Protective effect of quercetin against arsenite-induced COX-2 expression by targeting PI3K in rat liver epithelial cells

Journal of Agricultural and Food Chemistry

Volumn 58, Issue 9, 2010, Pages 5815-5820

  Lee, Kyung Mi ^a,b   Hwang, Mun Kyung ^a,b   Lee, Dong Eun ^a,b   Lee, Ki Won ^b   Lee, Hyong Joo ^a  

^a Seoul National University   (South Korea)

^b Konkuk University   (South Korea)

Author keywords

Arsenite; Cyclooxygenase 2; Phosphatidylinositol 3 kinase; Quercetin

Indexed keywords

ARSENIC TRIOXIDE; ARSENOUS ACID DERIVATIVE; CYCLOOXYGENASE 2; PHOSPHATIDYLINOSITOL 3 KINASE; QUERCETIN;

ANIMAL; ARTICLE; CHEMICALLY INDUCED DISORDER; ENZYMOLOGY; LIVER TUMOR; METABOLISM; RAT; TUMOR CELL CULTURE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ARSENITES; CYCLOOXYGENASE 2; LIVER NEOPLASMS, EXPERIMENTAL; QUERCETIN; RATS; TUMOR CELLS, CULTURED;

RATTUS;

EID: 77952203012     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf903698s     Document Type: Article

References (30)

1. Frumkin, H.; Thun, M. J. Arsenic CA Cancer J. Clin. 2001, 51 (4) 254-262
2. Rossman, T. G. Mechanism of arsenic carcinogenesis: an integrated approach Mutat. Res. 2003, 533 (1-2) 37-65
3. Chen, C. J.; Wang, C. J. Ecological correlation between arsenic level in well water and age-adjusted mortality from malignant neoplasms Cancer Res. 1990, 50 (17) 5470-5474
4. Chen, C. J.; Chuang, Y. C.; You, S. L.; Lin, T. M.; Wu, H. Y. A retrospective study on malignant neoplasms of bladder, lung and liver in blackfoot disease endemic area in Taiwan Br. J. Cancer 1986, 53 (3) 399-405
5. Waalkes, M. P.; Ward, J. M.; Liu, J.; Diwan, B. A. Transplacental carcinogenicity of inorganic arsenic in the drinking water: induction of hepatic, ovarian, pulmonary, and adrenal tumors in mice Toxicol. Appl. Pharmacol. 2003, 186 (1) 7-17
6. Pilbeam, C. C.; Kawaguchi, H.; Hakeda, Y.; Voznesensky, O.; Alander, C. B.; Raisz, L. G. Differential regulation of inducible and constitutive prostaglandin endoperoxide synthase in osteoblastic MC3T3-E1 cells J. Biol. Chem. 1993, 268 (34) 25643-25649
7. Feng, L.; Xia, Y.; Garcia, G. E.; Hwang, D.; Wilson, C. B. Involvement of reactive oxygen intermediates in cyclooxygenase-2 expression induced by interleukin-1, tumor necrosis factor-α, and lipopolysaccharide J. Clin. Invest. 1995, 95 (4) 1669-1675
8. Koga, H.; Sakisaka, S.; Ohishi, M.; Kawaguchi, T.; Taniguchi, E.; Sasatomi, K.; Harada, M.; Kusaba, T.; Tanaka, M.; Kimura, R.; Nakashima, Y.; Nakashima, O.; Kojiro, M.; Kurohiji, T.; Sata, M. Expression of cyclooxygenase-2 in human hepatocellular carcinoma: relevance to tumor dedifferentiation Hepatology 1999, 29 (3) 688-696
9. Bae, S. H.; Jung, E. S.; Park, Y. M.; Kim, B. S.; Kim, B. K.; Kim, D. G.; Ryu, W. S. Expression of cyclooxygenase-2 (COX-2) in hepatocellular carcinoma and growth inhibition of hepatoma cell lines by a COX-2 inhibitor, NS-398 Clin. Cancer Res. 2001, 7 (5) 1410-1418
10. Dixon, D. A. Regulation of COX-2 expression in human cancers Prog. Exp. Tumor Res. 2003, 37, 52-71
11. Engelman, J. A.; Luo, J.; Cantley, L. C. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism Nat. Rev. Genet. 2006, 7 (8) 606-619
12. Lee, J. W.; Soung, Y. H.; Kim, S. Y.; Lee, H. W.; Park, W. S.; Nam, S. W.; Kim, S. H.; Lee, J. Y.; Yoo, N. J.; Lee, S. H. PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas Oncogene 2005, 24 (8) 1477-1480
13. Carpenter, C. L.; Duckworth, B. C.; Auger, K. R.; Cohen, B.; Schaffhausen, B. S.; Cantley, L. C. Purification and characterization of phosphoinositide 3-kinase from rat liver J. Biol. Chem. 1990, 265 (32) 19704-19711
14. Roymans, D.; Slegers, H. Phosphatidylinositol 3-kinases in tumor progression Eur. J. Biochem. 2001, 268 (3) 487-498
15. Stephens, L. R.; Eguinoa, A.; Erdjument-Bromage, H.; Lui, M.; Cooke, F.; Coadwell, J.; Smrcka, A. S.; Thelen, M.; Cadwallader, K.; Tempst, P.; Hawkins, P. T. The G β γ sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101 Cell 1997, 89 (1) 105-114
16. Crozier, A.; Burns, J.; Aziz, A. A.; Stewart, A. J.; Rabiasz, H. S.; Jenkins, G. I.; Edwards, C. A.; Lean, M. E. Antioxidant flavonols from fruits, vegetables and beverages: measurements and bioavailability Biol. Res. 2000, 33 (2) 79-88
17. Birt, D. F.; Hendrich, S.; Wang, W. Dietary agents in cancer prevention: flavonoids and isoflavonoids Pharmacol. Ther. 2001, 90 (2-3) 157-177
18. Hertog, M. G.; Hollman, P. C. Potential health effects of the dietary flavonol quercetin Eur. J. Clin. Nutr. 1996, 50 (2) 63-71
19. Sasaki, T.; Hazeki, K.; Hazeki, O.; Ui, M.; Katada, T. Focal adhesion kinase (p125FAK) and paxillin are substrates for sphingomyelinase-induced tyrosine phosphorylation in Swiss 3T3 fibroblasts Biochem. J. 1996, 315 (Part 3) 1035-1040
20. Upham, B. L.; Koski, T. R.; Rummel, A. M.; Wilson, M. R.; Horvath, A.; Trosko, J. E. Differential roles of 2, 6, and 8 carbon ceramides on the modulation of gap junctional communication and apoptosis during carcinogenesis Cancer Lett. 2003, 191 (1) 27-34
21. Lee, K. W.; Kang, N. J.; Heo, Y. S.; Rogozin, E. A.; Pugliese, A.; Hwang, M. K.; Bowden, G. T.; Bode, A. M.; Lee, H. J.; Dong, Z. Raf and MEK protein kinases are direct molecular targets for the chemopreventive effect of quercetin, a major flavonol in red wine Cancer Res. 2008, 68 (3) 946-955
22. Fingar, D. C.; Blenis, J. Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression Oncogene 2004, 23 (18) 3151-3171
23. Kondo, M.; Yamamoto, H.; Nagano, H.; Okami, J.; Ito, Y.; Shimizu, J.; Eguchi, H.; Miyamoto, A.; Dono, K.; Umeshita, K.; Matsuura, N.; Wakasa, K.; Nakamori, S.; Sakon, M.; Monden, M. Increased expression of COX-2 in nontumor liver tissue is associated with shorter disease-free survival in patients with hepatocellular carcinoma Clin. Cancer Res. 1999, 5 (12) 4005-4012
24. Ikeda, T.; Tozuka, S.; Hasumura, Y.; Takeuchi, J. Prostaglandin-E- producing hepatocellular carcinoma with hypercalcemia Cancer 1988, 61 (9) 1813-1814
25. Kern, M. A.; Haugg, A. M.; Koch, A. F.; Schilling, T.; Breuhahn, K.; Walczak, H.; Fleischer, B.; Trautwein, C.; Michalski, C.; Schulze-Bergkamen, H.; Friess, H.; Stremmel, W.; Krammer, P. H.; Schirmacher, P.; Muller, M. Cyclooxygenase-2 inhibition induces apoptosis signaling via death receptors and mitochondria in hepatocellular carcinoma Cancer Res. 2006, 66 (14) 7059-7066
26. Kern, M. A.; Haugg, A. M.; Eiteneuer, E.; Konze, E.; Drebber, U.; Dienes, H. P.; Breuhahn, K.; Schirmacher, P.; Kasper, H. U. Ex vivo analysis of antineoplastic agents in precision-cut tissue slices of human origin: effects of cyclooxygenase-2 inhibition in hepatocellular carcinoma Liver Int. 2006, 26 (5) 604-612
27. Muller-Decker, K.; Kopp-Schneider, A.; Marks, F.; Seibert, K.; Furstenberger, G. Localization of prostaglandin H synthase isoenzymes in murine epidermal tumors: suppression of skin tumor promotion by inhibition of prostaglandin H synthase-2 Mol. Carcinog. 1998, 23 (1) 36-44
28. Nicholson, K. M.; Anderson, N. G. The protein kinase B/Akt signalling pathway in human malignancy Cell Signal. 2002, 14 (5) 381-395
29. Leng, J.; Han, C.; Demetris, A. J.; Michalopoulos, G. K.; Wu, T. Cyclooxygenase-2 promotes hepatocellular carcinoma cell growth through Akt activation: evidence for Akt inhibition in celecoxib-induced apoptosis Hepatology 2003, 38 (3) 756-768
30. Eblin, K. E.; Bredfeldt, T. G.; Buffington, S.; Gandolfi, A. J. Mitogenic signal transduction caused by monomethylarsonous acid in human bladder cells: role in arsenic-induced carcinogenesis Toxicol. Sci. 2007, 95 (2) 321-330