Carbon dioxide is the major metabolite of quercetin in humans

Journal of Nutrition

Volumn 131, Issue 10, 2001, Pages 2648-2652

  Walle, T ^a   Walle, U K ^a   Halushka, P V ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Carbon dioxide formation; Enterohepatic recirculation; Flavonoids; Humans; Intestinal absorption; Quercetin

Indexed keywords

CARBON 14; CARBON DIOXIDE; GLUCOSIDE; HYDROXIDE; METHANOL; QUERCETIN; THYMOLPHTHALEIN;

ABSORPTION; ADULT; ARTICLE; CLINICAL TRIAL; EXPIRED AIR; FECES ANALYSIS; FEMALE; HALF LIFE TIME; HUMAN; HYDROLYSIS; ILEOSTOMY; LIQUID SCINTILLATION COUNTING; MALE; METABOLITE; NORMAL HUMAN; PLASMA; RADIOACTIVITY; URINALYSIS;

EID: 0034795649     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/131.10.2648     Document Type: Article

References (33)

1. Variation of phenolic substances in onion
2. Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in the Netherlands
3. Intake of potentially anticarcinogenic flavonoids and their determinants in adults in the Netherlands
4. Dietary antioxidant flavonoids and risk of coronary heart disease: The Zutphen Elderly Study
5. Flavonoid intake and coronary mortality in Finland: A cohort study
6. Dietary flavonoids, antioxidant vitamins, and incidence of stroke: The Zutphen study
7. Consumption of onions and a reduced risk of stomach carcinoma
8. Dietary flavonoids and the risk of lung cancer and other malignant neoplasms
9. Intake of flavonoids and lung cancer
10. The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease, and cancer
11. Pharmacokinetics and bioavailability of the flavonol quercetin in humans
12. Metabolism of flavonoid compounds in germ-free rats
13. Absorption of dietary quercetin glycosides and quercetin in healthy ileostomy volunteers
14. Efflux of dietary flavonoid quercetin 4′-β-glucoside across human intestinal Caco-2 cell monolayers by apical multidrug resistance-associated protein-2
15. Cellular uptake of dietary fiavonoid quercetin 4′-β-glucoside by sodium-dependent glucose transporter SGLT1
16. Transport of quercetin and its glucosides across human intestinal epithelial Caco-2 cells
17. Quercetin glucosides are completely hydrolyzed in ileostomy patients before absorption
18. Deglycosylation of flavonoid and isoflavonoid glycosides by human small intestine and liver β-glucosidase activity
19. β-glucosidase activity in the rat small intestine toward quercetin monoglucosides
20. Dietary flavonoid and isoflavone glycosides are hydrolysed by the lactase site of lactase phlorizin hydrolase
21. Breath tests as noninvasive assays of P450s
22. Phase I clinical trial of the flavonoid quercetin: Pharmacokinetics and evidence for in vivo tyrosine kinase inhibition
23. Quercetin is recovered in human plasma as conjugated derivatives which retain antioxidant properties
24. Pharmacokinetics of quercetin from quercetin aglycone and rutin in healthy volunteers
25. Disposition of quercetin in man after single oral and intravenous doses
26. Relative bioavailability of the antioxidant flavonoid quercetin from various foods in man
27. Evidence of covalent binding of the flavonoid quercetin to protein in human cell cultures and in vivo
28. 14C]quercetin in the ACI rat
29. Autoxidation of quercetin in aqueous solution. An elucidation of the autoxidation reaction
30. Flavonoid antioxidants
31. Pharmacokinetics and bioavailability of quercetin glycosides in humans
32. Identification of quercetin 3-O-β-D-glucuronide as an antioxidative metabolite in rat plasma after oral administration of quercetin
33. Peroxidative metabolism of apigenin and naringenin versus luteolin and quercetin: Glutathione oxidation and conjugation