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Volumn 4, Issue 1, 2007, Pages 64-74

Protective effect of quercetin on the morphology of pancreatic β-cells of streptozotocin-treated diabetic rats

Author keywords

Antioxidant enzymes; Pancreatic cell; Quercetin; Streptozotocin

Indexed keywords

CATALASE; CITRIC ACID; GLUCOSE; GLUTATHIONE PEROXIDASE; INSULIN; MALONALDEHYDE; NITRIC OXIDE; QUERCETIN; STREPTOZOCIN; SUPEROXIDE DISMUTASE;

EID: 33846353847     PISSN: 01896016     EISSN: 01896016     Source Type: Journal    
DOI: 10.4314/ajtcam.v4i1.31196     Document Type: Article
Times cited : (103)

References (68)
  • 1
    • 0028026652 scopus 로고
    • Insulin-dependent diabetes mellitus as an autoimmune disease
    • Bach, J. F. (1994). Insulin-dependent diabetes mellitus as an autoimmune disease. Endicr. Rev., 15: 516-542.
    • (1994) Endicr. Rev. , vol.15 , pp. 516-542
    • Bach, J.F.1
  • 2
    • 0025732948 scopus 로고
    • Role of oxidative stress in the development of complications in diabetes
    • Baynes, J. W. (1991). Role of oxidative stress in the development of complications in diabetes. Diabetes, 40: 405-412.
    • (1991) Diabetes , vol.40 , pp. 405-412
    • Baynes, J.W.1
  • 3
    • 0035122488 scopus 로고    scopus 로고
    • Endocrine pancreas plasticity under physiological and pathological conditions
    • Bernard-Kargar, C. and Ktorza, A. (2001). Endocrine pancreas plasticity under physiological and pathological conditions. Diabetes, 50: 30S-35S.
    • (2001) Diabetes , vol.50
    • Bernard-Kargar, C.1    Ktorza, A.2
  • 4
    • 0021932655 scopus 로고
    • Kinetics of inhibitory effect of flavonoids on histamine secretion from mast cells
    • Bronner, C. and Landry, Y. (1985). Kinetics of inhibitory effect of flavonoids on histamine secretion from mast cells. Agents Action, 16: 147-151.
    • (1985) Agents Action , vol.16 , pp. 147-151
    • Bronner, C.1    Landry, Y.2
  • 5
    • 0037219411 scopus 로고    scopus 로고
    • Beta-cell deficit and increased β-cell apoptosis in humans with type2 diabetes
    • Butler, E. A., Janson, J., Bonner-Weir, S., Ritzel, R., Rizza, R. A., and Butler P. C. (2003). Beta-cell deficit and increased β-cell apoptosis in humans with type2 diabetes. Diabates, 52: 102-110.
    • (2003) Diabates , vol.52 , pp. 102-110
    • Butler, E.A.1    Janson, J.2    Bonner-Weir, S.3    Ritzel, R.4    Rizza, R.A.5    Butler, P.C.6
  • 6
    • 0027742757 scopus 로고
    • Inhibitory effects of flavonoids on xanthine oxidase
    • Chang, W. S., Lee, Y. J., Lu, F. J. and Chiang, H. C. (1993). Inhibitory effects of flavonoids on xanthine oxidase. Anticancer Res., 13: 2165-2170.
    • (1993) Anticancer Res. , vol.13 , pp. 2165-2170
    • Chang, W.S.1    Lee, Y.J.2    Lu, F.J.3    Chiang, H.C.4
  • 7
    • 0020621965 scopus 로고
    • Inhibition of human lens aldose reductase by flavonoids, sulindac, and indomethacin
    • Chaudry, P. S., Cabera, J., Juliann, H. R. and Varma, S. D. (1983). Inhibition of human lens aldose reductase by flavonoids, sulindac, and indomethacin. Biochem. Pharmacol., 32: 1995-1998.
    • (1983) Biochem. Pharmacol. , vol.32 , pp. 1995-1998
    • Chaudry, P.S.1    Cabera, J.2    Juliann, H.R.3    Varma, S.D.4
  • 8
    • 0025050374 scopus 로고
    • Flavonoids as superoxide scavengers and antioxidants
    • Chen, Y. T., Zheng, R. L., Jia, Z. J., and Ju, Y. (1990). Flavonoids as superoxide scavengers and antioxidants. Free Radic. Biol. Med., 9: 19-20.
    • (1990) Free Radic. Biol. Med. , vol.9 , pp. 19-20
    • Chen, Y.T.1    Zheng, R.L.2    Jia, Z.J.3    Ju, Y.4
  • 9
    • 0027534895 scopus 로고
    • Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans
    • (USA)
    • Corbbet, J. A., Sweetland, M. A., Wang, J. L., Lancaster, J. R. and McDaniel, M. L. (1993). Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans. Proc. Natl. Acad. Sci. (USA), 90: 1731-1735.
    • (1993) Proc. Natl. Acad. Sci. , vol.90 , pp. 1731-1735
    • Corbbet, J.A.1    Sweetland, M.A.2    Wang, J.L.3    Lancaster, J.R.4    McDaniel, M.L.5
  • 11
    • 0033953297 scopus 로고    scopus 로고
    • Antioxidants as modulator of immune functions
    • De la Fuente, M. and Victor, V. M. (2000). Antioxidants as modulator of immune functions. Immunol. Cell Biol., 78: 49-54.
    • (2000) Immunol. Cell Biol. , vol.78 , pp. 49-54
    • De la Fuente, M.1    Victor, V.M.2
  • 12
    • 0024247134 scopus 로고
    • Anti-inflammatory activity of benzopyrones that are inhibitors of cyclo-and lipo-oxygenases
    • Della-Logia, A., Ragazzi, E. and Tubaro, et al., (1988). Anti-inflammatory activity of benzopyrones that are inhibitors of cyclo-and lipo-oxygenases. Pharmacol. Res. Commun., 20: 91S-94S.
    • (1988) Pharmacol. Res. Commun. , vol.20
    • Della-Logia, A.1    Ragazzi, E.2    Tubaro3
  • 13
    • 0036270310 scopus 로고    scopus 로고
    • The effect of physical exercise on the dynamics of glucose and insulin
    • Derouich, M. and Boutayeb, A. (2002). The effect of physical exercise on the dynamics of glucose and insulin. J. Biochem., 35: 911-917.
    • (2002) J. Biochem. , vol.35 , pp. 911-917
    • Derouich, M.1    Boutayeb, A.2
  • 14
    • 0015146643 scopus 로고
    • Use of polythene glycol to separate free and antibody-bound peptide hormones in radioimmunoassay
    • Desbuquois, B. and Aurbach, G. D. (1971). Use of polythene glycol to separate free and antibody-bound peptide hormones in radioimmunoassay. Clin. Endocrinol. Metab., 37: 732-738.
    • (1971) Clin. Endocrinol. Metab. , vol.37 , pp. 732-738
    • Desbuquois, B.1    Aurbach, G.D.2
  • 15
    • 33846369003 scopus 로고
    • Flavonoids inhibit oxidative modification of low density lipoproteins
    • DeWhalley, C. V., Rankin, J. F. and Rankin, S. M. et al., (1990). Flavonoids inhibit oxidative modification of low density lipoproteins. Biochem. Pharmacol., 39: 1734-1749.
    • (1990) Biochem. Pharmacol. , vol.39 , pp. 1734-1749
    • DeWhalley, C.V.1    Rankin, J.F.2    Rankin, S.M.3
  • 16
    • 0033034807 scopus 로고    scopus 로고
    • Hyperglycemia-induced β-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes
    • Donath, M. Y., Gross, D. J., Cerasi, E. and Kaiser, N. (1999). Hyperglycemia-induced β-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes. Diabetes, 48: 738-744.
    • (1999) Diabetes , vol.48 , pp. 738-744
    • Donath, M.Y.1    Gross, D.J.2    Cerasi, E.3    Kaiser, N.4
  • 17
    • 1542322876 scopus 로고    scopus 로고
    • Challenges for gene therapy of type 1 diabetes
    • Dong, H., Anthony, K. and Morral, N. (2002). Challenges for gene therapy of type 1 diabetes. Curr. Gene Ther., 2: 403-414.
    • (2002) Curr. Gene Ther. , vol.2 , pp. 403-414
    • Dong, H.1    Anthony, K.2    Morral, N.3
  • 19
    • 0021288878 scopus 로고
    • Superoxide dismutase assays
    • Flohe, L. and Otting, F. (1984). Superoxide dismutase assays. Methods Enzymol., 105: 93-104.
    • (1984) Methods Enzymol. , vol.105 , pp. 93-104
    • Flohe, L.1    Otting, F.2
  • 21
    • 0029091212 scopus 로고
    • Hyper-proinsulinemia in the diabetic Psammomys obesus is a result of increased secretory demand on the β-cell
    • Gadot, M., Ariav, Y., Cerasi, E., Kaiser, N. and Gross, D. (1995). Hyper-proinsulinemia in the diabetic Psammomys obesus is a result of increased secretory demand on the β-cell. Endocrinology, 136: 4218-4223.
    • (1995) Endocrinology , vol.136 , pp. 4218-4223
    • Gadot, M.1    Ariav, Y.2    Cerasi, E.3    Kaiser, N.4    Gross, D.5
  • 22
    • 0031978984 scopus 로고    scopus 로고
    • Exercise, glucose tolerance, and insulin sensitivity
    • Goodyear, L. J. and Kahn, B. B. (1998). Exercise, glucose tolerance, and insulin sensitivity. Ann. Rev. Med., 49: 235-261.
    • (1998) Ann. Rev. Med. , vol.49 , pp. 235-261
    • Goodyear, L.J.1    Kahn, B.B.2
  • 23
    • 0019852821 scopus 로고
    • CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in the mouse
    • Grankvist, K., Marklund, S. L. and Taljedal, L. B. (1981). CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in the mouse. Biochem. J., 199: 393-398.
    • (1981) Biochem. J. , vol.199 , pp. 393-398
    • Grankvist, K.1    Marklund, S.L.2    Taljedal, L.B.3
  • 25
    • 0036598742 scopus 로고    scopus 로고
    • Effects of endurance training on tissue glutathione homoestasis and lipid peroxidation in streptozotocin-induced diabetic rats
    • Gul, M., Laaksonen, D. E., Atalay, M., Vider, L. and Hannien, O. (2002). Effects of endurance training on tissue glutathione homoestasis and lipid peroxidation in streptozotocin-induced diabetic rats. Scand. J. Med. Sci. Sports, 12: 163-170.
    • (2002) Scand. J. Med. Sci. Sports , vol.12 , pp. 163-170
    • Gul, M.1    Laaksonen, D.E.2    Atalay, M.3    Vider, L.4    Hannien, O.5
  • 26
    • 0025369970 scopus 로고
    • The measurement and mechanism of lipid peroxidation in biological systems
    • Gutteridge, J. M. and Halliwell, B. (1990). The measurement and mechanism of lipid peroxidation in biological systems. Trends Biochem Sci., 15: 129-135.
    • (1990) Trends Biochem Sci. , vol.15 , pp. 129-135
    • Gutteridge, J.M.1    Halliwell, B.2
  • 28
    • 0026323337 scopus 로고
    • Aminoguanidine treatment inhibits the development of experimental diabetic retinopathy
    • (USA)
    • Hammers, H. D., Martin, S., Fedesrlin, K., Geisen, K. and Bowler, M. (1991). Aminoguanidine treatment inhibits the development of experimental diabetic retinopathy. Proc. Natl. Acad. Sci. (USA), 88: 11555-11558.
    • (1991) Proc. Natl. Acad. Sci. , vol.88 , pp. 11555-11558
    • Hammers, H.D.1    Martin, S.2    Fedesrlin, K.3    Geisen, K.4    Bowler, M.5
  • 29
    • 0036021855 scopus 로고    scopus 로고
    • Invited review: Effects of acute exercise and exercise training on insulin resistance
    • Henriksen, E. J. (2002). Invited review: Effects of acute exercise and exercise training on insulin resistance. J. Appl. Physiol., 93: 788-796.
    • (2002) J. Appl. Physiol. , vol.93 , pp. 788-796
    • Henriksen, E.J.1
  • 30
    • 0003494840 scopus 로고
    • Clinical diagnosis and management by laboratory methods
    • 17th ED
    • Henry, J. D. (1984). Clinical diagnosis and management by laboratory methods. 17th ED., p.1433.
    • (1984) , pp. 1433
    • Henry, J.D.1
  • 31
    • 0030021661 scopus 로고    scopus 로고
    • Potential health effects of the dietary flavonol quercetin
    • Hertog, M. G. L. and Hollman, P. C. H. (1996). Potential health effects of the dietary flavonol quercetin. Eur. J. Clin. Nutr., 50: 63-71.
    • (1996) Eur. J. Clin. Nutr. , vol.50 , pp. 63-71
    • Hertog, M.G.L.1    Hollman, P.C.H.2
  • 32
    • 0025096104 scopus 로고
    • Autoxidative glycosylation and possible involvement of peroxides and free radicals in LDL modification by glucose
    • Hunt, J. V., Smith, C. C. and Wolff, S. P. (1990). Autoxidative glycosylation and possible involvement of peroxides and free radicals in LDL modification by glucose. Diabetes, 39: 1420-1424.
    • (1990) Diabetes , vol.39 , pp. 1420-1424
    • Hunt, J.V.1    Smith, C.C.2    Wolff, S.P.3
  • 34
    • 0023692586 scopus 로고
    • A spectrophotometric method for determination of catalase activity in small tissue samples
    • Johansson, L. H. and Borg, L. A. (1988). A spectrophotometric method for determination of catalase activity in small tissue samples. Anal Biochem., 174: 331-336.
    • (1988) Anal Biochem. , vol.174 , pp. 331-336
    • Johansson, L.H.1    Borg, L.A.2
  • 35
    • 0036169137 scopus 로고    scopus 로고
    • Gradual loss of pancreatic β-cell insulin, glucokinase and GLUT2 glucose transporter immunoreactivities during the time-course of nutritionally-induced type 2 diabetes in Psammomys obesus (sand rat)
    • Jorns, A., Tiedge, M., Ziv, E., Shafrir, E. and Lenzen, S. (2002). Gradual loss of pancreatic β-cell insulin, glucokinase and GLUT2 glucose transporter immunoreactivities during the time-course of nutritionally-induced type 2 diabetes in Psammomys obesus (sand rat). Virchows Arch, 440: 63-69.
    • (2002) Virchows Arch , vol.440 , pp. 63-69
    • Jorns, A.1    Tiedge, M.2    Ziv, E.3    Shafrir, E.4    Lenzen, S.5
  • 37
    • 1642544733 scopus 로고    scopus 로고
    • Partial regeneration/proliferation of β-cells in the islets of Langerhans by Nigella sativa Linn. in streptozotocin-induced diabetic rats
    • Kanter, M., Meral, I., Yener, Z., Ozbek, H. and Demir, H. (2003b). Partial regeneration/proliferation of β-cells in the islets of Langerhans by Nigella sativa Linn. in streptozotocin-induced diabetic rats. Tohoku J. Exp. Med., 201: 213-219.
    • (2003) Tohoku J. Exp. Med. , vol.201 , pp. 213-219
    • Kanter, M.1    Meral, I.2    Yener, Z.3    Ozbek, H.4    Demir, H.5
  • 38
    • 0038825044 scopus 로고    scopus 로고
    • Glucotoxicity and β-cell failure in type 2 diabetes mellitus
    • Kaiser, N., Leibowitz, G. and Nesher, R. (2003). Glucotoxicity and β-cell failure in type 2 diabetes mellitus. J. Pediat. Endocrinol. Metab., 16: 5-22.
    • (2003) J. Pediat. Endocrinol. Metab. , vol.16 , pp. 5-22
    • Kaiser, N.1    Leibowitz, G.2    Nesher, R.3
  • 40
    • 0023870117 scopus 로고
    • Measurement of rat's insulin: Enzyme-linked immunosorbent assay with increased sensitivity, high accuracy, and greater practicability than established radioimmunoassay
    • Kekow, J., Ulrichs, K., Muller-Ruchholtz, W. and Gross, W. L. (1988). Measurement of rat's insulin: enzyme-linked immunosorbent assay with increased sensitivity, high accuracy, and greater practicability than established radioimmunoassay. Diabetes, 37: 321P.
    • (1988) Diabetes , vol.37 , pp. 321
    • Kekow, J.1    Ulrichs, K.2    Muller-Ruchholtz, W.3    Gross, W.L.4
  • 41
    • 0031962808 scopus 로고    scopus 로고
    • Effects of naturally-occuring flavonoids and bio-flavonoids on epidermal cyclooxygenase from guinea-pigs
    • Kim, H. P., Mani, I. and Ziboh, V. A. (1998). Effects of naturally-occuring flavonoids and bio-flavonoids on epidermal cyclooxygenase from guinea-pigs. Prostaglandins Leukot. Essent. Fatty Acids, 58: 17-24.
    • (1998) Prostaglandins Leukot. Essent. Fatty Acids , vol.58 , pp. 17-24
    • Kim, H.P.1    Mani, I.2    Ziboh, V.A.3
  • 42
    • 0029257151 scopus 로고
    • Nitric oxide generation during cellular metabolization of the diabetogenic N-methyl-nitroso-urea: Streptozotocin contributes to islet cell DNA damage
    • Kröncke, K. D., Fehsel, K., Sommer, A., Rodriguez, M. L. and Kolb-Bachofen, V. (1995). Nitric oxide generation during cellular metabolization of the diabetogenic N-methyl-nitroso-urea: Streptozotocin contributes to islet cell DNA damage. Biol. Chem. Hoppe-Seyler, 376: 179-185.
    • (1995) Biol. Chem. Hoppe-Seyler , vol.376 , pp. 179-185
    • Kröncke, K.D.1    Fehsel, K.2    Sommer, A.3    Rodriguez, M.L.4    Kolb-Bachofen, V.5
  • 43
    • 0029075332 scopus 로고
    • Quercetin inhibits the growth of leukemic progenitors and induces the expression of transforming growth factor-B1 in these cells
    • Larocca, L. M., Teofili, L., and Sica, S et al., (1995). Quercetin inhibits the growth of leukemic progenitors and induces the expression of transforming growth factor-B1 in these cells. Blood, 85: 3654-3661.
    • (1995) Blood , vol.85 , pp. 3654-3661
    • Larocca, L.M.1    Teofili, L.2    Sica, S.3
  • 46
    • 0002914991 scopus 로고    scopus 로고
    • Time-course of changes in serum glucose, insulin, lipids and tissue lipase activities in macrosomic offspring of rats with streptozotocin-induced diabetes
    • Merzouk, H., Madani, S., Chabane, D., Prost, J., Bouchenak, M. and Belleville, J. (2000). Time-course of changes in serum glucose, insulin, lipids and tissue lipase activities in macrosomic offspring of rats with streptozotocin-induced diabetes. Clin. Sci., 98: 21-30.
    • (2000) Clin. Sci. , vol.98 , pp. 21-30
    • Merzouk, H.1    Madani, S.2    Chabane, D.3    Prost, J.4    Bouchenak, M.5    Belleville, J.6
  • 47
    • 0000682759 scopus 로고    scopus 로고
    • Antioxidant flavonoids: Structure, function and clinical usage
    • Miller, A. L. (1996). Antioxidant flavonoids: structure, function and clinical usage. Alt. Med. Rev., 1: 103-111.
    • (1996) Alt. Med. Rev. , vol.1 , pp. 103-111
    • Miller, A.L.1
  • 48
    • 0025883342 scopus 로고
    • Nitric Oxide: Physiology, pathophysiology, and pharmacology
    • Moncada, S., Polmer, R. M. J. and Higgs, E. A. (1991). Nitric Oxide: physiology, pathophysiology, and pharmacology. Pharm. Rev., 43: 109-142.
    • (1991) Pharm. Rev. , vol.43 , pp. 109-142
    • Moncada, S.1    Polmer, R.M.J.2    Higgs, E.A.3
  • 49
    • 0019180547 scopus 로고
    • Only aldehyde fuchsin made from pararosanilin stains pancreatic granules and elastic fibers in unoxidized microsections: Problems caused by unlabelling of certain basic fuchsins
    • Mowry, R. W., Longley, J. B., and Emmel, V. M. (1980). Only aldehyde fuchsin made from pararosanilin stains pancreatic granules and elastic fibers in unoxidized microsections: problems caused by unlabelling of certain basic fuchsins. Stain Technol., 55: 91-103.
    • (1980) Stain Technol. , vol.55 , pp. 91-103
    • Mowry, R.W.1    Longley, J.B.2    Emmel, V.M.3
  • 50
    • 0002418321 scopus 로고    scopus 로고
    • Free radicals, nitric oxide and diabetic complications
    • In: edited by D.L.E. Roith, S.I. Taylor and J.M. Olefsky, Lippincott-Raven Publishers, Philadelphia
    • Nadler, J. L. and Winter, L. (1996). Free radicals, nitric oxide and diabetic complications. In: 'Diabetes Mellitus', edited by D.L.E. Roith, S.I. Taylor and J.M. Olefsky, Lippincott-Raven Publishers, Philadelphia, pp. 840-847.
    • (1996) 'Diabetes Mellitus' , pp. 840-847
    • Nadler, J.L.1    Winter, L.2
  • 51
    • 0018384650 scopus 로고
    • Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
    • Ohkawa, H., Ohishi, N. and Yagi, K. (1979). Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem., 95: 351-358
    • (1979) Anal Biochem. , vol.95 , pp. 351-358
    • Ohkawa, H.1    Ohishi, N.2    Yagi, K.3
  • 52
    • 0032829394 scopus 로고    scopus 로고
    • Urinary isoprostane excretion is not confounded by the lipid content of the diet
    • Richelle, M., Turini, M. E., Guidoux, R., Tavazzi, I., Metairon, S. and Fay, L. B. (1999). Urinary isoprostane excretion is not confounded by the lipid content of the diet. FEBS Lett., 459: 259-262.
    • (1999) FEBS Lett. , vol.459 , pp. 259-262
    • Richelle, M.1    Turini, M.E.2    Guidoux, R.3    Tavazzi, I.4    Metairon, S.5    Fay, L.B.6
  • 53
    • 0018074911 scopus 로고
    • Complete protection from low-dose streptozotocin-induced diabetes in mice
    • Rossini, A. A., Williams, R. M., Appel, M. C. and Like, A. A. (1978). Complete protection from low-dose streptozotocin-induced diabetes in mice. Nature, 276: 182-184.
    • (1978) Nature , vol.276 , pp. 182-184
    • Rossini, A.A.1    Williams, R.M.2    Appel, M.C.3    Like, A.A.4
  • 54
    • 0029083486 scopus 로고
    • Flavonoids as antioxidant agents: Importance of their interaction with biomembranes
    • Saija, A., Scalese, M. and Lanza, M., et al., (1995). Flavonoids as antioxidant agents: importance of their interaction with biomembranes. Free Radic Biol. Med. 19: 481-486.
    • (1995) Free Radic Biol. Med. , vol.19 , pp. 481-486
    • Saija, A.1    Scalese, M.2    Lanza, M.3
  • 55
    • 0023755121 scopus 로고    scopus 로고
    • Superoxide production from non-enzymatically-glycated protein
    • Sakurai, T. and Tsuchiya, S. (1998). Superoxide production from non-enzymatically-glycated protein. FEBS Lett., 236: 406-410.
    • (1998) FEBS Lett. , vol.236 , pp. 406-410
    • Sakurai, T.1    Tsuchiya, S.2
  • 56
    • 0030894162 scopus 로고    scopus 로고
    • Oxidative stress: Oxidants and antioxidants
    • Sies, H. (1997). Oxidative stress: oxidants and antioxidants. Expt. Physiol., 82: 291-295.
    • (1997) Expt. Physiol. , vol.82 , pp. 291-295
    • Sies, H.1
  • 57
    • 0021763962 scopus 로고
    • Free-radical mechanisms in tissue injury
    • Slater, T. F. (1984). Free-radical mechanisms in tissue injury. Biochem. J., 222: 1-15.
    • (1984) Biochem. J. , vol.222 , pp. 1-15
    • Slater, T.F.1
  • 58
    • 0028067658 scopus 로고
    • Quercetin in our diet: From potent mutagen to probable anticarcinogen
    • Stavric, B. (1994). Quercetin in our diet: from potent mutagen to probable anticarcinogen. Clin. Biochem., 27:245P.
    • (1994) Clin. Biochem. , vol.27 , pp. 245
    • Stavric, B.1
  • 59
    • 33846382244 scopus 로고    scopus 로고
    • Quercetin: A review of clinical applications
    • Stephen-Cole, L. (1998). Quercetin: A review of clinical applications, Clin. Sci., 40: 234-238.
    • (1998) Clin. Sci. , vol.40 , pp. 234-238
    • Stephen-Cole, L.1
  • 60
    • 0017831243 scopus 로고
    • Glutathione peroxidase and hydroperoxides
    • Tappel, A. L. (1978). Glutathione peroxidase and hydroperoxides. Methods Enzymol., 52: 506-513.
    • (1978) Methods Enzymol. , vol.52 , pp. 506-513
    • Tappel, A.L.1
  • 61
    • 0030689041 scopus 로고    scopus 로고
    • Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells
    • Tiedge, M. Lortz, S. Drinkgern, J. Lenzen, S. (1997). Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells. Diabetes; 46:1733-1742.
    • (1997) Diabetes , vol.46 , pp. 1733-1742
    • Tiedge, M.1    Lortz, S.2    Drinkgern, J.3    Lenzen, S.4
  • 62
    • 0020315923 scopus 로고
    • Protection by superoxide dismutase, catalase and poly (ADP-ribose) sunthetase inhibitors against alloxan-and streptozotocin-induced islet DNA strand breaks and against the inhibition of proinsulin synthesis
    • Uchigata, Y., Yamamoto, H., Kawamura, A. and Okamoto, H. (1982). Protection by superoxide dismutase, catalase and poly (ADP-ribose) sunthetase inhibitors against alloxan-and streptozotocin-induced islet DNA strand breaks and against the inhibition of proinsulin synthesis. J. Biol. Chem., 257: 6084-6088.
    • (1982) J. Biol. Chem. , vol.257 , pp. 6084-6088
    • Uchigata, Y.1    Yamamoto, H.2    Kawamura, A.3    Okamoto, H.4
  • 63
    • 0032511583 scopus 로고    scopus 로고
    • Intensive blood-glucose control with sulfonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
    • UK Prospective Diabetes Study (UKPDS) Group
    • UK Prospective Diabetes Study (UKPDS) Group (1998). Intensive blood-glucose control with sulfonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 352: 837-853.
    • (1998) Lancet , vol.352 , pp. 837-853
  • 64
    • 0032742992 scopus 로고    scopus 로고
    • The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus
    • Weyer, C., Bogardus, C., Mott, D. M. and Pratley, R. E. (1999). The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J. Clin. Invest., 104: 787-794.
    • (1999) J. Clin. Invest. , vol.104 , pp. 787-794
    • Weyer, C.1    Bogardus, C.2    Mott, D.M.3    Pratley, R.E.4
  • 65
    • 0019981647 scopus 로고
    • Streptozotocin: A review of it pharmacology, efficacy and toxicity
    • Weiss, R. B. (1982). Streptozotocin: a review of it pharmacology, efficacy and toxicity. Cancer Treat. Rep., 66: 427-438.
    • (1982) Cancer Treat. Rep. , vol.66 , pp. 427-438
    • Weiss, R.B.1
  • 66
    • 33846370717 scopus 로고
    • World Health Organization. Report of a WHO study Group. Geneva, Tech. Rep. Ser., No. 727
    • World Health Organization. (1985). Report of a WHO study Group. Geneva, World Health Org. Diabetes Mellitus. Tech. Rep. Ser., No. 727.
    • (1985) World Health Org. Diabetes Mellitus


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