigues, A. Laires, and J. Rueff Chemical features offlavonols affecting their genotoxicity. Potential implications in their use as therapeutical agents Chem. Biol. Interact. 124 2000 29 51
    • (2000) Chem. Biol. Interact. , vol.124 , pp. 29-51
    • Silva, I.D.1    Gaspar, J.2    Da Costa, G.G.3    Rodrigues, A.S.4    Laires, A.5    Rueff, J.6
  • 15
    • 21244465966 scopus 로고    scopus 로고
    • Pharmacokinetics and modeling of quercetin and metabolites
    • X. Chen, O.Q. Yin, Z. Zuo, and M.S. Chow Pharmacokinetics and modeling of quercetin and metabolites Pharm. Res. 22 2005 892 901
    • (2005) Pharm. Res. , vol.22 , pp. 892-901
    • Chen, X.1    Yin, O.Q.2    Zuo, Z.3    Chow, M.S.4
  • 17
    • 84929461632 scopus 로고    scopus 로고
    • Quercetin and related polyphenols: New insights and implications for their bioactivity and bioavailability
    • K. Kawabata, R. Mukai, and A. Ishisaka Quercetin and related polyphenols: new insights and implications for their bioactivity and bioavailability Food Funct. 6 2015 1399 1417
    • (2015) Food Funct. , vol.6 , pp. 1399-1417
    • Kawabata, K.1    Mukai, R.2    Ishisaka, A.3
  • 18
    • 0031429882 scopus 로고    scopus 로고
    • Induction of zygotic polyembryos in wheat: Influence of auxin polar transport
    • C. Fischer, V. Speth, S. Fleig-Eberenz, and G. Neuhaus Induction of zygotic polyembryos in wheat: influence of auxin polar transport Plant Cell 9 1997 1767 1780
    • (1997) Plant Cell , vol.9 , pp. 1767-1780
    • Fischer, C.1    Speth, V.2    Fleig-Eberenz, S.3    Neuhaus, G.4
  • 19
    • 2042484435 scopus 로고
    • Research for vitamin P
    • M. Shiro Research for vitamin P J. Biochem. 29 1938 487 501
    • (1938) J. Biochem. , vol.29 , pp. 487-501
    • Shiro, M.1
  • 20
    • 3543098219 scopus 로고    scopus 로고
    • Antioxidant properties of complexes of flavonoids with metal ions
    • R.F. de Souza, and W.F. De Giovani Antioxidant properties of complexes of flavonoids with metal ions Redox Rep. 9 2004 97 104
    • (2004) Redox Rep. , vol.9 , pp. 97-104
    • De Souza, R.F.1    De Giovani, W.F.2
  • 21
    • 0036589679 scopus 로고    scopus 로고
    • Protection of flavonoids against lipid peroxidation: The structure activity relationship revisited
    • C.G. Heijnen, G.R.M.M. Haenen, R.M. Oostveen, E.M. Stalpers, and A. Bast Protection of flavonoids against lipid peroxidation: the structure activity relationship revisited Free Radic. Res. 36 2002 575 581
    • (2002) Free Radic. Res. , vol.36 , pp. 575-581
    • Heijnen, C.G.1    Haenen, G.R.M.M.2    Oostveen, R.M.3    Stalpers, E.M.4    Bast, A.5
  • 22
    • 0028318752 scopus 로고
    • The correlation between active oxygens scavenging and antioxidative effects of flavonoids
    • Y. Hanasaki, S. Ogawa, and S. Fukui The correlation between active oxygens scavenging and antioxidative effects of flavonoids Free Radic. Biol. Med. 16 1994 845 850
    • (1994) Free Radic. Biol. Med. , vol.16 , pp. 845-850
    • Hanasaki, Y.1    Ogawa, S.2    Fukui, S.3
  • 25
    • 0031740591 scopus 로고    scopus 로고
    • Nitric oxide radical scavenging of flavonoids
    • G.R.M.M. Haenen, and A. Bast Nitric oxide radical scavenging of flavonoids Methods Enzymol. 301 1999 490 503
    • (1999) Methods Enzymol. , vol.301 , pp. 490-503
    • Haenen, G.R.M.M.1    Bast, A.2
  • 28
    • 0030775534 scopus 로고    scopus 로고
    • Absorption, metabolism and health effects of dietary flavonoids in man
    • P.C.H. Hollman, and M.B. Katan Absorption, metabolism and health effects of dietary flavonoids in man Biomed. Pharmacother. 51 1997 305 310
    • (1997) Biomed. Pharmacother. , vol.51 , pp. 305-310
    • Hollman, P.C.H.1    Katan, M.B.2
  • 30
    • 0022975615 scopus 로고
    • Methodology for studying antioxidant activity and mechanisms of action of antioxidants
    • R. Kahl, and A.G. Hildebrandt Methodology for studying antioxidant activity and mechanisms of action of antioxidants Food Chem. Toxicol. 24 1986 1007 1014
    • (1986) Food Chem. Toxicol. , vol.24 , pp. 1007-1014
    • Kahl, R.1    Hildebrandt, A.G.2
  • 31
    • 0028129137 scopus 로고
    • Evidence of an oxidative challenge in the Alzheimer's brain
    • L. Balazs, and M. Leon Evidence of an oxidative challenge in the Alzheimer's brain Neurochem. Res. 19 1994 1131 1137
    • (1994) Neurochem. Res. , vol.19 , pp. 1131-1137
    • Balazs, L.1    Leon, M.2
  • 32
    • 61749103704 scopus 로고    scopus 로고
    • Protective effect of quercetin in primary neurons against Aβ (1-42): Relevance to Alzheimer's disease
    • M.A. Ansari, M.A. Hafiz, G. Joshi, W.O. Opii, and D.A. Butterfield Protective effect of quercetin in primary neurons against Aβ (1-42): relevance to Alzheimer's disease J. Nutr. Biochem. 20 2009 269 275
    • (2009) J. Nutr. Biochem. , vol.20 , pp. 269-275
    • Ansari, M.A.1    Hafiz, M.A.2    Joshi, G.3    Opii, W.O.4    Butterfield, D.A.5
  • 33
    • 0033252747 scopus 로고    scopus 로고
    • Quercetin in men with category III chronic prostatitis: A preliminary prospective, double blinded, placebo controlled trial
    • D.A. Shoskes, S.I. Zeitlin, A. Shahed, and J. Rajfer Quercetin in men with category III chronic prostatitis: a preliminary prospective, double blinded, placebo controlled trial Urology 54 1999 960 963
    • (1999) Urology , vol.54 , pp. 960-963
    • Shoskes, D.A.1    Zeitlin, S.I.2    Shahed, A.3    Rajfer, J.4
  • 34
    • 0036262211 scopus 로고    scopus 로고
    • Protective effect of quercetin against cigarette tar extract induced impairment of erythrocyte deformability
    • A.N. Begum, and J. Terao Protective effect of quercetin against cigarette tar extract induced impairment of erythrocyte deformability J. Nutr. Biochem. 13 2002 265 272
    • (2002) J. Nutr. Biochem. , vol.13 , pp. 265-272
    • Begum, A.N.1    Terao, J.2
  • 36
    • 3242707005 scopus 로고    scopus 로고
    • A new approach to assess the total antioxidant capacity using the TEAC assay
    • M.J.T.J. Arts, J.S. Dallinga, H.P. Voss, G.R.M.M. Haenen, and A. Bast A new approach to assess the total antioxidant capacity using the TEAC assay Food Chem. 88 2004 567 570
    • (2004) Food Chem. , vol.88 , pp. 567-570
    • Arts, M.J.T.J.1    Dallinga, J.S.2    Voss, H.P.3    Haenen, G.R.M.M.4    Bast, A.5
  • 37
    • 84855710389 scopus 로고    scopus 로고
    • In vivo protective effects of quercetin against sodium fluoride-induced oxidative stress in the hepatic tissue
    • S.M. Nabavi, S.F. Nabavi, S. Eslami, and A.H. Moghaddam In vivo protective effects of quercetin against sodium fluoride-induced oxidative stress in the hepatic tissue Food Chem. 132 2012 931 935
    • (2012) Food Chem. , vol.132 , pp. 931-935
    • Nabavi, S.M.1    Nabavi, S.F.2    Eslami, S.3    Moghaddam, A.H.4
  • 38
    • 84863872716 scopus 로고    scopus 로고
    • Ameliorative effects of quercetin on sodium fluoride-induced oxidative stress in rat's kidney
    • S.M. Nabavi, S.F. Nabavi, S. Habtemariam, A.H. Moghaddam, and A.M. Latifi Ameliorative effects of quercetin on sodium fluoride-induced oxidative stress in rat's kidney Ren. Fail. 34, 2012 901 906
    • (2012) Ren. Fail. , vol.34 , pp. 901-906
    • Nabavi, S.M.1    Nabavi, S.F.2    Habtemariam, S.3    Moghaddam, A.H.4    Latifi, A.M.5
  • 39
    • 84859364830 scopus 로고    scopus 로고
    • Protective effect of quercetin against sodium fluoride induced oxidative stress in rat's heart
    • S.F. Nabavi, S.M. Nabavi, M. Mirzaei, and A.H. Moghaddam Protective effect of quercetin against sodium fluoride induced oxidative stress in rat's heart Food Funct. 3 2012 437 441
    • (2012) Food Funct. , vol.3 , pp. 437-441
    • Nabavi, S.F.1    Nabavi, S.M.2    Mirzaei, M.3    Moghaddam, A.H.4
  • 41
    • 0015591140 scopus 로고
    • An improved bacterial test system for the detection and classification of mutagens and carcinogens
    • B.N. Ames, F.D. Lee, and W.E. Durston An improved bacterial test system for the detection and classification of mutagens and carcinogens Proc. Natl. Acad. Sci. U. S. A. 70 1973 782 786
    • (1973) Proc. Natl. Acad. Sci. U. S. A. , vol.70 , pp. 782-786
    • Ames, B.N.1    Lee, F.D.2    Durston, W.E.3
  • 42
    • 32944472519 scopus 로고    scopus 로고
    • Safety of quercetin for clinical application (review)
    • T. Okamoto Safety of quercetin for clinical application (review) Int. J. Mol. Med. 16 2005 275 278
    • (2005) Int. J. Mol. Med. , vol.16 , pp. 275-278
    • Okamoto, T.1
  • 44
    • 0036290290 scopus 로고    scopus 로고
    • The toxicity of antioxidants and their metabolites
    • A. Bast, and G.R.M.M. Haenen The toxicity of antioxidants and their metabolites Environ. Toxicol. Pharmacol. 11 2002 251 258
    • (2002) Environ. Toxicol. Pharmacol. , vol.11 , pp. 251-258
    • Bast, A.1    Haenen, G.R.M.M.2
  • 45
    • 0032819772 scopus 로고    scopus 로고
    • Dietary flavonoids: Intake, health effects and bioavailability
    • P.C. Hollman, and M.B. Katan Dietary flavonoids: intake, health effects and bioavailability Food Chem. Toxicol. 37 1999 937 942
    • (1999) Food Chem. Toxicol. , vol.37 , pp. 937-942
    • Hollman, P.C.1    Katan, M.B.2
  • 46
    • 0033795879 scopus 로고    scopus 로고
    • Potential health impacts of excessive flavonoid intake
    • C.F. Skibola, and M.T. Smith Potential health impacts of excessive flavonoid intake Free Radic. Biol. Med. 29 2000 375 383
    • (2000) Free Radic. Biol. Med. , vol.29 , pp. 375-383
    • Skibola, C.F.1    Smith, M.T.2
  • 47
    • 0037043543 scopus 로고    scopus 로고
    • Oxidative damage shifts from lipid peroxidation to thiol arylation by catechol-containing antioxidants
    • A.W. Boots, G.R.M.M. Haenen, G.J. den Hartog, and A. Bast Oxidative damage shifts from lipid peroxidation to thiol arylation by catechol-containing antioxidants Biochim. Biophys. Acta 1583 2002 279 284
    • (2002) Biochim. Biophys. Acta , vol.1583 , pp. 279-284
    • Boots, A.W.1    Haenen, G.R.M.M.2    Den Hartog, G.J.3    Bast, A.4
  • 48
    • 0043166966 scopus 로고    scopus 로고
    • Oxidized quercetin reacts with thiols rather than with ascorbate: Implication for quercetin supplementation
    • A.W. Boots, N. Kubben, G.R.M.M. Haenen, and A. Bast Oxidized quercetin reacts with thiols rather than with ascorbate: implication for quercetin supplementation Biochem. Biophys. Res. Commun. 308 2003 560 565
    • (2003) Biochem. Biophys. Res. Commun. , vol.308 , pp. 560-565
    • Boots, A.W.1    Kubben, N.2    Haenen, G.R.M.M.3    Bast, A.4
  • 49
    • 82955181000 scopus 로고    scopus 로고
    • Quercetin as a systemic chemopreventative agent: Structural and functional mechanisms
    • E.E. Mendoza, and R. Burd Quercetin as a systemic chemopreventative agent: structural and functional mechanisms Mini-Rev. Med. Chem. 11 2011 1216 1221
    • (2011) Mini-Rev. Med. Chem. , vol.11 , pp. 1216-1221
    • Mendoza, E.E.1    Burd, R.2
  • 50
    • 0018854928 scopus 로고
    • A review of the genetic effects of naturally occurring flavonoids, anthraquinones and related compounds
    • J.T. Brown A review of the genetic effects of naturally occurring flavonoids, anthraquinones and related compounds Mutat. Res. 75 1980 243 277
    • (1980) Mutat. Res. , vol.75 , pp. 243-277
    • Brown, J.T.1
  • 51
    • 34547769938 scopus 로고    scopus 로고
    • Ten-year comparison of the influence of organic and conventional crop management practices on the content of flavonoids in tomatoes
    • A.E. Mitchell, Y.J. Hong, E. Koh, D.M. Barrett, D.E. Bryant, R.F. Denison, and S. Kaffka Ten-year comparison of the influence of organic and conventional crop management practices on the content of flavonoids in tomatoes J. Agric. Food Chem. 55 2007 6154 6159
    • (2007) J. Agric. Food Chem. , vol.55 , pp. 6154-6159
    • Mitchell, A.E.1    Hong, Y.J.2    Koh, E.3    Barrett, D.M.4    Bryant, D.E.5    Denison, R.F.6    Kaffka, S.7
  • 52
    • 0033291872 scopus 로고    scopus 로고
    • Human metabolism of dietary quercetin glycosides
    • Gross, G.G.; Hemingway, R.W.; Yoshida, T. (Eds.); Kluwer Academic/Plenum Publishers: New York
    • Day, A.J.; Williamson, G. Human metabolism of dietary quercetin glycosides. In: Plant Polyphenols 2: Chemistry, Biology, Pharmacology, Ecology. Basic Life Sciences, Gross, G.G.; Hemingway, R.W.; Yoshida, T. (Eds.); Kluwer Academic/Plenum Publishers: New York, 1999; 66, pp. 415-434.
    • (1999) Plant Polyphenols 2: Chemistry, Biology, Pharmacology, Ecology. Basic Life Sciences , vol.66 , pp. 415-415
    • Day, A.J.1    Williamson, G.2
  • 54
    • 0347197907 scopus 로고
    • Content of potentially anticarcinogenic flavonoids of tea infusions, wines, and fruit juices
    • M.G.L. Hertog, P.C.H. Hollman, and B. van de Putte Content of potentially anticarcinogenic flavonoids of tea infusions, wines, and fruit juices J. Agric. Food Chem. 41 1993 1242 1246
    • (1993) J. Agric. Food Chem. , vol.41 , pp. 1242-1246
    • Hertog, M.G.L.1    Hollman, P.C.H.2    Van De Putte, B.3
  • 56
    • 0011391862 scopus 로고
    • Flavonoids from Ageratina calophylla
    • N. Fang, S. Yu, and T.J. Mabry Flavonoids from Ageratina calophylla Phytochemistry 25 1986 2684 2686
    • (1986) Phytochemistry , vol.25 , pp. 2684-2686
    • Fang, N.1    Yu, S.2    Mabry, T.J.3
  • 58
    • 84942533965 scopus 로고    scopus 로고
    • The plasticity of the grapevine berry transcriptome
    • S. Del Santo, and F. Guzzo The plasticity of the grapevine berry transcriptome MetaboLights 39 2013
    • (2013) MetaboLights , vol.39
    • Del Santo, S.1    Guzzo, F.2
  • 59
    • 0016906546 scopus 로고
    • The flavonoids: A class of semi-essential food components: Their role in human nutrition
    • J. Kühnau The flavonoids: a class of semi-essential food components: their role in human nutrition World Rev. Nutr. Diet. 24 1976 117 191
    • (1976) World Rev. Nutr. Diet. , vol.24 , pp. 117-191
    • Kühnau, J.1
  • 60
    • 0019917133 scopus 로고
    • Quercetin, flavonoids and the life-span of mice
    • E. Jones, and R.E. Hughes Quercetin, flavonoids and the life-span of mice Exp. Gerontol. 17 1982 213 221
    • (1982) Exp. Gerontol. , vol.17 , pp. 213-221
    • Jones, E.1    Hughes, R.E.2
  • 61
    • 0030240388 scopus 로고    scopus 로고
    • Relation between intake of flavonoids and risk for coronary heart disease in male health professionals
    • E.C. Rimm, M.B. Katan, A. Ascherio, M.J. Stampfer, and W.C. Willett Relation between intake of flavonoids and risk for coronary heart disease in male health professionals Ann. Intern. Med. 125 1996 384 389
    • (1996) Ann. Intern. Med. , vol.125 , pp. 384-389
    • Rimm, E.C.1    Katan, M.B.2    Ascherio, A.3    Stampfer, M.J.4    Willett, W.C.5
  • 64
    • 0008589879 scopus 로고    scopus 로고
    • Japanese intake of flavonoids and isoflavonoids from foods
    • M. Kimira, Y. Arai, K. Shimoi, and S. Watanabe Japanese intake of flavonoids and isoflavonoids from foods J. Epidemiol. 8 1998 168 175
    • (1998) J. Epidemiol. , vol.8 , pp. 168-175
    • Kimira, M.1    Arai, Y.2    Shimoi, K.3    Watanabe, S.4
  • 65
    • 33846842450 scopus 로고    scopus 로고
    • Age-related variations in flavonoid intake and sources in the Australian population
    • L. Johannot, and S.M. Somerset Age-related variations in flavonoid intake and sources in the Australian population Public Health Nutr. 9 2006 1045 1054
    • (2006) Public Health Nutr. , vol.9 , pp. 1045-1054
    • Johannot, L.1    Somerset, S.M.2
  • 67
    • 0031026440 scopus 로고    scopus 로고
    • The assessment of bioavailability of micronutrients: Introduction
    • M.J. Jackson The assessment of bioavailability of micronutrients: introduction Eur. J. Clin. Nutr. 51 1997 S1 S2
    • (1997) Eur. J. Clin. Nutr. , vol.51 , pp. S1-S2
    • Jackson, M.J.1
  • 69
    • 35348944842 scopus 로고    scopus 로고
    • Interactions affecting the bioavailability of dietary polyphenols in vivo
    • S. Scholz, and G. Williamson Interactions affecting the bioavailability of dietary polyphenols in vivo Int. J. Vitam. Nutr. Res. 77 2007 224 235
    • (2007) Int. J. Vitam. Nutr. Res. , vol.77 , pp. 224-235
    • Scholz, S.1    Williamson, G.2
  • 70
    • 0016811010 scopus 로고
    • Disposition of quercetin in man after single oral and intravenous doses
    • R. Gugler, M. Leschik, and H.J. Dengler Disposition of quercetin in man after single oral and intravenous doses Eur. J. Clin. Pharmacol. 9 1975 229 234
    • (1975) Eur. J. Clin. Pharmacol. , vol.9 , pp. 229-234
    • Gugler, R.1    Leschik, M.2    Dengler, H.J.3
  • 71
    • 0034795649 scopus 로고    scopus 로고
    • Carbon dioxide is the major metabolite of quercetin in humans
    • T. Walle, U.K. Walle, and P.V. Halushka Carbon dioxide is the major metabolite of quercetin in humans J. Nutr. 131 2001 2648 2652
    • (2001) J. Nutr. , vol.131 , pp. 2648-2652
    • Walle, T.1    Walle, U.K.2    Halushka, P.V.3
  • 73
    • 43049176634 scopus 로고    scopus 로고
    • Health effects of quercetin: From antioxidant to nutraceutical
    • A.W. Boots, G.R. Haenen, and A. Bast Health effects of quercetin: from antioxidant to nutraceutical Eur. J. Pharmacol. 585 2008 325 337
    • (2008) Eur. J. Pharmacol. , vol.585 , pp. 325-337
    • Boots, A.W.1    Haenen, G.R.2    Bast, A.3
  • 74
    • 13844281685 scopus 로고    scopus 로고
    • Bioavailability and bioefficacy of polyphenols in humans. Review of 97 bioavailability studies
    • C. Manach, G. Williamson, C. Morand, A. Scalbert, and C. Remesy Bioavailability and bioefficacy of polyphenols in humans. Review of 97 bioavailability studies Am. J. Clin. Nutr. 81 2005 230S 242S
    • (2005) Am. J. Clin. Nutr. , vol.81 , pp. 230S-242S
    • Manach, C.1    Williamson, G.2    Morand, C.3    Scalbert, A.4    Remesy, C.5
  • 75
    • 0343337329 scopus 로고
    • Fecalase: A model for activation of dietary glycosides to mutagens by intestinal flora
    • G. Tamura, C. Gold, A. Ferro-Luzzi, and B.N. Ames Fecalase: a model for activation of dietary glycosides to mutagens by intestinal flora Proc. Natl. Acad. Sci. U. S. A. 77 1980 4961 4965
    • (1980) Proc. Natl. Acad. Sci. U. S. A. , vol.77 , pp. 4961-4965
    • Tamura, G.1    Gold, C.2    Ferro-Luzzi, A.3    Ames, B.N.4
  • 76
    • 0032562766 scopus 로고    scopus 로고
    • Quercetin is recovered in human plasma as conjugated derivatives which retain antioxidant properties
    • C. Manach, C. Morand, V. Crespy, C. Demigné, O. Texier, F. Régérat, and C. Rémésy Quercetin is recovered in human plasma as conjugated derivatives which retain antioxidant properties FEBS Lett. 426 1998 331 336
    • (1998) FEBS Lett. , vol.426 , pp. 331-336
    • Manach, C.1    Morand, C.2    Crespy, V.3    Demigné, C.4    Texier, O.5    Régérat, F.6    Rémésy, C.7
  • 78
    • 0035370769 scopus 로고    scopus 로고
    • Identification of quercetin 3-O-β-d-glucuronide an antioxidative metabolite in rat plasma after oral administration of quercetin
    • J. Moon, T. Tsushida, K. Nakahara, and J. Terao Identification of quercetin 3-O-β-d-glucuronide an antioxidative metabolite in rat plasma after oral administration of quercetin Free Radic. Biol. Med. 30 2001 1274 1285
    • (2001) Free Radic. Biol. Med. , vol.30 , pp. 1274-1285
    • Moon, J.1    Tsushida, T.2    Nakahara, K.3    Terao, J.4
  • 79
    • 0030199757 scopus 로고    scopus 로고
    • Dietary quercetin is recovered in rat plasma as conjugated derivatives of isorhamnetin and quercetin
    • C. Manach, O. Texier, F. Régérat, G. Agullo, C. Demigné, and C. Rémésy Dietary quercetin is recovered in rat plasma as conjugated derivatives of isorhamnetin and quercetin Nutr. Biochem. 7 1996 375 380
    • (1996) Nutr. Biochem. , vol.7 , pp. 375-380
    • Manach, C.1    Texier, O.2    Régérat, F.3    Agullo, G.4    Demigné, C.5    Rémésy, C.6
  • 80
    • 0032479204 scopus 로고    scopus 로고
    • Quercetin metabolites inhibit copper ion-induced lipid peroxidation in rat plasma
    • E.L. da Silva, M.K. Piskula, N. Yamamoto, J.H. Moon, and J. Terao Quercetin metabolites inhibit copper ion-induced lipid peroxidation in rat plasma FEBS Lett. 430 1998 405 408
    • (1998) FEBS Lett. , vol.430 , pp. 405-408
    • Da Silva, E.L.1    Piskula, M.K.2    Yamamoto, N.3    Moon, J.H.4    Terao, J.5
  • 81
    • 84927664696 scopus 로고    scopus 로고
    • Endogenous and exogenous mediators of quercetin bioavailability
    • Y. Guo, and R.S. Bruno Endogenous and exogenous mediators of quercetin bioavailability J. Nutr. Biochem. 26 2015 201 210
    • (2015) J. Nutr. Biochem. , vol.26 , pp. 201-210
    • Guo, Y.1    Bruno, R.S.2
  • 83
    • 0031956125 scopus 로고    scopus 로고
    • Supplementation with quercetin markedly increases plasma quercetin concentration without effect on selected risk factors for heart disease in healthy subjects
    • J.A. Conquer, G. Maiani, E. Azzini, A. Raguzzini, and B.J. Holub Supplementation with quercetin markedly increases plasma quercetin concentration without effect on selected risk factors for heart disease in healthy subjects J. Nutr. 128 1998 593 597
    • (1998) J. Nutr. , vol.128 , pp. 593-597
    • Conquer, J.A.1    Maiani, G.2    Azzini, E.3    Raguzzini, A.4    Holub, B.J.5
  • 84
    • 55149104161 scopus 로고    scopus 로고
    • Quercetin: Potentials in the prevention and therapy of disease
    • S.C. Bischoff Quercetin: potentials in the prevention and therapy of disease Curr. Opin. Clin. Nutr. Metab. Care 11 2008 733 740
    • (2008) Curr. Opin. Clin. Nutr. Metab. Care , vol.11 , pp. 733-740
    • Bischoff, S.C.1
  • 86
    • 0032806702 scopus 로고    scopus 로고
    • Part of quercetin absorbed in the small intestine is conjugated and further secreted in the intestinal lumen
    • V. Crespy, C. Morand, C. Manach, C. Besson, C. Demigne, and C. Remesy Part of quercetin absorbed in the small intestine is conjugated and further secreted in the intestinal lumen Am. J. Physiol. 277 1999 120 126
    • (1999) Am. J. Physiol. , vol.277 , pp. 120-126
    • Crespy, V.1    Morand, C.2    Manach, C.3    Besson, C.4    Demigne, C.5    Remesy, C.6
  • 88
    • 3142621340 scopus 로고    scopus 로고
    • The type of sugar moiety is a major determinant of the small intestinal uptake and subsequent biliary excretion of dietary quercetin glycosides
    • I.C. Arts, A.L. Sesink, M. Faassen-Peters, and P.C. Hollman The type of sugar moiety is a major determinant of the small intestinal uptake and subsequent biliary excretion of dietary quercetin glycosides Br. J. Nutr. 91 2004 841 847
    • (2004) Br. J. Nutr. , vol.91 , pp. 841-847
    • Arts, I.C.1    Sesink, A.L.2    Faassen-Peters, M.3    Hollman, P.C.4
  • 89
    • 0037219688 scopus 로고    scopus 로고
    • Deglycosylation by small intestinal epithelial cell β-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans
    • K. Nemeth, G.W. Plumb, J.G. Berrin, N. Juge, R. Jacob, H.Y. Naim, G. Williamson, D.M. Swallow, and P.A. Kroon Deglycosylation by small intestinal epithelial cell β-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans Eur. J. Nutr. 42 2003 29 42
    • (2003) Eur. J. Nutr. , vol.42 , pp. 29-42
    • Nemeth, K.1    Plumb, G.W.2    Berrin, J.G.3    Juge, N.4    Jacob, R.5    Naim, H.Y.6    Williamson, G.7    Swallow, D.M.8    Kroon, P.A.9
  • 90
    • 0037377562 scopus 로고    scopus 로고
    • Absorption of quercetin-3-glucoside and quercetin-4′-glucoside in the rat small intestine: The role of lactase phlorizin hydrolase and the sodium-dependent glucose transporter
    • A.J. Day, J.M. Gee, M.S. DuPont, I.T. Johnson, and G. Williamson Absorption of quercetin-3-glucoside and quercetin-4′-glucoside in the rat small intestine: the role of lactase phlorizin hydrolase and the sodium-dependent glucose transporter Biochem. Pharmacol. 65 2003 1199 1206
    • (2003) Biochem. Pharmacol. , vol.65 , pp. 1199-1206
    • Day, A.J.1    Gee, J.M.2    DuPont, M.S.3    Johnson, I.T.4    Williamson, G.5
  • 91
    • 33749249943 scopus 로고    scopus 로고
    • The relative contribution of the small and large intestine to the absorption and metabolism of rutin in man
    • I.B. Jaganath, W. Mullen, C.A. Edwards, and A. Crozier The relative contribution of the small and large intestine to the absorption and metabolism of rutin in man Free Radic. Res. 40 2006 1035 1046
    • (2006) Free Radic. Res. , vol.40 , pp. 1035-1046
    • Jaganath, I.B.1    Mullen, W.2    Edwards, C.A.3    Crozier, A.4
  • 92
    • 0031987813 scopus 로고    scopus 로고
    • Intestinal bacterial metabolism of flavonoids and its relation to some biological activities
    • D.H. Kim, E.A. Jung, I.S. Sohng, J.A. Han, T.H. Kim, and M.J. Han Intestinal bacterial metabolism of flavonoids and its relation to some biological activities Arch. Pharm. Res. 21 1998 17 23
    • (1998) Arch. Pharm. Res. , vol.21 , pp. 17-23
    • Kim, D.H.1    Jung, E.A.2    Sohng, I.S.3    Han, J.A.4    Kim, T.H.5    Han, M.J.6
  • 94
    • 84875953344 scopus 로고    scopus 로고
    • Dietary (poly)phenolics in human health: Structures, bioavailability, and evidence of protective effects against chronic diseases
    • D. Del Rio, A. Rodriguez-Mateos, J.P. Spencer, M. Tognolini, G. Borges, and A. Crozier Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases Antioxid. Redox Signal. 18 2013 1818 1892
    • (2013) Antioxid. Redox Signal. , vol.18 , pp. 1818-1892
    • Del Rio, D.1    Rodriguez-Mateos, A.2    Spencer, J.P.3    Tognolini, M.4    Borges, G.5    Crozier, A.6
  • 95
    • 79952074453 scopus 로고    scopus 로고
    • Xenobiotic metabolism, disposition, and regulation by receptors: From biochemical phenomenon to predictors of major toxicities
    • C.J. Omiecinski, J.P. Vanden Heuvel, G.H. Perdew, and J.M. Peters Xenobiotic metabolism, disposition, and regulation by receptors: from biochemical phenomenon to predictors of major toxicities Toxicol. Sci. 120 2011 49 75
    • (2011) Toxicol. Sci. , vol.120 , pp. 49-75
    • Omiecinski, C.J.1    Vanden Heuvel, J.P.2    Perdew, G.H.3    Peters, J.M.4
  • 96
    • 1642539168 scopus 로고    scopus 로고
    • Metabolism of apigenin by rat liver phase i and phase II enzymes and by isolated perfused rat liver
    • A. Gradolatto, M.C. Canivenc-Lavier, J.P. Basly, M.H. Siess, and C. Teyssier Metabolism of apigenin by rat liver phase I and phase ii enzymes and by isolated perfused rat liver Drug Metab. Dispos. 32 2004 58 65
    • (2004) Drug Metab. Dispos. , vol.32 , pp. 58-65
    • Gradolatto, A.1    Canivenc-Lavier, M.C.2    Basly, J.P.3    Siess, M.H.4    Teyssier, C.5
  • 97
    • 8844236064 scopus 로고    scopus 로고
    • Identification of 14 quercetin phase II mono- and mixed conjugates and their formation by rat and human phase II in vitro model systems
    • H. van der Woude, M.G. Boersma, J. Vervoort, and I.M. Rietjens Identification of 14 quercetin phase II mono- and mixed conjugates and their formation by rat and human phase II in vitro model systems Chem. Res. Toxicol. 17 2004 1520 1530
    • (2004) Chem. Res. Toxicol. , vol.17 , pp. 1520-1530
    • Van Der Woude, H.1    Boersma, M.G.2    Vervoort, J.3    Rietjens, I.M.4
  • 99
    • 84878417307 scopus 로고    scopus 로고
    • Influence of fatty acid patterns on the intestinal absorption pathway of quercetin in thoracic lymph duct-cannulated rats
    • K. Murota, R. Cermak, J. Terao, and S. Wolffram Influence of fatty acid patterns on the intestinal absorption pathway of quercetin in thoracic lymph duct-cannulated rats Br. J. Nutr. 109 2013 2147 2153
    • (2013) Br. J. Nutr. , vol.109 , pp. 2147-2153
    • Murota, K.1    Cermak, R.2    Terao, J.3    Wolffram, S.4
  • 100
    • 21744461919 scopus 로고    scopus 로고
    • Breast cancer resistance protein (Bcrp1/Abcg2) limits net intestinal uptake of quercetin in rats by facilitating apical efflux of glucuronides
    • A.L. Sesink, I.C. Arts, V.C. de Boer, P. Breedveld, J.H. Schellens, P.C. Hollman, and F.G. Russel Breast cancer resistance protein (Bcrp1/Abcg2) limits net intestinal uptake of quercetin in rats by facilitating apical efflux of glucuronides Mol. Pharmacol. 67 2005 1999 2006
    • (2005) Mol. Pharmacol. , vol.67 , pp. 1999-2006
    • Sesink, A.L.1    Arts, I.C.2    De Boer, V.C.3    Breedveld, P.4    Schellens, J.H.5    Hollman, P.C.6    Russel, F.G.7
  • 102
    • 84864122633 scopus 로고    scopus 로고
    • Carrier-mediated transport of quercetin conjugates: Involvement of organic anion transporters and organic anion transporting polypeptides
    • C.C. Wong, Y. Akiyama, T. Abe, J.D. Lippiat, C. Orfila, and G. Williamson Carrier-mediated transport of quercetin conjugates: involvement of organic anion transporters and organic anion transporting polypeptides Biochem. Pharmacol. 84 2012 564 570
    • (2012) Biochem. Pharmacol. , vol.84 , pp. 564-570
    • Wong, C.C.1    Akiyama, Y.2    Abe, T.3    Lippiat, J.D.4    Orfila, C.5    Williamson, G.6
  • 103
    • 0037300834 scopus 로고    scopus 로고
    • Metabolism of quercetin-7- and quercetin-3-glucuronides by an in vitro hepatic model: The role of human beta glucuronidase, sulfotransferase, catechol-O-methyltransferase and multi-resistant protein 2 (MRP2) in flavonoid metabolism
    • K.A. O'Leary, A.J. Day, P.W. Needs, F.A. Mellon, N.M. O'Brien, and G. Williamson Metabolism of quercetin-7- and quercetin-3-glucuronides by an in vitro hepatic model: the role of human beta glucuronidase, sulfotransferase, catechol-O-methyltransferase and multi-resistant protein 2 (MRP2) in flavonoid metabolism Biochem. Pharmacol. 65 2003 479 491
    • (2003) Biochem. Pharmacol. , vol.65 , pp. 479-491
    • O'Leary, K.A.1    Day, A.J.2    Needs, P.W.3    Mellon, F.A.4    O'Brien, N.M.5    Williamson, G.6
  • 105
    • 33746698897 scopus 로고    scopus 로고
    • Absorption, excretion and metabolite profiling of methyl-, glucuronyl-, glucosyl- and sulpho-conjugates of quercetin in human plasma and urine after ingestion of onions
    • W. Mullen, C.A. Edwards, and A. Crozier Absorption, excretion and metabolite profiling of methyl-, glucuronyl-, glucosyl- and sulpho-conjugates of quercetin in human plasma and urine after ingestion of onions Br. J. Nutr. 96 2006 107 116
    • (2006) Br. J. Nutr. , vol.96 , pp. 107-116
    • Mullen, W.1    Edwards, C.A.2    Crozier, A.3
  • 108
  • 109
    • 84883860974 scopus 로고    scopus 로고
    • Does quercetin improve cardiovascular risk factors and inflammatory biomarkers in women with type 2 diabetes: A double-blind randomized controlled clinical trial
    • M. Zahedi, R. Ghiasvand, A. Feizi, G. Asgari, and L. Darvish Does quercetin improve cardiovascular risk factors and inflammatory biomarkers in women with type 2 diabetes: a double-blind randomized controlled clinical trial Int. J. Prev. Med. 4 2013 777 785
    • (2013) Int. J. Prev. Med. , vol.4 , pp. 777-785
    • Zahedi, M.1    Ghiasvand, R.2    Feizi, A.3    Asgari, G.4    Darvish, L.5
  • 110
    • 84929657335 scopus 로고    scopus 로고
    • Effects of the pure flavonoids epicatechin and quercetin on vascular function and cardiometabolic health: A randomized, double-blind, placebo-controlled, crossover trial
    • J.I. Dower, J.M. Geleijnse, L. Gijsbers, P.L. Zock, D. Kromhout, and P.C. Hollman Effects of the pure flavonoids epicatechin and quercetin on vascular function and cardiometabolic health: a randomized, double-blind, placebo-controlled, crossover trial Am. J. Clin. Nutr. 101 2015 914 921
    • (2015) Am. J. Clin. Nutr. , vol.101 , pp. 914-921
    • Dower, J.I.1    Geleijnse, J.M.2    Gijsbers, L.3    Zock, P.L.4    Kromhout, D.5    Hollman, P.C.6
  • 111
    • 84935509803 scopus 로고    scopus 로고
    • Supplementation of the pure flavonoids epicatechin and quercetin affects some biomarkers of endothelial dysfunction and inflammation in (pre)hypertensive adults: A randomized double-blind, placebo-controlled, crossover trial
    • J.I. Dower, J.M. Geleijnse, L. Gijsbers, C. Schalkwijk, D. Kromhout, and P.C. Hollman Supplementation of the pure flavonoids epicatechin and quercetin affects some biomarkers of endothelial dysfunction and inflammation in (pre)hypertensive adults: a randomized double-blind, placebo-controlled, crossover trial J. Nutr. 145 2015 1459 1463
    • (2015) J. Nutr. , vol.145 , pp. 1459-1463
    • Dower, J.I.1    Geleijnse, J.M.2    Gijsbers, L.3    Schalkwijk, C.4    Kromhout, D.5    Hollman, P.C.6
  • 113
    • 0016362593 scopus 로고
    • Extension of the lifespan of cultured normal human diploid cells by Vitamin E
    • L. Packer, and J.R. Smith Extension of the lifespan of cultured normal human diploid cells by vitamin E Proc. Natl. Acad. Sci. U. S. A. 71 1974 4763 4767
    • (1974) Proc. Natl. Acad. Sci. U. S. A. , vol.71 , pp. 4763-4767
    • Packer, L.1    Smith, J.R.2
  • 114
    • 0028305934 scopus 로고
    • Kinetin delays the onset of ageing characteristics in human fibroblasts
    • S.I. Rattan, and B.F. Clark Kinetin delays the onset of ageing characteristics in human fibroblasts Biochem. Biophys. Res. Commun. 201 1994 665 672
    • (1994) Biochem. Biophys. Res. Commun. , vol.201 , pp. 665-672
    • Rattan, S.I.1    Clark, B.F.2
  • 115
    • 0028235687 scopus 로고
    • Retardation of the senescence of cultured human diploidfibroblasts by carnosine
    • G.A. McFarland, and R. Holliday Retardation of the senescence of cultured human diploidfibroblasts by carnosine Exp. Cell Res. 212 1994 167 175
    • (1994) Exp. Cell Res. , vol.212 , pp. 167-175
    • McFarland, G.A.1    Holliday, R.2
  • 116
    • 0028238182 scopus 로고
    • Testing garlic for possible anti-ageing effects on long-term growth characteristics, morphology and macromolecular synthesis of humanfibroblasts in culture
    • L. Svendsen, S.I. Rattan, and B.F. Clark Testing garlic for possible anti-ageing effects on long-term growth characteristics, morphology and macromolecular synthesis of humanfibroblasts in culture J. Ethnopharmacol. 43 1994 125 133
    • (1994) J. Ethnopharmacol. , vol.43 , pp. 125-133
    • Svendsen, L.1    Rattan, S.I.2    Clark, B.F.3
  • 120
    • 84941285507 scopus 로고    scopus 로고
    • Inflammation and cellular senescence: Potential contribution to chronic diseases and disabilities with aging
    • J.L. Kirkland Inflammation and cellular senescence: potential contribution to chronic diseases and disabilities with aging Public Policy Aging Rep. 23 2013 12 15
    • (2013) Public Policy Aging Rep. , vol.23 , pp. 12-15
    • Kirkland, J.L.1
  • 121
    • 84931581207 scopus 로고    scopus 로고
    • Clinical strategies and animal models for developing senolytic agents
    • J.L. Kirkland, and T. Tchkonia Clinical strategies and animal models for developing senolytic agents Exp. Gerontol. S0531-5565 2014 291 295
    • (2014) Exp. Gerontol. , vol.S - , pp. 291-295
    • Kirkland, J.L.1    Tchkonia, T.2
  • 123
    • 79959246025 scopus 로고    scopus 로고
    • Quercetin as a potential anti-allergic drug: Which perspectives?
    • S. Chirumbolo Quercetin as a potential anti-allergic drug: which perspectives? Iran. J. Allergy Asthma Immunol. 10 2011 139 140
    • (2011) Iran. J. Allergy Asthma Immunol. , vol.10 , pp. 139-140
    • Chirumbolo, S.1
  • 124
    • 80053350898 scopus 로고    scopus 로고
    • Antiatherogenic effect of quercetin is mediated by proteasome inhibition in the aorta and circulating leukocytes
    • D.A. Pashevin, L.V. Tumanovska, V.E. Dosenko, V.S. Nagibin, V.L. Gurianova, and A.A. Moibenko Antiatherogenic effect of quercetin is mediated by proteasome inhibition in the aorta and circulating leukocytes Pharmacol. Rep. 63 2011 1009 1018
    • (2011) Pharmacol. Rep. , vol.63 , pp. 1009-1018
    • Pashevin, D.A.1    Tumanovska, L.V.2    Dosenko, V.E.3    Nagibin, V.S.4    Gurianova, V.L.5    Moibenko, A.A.6
  • 125
    • 78649635059 scopus 로고    scopus 로고
    • Flavonols and cardiovascular disease
    • F. Perez-Vizcaino, and J. Duarte Flavonols and cardiovascular disease Mol. Asp. Med. 31 2010 478 494
    • (2010) Mol. Asp. Med. , vol.31 , pp. 478-494
    • Perez-Vizcaino, F.1    Duarte, J.2
  • 126
    • 84862251868 scopus 로고    scopus 로고
    • Therapeutic potential of quercetin to decrease blood pressure: Review of efficacy and mechanisms
    • A.J. Larson, J.D. Symons, and T. Jalili Therapeutic potential of quercetin to decrease blood pressure: review of efficacy and mechanisms Adv. Nutr. 3 2012 39 46
    • (2012) Adv. Nutr. , vol.3 , pp. 39-46
    • Larson, A.J.1    Symons, J.D.2    Jalili, T.3
  • 127
    • 84930216510 scopus 로고    scopus 로고
    • Combination of quercetin and 2-methoxyestradiol enhances inhibition of human prostate cancer lncap and PC-3 cells xenograft tumor growth
    • F. Yang, L. Song, H. Wang, J. Wang, Z. Xu, and N. Xing Combination of quercetin and 2-methoxyestradiol enhances inhibition of human prostate cancer lncap and PC-3 cells xenograft tumor growth PLoS One 26 2015
    • (2015) PLoS One , vol.26
    • Yang, F.1    Song, L.2    Wang, H.3    Wang, J.4    Xu, Z.5    Xing, N.6
  • 128
    • 84942827004 scopus 로고    scopus 로고
    • Quercetin is a potent anti-atherosclerotic compound by activation of SIRT1 signaling under oxLDL stimulation
    • (Jul 23 [Epub ahead of print])
    • C.H. Hung, S.H. Chan, P.M. Chu, and K.L. Tsai Quercetin is a potent anti-atherosclerotic compound by activation of SIRT1 signaling under oxLDL stimulation Mol. Nutr. Food Res. 2015 (Jul 23 [Epub ahead of print])
    • (2015) Mol. Nutr. Food Res.
    • Hung, C.H.1    Chan, S.H.2    Chu, P.M.3    Tsai, K.L.4
  • 129
    • 84877812825 scopus 로고    scopus 로고
    • Quercetin in cancer prevention and therapy
    • S. Chirumbolo Quercetin in cancer prevention and therapy Integr. Cancer Ther. 12 2013 97 102
    • (2013) Integr. Cancer Ther. , vol.12 , pp. 97-102
    • Chirumbolo, S.1
  • 130
    • 84937913443 scopus 로고    scopus 로고
    • Polyphenols as mitochondria-targeted anticancer drugs
    • S. Gorlach, J. Fichna, and U. Lewandowska Polyphenols as mitochondria-targeted anticancer drugs Cancer Lett. 366 2015 141 149
    • (2015) Cancer Lett. , vol.366 , pp. 141-149
    • Gorlach, S.1    Fichna, J.2    Lewandowska, U.3
  • 131
    • 84866045756 scopus 로고    scopus 로고
    • Life or death: Neuroprotective and anticancer effects of quercetin
    • F. Dajas Life or death: neuroprotective and anticancer effects of quercetin J. Ethnopharmacol. 143 2012 383 396
    • (2012) J. Ethnopharmacol. , vol.143 , pp. 383-396
    • Dajas, F.1
  • 133
    • 84882767539 scopus 로고    scopus 로고
    • Inhibition of mTOR signaling by quercetin in cancer treatment and prevention
    • A. Bruning Inhibition of mTOR signaling by quercetin in cancer treatment and prevention Anti Cancer Agents Med. Chem. 13 2013 1025 1031
    • (2013) Anti Cancer Agents Med. Chem. , vol.13 , pp. 1025-1031
    • Bruning, A.1
  • 134
    • 84949098454 scopus 로고    scopus 로고
    • Modulation of PKC signaling and induction of apoptosis through suppression of reactive oxygen species and tumor necrosis factor receptor 1 (TNFR1): Key role of quercetin in cancer prevention
    • (Jun 16 [Epub ahead of print])
    • A.K. Maurya, and M. Vinayak Modulation of PKC signaling and induction of apoptosis through suppression of reactive oxygen species and tumor necrosis factor receptor 1 (TNFR1): key role of quercetin in cancer prevention Tumour Biol. 2015 (Jun 16 [Epub ahead of print])
    • (2015) Tumour Biol.
    • Maurya, A.K.1    Vinayak, M.2
  • 135
    • 84895170428 scopus 로고    scopus 로고
    • Site-specific anticancer effects of dietary flavonoid quercetin
    • K. Sak Site-specific anticancer effects of dietary flavonoid quercetin Nutr. Cancer 66 2014 177 193
    • (2014) Nutr. Cancer , vol.66 , pp. 177-193
    • Sak, K.1
  • 136
    • 0031962808 scopus 로고    scopus 로고
    • Effects of naturally-occurring flavonoids and bioflavonoids on epidermal cyclooxygenase from Guinea pigs
    • H.P. Kim, I. Mani, and V.A. Ziboh Effects of naturally-occurring flavonoids and bioflavonoids on epidermal cyclooxygenase from guinea pigs Prostaglandins Leukot. Essent. Fat. Acids 58 1998 17 24
    • (1998) Prostaglandins Leukot. Essent. Fat. Acids , vol.58 , pp. 17-24
    • Kim, H.P.1    Mani, I.2    Ziboh, V.A.3
  • 137
    • 77952203012 scopus 로고    scopus 로고
    • Protective effect of quercetin against arsenite-induced COX-2 expression by targeting PI3K in rat liver epithelial cells
    • K.M. Lee, M.K. Hwang, D.E. Lee, K.W. Lee, and H.J. Lee Protective effect of quercetin against arsenite-induced COX-2 expression by targeting PI3K in rat liver epithelial cells J. Agric. Food Chem. 58 2010 5815 5820
    • (2010) J. Agric. Food Chem. , vol.58 , pp. 5815-5820
    • Lee, K.M.1    Hwang, M.K.2    Lee, D.E.3    Lee, K.W.4    Lee, H.J.5
  • 138
    • 84864833156 scopus 로고    scopus 로고
    • Anti-inflammatory effect of quercetin in a whole orbital tissue culture of Graves' orbitopathy
    • J.S. Yoon, M.K. Chae, S.Y. Lee, and E.J. Lee Anti-inflammatory effect of quercetin in a whole orbital tissue culture of Graves' orbitopathy Br. J. Ophthalmol. 96 2012 1117 1121
    • (2012) Br. J. Ophthalmol. , vol.96 , pp. 1117-1121
    • Yoon, J.S.1    Chae, M.K.2    Lee, S.Y.3    Lee, E.J.4
  • 139
    • 84862286961 scopus 로고    scopus 로고
    • Quercetin reduces inflammatory responses in LPS-stimulated cardiomyoblasts
    • C. Angeloni, and S. Hrelia Quercetin reduces inflammatory responses in LPS-stimulated cardiomyoblasts Oxidative Med. Cell. Longev. 2012 2012 837104
    • (2012) Oxidative Med. Cell. Longev. , vol.2012 , pp. 837104
    • Angeloni, C.1    Hrelia, S.2
  • 140
    • 79751471302 scopus 로고    scopus 로고
    • The role of quercetin, flavonols and flavones in modulating inflammatory cell function
    • S. Chirumbolo The role of quercetin, flavonols and flavones in modulating inflammatory cell function Inflamm. Allergy Drug Targets 9 2010 263 285
    • (2010) Inflamm. Allergy Drug Targets , vol.9 , pp. 263-285
    • Chirumbolo, S.1
  • 141
    • 48949115243 scopus 로고    scopus 로고
    • The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways
    • J. Ahn, H. Lee, S. Kim, J. Park, and T. Ha The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways Biochem. Biophys. Res. Commun. 373 2008 545 549
    • (2008) Biochem. Biophys. Res. Commun. , vol.373 , pp. 545-549
    • Ahn, J.1    Lee, H.2    Kim, S.3    Park, J.4    Ha, T.5
  • 142
    • 84872089657 scopus 로고    scopus 로고
    • Quercetin reduces high-fat diet-induced fat accumulation in the liver by regulating lipid metabolism genes
    • C.H. Jung, I. Cho, J. Ahn, T.I. Jeon, and T.Y. Ha Quercetin reduces high-fat diet-induced fat accumulation in the liver by regulating lipid metabolism genes Phytother. Res. 27 2013 139 143
    • (2013) Phytother. Res. , vol.27 , pp. 139-143
    • Jung, C.H.1    Cho, I.2    Ahn, J.3    Jeon, T.I.4    Ha, T.Y.5
  • 144
    • 84902570382 scopus 로고    scopus 로고
    • Dietary quercetin and other polyphenols: Attenuation of obesity
    • R.R. Watson, V.R. Preedy, S. Zibadi, Elsevier Science B. V Amsterdam
    • M. Kobori Dietary quercetin and other polyphenols: attenuation of obesity R.R. Watson, V.R. Preedy, S. Zibadi, Polyphenols in Human Health and Disease 2014 Elsevier Science B. V Amsterdam 163 175
    • (2014) Polyphenols in Human Health and Disease , pp. 163-175
    • Kobori, M.1
  • 145
    • 69449096565 scopus 로고    scopus 로고
    • Effects of antioxidant supplements intervention on the level of plasma inflammatory molecules and disease severity of rheumatoid arthritis patients
    • S.C. Bae, W.J. Jung, E.J. Lee, R. Yu, and M.K. Sung Effects of antioxidant supplements intervention on the level of plasma inflammatory molecules and disease severity of rheumatoid arthritis patients J. Am. Coll. Nutr. 28 2009 56 62
    • (2009) J. Am. Coll. Nutr. , vol.28 , pp. 56-62
    • Bae, S.C.1    Jung, W.J.2    Lee, E.J.3    Yu, R.4    Sung, M.K.5
  • 146
    • 65249141120 scopus 로고    scopus 로고
    • Effects of an oral administration of glucosamine-chondroitin-quercetin glucoside on the synovial fluid properties in patients with osteoarthritis and rheumatoid arthritis
    • H. Matsuno, H. Nakamura, K. Katayama, S. Hayashi, S. Kano, K. Yudoh, and Y. Kiso Effects of an oral administration of glucosamine-chondroitin-quercetin glucoside on the synovial fluid properties in patients with osteoarthritis and rheumatoid arthritis Biosci. Biotechnol. Biochem. 73 2009 288 292
    • (2009) Biosci. Biotechnol. Biochem. , vol.73 , pp. 288-292
    • Matsuno, H.1    Nakamura, H.2    Katayama, K.3    Hayashi, S.4    Kano, S.5    Yudoh, K.6    Kiso, Y.7
  • 150
    • 84864236699 scopus 로고    scopus 로고
    • Quercetin ameliorates hyperglycemia and dyslipidemia and improves antioxidant status in type 2 diabetic db/db mice
    • S.M. Jeong, M.J. Kang, H.N. Choi, J.H. Kim, and J.I. Kim Quercetin ameliorates hyperglycemia and dyslipidemia and improves antioxidant status in type 2 diabetic db/db mice Nutr. Res. Pract. 6 2012 201 207
    • (2012) Nutr. Res. Pract. , vol.6 , pp. 201-207
    • Jeong, S.M.1    Kang, M.J.2    Choi, H.N.3    Kim, J.H.4    Kim, J.I.5
  • 151
    • 84055184613 scopus 로고    scopus 로고
    • Quercetin ameliorates diabetic nephropathy by reducing the expressions of transforming growth factor-β1 and connective tissue growth factor in streptozotocin-induced diabetic rats
    • P.B. Lai, L. Zhang, and L.Y. Yang Quercetin ameliorates diabetic nephropathy by reducing the expressions of transforming growth factor-β1 and connective tissue growth factor in streptozotocin-induced diabetic rats Ren. Fail. 34 2012 83 87
    • (2012) Ren. Fail. , vol.34 , pp. 83-87
    • Lai, P.B.1    Zhang, L.2    Yang, L.Y.3
  • 152
    • 0020621965 scopus 로고
    • Inhibition of human lens aldose reductase by flavonoids, sulindac, and indomethacin
    • P.S. Chaudry, J. Cabera, H.R. Juliani, and S.D. Varma Inhibition of human lens aldose reductase by flavonoids, sulindac, and indomethacin Biochem. Pharmacol. 32 1983 1995 1998
    • (1983) Biochem. Pharmacol. , vol.32 , pp. 1995-1998
    • Chaudry, P.S.1    Cabera, J.2    Juliani, H.R.3    Varma, S.D.4
  • 153
    • 0016738950 scopus 로고
    • Flavonoids as inhibitors of lens aldose reductase
    • S.D. Varma, I. Mikuni, and J.H. Kinoshita Flavonoids as inhibitors of lens aldose reductase Science 188 1975 1215 1216
    • (1975) Science , vol.188 , pp. 1215-1216
    • Varma, S.D.1    Mikuni, I.2    Kinoshita, J.H.3
  • 154
    • 0017337516 scopus 로고
    • Diabetic cataracts and flavonoids
    • S.D. Varma, A. Mizuno, and J.H. Kinoshita Diabetic cataracts and flavonoids Science 195 1977 205 206
    • (1977) Science , vol.195 , pp. 205-206
    • Varma, S.D.1    Mizuno, A.2    Kinoshita, J.H.3
  • 155
    • 23844553170 scopus 로고    scopus 로고
    • A multicenter, double-blind, safety study of QR-333 for the treatment of symptomatic diabetic peripheral neuropathy: A preliminary report
    • P. Valensia, C.L. Devehath, J.L. Richards, C. Farez, T. Khodabandehlou, R.A. Rosenbloom, and C. LeFante A multicenter, double-blind, safety study of QR-333 for the treatment of symptomatic diabetic peripheral neuropathy: a preliminary report J. Diabetes Complicat. 19 2005 247 253
    • (2005) J. Diabetes Complicat. , vol.19 , pp. 247-253
    • Valensia, P.1    Devehath, C.L.2    Richards, J.L.3    Farez, C.4    Khodabandehlou, T.5    Rosenbloom, R.A.6    LeFante, C.7
  • 156
    • 84961288585 scopus 로고    scopus 로고
    • The molecular basis of the antidiabetic action of quercetin in cultured skeletal muscle cells and hepatocytes
    • H.M. Eid, A. Nachar, F. Thong, G. Sweeney, and P.S. Haddad The molecular basis of the antidiabetic action of quercetin in cultured skeletal muscle cells and hepatocytes Pharmacogn. Mag. 11 2015 74 81
    • (2015) Pharmacogn. Mag. , vol.11 , pp. 74-81
    • Eid, H.M.1    Nachar, A.2    Thong, F.3    Sweeney, G.4    Haddad, P.S.5
  • 157
    • 81355138848 scopus 로고    scopus 로고
    • Quercetin and endurance exercise capacity: A systematic review and meta-analysis
    • J. Kressler, M. Millard-Stafford, and G.L. Warren Quercetin and endurance exercise capacity: a systematic review and meta-analysis Med. Sci. Sports Exerc. 43 2011 2396 2404
    • (2011) Med. Sci. Sports Exerc. , vol.43 , pp. 2396-2404
    • Kressler, J.1    Millard-Stafford, M.2    Warren, G.L.3
  • 158
    • 0028366463 scopus 로고
    • Antiulcer and gastroprotective effects of quercetin: A gross and histologic study
    • C. Alarcón de la Lastra, M.J. Martín, and V. Motilva Antiulcer and gastroprotective effects of quercetin: a gross and histologic study Pharmacology 48 1994 56 62
    • (1994) Pharmacology , vol.48 , pp. 56-62
    • Alarcón De La Lastra, C.1    Martín, M.J.2    Motilva, V.3
  • 159
    • 0023222605 scopus 로고
    • Effect of antiperoxidative drugs on gastric damage induced by ethanol in rats
    • T. Mizui, H. Sato, F. Hirose, and M. Doteuchi Effect of antiperoxidative drugs on gastric damage induced by ethanol in rats Life Sci. 41 1987 755 763
    • (1987) Life Sci. , vol.41 , pp. 755-763
    • Mizui, T.1    Sato, H.2    Hirose, F.3    Doteuchi, M.4
  • 160
    • 47549111114 scopus 로고    scopus 로고
    • Effect of quercetin, flavonoids and alpha-tocopherol, an antioxidant vitamin, on experimental reflux oesophagitis in rats
    • C.V. Rao, and M. Vijayakumar Effect of quercetin, flavonoids and alpha-tocopherol, an antioxidant vitamin, on experimental reflux oesophagitis in rats Eur. J. Pharmacol. 589 2008 233 238
    • (2008) Eur. J. Pharmacol. , vol.589 , pp. 233-238
    • Rao, C.V.1    Vijayakumar, M.2
  • 161
    • 84937041605 scopus 로고    scopus 로고
    • Protective effects of quercetin against chronic mixed reflux esophagitis in rats by inhibiting the nuclear factor-κB p65 and interleukin-8 signaling pathways
    • P. Wu, L. Zhou, Y.J. Li, B. Luo, L.S. Yi, S.F. Chen, H.H. Sun, Y. Chen, Z.J. Cao, and S.C. Xu Protective effects of quercetin against chronic mixed reflux esophagitis in rats by inhibiting the nuclear factor-κB p65 and interleukin-8 signaling pathways J. Dig. Dis. 16 2015 319 326
    • (2015) J. Dig. Dis. , vol.16 , pp. 319-326
    • Wu, P.1    Zhou, L.2    Li, Y.J.3    Luo, B.4    Yi, L.S.5    Chen, S.F.6    Sun, H.H.7    Chen, Y.8    Cao, Z.J.9    Xu, S.C.10
  • 162
    • 16444374395 scopus 로고    scopus 로고
    • In vitro inhibitory effect of flavonoids on growth, infection and vacuolation of Helicobacter pylori
    • J.E. Shin, J.M. Kim, E.A. Bae, Y.J. Hyun, and D.H. Kim In vitro inhibitory effect of flavonoids on growth, infection and vacuolation of Helicobacter pylori Planta Med. 71 2005 197 201
    • (2005) Planta Med. , vol.71 , pp. 197-201
    • Shin, J.E.1    Kim, J.M.2    Bae, E.A.3    Hyun, Y.J.4    Kim, D.H.5
  • 164
    • 80053402817 scopus 로고    scopus 로고
    • Management of aphthous ulceration with topical quercetin: A randomized clinical trial
    • A.A. Hamdy, and M.A. Ibrahem Management of aphthous ulceration with topical quercetin: a randomized clinical trial J. Contemp. Dent. Pract. 11 2010 E009 E016
    • (2010) J. Contemp. Dent. Pract. , vol.11 , pp. E009-E016
    • Hamdy, A.A.1    Ibrahem, M.A.2
  • 165
    • 84924341468 scopus 로고    scopus 로고
    • Quercetin protects gastric epithelial cell from oxidative damage in vitro and in vivo
    • X.T. Hu, C. Ding, N. Zhou, and C. Xu Quercetin protects gastric epithelial cell from oxidative damage in vitro and in vivo Eur. J. Pharmacol. 754 2015 115 124
    • (2015) Eur. J. Pharmacol. , vol.754 , pp. 115-124
    • Hu, X.T.1    Ding, C.2    Zhou, N.3    Xu, C.4
  • 167
    • 84555208787 scopus 로고    scopus 로고
    • Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): Implications for nutritional transcriptomics and multi-target therapy
    • M.R. Noori-Daloii, M. Momeny, M. Yousefi, F.G. Shirazi, M. Yaseri, N. Motamed, N. Kazemialiakbar, and S. Hashemi Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy Med. Oncol. 28 2011 1395 1404
    • (2011) Med. Oncol. , vol.28 , pp. 1395-1404
    • Noori-Daloii, M.R.1    Momeny, M.2    Yousefi, M.3    Shirazi, F.G.4    Yaseri, M.5    Motamed, N.6    Kazemialiakbar, N.7    Hashemi, S.8
  • 168
    • 56049123402 scopus 로고
    • The dietary bioflavonoid, quercetin, selectively induces apoptosis of prostate cancer cells by down-regulating the expression of heat shock protein 90
    • R. Aalinkeel, B. Bindukumar, J.L. Reynolds, D.E. Sykes, S.D. Mahajan, K.C. Chadha, and S.A. Schwartz The dietary bioflavonoid, quercetin, selectively induces apoptosis of prostate cancer cells by down-regulating the expression of heat shock protein 90 Prostate 2008 1773-1789 68
    • (1773) Prostate , vol.2008 , pp. 68
    • Aalinkeel, R.1    Bindukumar, B.2    Reynolds, J.L.3    Sykes, D.E.4    Mahajan, S.D.5    Chadha, K.C.6    Schwartz, S.A.7
  • 169
    • 77952288243 scopus 로고    scopus 로고
    • Suppression of the androgen receptor function by quercetin through protein-protein interactions of Sp1, c-Jun, and the androgen receptor in human prostate cancer cells
    • C.Y. Young, Y. Tian, Z. Liu, M. Zhang, and H. Lou Suppression of the androgen receptor function by quercetin through protein-protein interactions of Sp1, c-Jun, and the androgen receptor in human prostate cancer cells Mol. Cell. Biochem. 339 2010 253 262
    • (2010) Mol. Cell. Biochem. , vol.339 , pp. 253-262
    • Young, C.Y.1    Tian, Y.2    Liu, Z.3    Zhang, M.4    Lou, H.5
  • 170
    • 84930216510 scopus 로고    scopus 로고
    • Combination of quercetin and 2-methoxyestradiol enhances inhibition of human prostate cancer LNCaP and PC-3 cells xenograft tumor growth
    • F. Yang, L. Song, H. Wang, J. Wang, Z. Xu, and N. Xing Combination of quercetin and 2-methoxyestradiol enhances inhibition of human prostate cancer LNCaP and PC-3 cells xenograft tumor growth PLoS One 10 2015
    • (2015) PLoS One , vol.10
    • Yang, F.1    Song, L.2    Wang, H.3    Wang, J.4    Xu, Z.5    Xing, N.6
  • 171
    • 84928905615 scopus 로고    scopus 로고
    • Quercetin in prostate cancer: Chemotherapeutic and chemopreventive effects, mechanisms and clinical application potential (review)
    • F. Yang, L. Song, H. Wang, J. Wang, Z. Xu, and N. Xing Quercetin in prostate cancer: chemotherapeutic and chemopreventive effects, mechanisms and clinical application potential (review) Oncol. Rep. 33 2015 2659 2668
    • (2015) Oncol. Rep. , vol.33 , pp. 2659-2668
    • Yang, F.1    Song, L.2    Wang, H.3    Wang, J.4    Xu, Z.5    Xing, N.6
  • 172
    • 0022006859 scopus 로고
    • Antiviral effect of flavonoids on human viruses
    • T.N. Kaul, E. Middleton Jr., and P.L. Ogra Antiviral effect of flavonoids on human viruses J. Med. Virol. 15 1985 71 79
    • (1985) J. Med. Virol. , vol.15 , pp. 71-79
    • Kaul, T.N.1    Middleton, E.2    Ogra, P.L.3
  • 176
    • 84940547044 scopus 로고    scopus 로고
    • In vitro activity of epigallocatechin gallate and quercetin alone and in combination versus clinical isolates of methicillin-resistant Staphylococcus aureus
    • (Aug 12 [Epub ahead of print])
    • J.W. Betts, A.S. Sharili, L.M. Phee, and D.W. Wareham In vitro activity of epigallocatechin gallate and quercetin alone and in combination versus clinical isolates of methicillin-resistant Staphylococcus aureus J. Nat. Prod. 2015 (Aug 12 [Epub ahead of print])
    • (2015) J. Nat. Prod.
    • Betts, J.W.1    Sharili, A.S.2    Phee, L.M.3    Wareham, D.W.4
  • 177
    • 1642494640 scopus 로고    scopus 로고
    • Antidepressant activity of quercetin, a bioflavonoid, in streptozotocin-induced diabetic mice
    • M. Anjaneyulu, K. Chopra, and I. Kaur Antidepressant activity of quercetin, a bioflavonoid, in streptozotocin-induced diabetic mice J. Med. Food 6 2003 391 395
    • (2003) J. Med. Food , vol.6 , pp. 391-395
    • Anjaneyulu, M.1    Chopra, K.2    Kaur, I.3
  • 180
    • 33846353847 scopus 로고    scopus 로고
    • Protective effect of quercetin on the morphology of pancreatic beta-cells of streptozotocintreated diabetic rats
    • S.O. Adewole, E.A. Caxton-Martins, and J.A. Ojewole Protective effect of quercetin on the morphology of pancreatic beta-cells of streptozotocintreated diabetic rats Afr. J. Tradit. Complement. Altern. Med. 4 2006 64 74
    • (2006) Afr. J. Tradit. Complement. Altern. Med. , vol.4 , pp. 64-74
    • Adewole, S.O.1    Caxton-Martins, E.A.2    Ojewole, J.A.3
  • 181
    • 84937575629 scopus 로고    scopus 로고
    • Antidepressant-like effect of quercetin in bulbectomized mice and involvement of the antioxidant defenses, and the glutamatergic and oxidonitrergic pathways
    • I. Holzmann, L.M. da Silva, J.A. Corrêa da Silva, V.M. Steimbach, and M.M. de Souza Antidepressant-like effect of quercetin in bulbectomized mice and involvement of the antioxidant defenses, and the glutamatergic and oxidonitrergic pathways Pharmacol. Biochem. Behav. 136 2015 55 63
    • (2015) Pharmacol. Biochem. Behav. , vol.136 , pp. 55-63
    • Holzmann, I.1    Da Silva, L.M.2    Corrêa Da Silva, J.A.3    Steimbach, V.M.4    De Souza, M.M.5
  • 182
    • 27144438213 scopus 로고    scopus 로고
    • Protective effect of quercetin on alcohol abstinence-induced anxiety and convulsions
    • D. Joshi, P.S. Naidu, A. Singh, and S.K. Kulkarni Protective effect of quercetin on alcohol abstinence-induced anxiety and convulsions J. Med. Food 8 2005 392 396
    • (2005) J. Med. Food , vol.8 , pp. 392-396
    • Joshi, D.1    Naidu, P.S.2    Singh, A.3    Kulkarni, S.K.4
  • 183
    • 80051664647 scopus 로고    scopus 로고
    • Dietary inhibitors of monoamine oxidase A
    • S.E. Dixon Clarke, and R.R. Ramsay Dietary inhibitors of monoamine oxidase A J. Neural Transm. 118 2011 1031 1041
    • (2011) J. Neural Transm. , vol.118 , pp. 1031-1041
    • Dixon Clarke, S.E.1    Ramsay, R.R.2
  • 184
    • 77951499001 scopus 로고    scopus 로고
    • Suppressive effect of quercetin on acute stress-induced hypothalamic-pituitary adrenal axis response in Wistar rats
    • K. Kawabata, Y. Kawai, and J. Terao Suppressive effect of quercetin on acute stress-induced hypothalamic-pituitary adrenal axis response in Wistar rats J. Nutr. Biochem. 21 2010 374 380
    • (2010) J. Nutr. Biochem. , vol.21 , pp. 374-380
    • Kawabata, K.1    Kawai, Y.2    Terao, J.3
  • 185
    • 84898949963 scopus 로고    scopus 로고
    • Quercetin mitigates lead acetate-induced behavioral and histological alterations via suppression of oxidative stress, Hsp-70, Bak and upregulation of Bcl-2
    • K. Chander, K. Vaibhav, M. Ejaz Ahmed, H. Javed, R. Tabassum, A. Khan, M. Kumar, A. Katyal, F. Islam, and M.S. Siddiqui Quercetin mitigates lead acetate-induced behavioral and histological alterations via suppression of oxidative stress, Hsp-70, Bak and upregulation of Bcl-2 Food Chem. Toxicol. 68 2014 297 306
    • (2014) Food Chem. Toxicol. , vol.68 , pp. 297-306
    • Chander, K.1    Vaibhav, K.2    Ejaz Ahmed, M.3    Javed, H.4    Tabassum, R.5    Khan, A.6    Kumar, M.7    Katyal, A.8    Islam, F.9    Siddiqui, M.S.10
  • 187
    • 33644891064 scopus 로고    scopus 로고
    • MDR- and CYP3A4-mediated drug-herbal interactions
    • D. Pal, and A.K. Mitra MDR- and CYP3A4-mediated drug-herbal interactions Life Sci. 78 2006 2131 2145
    • (2006) Life Sci. , vol.78 , pp. 2131-2145
    • Pal, D.1    Mitra, A.K.2
  • 188
    • 79960407129 scopus 로고    scopus 로고
    • Effects of quercetin on the bioavailability of doxorubicin in rats: Role of CYP3A4 and P-gp inhibition by quercetin
    • J.S. Choi, Y.J. Piao, and K.W. Kang Effects of quercetin on the bioavailability of doxorubicin in rats: role of CYP3A4 and P-gp inhibition by quercetin Arch. Pharm. Res. 34 2011 607 613
    • (2011) Arch. Pharm. Res. , vol.34 , pp. 607-613
    • Choi, J.S.1    Piao, Y.J.2    Kang, K.W.3
  • 189
    • 68549120981 scopus 로고    scopus 로고
    • Simultaneous action of the flavonoid quercetin on cytochrome P450 (CYP) 1A2, CYP2A6, N-acetyltransferase and xanthine oxidase activity in healthy volunteers
    • Y. Chen, P. Xiao, D.S. Ou-Yang, L. Fan, D. Guo, Y.N. Wang, Y. Han, J.H. Tu, G. Zhou, Y.F. Huang, and H.H. Zhou Simultaneous action of the flavonoid quercetin on cytochrome P450 (CYP) 1A2, CYP2A6, N-acetyltransferase and xanthine oxidase activity in healthy volunteers Clin. Exp. Pharmacol. Physiol. 36 2009 828 833
    • (2009) Clin. Exp. Pharmacol. Physiol. , vol.36 , pp. 828-833
    • Chen, Y.1    Xiao, P.2    Ou-Yang, D.S.3    Fan, L.4    Guo, D.5    Wang, Y.N.6    Han, Y.7    Tu, J.H.8    Zhou, G.9    Huang, Y.F.10    Zhou, H.H.11
  • 190
    • 68849107630 scopus 로고    scopus 로고
    • Short-term effect of quercetin on the pharmacokinetics of fexofenadine, a substrate of P-glycoprotein, in healthy volunteers
    • K.A. Kim, P.W. Park, and J.Y. Park Short-term effect of quercetin on the pharmacokinetics of fexofenadine, a substrate of P-glycoprotein, in healthy volunteers Eur. J. Clin. Pharmacol. 65 2009 609 614
    • (2009) Eur. J. Clin. Pharmacol. , vol.65 , pp. 609-614
    • Kim, K.A.1    Park, P.W.2    Park, J.Y.3
  • 192
    • 85047681120 scopus 로고    scopus 로고
    • Effect of rutin on warfarin anticoagulation and pharmacokinetics of warfarin enantiomers in rats
    • E. Chan, A. Hegde, and X. Chen Effect of rutin on warfarin anticoagulation and pharmacokinetics of warfarin enantiomers in rats J. Pharm. Pharmacol. 61 2009 451 458
    • (2009) J. Pharm. Pharmacol. , vol.61 , pp. 451-458
    • Chan, E.1    Hegde, A.2    Chen, X.3
  • 193
    • 75749143821 scopus 로고    scopus 로고
    • Studies on the effects of oral administration of nutrient mixture, quercetin and red onions on the bioavailability of epigallocatechin gallate from green tea extract
    • A. Kale, S. Gawande, S. Kotwal, S. Netke, W. Roomi, V. Ivanov, A. Niedzwiecki, and M. Rath Studies on the effects of oral administration of nutrient mixture, quercetin and red onions on the bioavailability of epigallocatechin gallate from green tea extract Phytother. Res. 24 2010 S48 S55
    • (2010) Phytother. Res. , vol.24 , pp. S48-S55
    • Kale, A.1    Gawande, S.2    Kotwal, S.3    Netke, S.4    Roomi, W.5    Ivanov, V.6    Niedzwiecki, A.7    Rath, M.8
  • 194
    • 37549031270 scopus 로고    scopus 로고
    • Pharmacokinetics and bioavailability of the bioflavonoid biochanin A: Effects of quercetin and EGCG on biochanin A disposition in rats
    • Y.J. Moon, and M.E. Morris Pharmacokinetics and bioavailability of the bioflavonoid biochanin A: effects of quercetin and EGCG on biochanin A disposition in rats Mol. Pharm. 4 2007 865 872
    • (2007) Mol. Pharm. , vol.4 , pp. 865-872
    • Moon, Y.J.1    Morris, M.E.2
  • 195
    • 0141593549 scopus 로고    scopus 로고
    • Possible mechanisms of action in quercetin reversal of morphine tolerance and dependence
    • P.S. Naidu, A. Singh, D. Joshi, and S.K. Kulkarni Possible mechanisms of action in quercetin reversal of morphine tolerance and dependence Addict. Biol. 8 2003 327 336
    • (2003) Addict. Biol. , vol.8 , pp. 327-336
    • Naidu, P.S.1    Singh, A.2    Joshi, D.3    Kulkarni, S.K.4
  • 196
    • 77956414625 scopus 로고    scopus 로고
    • Quercetin: A potential drug to reverse multidrug resistance
    • C. Chen, J. Zhou, and C. Ji Quercetin: a potential drug to reverse multidrug resistance Life Sci. 87 2010 333 338
    • (2010) Life Sci. , vol.87 , pp. 333-338
    • Chen, C.1    Zhou, J.2    Ji, C.3
  • 197
  • 198
    • 77954925611 scopus 로고    scopus 로고
    • Quercetin and naringenin reduce abnormal development of mouse embryos produced by hydroxyurea
    • R. Pérez-Pastén, E. Martínez-Galero, and G. Chamorro-Cevallos Quercetin and naringenin reduce abnormal development of mouse embryos produced by hydroxyurea J. Pharm. Pharmacol. 62 2010 1003 1009
    • (2010) J. Pharm. Pharmacol. , vol.62 , pp. 1003-1009
    • Pérez-Pastén, R.1    Martínez-Galero, E.2    Chamorro-Cevallos, G.3
  • 200
    • 33749622815 scopus 로고    scopus 로고
    • Topoisomerase II inhibition and high yield of endoreduplication induced by the flavonoids luteolin and quercetin
    • G. Cantero, C. Campanella, S. Mateos, and F. Corte's Topoisomerase II inhibition and high yield of endoreduplication induced by the flavonoids luteolin and quercetin Mutagenesis 21 2006 321 325
    • (2006) Mutagenesis , vol.21 , pp. 321-325
    • Cantero, G.1    Campanella, C.2    Mateos, S.3    Corte'S, F.4
  • 201
    • 84902271842 scopus 로고    scopus 로고
    • Quercetin-3-O-glucoside induces human DNA topoisomerase II inhibition, cell cycle arrest and apoptosis in hepatocellular carcinoma cells
    • S. Sudan, and H.P. Rupasinghe Quercetin-3-O-glucoside induces human DNA topoisomerase II inhibition, cell cycle arrest and apoptosis in hepatocellular carcinoma cells Anticancer Res. 34 2014 1691 1699
    • (2014) Anticancer Res. , vol.34 , pp. 1691-1699
    • Sudan, S.1    Rupasinghe, H.P.2
  • 202
    • 84931098268 scopus 로고    scopus 로고
    • Antiproliferative activity of long chain acylated esters of quercetin-3-O-glucoside in hepatocellular carcinoma HepG2 cells
    • (Feb 13 [Epub ahead of print])
    • S. Sudan, and H.V. Rupasinghe Antiproliferative activity of long chain acylated esters of quercetin-3-O-glucoside in hepatocellular carcinoma HepG2 cells Exp. Biol. Med. (Maywood) 2015 (Feb 13 [Epub ahead of print])
    • (2015) Exp. Biol. Med. (Maywood)
    • Sudan, S.1    Rupasinghe, H.V.2
  • 203
    • 79958140054 scopus 로고    scopus 로고
    • Quercetin diacylglycoside analogues showing dual inhibition of DNA gyrase and topoisomerase IV as novel antibacterial agents
    • A.M. Hossion, Y. Zamami, R.K. Kandahary, T. Tsuchiya, W. Ogawa, A. Iwado, and K. Sasaki Quercetin diacylglycoside analogues showing dual inhibition of DNA gyrase and topoisomerase IV as novel antibacterial agents J. Med. Chem. 54 2011 3686 3703
    • (2011) J. Med. Chem. , vol.54 , pp. 3686-3703
    • Hossion, A.M.1    Zamami, Y.2    Kandahary, R.K.3    Tsuchiya, T.4    Ogawa, W.5    Iwado, A.6    Sasaki, K.7
  • 204
    • 84908892295 scopus 로고    scopus 로고
    • Molecular and physiological actions of quercetin: Need for clinical trials to assess its benefits in human disease
    • S.L. Miles, M. McFarland, and R.M. Niles Molecular and physiological actions of quercetin: need for clinical trials to assess its benefits in human disease Nutr. Rev. 72 2014 720 734
    • (2014) Nutr. Rev. , vol.72 , pp. 720-734
    • Miles, S.L.1    McFarland, M.2    Niles, R.M.3
  • 207
    • 84942522928 scopus 로고    scopus 로고
    • December 2013, Slightly revised, May 2014, prepared by Bhagwat, S.; Haytowitz, D.B.; Holden, J.M. (ret.), (Accessed September 16).
    • USDA Database for the Flavonoid Content of Selected Foods, Release 3.1, December 2013, Slightly revised, May 2014, prepared by Bhagwat, S.; Haytowitz, D.B.; Holden, J.M. (ret.), http://www.ars.usda.gov/News/docs.htm?docid=6231 (Accessed September 16, 2015).
    • (2015) Release 3.1
  • 208
    • 84942533972 scopus 로고    scopus 로고
    • (Accessed September 16).
    • Medscape, Drug & Disease, Quercetin (Herbs/Suppl.), http://reference.medscape.com/drug/quercetin-344495#3 (Accessed September 16, 2015).
    • (2015) Drug & Disease, Quercetin (Herbs/Suppl.)
  • 209
    • 84942533973 scopus 로고    scopus 로고
    • (Accessed September 16).
    • Medscape, Drug & Disease, Quercetin (Herbs/Suppl.), http://reference.medscape.com/drug/quercetin-344495#2 (Accessed September 16, 2015).
    • (2015) Quercetin (Herbs/Suppl.)


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.