Quercetin mitigates lead acetate-induced behavioral and histological alterations via suppression of oxidative stress, Hsp-70, Bak and upregulation of Bcl-2

Food and Chemical Toxicology

Volumn 68, Issue , 2014, Pages 297-306

  Chander, Krishan ^a   Vaibhav, Kumar ^a,b,c   Ejaz Ahmed, Md ^a   Javed, Hayate ^a,d   Tabassum, Rizwana ^a   Khan, Andleeb ^a,e   Kumar, Mukesh ^b   Katyal, Anju ^b   Islam, Fakhrul ^a,e   Saeed Siddiqui, M ^a  

^a HAMDARD UNIVERSITY   (India)

^b UNIVERSITY OF DELHI   (India)

^c AUGUSTA UNIVERSITY   (United States)

^d UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

^e JAZAN UNIVERSITY   (Saudi Arabia)

Author keywords

Bak; Bcl 2; Hsp 70; Lead; Oxidative stress; Quercetin

Indexed keywords

BAK1 PROTEIN, RAT; BAX PROTEIN, RAT; HEAT SHOCK PROTEIN 70; LEAD ACETATE; ORGANOMETALLIC COMPOUND; PROTEIN BAK; PROTEIN BAX; QUERCETIN;

ANIMAL; BRAIN; COGNITION DISORDERS; DRUG EFFECTS; GENETICS; LEAD POISONING; MALE; METABOLISM; OXIDATIVE STRESS; PATHOLOGY; RAT; TOXICITY; UPREGULATION; WISTAR RAT;

ANIMALS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; BRAIN; COGNITION DISORDERS; HSP70 HEAT-SHOCK PROTEINS; LEAD POISONING; MALE; ORGANOMETALLIC COMPOUNDS; OXIDATIVE STRESS; QUERCETIN; RATS; RATS, WISTAR; UP-REGULATION;

EID: 84898949963     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2014.02.012     Document Type: Article

References (43)

1. Abdalla F.H., Cardoso A.M., Pereira L.B., Schmatz R., Gonçalves J.F., Stefanello N., Fiorenza A.M., Gutierres J.M., Serres J.D., Zanini D., Pimentel V.C., Vieira J.M., Schetinger M.R., Morsch V.M., Mazzanti C.M. Neuroprotective effect of quercetin in ectoenzymes and acetylcholinesterase activities in cerebral cortex synaptosomes of cadmium-exposed rats. Mol. Cell Biochem. 2013, 381:1-8.
2. Abdel Moneim A.E., Dkhil M.A., Al-Quraishy S. Effects of flaxseed oil on lead acetate-induced neurotoxicity in rats. Biol. Trace Elem. Res. 2011, 144:904-913.
3. Ahamed M., Siddiqui M.K.J. Low level lead exposure and oxidative stress: current opinions. Clin. Chim. Acta 2007, 383:57-64.
4. Ahmad F., Rashid H., Bhatia K., Rehman H., Kaur M., Anjum S., Ansari R.A., Raisuddin S. Modulatory effect of a Unani formulation (Jawarish amla sada) on cyclophosphamide induced toxicity in tumour bearing mice. Br. J. Med. Med. Res. 2012, 2:454-468.
5. Bouet V., Freret T., Toutain J., Divoux D., Boulouard M., Schumann-Bard P. Sensorimotor and cognitive deficits after transient middle cerebral artery occlusion in the mouse. Exp. Neurol. 2007, 203:555-567.
6. Danial N.N., Korsmeyer S.J. Cell death: critical control points. Cell 2004, 116:205-219.
7. Das S., Mandal A.K., Ghosh A., Panda S., Das N., Sarkar S. Nanoparticulated quercetin in combating age related cerebral oxidative injury. Curr. Aging Sci. 2008, 1:169-174.
8. Ejaz Ahmed M., Moshahid Khan M., Javed H., Vaibhav K., Khan A., Tabassum R., Ashafaq M., Islam F., Safhi M.M., Islam F. Amelioration of cognitive impairment and neurodegeneration by catechin hydrate in rat model of streptozotocin-induced experimental dementia of Alzheimer's type. Neurochem. Int. 2013, 62:492-501.
9. Ercal N., Gurer-Orhan H., Aykin-Burns N. Toxic metals and oxidative stress part I: mechanisms involved in metal-induced oxidative damage. Curr. Top. Med. Chem. 2001, 1:529-539.
10. Flora S.J., Flora G., Saxena G., Mishra M. Arsenic and lead induced free radical generation and their reversibility following chelation. Cell. Mol. Biol. (Noisy-le-grand) 2007, 53:26-47.
11. Flora G., Gupta D., Tiwari A. Toxicity of lead: a review with recent updates. Interdiscip. Toxicol. 2012, 5:47-58.
12. Formica J.V., Regelson W. Review of the biology of quercetin and related bioflavonoids. Food Chem. Toxicol. 1995, 33:1061-1080.
13. Ganter M.T., Ware L.B., Howard M., Roux J., Gartland B., Matthay M.A., Fleshner M., Pittet J.F. Extracellular heat shock protein 72 is a marker of the stress protein response in acute lung injury. Am. J. Physiol. Lung Cell. Mol. Physiol. 2006, 291:L354-L361.
14. Jaya-Prasanthi R.P., Hariprasad Reddy G., Bhuvaneswari Devi C., Rajarami Reddy G. Zinc and calcium reduce lead induced perturbations in the aminergic system of developing brain. Biometals 2005, 18:615-626.
15. (1)H magnetic resonance spectroscopy. Toxicol. Lett. 2008, 181:118-125.
16. Kaushal N., Bansal M.P. Diminished reproductive potential of male mice in response to selenium-induced oxidative stress: involvement of Hsp70, Hsp70-2, and MSJ-1. J. Biochem. Mol. Toxicol. 2009, 23:125-136.
17. Lateef A., Khan A.Q., Tahir M., Khan R., Rehman M.U., Ali F., Hamiza O.O., Sultana S. Androgen deprivation by flutamide modulates uPAR, MMP-9 expressions, lipid profile, and oxidative stress: amelioration by daidzein. Mol. Cell. Biochem. 2013, 374:49-59.
18. Lowry O.H., Rosenbrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 1951, 193:265-275.
19. Mansouri M.T., Cauli O. Motor alterations induced by chronic lead exposure. Environ. Toxicol. Pharmacol. 2009, 27:307-313.
20. Matsumori Y., Hong S.M., Aoyama K., Fan Y., Kayama T., Sheldon R.A., Vexler Z.S., Ferriero D.M., Weinstein P.R., Liu J. Hsp70 overexpression sequesters AIF and reduces neonatal hypoxic/ischemic brain injury. J. Cereb. Blood Flow Metab. 2005, 25:899-910.
21. Matsumori Y., Northington F.J., Hong S.M., Kayama T., Sheldon R.A., Vexler Z.S., Ferriero D.M., Weinstein P.R., Liu J. Reduction of caspase-8 and -9 cleavage is associated with increased c-FLIP and increased binding of Apaf-1 and Hsp70 after neonatal hypoxic/ischemic injury in mice over expressing Hsp70. Stroke 2006, 37:507-512.
22. Maurissen J.P., Marable B.R., Andrus A.K., Stebbins K.E. Factors affecting grip strength testing. Neurotoxicol. Teratol. 2003, 25:543-553.
23. Nakayama H., Ginsberg M.D., Dietrich W.D. (S)-Emopamil, 539 a novel calcium channel blocker and serotonin S2 antagonist, 540 markedly reduces infarct size following middle cerebral artery occlusion in rat. Neurology 1988, 38:1667-1673.
24. Newmeyer D.D., Ferguson-Miller S. Mitochondria: releasing power for life and unleashing the machineries of death. Cell 2003, 112:481-490.
25. Patra R., Swarup D., Dwivedi S. Antioxidant effects of α-tocopherol, ascorbic acid and l-methionine on lead induced oxidative stress to the liver, kidney and brain in rats. Toxicology 2001, 162:81-88.
26. Raouf G.A.M., Vaibhav K., Khan A., Tabassum R., Ahmed M.E., Javed H., Chander K., Islam F., Siddiqui M.S. Terminalia arjuna bark extract inhibits histological alterations by mitigating oxidative stress in lead intoxicated mice. OPEM 2013, 10.1007/s13596-013-0112-8.
27. Sanchez-Gonzalez P.D., Lopez-Hernandez F.J., Perez-Barriocanal F., Morales A.I., Lopez-Novoa J.M. Quercetin reduces cisplatin nephrotoxicity in rats without compromising its anti-tumour activity. Nephrol. Dial. Transplant. 2011, 26:3484-3495.
28. Sansar W., Ahboucha S., Gamrani H. Chronic lead intoxication affects glial and neural systems and induces hypoactivity in adult rat. Acta Histochem. 2011, 113:601-607.
29. Schmitt E., Gehrmann M., Brunet M., Multhoff G., Garrido C. Intracellular and extracellular functions of heat shock proteins: repercussions in cancer therapy. J. Leukoc. Biol. 2007, 81:15-27.
30. Shiotsuki H., Yoshimi K., Shimo Y., Funayama M., Takamatsu Y., Ikeda K., Takahashi R., Kitazawa S., Hattori N. A rotarod test for evaluation of motor skill learning. J. Neurosci. Methods 2010, 189:180-185.
31. Shrivastava P., Vaibhav K., Tabassum R., Khan A., Ishrat T., Khan M.M., Ahmad A., Islam F., Safhi M.M., Islam F. Anti-apoptotic and anti-inflammatory effect of piperine on 6-OHDA induced Parkinson's Rat model. J. Nutr. Biochem. 2013, 24:680-687.
32. Stevens M.J., Obrosova I., Cao X., Van Huysen C., Greene D.A. Effect of DL-alphalipidic acid on peripheral nerve conduction, blood flow, energy metabolism and oxidative stress in experimental diabetic neuropathy. Diabetes 2000, 49:1006-1015.
33. Tabassum R., Vaibhav K., Shrivastava P., Khan A., Ejaz Ahmed M., Javed H., Islam F., Ahmad S., Saeed Siddiqui M., Safhi M.M., Islam F. Centella asiatica attenuates the neurobehavioral, neurochemical and histological changes in transient focal middle cerebral artery occlusion rats. Neurol. Sci. 2013, 34:925-933.
34. Turturici G., Sconzo G., Geraci F. Hsp70 and its molecular role in nervous system diseases. Biochem. Res. Int. 2011, http://dx.doi.org/10.1155/2011/618127.
35. Vaibhav K., Shrivastava P., Javed H., Khan A., Ahmed M.E., Tabassum R., Khan M.M., Khuwaja G., Islam F., Saeed Siddiqui M., Safhi M.M., Islam F. Piperine suppresses cerebral ischemia-reperfusion-induced inflammation through the repression of COX-2, NOS-2, and NF-κB in middle cerebral artery occlusion rat model. Mol. Cell. Biochem. 2012, 367:73-84.
36. Vaibhav K., Shrivastava P., Khan A., Javed H., Tabassum R., Ahmed M.E., Khan M.B., Moshahid Khan M., Islam F., Ahmad S., Siddiqui M.S., Safhi M.M., Islam F. Azadirachta indica mitigates behavioral impairments, oxidative damage, histological alterations and apoptosis in focal cerebral ischemia-reperfusion model of rats. Neurol. Sci. 2013, 34:1321-1330.
37. Vaibhav K., Shrivastava P., Tabassum R., Khan A., Javed H., Ahmed M.E., Islam F., Safhi M.M., Islam F. Delayed administration of zingerone mitigates the behavioral and histological alteration via repression of oxidative stress and intrinsic programmed cell death in focal transient ischemic rats. Pharmacol. Biochem. Behav. 2013, 113:53-62.
38. Valverde M., Trejo C., Rojas E. Is the capacity of lead acetate and cadmium chloride to induce genotoxic damage due to direct DNA-metal interaction?. Mutagenesis 2001, 16:265-270.
39. Veis D.J., Sorenson C.M., Shutter J.R., Korsmeyer S.J. Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell 1993, 75:229-240.
40. Walter L., Rauh F., Gunther E. Comparative analysis of the three major histocompatibility complex-linked heat shock protein 70 (Hsp70) genes of the rat. Immunogenetics 1994, 40:325-330.
41. Wang L., Li J., Liu Z. Effects of lead and/or cadmium on the oxidative damage of rat kidney cortex mitochondria. Biol. Trace Elem. Res. 2009, 137:69-78.
42. Xia D., Yu X., Liao S., Shao Q., Mou H., Ma W. Protective effect of Smilax glabra extract against lead-induced oxidative stress in rats. J. Ethnopharmacol. 2010, 130:414-420.
43. Xu Y., Li G., Han C., Sun L., Zhao R., Cui S. Protective effects of Hippophae rhamnoides L. juice on lead-induced neurotoxicity in mice. Biol. Pharm. Bull. 2005, 28:490-494.