Studies on the effects of oral administration of nutrient mixture, quercetin and red onions on the bioavailability of epigallocatechin gallate from green tea extract

Phytotherapy Research

Volumn 24, Issue SUPPL. 1, 2010, Pages

  Kale, Anup ^a,c   Gawande, Sonia ^a,d   Kotwal, Swati ^a   Netke, Shrirang ^b   Roomi, Waheed ^b   Ivanov, Vadim ^b   Niedzwiecki, Aleksandra ^b   Rath, Matthias ^b  

^a RTM NAGPUR UNIVERSITY   (India)

^b Dr Rath Research Institute   (United States)

^c NATIONAL CHEMICAL LABORATORY   (India)

^d NATIONAL CENTRE FOR CELL SCIENCE   (India)

Author keywords

( ) epigallocatechin gallate; Bioavailability; Bioenhancers; Green tea extract; Quercetin; Red onions

Indexed keywords

ACETYLCYSTEINE; ARGININE; ASCORBIC ACID; CALCIUM; COPPER; EPIGALLOCATECHIN GALLATE; FLAVONOL; GREEN TEA EXTRACT; LYSINE; MAGNESIUM; MANGANESE; ONION EXTRACT; PROLINE; QUERCETIN; SELENIUM;

ADULT; ANALYTICAL PARAMETERS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; BREAST CANCER; CONTROLLED STUDY; DRUG ADMINISTRATION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DOSE INCREASE; DRUG ELIMINATION; DRUG METABOLISM; DRUG OXIDATION; DRUG POTENTIATION; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; NONHUMAN; NORMAL HUMAN; NUTRIENT AVAILABILITY; ONION; RAT; SUPPLEMENTATION;

ADMINISTRATION, ORAL; ADULT; ANIMALS; BIOLOGICAL AVAILABILITY; CATECHIN; DIETARY SUPPLEMENTS; FEMALE; HUMANS; MALE; MIDDLE AGED; ONIONS; PLANT EXTRACTS; QUERCETIN; RATS; RATS, WISTAR; TEA;

ALLIUM ATRORUBENS; RATTUS;

EID: 75749143821     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2899     Document Type: Article

References (33)

1. Borrelli F, Capasso R, Russo A, Ernst E. 2004. Systematic review: green tea and gastrointestinal cancer risk. Aliment Pharmacol Ther 19: 497-510.
2. Cai Y, Nathan DA, Chow HS. 2002. Contribution of presystemic hepatic extraction to the low oral bioavailability of green tea catechins in rats. Drug Metab Dispos 30: 1246-1249.
3. Chang C, Yang M, Wen H, Chern J. 2002. Estimation of total flavonoid content in propolis by two complementary colorimetric methods. J Food Drug Anal 10: 178-182.
4. Chen Z, Zhu QY, Zhang HY. 1998. Stabilizing effect of ascorbic acid on green tea catechins. J Agric Food Chem 46: 2512-2516.
5. Chow H-HS, Cai Y, Alberts DS et al. 2001. Phase I pharmacokinetic study of tea polyphenols following single-dose administration of epigallocatechin gallate and polyphenon E. Cancer Epidemiol Biomark Prev 10: 53-58.
6. Chow H-HS, Cai Y, Hakim IA et al. 2003. Pharmacokinetics and safety of green tea polyphenols after multiple-dose administration of epigallocatechin gallate and polyphenon E in healthy individuals. Clin Can Res 9: 3312-3319.
7. Chow H-HS, Hakim IA, Vining DR et al. 2005. Effects of dosing conditions on the oral bioavailability of green tea catechins after single-dose administration of Polyphenon E in healthy individuals. Clin Cancer Res 11: 4627-4633.
8. Chung F, Schwartz J, Herzog CR, Yang YM. 2003. Tea and cancer prevention: studies in animals and humans. J Nutr 133: 3268S-3274S.
9. Conquer JA, Maiani G, Azzini E, Raguzzini A, Holub BJ. 1998. Supplementation with quercetin markedly increases plasma quercetin concentration without effect on selected risk factors for heart disease in healthy subjects. J Nutr 128: 593-597.
10. Formica JV, Regelson W. 1995. Review of biology of quercetin and related bioflavonoids. Food Chem Toxicol 33: 1061-1080.
11. Gawande S, Kale A, Kotwal S. 2008. Effect of nutrient mixture and black grapes on the pharmacokinetics of orally administered (-) epigallocatechin-3- gallate from green tea extract: a human study. Phytother Res 22: 802-808.
12. Graham HD. 1992. Stabilization of prussian blue color in the determination of polyphenols. J Agric Food Chem 40: 801-805.
13. Hong J, Lambert JD, Lee SH, Sinko PJ, Yang CS. 2003. Involvement of multidrug resistance-associated proteins in regulating cellular levels of (-)-epigallocatechin-3-gallate and its methyl metabolites. Biochem Biophys Res Commun 310: 222-227.
14. Kale A, Gawande S, Kotwal S. 2008. Cancer phytotherapeutics: Role for flavonoids at the cellular level. Phytother Res 22: 567-577.
15. Kelly RG, Nally K, Shanahan F, O'Connell J. 2002. Type I insulin-like growth factor receptor expression on colorectal adenocarcinoma cell line is decreased in response to chemoprotective agent N-acetyl cysteine. Ann NY Acad Sci 973: 555-558.
16. Kristin RLP, Huo C, Chen D. 2007. A novel prodrug of the green tea polyphenol (-)-epigallocatechin-3-gallate as a potential anticancer agent. Cancer Res 67: 4303-4310.
17. Lambert JD, Hong J, Kim DH, Mishin VM, Yang CS. 2004. Piperine enhances the bioavailability of the tea polyphenol (-)-epigallocatechin-3-gallate in mice. J Nutr 134: 1948-1952.
18. Lambert JD, Sang S, Hong J et al. 2006. Peracetylation as a means of enhancing in vitro bioactivity and bioavailability of epigallocatechin gallate. Drug Metab Dispos 34: 2111-2116.
19. Lee M-J, Wang Z-Y, Li H et al. 1995. Analysis of plasma and urinary tea polyphenols in human subjects. Cancer Epidemiol Biomark Prev 4: 393-399.
20. Lee SI, Kim HJ, Boo YC. 2008. Effect of green tea and (-)- epigallocatechin gallate on ethanol-induced toxicity in HepG2 cells. Phytother Res 22: 669-674.
21. Netke SP, Roomi MW, Ivanov V, Rath M, Niedzwiecki A. 2003. A specific combination of ascorbic acid, lysine, proline and epigallocatechin gallate inhibits proliferation of extracellular matrix invasion of various cancer cell lines. Res Commun Pharmacol Toxicol Emerging Drugs 2: 37-50.
22. Oguni I, Nasu K, Kanaya S, Ota Y, Yamamoto S, Nomura T. 1989. Epidemiological and experimental studies on the antitumor activity by green tea extracts. Jpn J Nutr 47: 93-102.
23. Roomi MW, Ivanov V, Kalinovsky T, Rath M, Niedzwiecki A. 2005. In vivo and in vitro antitumorogenic activity of a mixture of lysine, proline, ascorbic acid and green tea extract on human breast cancer line MDA-MB-231 and MCF 7. Med Oncol 22: 129-138.
24. Roomi MW, Ivanov V, Netke S, Rath M, Niedzwiecki A. 2006. In vivo and in vitro antitumor effect of ascorbic acid, lysine, proline and green tea extract on human melanoma cell line A2058. In Vivo 20: 25-32.
25. Roomi MW, Ivanov I Netke SP, Rath M, Niedzwiecki A. 2003. Anti-metastatic activity of nutrient synergy on human colon cancer cell HCT 116. Presented at International Research Conference on Food, Nutrition and Cancer, Washington DC, July 17-18.
26. Takatsuka S, Kitazawa T, Morita T, Horikiri Y, Yoshino H. 2006. Enhancement of intestinal absorption of poorly absorbed hydrophilic compounds by simultaneous use of mucolytic agent and non-ionic surfactant. Eur J Pharm Biopharm 62: 52-58.
27. Tamai I, Sai Y, Ono A et al. 1999. Immunohistochemical and functional characterization of pH dependent intestinal absorption of weak organic acids by the monocarboxylic acid transporter MCT 1. J Phar Pharmacol 51: 1113-1121.
28. Vaidyanathan JB, Walle T. 2003. Cellular uptake and efflux of the tea flavonoids (-) epicatechin-3-gallate in the human intestinal cell line Caco-2. J Pharmacol Exp Ther 307: 745-752.
29. van Zanden JJ, Wortelboer HM, Bijlsma S et al. 2005. Quantitative structure activity relationship studies on the flavonoid mediated inhibition of multidrug resistance proteins 1 and 2. Biochem Pharmacol 69: 699-708.
30. Xie K, Huang S. 2003. Contribution of nitric oxide-mediated apoptosis to cancer metastasis inefficiency. Free Radic Biol Med 34: 969-986.
31. Yang CS, Maliakal P, Meng X. 2002. Inhibition of carcinogenesis by tea. Annu Rev Pharmacol Toxicol 42: 25-54.
32. Yoon SO, Kim MM, Chung AS. 2001. Inhibitory effects of selenite on invasion of HT 1080 tumor cells. J Biol Chem 276: 20085-20092.
33. Yoshino K, Sasaki K, Miyase T, Sano M. 1999. Formation of antioxidants from (-) epigallocatechin gallate in mild alkaline fluids, such as authentic intestinal juice and mouse plasma. J Nutr Biochem 10: 223-229.