Preventative effect of a flavonoid, enzymatically modified isoquercitrin on ocular symptoms of Japanese cedar pollinosis

Allergology International

Volumn 58, Issue 3, 2009, Pages 373-382

  Hirano, Toru ^a   Kawai, Mari ^a   Arimitsu, Junsuke ^a   Ogawa, Masako ^a   Kuwahara, Yusuke ^a   Hagihara, Keisuke ^a   Shima, Yoshihito ^a   Narazaki, Masashi ^a   Ogata, Atsushi ^a   Koyanagi, Mihoko ^a   Kai, Tomoko ^a   Shimizu, Ryosuke ^a   Moriwaki, Masamitsu ^a   Suzuki, Yukio ^a   Ogino, Satoshi ^b   Kawase, Ichiro ^a   Tanaka, Toshio ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b SAN EI GEN F F I INC   (Japan)

Author keywords

Diet therapy; Flavonoid; Japanese cedar pollen; Pollinosis; Quercetin

Indexed keywords

FLAVONE DERIVATIVE; FLAVONOID; IMMUNOGLOBULIN E; ISOQUERCITRIN; ISORHAMNETIN; PLACEBO; QUERCETIN; TAMARIXETIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BLOOD SAMPLING; CARDIOVASCULAR DISEASE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DAILY LIFE ACTIVITY; DOUBLE BLIND PROCEDURE; DOWN REGULATION; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG HYPERSENSITIVITY; DRUG STRUCTURE; DRUG UTILIZATION; ENZYME MODIFICATION; EYE DISEASE; FEMALE; GASTROINTESTINAL SYMPTOM; HUMAN; JAPANESE CEDAR; LACRIMATION; MALE; OCULAR PRURITUS; PARALLEL DESIGN; POLLEN ALLERGY; PRIORITY JOURNAL; QUALITY OF LIFE; RADIOALLERGOSORBENT TEST; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; SYMPTOM; TREATMENT DURATION; TREATMENT OUTCOME;

EID: 70450178419     PISSN: 13238930     EISSN: 14401592     Source Type: Journal    
DOI: 10.2332/allergolint.08-OA-0070     Document Type: Article

References (44)

1. Holgate ST. The epidemic of allergy and asthma. Nature 1999;402:B2-4.
2. Eder W, Ege MJ, von Mutius E. The asthma epidemic. N Engl J Med 2006;355:2226-2235
3. Nolte H, Backer V, Porsbjerg C. Environmental factors as a cause for the increase in allergic disease. Ann Allergy Asthma Immunol 2001;87:S7-S11. (Pubitemid 34001017)
4. McKeever TM, Britton J. Diet and asthma. Am J Respir Crit Care Med 2004;170:725-729
5. Devereux G, Seaton A. Diet as a risk factor for atopy and asthma. J Allergy Clin Immunol 2005;115:1109-1117 (Pubitemid 40824576)
6. Devereux G. The increase in the prevalence of asthma and allergy: food for thought. Nature Rev 2006;6:869-874 (Pubitemid 44631655)
7. Tricon S, Willers S, Smit HA et al. Nutrition and allergic disease. Clin Exp Allergy Rev 2006;6:117-188
8. Harborne JB, Williams CA. Advance in flavonoid research since 1992. Phytochemistry 2000;55:481-504.
9. Higa S, Hirano T, Kotani M et al. Fisetin, a flavonol, inhibits T helper 2 (Th2) type cytokine production by activated human basophils. J Allergy Clin Immunol 2003;111:1299-1306 (Pubitemid 36683686)
10. Hirano T, Higa S, Arimitsu J et al. Flavonoids such as luteolin, fisetin and apigenin are inhibitors of interleukin-4 and interleukin-13 production by activated human basophils. Int Arch Allergy Immunol 2004;134:135-140 (Pubitemid 38716259)
11. Hirano T, Arimitsu J, Higa S et al. Luteolin, a flavonoid, inhibits CD40 ligand expression by activated human basophils. Int Arch Allergy Immunol 2006;140:150-156 (Pubitemid 43725809)
12. Kotani M, Matsumoto M, Fujita A et al. Persimmon leaf extract and astragalin inhibit development of dermatitis and IgE elevation in NC/Nga mice. J Allergy Clin Immunol 2000;106:159-166 (Pubitemid 30482866)
13. Matsumoto M, Kotani M, Fujita A et al. Oral administration of persimmon leaf extract ameliorates skin symptoms and transepidermal water loss in atopic dermatitis model mice, NC/Nga. Brit J Dermatol 2002;146:221-227 (Pubitemid 34264391)
14. Tanaka T, Higa S, Hirano T et al. Flavonoids as potential anti-allergic substances. Cur Med Chem-Anti-inflammatory & anti-allergy agents 2003;2:57-65.
15. Kawai M, Hirano T, Higa S et al. Flavonoids and related compounds as anti-allergic substances. Allergol Int 2007; 56:113-123 (Pubitemid 46984239)
16. Kawai M, Hirano T, Arimitsu J et al. Effect of enzymatically modified isoquercitrin, a flavonoid, on symptoms of Japanese cedar pollinosis: a randomized double-blind placebo-controlled trial. Int Arch Allergy Immunol 2009; 149:359-368
17. Ministry of Health, Labour and Welfare, Japan. [Japan's Specifications and Standards for Food Additives]. 8th edn. 2007;346-347 (in Japanese).
18. Salim EI, Kaneko M, Wanibuchi H, Morimura K, Fukushima S. Lack of carcinogenicity of enzymatically modified isoquercitrin in F344/DuCrj rats. Food Chem Toxicol 2004;42:1949-1969 (Pubitemid 39421496)
19. Baba K, Konno A, Takenaka Y et al. [Practical Guideline for the Management of Allergic Rhinitis in Japan], 4th edn. Tokyo: Life Science, 2002 (in Japanese).
20. Bielory L. Ocular symptom reduction in patients with seasonal allergic rhinitis treated with the intranasal corticosteroid mometasone furoate. Ann Allergy Asthma Immunol 2008;100:272-279
21. Anolik R, Nathan RA, Schenkel E, Danzig MR, Gates D, Varghese S. Intranasal momotasone furoate alleviates the ocular symptoms associated with seasonal allergic rhinitis: results of a post hoc analysis. Int Arch Allergy Immunol 2008;147:323-330
22. Okuda M, Ohkubo K, Goto M, Okamoto Y, Konno A, Baba K. [Japanese allergic rhinitis quality of life questionnaire]. Jpn J Allergol 2003;52(Suppl 1):21-56 (in Japanese).
23. Radtke J, Linseisen J, Wolfram G. Fasting plasma concentrations of selected flavonoids as markers of their ordinary dietary intake. Eur J Nutr 2002;41:203-209 (Pubitemid 36056318)
24. Rosenwasser L. New insights into the pathophysiology of allergic rhinitis. Allergy Asthma Proc 2007;28:10-15
25. Hollman PC, Bijsman MN, van Gameren Y, Cnossen EP, de Vries JH, Katan MB. The sugar moiety is a major determinant of the absorption of dietary flavonoid glycosides in man. Free Radic Res 1999;31:569-573
26. Erlund I, Kosonen T, Alfthan G et al. Pharmacokinetics of quercetin from quercetin aglycone and rutin in healthy volunteers. Eur J Clin Pharmacol 2000;56:545-553
27. Moon YJ, Wang L, DiCenzo R, Morris ME. Quercetin pharmacokinetics in humans. Biopharm Drug Dispos 2008;29:205-217
28. Van der Woude H, Boersma MG, Vervoort J, Rietjens IM. Identification of 14 quercetin phase II mono- and mixed conjugates and their formation by rat and human phase II in vitro model systems. Chem Res Toxicol 2004;17:1520-1530 (Pubitemid 39532321)
29. Williams RJ, Spencer JP, Rice-Evans C. Flavonoids: antioxidants or signaling molecules? Free Radic Biol Med 2004;36:838-849
30. Das M, Ram A, Ghosh B. Luteolin alleviates bronchoconstriction and airway hyperreactivity in ovalbumin sensitized mice. Inflamm Res 2003;52:101-106 (Pubitemid 36470069)
31. Ko WC, Shih CM, Chen MC et al. Suppressive effects of 3-O-methylquercetin on ovalbumin-induced airway hyperresponsiveness. Planta Med 2004;70:1123-1127
32. Wu YQ, Zhou CH, Tao J, Li SN. Antagonistic effects of nobiletin, a polymethoxyflavonoid, on eosinophillic airway inflammation of asthmatic rats and relevant mechanisms. Life Sci 2006;78:2689-2696
33. Rogerio AP, Kanashiro A, Fontanari C et al. Antiinflammatory activity of quercetin and isoquercitrin in experimental murine allergic asthma. Inflamm Res 2007;56: 402-408 (Pubitemid 350160416)
34. Jung CH, Lee JY, Cho CH, Kim CJ. Anti-asthmatic action of quercetin and rutin in conscious guinea-pigs challenged with aerosolized ovalbumin. Arch Pharm Res 2007; 30:1599-1607
35. Funaguchi N, Ohno Y, La BLB et al. Narirutin inhibits airway inflammation in an allergic mouse model. Clin Exp Pharmacol Physiol 2007;34:766-770 (Pubitemid 47013490)
36. Bacsi A, Dharajiya N, Choudhury B, Sur S, Boldogh I. Effect of pollen-mediated oxidative stress on immediate hypersensitivity reactions and late-phase inflammation in allergic conjunctivitis. J Allergy Clin Immunol 2005;116: 836-843 (Pubitemid 41400549)
37. Fewtrell CM, Gomperts BD. Effect of flavone inhibitors on transport ATPases on histamine release. Nature 1977; 265:635-636
38. Middleton EJ, Kandaswami C. Effects of flavonoids on immune and inflammatory cell functions. Biochem Pharmacol 1992;43:1167-1179
39. Cheong H, Ryu SY, Oak MH, Cheon SH, Yoo GS, Kim KM. Studies of structure activity relationship of flavonoids for the anti-allergic actions. Arch Pharm Res 1998;21:478-480 (Pubitemid 128661839)
40. Matsuda H, Morikawa T, Ueda K, Managi H, Yoshikawa M. Structure requirements of flavonoids for inhibition of antigen-induced degranulation, TNF-α and IL-4 production from RBL-2H3 cells. Bioorg Med Chem 2002;10:3123-3128 (Pubitemid 34855385)
41. Tanaka T, Higa S, Hirano T et al. Is an appropriate intake of flavonoids a prophylactic means or complementary and alternative medicine for allergic diseases? Recent Res Devel Allergy & Clin Immunol 2004;5:1-14.
42. Ho PP, Steinman L. The aryl hydrocarbon receptor: a regulator of Th17 and Treg cell development in disease. Cell Res 2008;18:605-608 (Pubitemid 351793116)
43. Amakura Y, Tsutsumi T, Sasaki K, Nakamura M, Yoshida T, Maitani T. Influence of food polyphenols on aryl hydrocarbon receptor-signaling pathway estimated by in vitro bioassay. Phytochemistry 2008;69:3117-3130
44. Knekt P, Kumpulainen J, Jarvinen R et al. Flavonoids intake and risk of chronic diseases. Am J Clin Nutr 2002; 76:560-568 (Pubitemid 34920833)