Oxidative damage shifts from lipid peroxidation to thiol arylation by catechol-containing antioxidants

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1583, Issue 3, 2002, Pages 279-284

  Boots, Agnes W ^a   Haenen, Guido R M M ^a   Den Hartog, Gertjan J M ^a   Bast, Aalt ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Antioxidant; Catechol; Lipid peroxidation; Quinone; Semiquinone radical; Toxicity

Indexed keywords

4 METHYLCATECHOL; ADENOSINE TRIPHOSPHATASE (CALCIUM); ANTIOXIDANT; CALCIUM; CATECHOL; ENZYME; FREE RADICAL; GLUTATHIONE; LIPID; OXIDOREDUCTASE; QUINONE DERIVATIVE; RADICAL; SCAVENGER; SEMIQUINONE; THIOL; THIOL DERIVATIVE;

ANTIOXIDANT ACTIVITY; ARTICLE; ARYLATION; CHEMICAL REACTION; CONTROLLED STUDY; ENZYME ASSAY; LIPID PEROXIDATION; LIVER MICROSOME; MALE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTECTION; RAT;

ANIMALS; ANTIOXIDANTS; BENZOQUINONES; CALCIUM-TRANSPORTING ATPASES; CATECHOLS; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHYLMALEIMIDE; FREE RADICALS; GLUTATHIONE; LIPID PEROXIDATION; MALE; MICROSOMES, LIVER; OXIDATIVE STRESS; RATS; RATS, WISTAR; SULFHYDRYL COMPOUNDS; SULFHYDRYL REAGENTS;

EID: 0037043543     PISSN: 13881981     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1388-1981(02)00247-0     Document Type: Article

References (26)

1. Functional food science and defence against reactive oxidative species
2. Oxidants and antioxidants: State of the art
3. 2+ sequestration by toxic agents
4. Protection against lipid peroxidation by a microsomal glutathione-dependent labile factor
5. Glutathione-dependent factors and inhibition of rat liver microsomal lipid peroxidation
6. Evidence that alpha-tocopherol functions cyclically to quench free radicals in hepatic microsomes. Requirement for glutathione and a heat-labile factor
7. The protection by ascorbate and glutathione against microsomal lipid peroxidation is dependent on vitamin E
8. Glutathione-dependent protection by rat liver microsomal protein against lipid peroxidation
9. Oxidative stress in chronic obstructive pulmonary disease
10. Oxidative stress in cardiovascular disease
11. The role of oxidative stress in the onset and progression of diabetes and its complications: A summary of a Congress Series sponsored by UNESCO-MCBN, the American Diabetes Association and the German Diabetes Society
12. Peroxynitrite scavenging of flavonoids: Structure activity relationship
13. Antioxidant and pro-oxidant actions of flavonoids: Effects on DNA damage induced by nitric oxide, peroxynitrite and nitroxyl anion
14. Flavonoids as peroxynitrite scavengers: The role of the hydroxyl groups
15. Structure-activity study on the quinone-quinone methide chemistry of flavonoids
16. Quercitin may act as a cytotoxic pro-oxidant after its metabolic activation to semiquinone and quinoidal product
17. Covalent binding of catechols to proteins through the sulfhydryl group
18. Potential oxidative pathways of brain catecholamines
19. Activation of the microsomal glutathione S-transferase by metabolites of alpha-methyldopa
20. Ueber o-chinon
21. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding
22. New synthetic flavonoids as potent protectors against doxorubicin-induced cardiotoxicity
23. Semiquinone anion radicals from addition of amino acids, peptides and proteins to quinones derived from oxidation of catechols and catecholamines
24. Contemporary issues in toxicology: Quinone chemistry and toxicity
25. Oxidation of α-methyldopa and other catechols by cytochrome P-450-generated superoxide anion: Possible mechanism of methyldopa hepatitis
26. The Toxicity of Antioxidants and their Metabolites