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Volumn 16, Issue 9, 2015, Pages 22368-22401

Neuroprotective strategies after neonatal hypoxic ischemic encephalopathy

Author keywords

Intervention strategy; Neonatal hypoxic ischemic encephalopathy; Neuroprotection

Indexed keywords

BETA INTERFERON; MELATONIN; OSTEOPONTIN; TOPIRAMATE; XENON; NEUROPROTECTIVE AGENT;

EID: 84941695616     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms160922368     Document Type: Review
Times cited : (148)

References (220)
  • 1
    • 84925275079 scopus 로고    scopus 로고
    • Neonatal seizures in hypoxic-ischaemic encephalopathy-risks and benefits of anticonvulsant therapy
    • Shetty, J. Neonatal seizures in hypoxic-ischaemic encephalopathy-risks and benefits of anticonvulsant therapy. Dev. Med. Child. Neurol. 2015, 57, 40-43.
    • (2015) Dev. Med. Child. Neurol , vol.57 , pp. 40-43
    • Shetty, J.1
  • 2
    • 0035101941 scopus 로고    scopus 로고
    • Perinatal brain injury: From pathogenesis to neuroprotection
    • Volpe, J.J. Perinatal brain injury: From pathogenesis to neuroprotection. Ment. Retard. Dev. Disabil. Res. Rev. 2001, 7, 56-64.
    • (2001) Ment. Retard. Dev. Disabil. Res. Rev , vol.7 , pp. 56-64
    • Volpe, J.J.1
  • 3
    • 84875054862 scopus 로고    scopus 로고
    • Granulocyte-colony stimulating factor in combination with stem cell factor confers greater neuroprotection after hypoxic-ischemic brain damage in the neonatal rats than a solitary treatment
    • Doycheva, D.; Shih, G.; Chen, H.; Applegate, R.; Zhang, J.H.; Tang, J. Granulocyte-colony stimulating factor in combination with stem cell factor confers greater neuroprotection after hypoxic-ischemic brain damage in the neonatal rats than a solitary treatment. Transl. Stroke Res. 2013, 4, 171-178.
    • (2013) Transl. Stroke Res , vol.4 , pp. 171-178
    • Doycheva, D.1    Shih, G.2    Chen, H.3    Applegate, R.4    Zhang, J.H.5    Tang, J.6
  • 5
    • 56349117483 scopus 로고    scopus 로고
    • Hypoxia ischemia-mediated cell death in neonatal rat brain
    • Gill, M.B.; Perez-Polo, J.R. Hypoxia ischemia-mediated cell death in neonatal rat brain. Neurochem. Res. 2008, 33, 2379-2389.
    • (2008) Neurochem. Res , vol.33 , pp. 2379-2389
    • Gill, M.B.1    Perez-Polo, J.R.2
  • 6
    • 33744783132 scopus 로고    scopus 로고
    • Brain injury in the infant: The old, the new, and the uncertain
    • Badr Zahr, L.K.; Purdy, I. Brain injury in the infant: The old, the new, and the uncertain. J. Perinat. Neonatal Nurs. 2006, 20, 163-175.
    • (2006) J. Perinat. Neonatal Nurs , vol.20 , pp. 163-175
    • Badr Zahr, L.K.1    Purdy, I.2
  • 7
    • 84869784639 scopus 로고    scopus 로고
    • Hypoxic-ischemic encephalopathy and novel strategies for neuroprotection
    • Shankaran, S. Hypoxic-ischemic encephalopathy and novel strategies for neuroprotection. Clin. Perinat. 2012, 39, 919-929.
    • (2012) Clin. Perinat , vol.39 , pp. 919-929
    • Shankaran, S.1
  • 8
    • 77955927077 scopus 로고    scopus 로고
    • Long-term evaluation of granulocyte-colony stimulating factor on hypoxic-ischemic brain damage in infant rats
    • Fathali, N.; Lekic, T.; Zhang, J.H.; Tang, J. Long-term evaluation of granulocyte-colony stimulating factor on hypoxic-ischemic brain damage in infant rats. Intensive Care Med. 2010, 36, 1602-1608.
    • (2010) Intensive Care Med , vol.36 , pp. 1602-1608
    • Fathali, N.1    Lekic, T.2    Zhang, J.H.3    Tang, J.4
  • 10
    • 84928243581 scopus 로고    scopus 로고
    • Hypoxic-ischemic encephalopathy: A review for the clinician
    • Douglas-Escobar, M.; Weiss, M.D. Hypoxic-ischemic encephalopathy: A review for the clinician. JAMA Pediatr. 2015, 169, 397-403.
    • (2015) JAMA Pediatr , vol.169 , pp. 397-403
    • Douglas-Escobar, M.1    Weiss, M.D.2
  • 12
    • 84880604637 scopus 로고    scopus 로고
    • Epidemiology and aetiology of neonatal seizures
    • Vasudevan, C.; Levene, M. Epidemiology and aetiology of neonatal seizures. Semin. Fetal Neonatal Med. 2013, 18, 185-191.
    • (2013) Semin. Fetal Neonatal Med , vol.18 , pp. 185-191
    • Vasudevan, C.1    Levene, M.2
  • 13
    • 34249801473 scopus 로고    scopus 로고
    • Neonatal seizures: Gaps between the laboratory and the clinic
    • Lombroso, C.T. Neonatal seizures: Gaps between the laboratory and the clinic. Epilepsia 2007, 48, 83-106.
    • (2007) Epilepsia , vol.48 , pp. 83-106
    • Lombroso, C.T.1
  • 14
    • 0032904681 scopus 로고    scopus 로고
    • Electroencephalogram confirmatory rate in neonatal seizures
    • Sheth, R.D. Electroencephalogram confirmatory rate in neonatal seizures. Pediatr. Neurol. 1999, 20, 27-30.
    • (1999) Pediatr. Neurol , vol.20 , pp. 27-30
    • Sheth, R.D.1
  • 16
    • 84925255772 scopus 로고    scopus 로고
    • The long-term health, social, and financial burden of hypoxic-ischaemic encephalopathy
    • Eunson, P. The long-term health, social, and financial burden of hypoxic-ischaemic encephalopathy. Dev. Med. Child. Neurol. 2015, 57, 48-50.
    • (2015) Dev. Med. Child. Neurol , vol.57 , pp. 48-50
    • Eunson, P.1
  • 17
    • 84865596546 scopus 로고    scopus 로고
    • Neonatal encephalopathy: An inadequate term for hypoxic-ischemic encephalopathy
    • Volpe, J.J. Neonatal encephalopathy: An inadequate term for hypoxic-ischemic encephalopathy. Ann. Neurol. 2012, 72, 156-166.
    • (2012) Ann. Neurol , vol.72 , pp. 156-166
    • Volpe, J.J.1
  • 18
    • 33745905923 scopus 로고    scopus 로고
    • Follow-up of the term infant after hypoxic-ischemic encephalopathy
    • Robertson, C.M.; Perlman, M. Follow-up of the term infant after hypoxic-ischemic encephalopathy. Paediatr. Child. Health 2006, 11, 278-282.
    • (2006) Paediatr. Child. Health , vol.11 , pp. 278-282
    • Robertson, C.M.1    Perlman, M.2
  • 19
    • 79960680409 scopus 로고    scopus 로고
    • The evolving landscape of neuroinflammation after neonatal hypoxia-ischemia. Acta Neurochir
    • Fathali, N.; Khatibi, N.H.; Ostrowski, R.P.; Zhang, J.H. The evolving landscape of neuroinflammation after neonatal hypoxia-ischemia. Acta Neurochir. Suppl. 2011, 111, 93-100.
    • (2011) Suppl , vol.111 , pp. 93-100
    • Fathali, N.1    Khatibi, N.H.2    Ostrowski, R.P.3    Zhang, J.H.4
  • 21
    • 59749101438 scopus 로고    scopus 로고
    • Animal models of perinatal hypoxic-ischemic brain damage
    • Yager, J.Y.; Ashwal, S. Animal models of perinatal hypoxic-ischemic brain damage. Pediatr. Neurol. 2009, 40, 156-167.
    • (2009) Pediatr. Neurol , vol.40 , pp. 156-167
    • Yager, J.Y.1    Ashwal, S.2
  • 22
    • 80051761494 scopus 로고    scopus 로고
    • Hypoxic ischemic encephalopathy: Pathophysiology and experimental treatments
    • Allen, K.A.; Brandon, D.H. Hypoxic ischemic encephalopathy: Pathophysiology and experimental treatments. Newborn Infant Nurs. Rev. 2011, 11, 125-133.
    • (2011) Newborn Infant Nurs. Rev , vol.11 , pp. 125-133
    • Allen, K.A.1    Brandon, D.H.2
  • 23
    • 84870899637 scopus 로고    scopus 로고
    • Vulnerability of the developing brain to hypoxic-ischemic damage: Contribution of the cerebral vasculature to injury and repair? Front
    • Baburamani, A.A.; Ek, C.J.; Walker, D.W.; Castillo-Melendez, M. Vulnerability of the developing brain to hypoxic-ischemic damage: Contribution of the cerebral vasculature to injury and repair? Front. Physiol. 2012, 3, 424.
    • (2012) Physiol , vol.3 , pp. 424
    • Baburamani, A.A.1    Ek, C.J.2    Walker, D.W.3    Castillo-Melendez, M.4
  • 24
    • 73849114180 scopus 로고    scopus 로고
    • Enhancement of autophagic flux after neonatal cerebral hypoxia-ischemia and its region-specific relationship to apoptotic mechanisms
    • Ginet, V.; Puyal, J.; Clarke, P.G.; Truttmann, A.C. Enhancement of autophagic flux after neonatal cerebral hypoxia-ischemia and its region-specific relationship to apoptotic mechanisms. Am. J. Pathol. 2009, 175, 1962-1974.
    • (2009) Am. J. Pathol. , vol.175 , pp. 1962-1974
    • Ginet, V.1    Puyal, J.2    Clarke, P.G.3    Truttmann, A.C.4
  • 25
    • 77955661790 scopus 로고    scopus 로고
    • Magnetic resonance imaging of brain angiogenesis after stroke
    • Seevinck, P.R.; Deddens, L.H.; Dijkhuizen, R.M. Magnetic resonance imaging of brain angiogenesis after stroke. Angiogenesis 2010, 13, 101-111.
    • (2010) Angiogenesis , vol.13 , pp. 101-111
    • Seevinck, P.R.1    Deddens, L.H.2    Dijkhuizen, R.M.3
  • 26
    • 0034991340 scopus 로고    scopus 로고
    • Neurobiology of hypoxic-ischemic injury in the developing brain
    • Johnston, M.V.; Trescher, W.H.; Ishida, A.; Nakajima, W. Neurobiology of hypoxic-ischemic injury in the developing brain. Pediatr. Res. 2001, 49, 735-741.
    • (2001) Pediatr. Res , vol.49 , pp. 735-741
    • Johnston, M.V.1    Trescher, W.H.2    Ishida, A.3    Nakajima, W.4
  • 27
    • 79251563456 scopus 로고    scopus 로고
    • Perinatal hypoxic-ischemic encephalopathy
    • 2011
    • Lai, M.C.; Yang, S.N. Perinatal hypoxic-ischemic encephalopathy. J. Biomed. Biotechnol. 2011, 2011, 609813.
    • (2011) J. Biomed. Biotechnol
    • Lai, M.C.1    Yang, S.N.2
  • 28
    • 84941682225 scopus 로고    scopus 로고
    • Resuscitation of the Fetus and Newborn, an Issue of Clinics in Perinatology
    • Philadelphia, PA, USA
    • Kumar, P.; Halamek, L.P. Resuscitation of the Fetus and Newborn, an Issue of Clinics in Perinatology; Elsevier Health Sciences: Philadelphia, PA, USA, 2012.
    • (2012) Elsevier Health Sciences
    • Kumar, P.1    Halamek, L.P.2
  • 29
    • 84893719497 scopus 로고    scopus 로고
    • Pharmacologic neuroprotective strategies in neonatal brain injury
    • Juul, S.E.; Ferriero, D.M. Pharmacologic neuroprotective strategies in neonatal brain injury. Clin. Perinatol. 2014, 41, 119-131.
    • (2014) Clin. Perinatol , vol.41 , pp. 119-131
    • Juul, S.E.1    Ferriero, D.M.2
  • 30
    • 0028079731 scopus 로고
    • Delayed ("secondary") cerebral energy failure after acute hypoxia-ischemia in the newborn piglet: Continuous 48-hour studies by phosphorus magnetic resonance spectroscopy
    • Lorek, A.; Takei, Y.; Cady, E.B.; Wyatt, J.S.; Penrice, J.; Edwards, A.D.; Peebles, D.; Wylezinska, M.; Owen-Reece, H.; Kirkbride, V. et al. Delayed ("secondary") cerebral energy failure after acute hypoxia-ischemia in the newborn piglet: Continuous 48-hour studies by phosphorus magnetic resonance spectroscopy. Pediatr. Res. 1994, 36, 699-706.
    • (1994) Pediatr. Res , vol.36 , pp. 699-706
    • Lorek, A.1    Takei, Y.2    Cady, E.B.3    Wyatt, J.S.4    Penrice, J.5    Edwards, A.D.6    Peebles, D.7    Wylezinska, M.8    Owen-Reece, H.9    Kirkbride, V.10
  • 31
    • 4944263626 scopus 로고    scopus 로고
    • Secondary energy failure after cerebral hypoxia-ischemia in the immature rat
    • Vannucci, R.C.; Towfighi, J.; Vannucci, S.J. Secondary energy failure after cerebral hypoxia-ischemia in the immature rat. J. Cereb. Blood Flow Metab. 2004, 24, 1090-1097.
    • (2004) J. Cereb. Blood Flow Metab , vol.24 , pp. 1090-1097
    • Vannucci, R.C.1    Towfighi, J.2    Vannucci, S.J.3
  • 32
    • 84922395972 scopus 로고    scopus 로고
    • The importance of temperature on the neurovascular unit
    • Laptook, A. The importance of temperature on the neurovascular unit. Early Hum. Dev. 2014, 90, 713-717.
    • (2014) Early Hum. Dev , vol.90 , pp. 713-717
    • Laptook, A.1
  • 33
    • 2342471420 scopus 로고    scopus 로고
    • The blood-brain barrier: An overview: Structure, regulation, and clinical implications
    • Ballabh, P.; Braun, A.; Nedergaard, M. The blood-brain barrier: An overview: Structure, regulation, and clinical implications. Neurobiol. Dis. 2004, 16, 1-13.
    • (2004) Neurobiol. Dis , vol.16 , pp. 1-13
    • Ballabh, P.1    Braun, A.2    Nedergaard, M.3
  • 34
    • 51649124497 scopus 로고    scopus 로고
    • Free radical injury and blood-brain barrier permeability in hypoxic-ischemic encephalopathy
    • Kumar, A.; Mittal, R.; Khanna, H.D.; Basu, S. Free radical injury and blood-brain barrier permeability in hypoxic-ischemic encephalopathy. Pediatrics 2008, 122, 722-727.
    • (2008) Pediatrics , vol.122 , pp. 722-727
    • Kumar, A.1    Mittal, R.2    Khanna, H.D.3    Basu, S.4
  • 36
    • 84920081368 scopus 로고    scopus 로고
    • Ang-(1-7) exerts protective role in blood-brain barrier damage by the balance of timp-1/mmp-9
    • Wu, J.; Zhao, D.; Wu, S.; Wang, D. Ang-(1-7) exerts protective role in blood-brain barrier damage by the balance of timp-1/mmp-9. Eur. J. Pharmacol. 2015, 748, 30-36.
    • (2015) Eur. J. Pharmacol , vol.748 , pp. 30-36
    • Wu, J.1    Zhao, D.2    Wu, S.3    Wang, D.4
  • 37
    • 84905709097 scopus 로고    scopus 로고
    • Pretreatment by evodiamine is neuroprotective in cerebral ischemia: Up-regulated pakt, pgsk3beta, down-regulated nf-kappab expression, and ameliorated bbb permeability
    • Zhao, T.; Zhang, X.; Zhao, Y.; Zhang, L.; Bai, X.; Zhang, J.; Zhao, X.; Chen, L.; Wang, L.; Cui, L. Pretreatment by evodiamine is neuroprotective in cerebral ischemia: Up-regulated pakt, pgsk3beta, down-regulated nf-kappab expression, and ameliorated bbb permeability. Neurochem. Res. 2014, 39, 1612-1620.
    • (2014) Neurochem. Res , vol.39 , pp. 1612-1620
    • Zhao, T.1    Zhang, X.2    Zhao, Y.3    Zhang, L.4    Bai, X.5    Zhang, J.6    Zhao, X.7    Chen, L.8    Wang, L.9    Cui, L.10
  • 38
    • 84898540821 scopus 로고    scopus 로고
    • Protective effect of a sesamin derivative, 3-bis (3-methoxybenzyl) butane-1, 4-diol on ischemic and hypoxic neuronal injury
    • Hou, C.W.; Chen, Y.L.; Chuang, S.H.; Wang, J.S.; Jeng, K.C. Protective effect of a sesamin derivative, 3-bis (3-methoxybenzyl) butane-1, 4-diol on ischemic and hypoxic neuronal injury. J. Biomed. Sci. 2014, 21, 15.
    • (2014) J. Biomed. Sci. , vol.21 , pp. 15
    • Hou, C.W.1    Chen, Y.L.2    Chuang, S.H.3    Wang, J.S.4    Jeng, K.C.5
  • 39
    • 84885184477 scopus 로고    scopus 로고
    • Curcumin ameliorates the permeability of the blood-brain barrier during hypoxia by upregulating heme oxygenase-1 expression in brain microvascular endothelial cells
    • Wang, Y.F.; Gu, Y.T.; Qin, G.H.; Zhong, L.; Meng, Y.N. Curcumin ameliorates the permeability of the blood-brain barrier during hypoxia by upregulating heme oxygenase-1 expression in brain microvascular endothelial cells. J. Mol. Neurosci. 2013, 51, 344-351.
    • (2013) J. Mol. Neurosci , vol.51 , pp. 344-351
    • Wang, Y.F.1    Gu, Y.T.2    Qin, G.H.3    Zhong, L.4    Meng, Y.N.5
  • 40
    • 84919883208 scopus 로고    scopus 로고
    • The effect of ask1 on vascular permeability and edema formation in cerebral ischemia
    • Song, J.; Cheon, S.Y.; Lee, W.T.; Park, K.A.; Lee, J.E. The effect of ask1 on vascular permeability and edema formation in cerebral ischemia. Brain Res. 2015, 1595, 143-155.
    • (2015) Brain Res , vol.1595 , pp. 143-155
    • Song, J.1    Cheon, S.Y.2    Lee, W.T.3    Park, K.A.4    Lee, J.E.5
  • 41
    • 84945484823 scopus 로고    scopus 로고
    • G-csf attenuates neuroinflammation and stabilizes the blood-brain barrier via the pi3k/akt/gsk-3beta signaling pathway following neonatal hypoxia-ischemia in rats
    • Li, L.; McBride, D.W.; Doycheva, D.; Dixon, B.J.; Krafft, P.R.; Zhang, J.H.; Tang, J. G-csf attenuates neuroinflammation and stabilizes the blood-brain barrier via the pi3k/akt/gsk-3beta signaling pathway following neonatal hypoxia-ischemia in rats. Exp. Neurol. 2015, doi:10.1016/j.expneurol.2014.12.020.
    • (2015) Exp. Neurol
    • Li, L.1    McBride, D.W.2    Doycheva, D.3    Dixon, B.J.4    Krafft, P.R.5    Zhang, J.H.6    Tang, J.7
  • 42
    • 67650488410 scopus 로고    scopus 로고
    • Therapeutic administration of plasminogen activator inhibitor-1 prevents hypoxic-ischemic brain injury in newborns
    • Yang, D.; Nemkul, N.; Shereen, A.; Jone, A.; Dunn, R.S.; Lawrence, D.A.; Lindquist, D.; Kuan, C.Y. Therapeutic administration of plasminogen activator inhibitor-1 prevents hypoxic-ischemic brain injury in newborns. J. Neurosci. 2009, 29, 8669-8674.
    • (2009) J. Neurosci , vol.29 , pp. 8669-8674
    • Yang, D.1    Nemkul, N.2    Shereen, A.3    Jone, A.4    Dunn, R.S.5    Lawrence, D.A.6    Lindquist, D.7    Kuan, C.Y.8
  • 43
    • 84929310642 scopus 로고    scopus 로고
    • Differential responses of blood-brain barrier associated cells to hypoxia and ischemia: A comparative study
    • Engelhardt, S.; Huang, S.F.; Patkar, S.; Gassmann, M.; Ogunshola, O.O. Differential responses of blood-brain barrier associated cells to hypoxia and ischemia: A comparative study. Fluids Barriers CNS 2015, 12, 4.
    • (2015) Fluids Barriers CNS , vol.12 , pp. 4
    • Engelhardt, S.1    Huang, S.F.2    Patkar, S.3    Gassmann, M.4    Ogunshola, O.O.5
  • 45
    • 84930617141 scopus 로고    scopus 로고
    • Angiogenesis dysregulation in term asphyxiated newborns treated with hypothermia
    • Shaikh, H.; Boudes, E.; Khoja, Z.; Shevell, M.; Wintermark, P. Angiogenesis dysregulation in term asphyxiated newborns treated with hypothermia. PLoS ONE 2015, 10, 128028.
    • (2015) Plos ONE , vol.10
    • Shaikh, H.1    Boudes, E.2    Khoja, Z.3    Shevell, M.4    Wintermark, P.5
  • 46
    • 84864317687 scopus 로고    scopus 로고
    • Umbilical cord blood mononuclear cell transplantation for neonatal hypoxic-ischemic encephalopathy
    • Pimentel-Coelho, P.M.; Rosado-de-Castro, P.H.; da Fonseca, L.M.; Mendez-Otero, R. Umbilical cord blood mononuclear cell transplantation for neonatal hypoxic-ischemic encephalopathy. Pediatr. Res. 2012, 71, 464-473.
    • (2012) Pediatr. Res , vol.71 , pp. 464-473
    • Pimentel-Coelho, P.M.1    Rosado-De-Castro, P.H.2    Da Fonseca, L.M.3    Mendez-Otero, R.4
  • 47
    • 84883434758 scopus 로고    scopus 로고
    • The neuroprotective roles of bdnf in hypoxic ischemic brain injury
    • Chen, A.; Xiong, L.J.; Tong, Y.; Mao, M. The neuroprotective roles of bdnf in hypoxic ischemic brain injury. Biomed. Rep. 2013, 1, 167-176.
    • (2013) Biomed. Rep , vol.1 , pp. 167-176
    • Chen, A.1    Xiong, L.J.2    Tong, Y.3    Mao, M.4
  • 49
    • 79957849578 scopus 로고    scopus 로고
    • Postnatal neurogenesis in the hippocampal dentate gyrus and subventricular zone of the gottingen minipig
    • Guidi, S.; Bianchi, P.; Alstrup, A.K.; Henningsen, K.; Smith, D.F.; Bartesaghi, R. Postnatal neurogenesis in the hippocampal dentate gyrus and subventricular zone of the gottingen minipig. Brain Res. Bull. 2011, 85, 169-179.
    • (2011) Brain Res. Bull , vol.85 , pp. 169-179
    • Guidi, S.1    Bianchi, P.2    Alstrup, A.K.3    Henningsen, K.4    Smith, D.F.5    Bartesaghi, R.6
  • 50
    • 84877583133 scopus 로고    scopus 로고
    • The endogenous regenerative capacity of the damaged newborn brain: Boosting neurogenesis with mesenchymal stem cell treatment
    • Donega, V.; van Velthoven, C.T.; Nijboer, C.H.; Kavelaars, A.; Heijnen, C.J. The endogenous regenerative capacity of the damaged newborn brain: Boosting neurogenesis with mesenchymal stem cell treatment. J. Cereb. Blood Flow Metab. 2013, 33, 625-634.
    • (2013) J. Cereb. Blood Flow Metab , vol.33 , pp. 625-634
    • Donega, V.1    Van Velthoven, C.T.2    Nijboer, C.H.3    Kavelaars, A.4    Heijnen, C.J.5
  • 51
    • 24344506586 scopus 로고    scopus 로고
    • Hypoxic-ischemic injury stimulates subventricular zone proliferation and neurogenesis in the neonatal rat
    • Ong, J.; Plane, J.M.; Parent, J.M.; Silverstein, F.S. Hypoxic-ischemic injury stimulates subventricular zone proliferation and neurogenesis in the neonatal rat. Pediatr. Res. 2005, 58, 600-606.
    • (2005) Pediatr. Res , vol.58 , pp. 600-606
    • Ong, J.1    Plane, J.M.2    Parent, J.M.3    Silverstein, F.S.4
  • 52
    • 77951621676 scopus 로고    scopus 로고
    • Mesenchymal stem cell treatment after neonatal hypoxic-ischemic brain injury improves behavioral outcome and induces neuronal and oligodendrocyte regeneration
    • Van Velthoven, C.T.; Kavelaars, A.; van Bel, F.; Heijnen, C.J. Mesenchymal stem cell treatment after neonatal hypoxic-ischemic brain injury improves behavioral outcome and induces neuronal and oligodendrocyte regeneration. Brain Behav. Immun. 2010, 24, 387-393.
    • (2010) Brain Behav. Immun , vol.24 , pp. 387-393
    • Van Velthoven, C.T.1    Kavelaars, A.2    Van Bel, F.3    Heijnen, C.J.4
  • 54
    • 84891745088 scopus 로고    scopus 로고
    • Historical landmarks of autophagy research
    • Ohsumi, Y. Historical landmarks of autophagy research. Cell. Res. 2014, 24, 9-23.
    • (2014) Cell. Res , vol.24 , pp. 9-23
    • Ohsumi, Y.1
  • 57
    • 84883370400 scopus 로고    scopus 로고
    • Neuroprotective effect of brain-derived neurotrophic factor mediated by autophagy through the pi3k/akt/mtor pathway
    • Chen, A.; Xiong, L.J.; Tong, Y.; Mao, M. Neuroprotective effect of brain-derived neurotrophic factor mediated by autophagy through the pi3k/akt/mtor pathway. Mol. Med. Rep. 2013, 8, 1011-1016.
    • (2013) Mol. Med. Rep , vol.8 , pp. 1011-1016
    • Chen, A.1    Xiong, L.J.2    Tong, Y.3    Mao, M.4
  • 58
    • 4644236077 scopus 로고    scopus 로고
    • Hypoxia-ischemia in the immature brain
    • Vannucci, S.J.; Hagberg, H. Hypoxia-ischemia in the immature brain. J. Exp. Biol. 2004, 207, 3149-3154.
    • (2004) J. Exp. Biol , vol.207 , pp. 3149-3154
    • Vannucci, S.J.1    Hagberg, H.2
  • 59
    • 70349292567 scopus 로고    scopus 로고
    • Are in vitro tests suitable for regulatory use?
    • Hartung, T.; Daston, G. Are in vitro tests suitable for regulatory use? Toxicol. Sci. 2009, 111, 233-237.
    • (2009) Toxicol. Sci , vol.111 , pp. 233-237
    • Hartung, T.1    Daston, G.2
  • 60
    • 25144513582 scopus 로고    scopus 로고
    • Recent highlights in the development of new antiviral drugs
    • De Clercq, E. Recent highlights in the development of new antiviral drugs. Curr. Opin. Microbiol. 2005, 8, 552-560.
    • (2005) Curr. Opin. Microbiol. , vol.8 , pp. 552-560
    • De Clercq, E.1
  • 62
    • 33749615999 scopus 로고    scopus 로고
    • Translation of research evidence from animals to humans
    • Hackam, D.G.; Redelmeier, D.A. Translation of research evidence from animals to humans. JAMA 2006, 296, 1731-1732.
    • (2006) JAMA , vol.296 , pp. 1731-1732
    • Hackam, D.G.1    Redelmeier, D.A.2
  • 65
    • 33846999907 scopus 로고    scopus 로고
    • Comparison of two neonatal ischemic injury models using magnetic resonance imaging
    • Ashwal, S.; Tone, B.; Tian, H.R.; Chong, S.; Obenaus, A. Comparison of two neonatal ischemic injury models using magnetic resonance imaging. Pediatr. Res. 2007, 61, 9-14.
    • (2007) Pediatr. Res , vol.61 , pp. 9-14
    • Ashwal, S.1    Tone, B.2    Tian, H.R.3    Chong, S.4    Obenaus, A.5
  • 66
    • 79952989816 scopus 로고    scopus 로고
    • A clinically relevant model of perinatal global ischemic brain damage in rats
    • Yang, T.; Zhuang, L.; Terrando, N.; Wu, X.; Jonhson, M.R.; Maze, M.; Ma, D. A clinically relevant model of perinatal global ischemic brain damage in rats. Brain Res. 2011, 1383, 317-323.
    • (2011) Brain Res , vol.1383 , pp. 317-323
    • Yang, T.1    Zhuang, L.2    Terrando, N.3    Wu, X.4    Jonhson, M.R.5    Maze, M.6    Ma, D.7
  • 67
    • 84891935497 scopus 로고    scopus 로고
    • Impact of perinatal systemic hypoxic-ischemic injury on the brain of male offspring rats: An improved model of neonatal hypoxic-ischemic encephalopathy in early preterm newborns
    • Huang, Y.; Lai, H.; Xu, H.; Wu, W.; Lai, X.; Ho, G.; Ma, L.; Chen, Y. Impact of perinatal systemic hypoxic-ischemic injury on the brain of male offspring rats: An improved model of neonatal hypoxic-ischemic encephalopathy in early preterm newborns. PLoS ONE 2013, 8, 82502.
    • (2013) Plos ONE , vol.8
    • Huang, Y.1    Lai, H.2    Xu, H.3    Wu, W.4    Lai, X.5    Ho, G.6    Ma, L.7    Chen, Y.8
  • 69
    • 29544443469 scopus 로고    scopus 로고
    • Brief update on animal models of hypoxic-ischemic encephalopathy and neonatal stroke
    • Northington, F.J. Brief update on animal models of hypoxic-ischemic encephalopathy and neonatal stroke. ILAR J. 2006, 47, 32-38.
    • (2006) ILAR J , vol.47 , pp. 32-38
    • Northington, F.J.1
  • 70
    • 84920860684 scopus 로고    scopus 로고
    • What are the best animal models for testing early intervention in cerebral palsy? Front
    • Clowry, G.J.; Basuodan, R.; Chan, F. What are the best animal models for testing early intervention in cerebral palsy? Front. Neurol. 2014, 5, 258.
    • (2014) Neurol , vol.5 , pp. 258
    • Clowry, G.J.1    Basuodan, R.2    Chan, F.3
  • 71
    • 85027955126 scopus 로고    scopus 로고
    • A reproducible and translatable model of focal ischemia in the visual cortex of infant and adult marmoset monkeys
    • Teo, L.; Bourne, J.A. A reproducible and translatable model of focal ischemia in the visual cortex of infant and adult marmoset monkeys. Brain Pathol. 2014, 24, 459-474.
    • (2014) Brain Pathol , vol.24 , pp. 459-474
    • Teo, L.1    Bourne, J.A.2
  • 72
    • 34548475597 scopus 로고    scopus 로고
    • How can we improve the pre-clinical development of drugs for stroke?
    • Sena, E.; van der Worp, H.B.; Howells, D.; Macleod, M. How can we improve the pre-clinical development of drugs for stroke? Trends Neurosci. 2007, 30, 433-439.
    • (2007) Trends Neurosci , vol.30 , pp. 433-439
    • Sena, E.1    Van Der Worp, H.B.2    Howells, D.3    Macleod, M.4
  • 74
    • 0032961564 scopus 로고    scopus 로고
    • Infarct volume as a surrogate or auxiliary outcome measure in ischemic stroke clinical trials
    • Saver, J.L.; Johnston, K.C.; Homer, D.; Wityk, R.; Koroshetz, W.; Truskowski, L.L.; Haley, E.C. Infarct volume as a surrogate or auxiliary outcome measure in ischemic stroke clinical trials. Stroke 1999, 30, 293-298.
    • (1999) Stroke , vol.30 , pp. 293-298
    • Saver, J.L.1    Johnston, K.C.2    Homer, D.3    Wityk, R.4    Koroshetz, W.5    Truskowski, L.L.6    Haley, E.C.7
  • 75
    • 0033667417 scopus 로고    scopus 로고
    • Effect of intravenous recombinant tissue plasminogen activator on ischemic stroke lesion size measured by computed tomography
    • The National Institute of Neurological Disorders and Stroke (Ninds) rt-pa Stroke Study Group. Effect of intravenous recombinant tissue plasminogen activator on ischemic stroke lesion size measured by computed tomography. Stroke 2000, 31, 2912-2919.
    • (2000) Stroke , vol.31 , pp. 2912-2919
  • 76
    • 25144439926 scopus 로고    scopus 로고
    • Methodological quality of animal studies on neuroprotection in focal cerebral ischaemia
    • Van der Worp, H.B.; de Haan, P.; Morrema, E.; Kalkman, C.J. Methodological quality of animal studies on neuroprotection in focal cerebral ischaemia. J. Neurol. 2005, 252, 1108-1114.
    • (2005) J. Neurol , vol.252 , pp. 1108-1114
    • Van Der Worp, H.B.1    De Haan, P.2    Morrema, E.3    Kalkman, C.J.4
  • 77
    • 34548722771 scopus 로고    scopus 로고
    • Replacing animal experiments: Choices, chances and challenges
    • Langley, G.; Evans, T.; Holgate, S.T.; Jones, A. Replacing animal experiments: Choices, chances and challenges. BioEssays 2007, 29, 918-926.
    • (2007) Bioessays , vol.29 , pp. 918-926
    • Langley, G.1    Evans, T.2    Holgate, S.T.3    Jones, A.4
  • 78
    • 77950572352 scopus 로고    scopus 로고
    • Publication bias in reports of animal stroke studies leads to major overstatement of efficacy
    • Sena, E.S.; van der Worp, H.B.; Bath, P.M.; Howells, D.W.; Macleod, M.R. Publication bias in reports of animal stroke studies leads to major overstatement of efficacy. PLoS Biol. 2010, 8, 1000344.
    • (2010) Plos Biol , vol.8
    • Sena, E.S.1    Van Der Worp, H.B.2    Bath, P.M.3    Howells, D.W.4    Macleod, M.R.5
  • 79
    • 84911881604 scopus 로고    scopus 로고
    • Drug delivery systems, cns protection, and the blood brain barrier
    • 2014
    • Upadhyay, R.K. Drug delivery systems, cns protection, and the blood brain barrier. Biomed. Res. Int. 2014, 2014, 869269.
    • (2014) Biomed. Res. Int
    • Upadhyay, R.K.1
  • 80
    • 25844469583 scopus 로고    scopus 로고
    • Drug metabolism and pharmacokinetics, the blood-brain barrier, and central nervous system drug discovery
    • Alavijeh, M.S.; Chishty, M.; Qaiser, M.Z.; Palmer, A.M. Drug metabolism and pharmacokinetics, the blood-brain barrier, and central nervous system drug discovery. NeuroRx 2005, 2, 554-571.
    • (2005) Neurorx , vol.2 , pp. 554-571
    • Alavijeh, M.S.1    Chishty, M.2    Qaiser, M.Z.3    Palmer, A.M.4
  • 81
    • 12344273726 scopus 로고    scopus 로고
    • The blood-brain barrier: Bottleneck in brain drug development
    • Pardridge, W.M. The blood-brain barrier: Bottleneck in brain drug development. NeuroRx 2005, 2, 3-14.
    • (2005) Neurorx , vol.2 , pp. 3-14
    • Pardridge, W.M.1
  • 84
    • 84902504729 scopus 로고    scopus 로고
    • Clinical pharmacology in neonates: Small size, huge variability
    • Allegaert, K.; van den Anker, J.N. Clinical pharmacology in neonates: Small size, huge variability. Neonatology 2014, 105, 344-349.
    • (2014) Neonatology , vol.105 , pp. 344-349
    • Allegaert, K.1    Van Den Anker, J.N.2
  • 85
    • 80054950146 scopus 로고    scopus 로고
    • Neonatal drug development
    • Turner, M.A. Neonatal drug development. Early Hum. Dev. 2011, 87, 763-768.
    • (2011) Early Hum. Dev , vol.87 , pp. 763-768
    • Turner, M.A.1
  • 86
    • 84856275096 scopus 로고    scopus 로고
    • Medication safety in neonates
    • Dabliz, R.; Levine, S. Medication safety in neonates. Am. J. Perinatol. 2012, 29, 49-56.
    • (2012) Am. J. Perinatol , vol.29 , pp. 49-56
    • Dabliz, R.1    Levine, S.2
  • 88
    • 84864692645 scopus 로고    scopus 로고
    • 'Formulating better medicines for children'—Still paving the road
    • Tuleu, C. 'Formulating better medicines for children'—Still paving the road. Int. J. Pharm. 2012, 435, 99-100.
    • (2012) Int. J. Pharm , vol.435 , pp. 99-100
    • Tuleu, C.1
  • 89
    • 83055172190 scopus 로고    scopus 로고
    • Clinical pharmacology in neonates and young infants: The benefit of a population-tailored approach
    • Van den Anker, J.; Allegaert, K. Clinical pharmacology in neonates and young infants: The benefit of a population-tailored approach. Exp. Rev. Clin. Pharmacol. 2012, 5, 5-8.
    • (2012) Exp. Rev. Clin. Pharmacol. , vol.5 , pp. 5-8
    • Van Den Anker, J.1    Allegaert, K.2
  • 90
    • 45549103783 scopus 로고    scopus 로고
    • Who wants safer medicines for children
    • Choonara, I. Who wants safer medicines for children. Arch. Dis. Child. 2008, 93, 456-457.
    • (2008) Arch. Dis. Child , vol.93 , pp. 456-457
    • Choonara, I.1
  • 91
    • 84864666274 scopus 로고    scopus 로고
    • The step (Safety and toxicity of excipients for paediatrics) database. Part 1—A need assessment study
    • Salunke, S.; Giacoia, G.; Tuleu, C. The step (safety and toxicity of excipients for paediatrics) database. Part 1—A need assessment study. Int. J. Pharm. 2012, 435, 101-111.
    • (2012) Int. J. Pharm , vol.435 , pp. 101-111
    • Salunke, S.1    Giacoia, G.2    Tuleu, C.3
  • 92
    • 70350462578 scopus 로고    scopus 로고
    • Safety of “inert” additives or excipients in paediatric medicines. Arch. Dis. child
    • Nahata, M.C. Safety of “inert” additives or excipients in paediatric medicines. Arch. Dis. child. Fetal Neonatal Ed. 2009, 94, 392-393.
    • (2009) Fetal Neonatal Ed , vol.94 , pp. 392-393
    • Nahata, M.C.1
  • 93
    • 84875983306 scopus 로고    scopus 로고
    • European study for neonatal excipient exposure (Esnee)
    • Turner, M.A.; Storme, T. European study for neonatal excipient exposure (esnee). Eur. J. Hosp. Pharm. 2012, 19, 67.
    • (2012) Eur. J. Hosp. Pharm , vol.19 , pp. 67
    • Turner, M.A.1    Storme, T.2
  • 94
    • 79952722818 scopus 로고    scopus 로고
    • Treatment advances in neonatal neuroprotection and neurointensive care
    • Johnston, M.V.; Fatemi, A.; Wilson, M.A.; Northington, F. Treatment advances in neonatal neuroprotection and neurointensive care. Lancet Neurol. 2011, 10, 372-382.
    • (2011) Lancet Neurol , vol.10 , pp. 372-382
    • Johnston, M.V.1    Fatemi, A.2    Wilson, M.A.3    Northington, F.4
  • 95
    • 0034455957 scopus 로고    scopus 로고
    • Osteopontin: A key cytokine in cell-mediated and granulomatous inflammation
    • O'Regan, A.; Berman, J.S. Osteopontin: A key cytokine in cell-mediated and granulomatous inflammation. Int. J. Exp. Pathol. 2000, 81, 373-390.
    • (2000) Int. J. Exp. Pathol , vol.81 , pp. 373-390
    • O'regan, A.1    Berman, J.S.2
  • 96
    • 0030811129 scopus 로고    scopus 로고
    • Microglial production of tnf-alpha is induced by activated T lymphocytes. Involvement of vla-4 and inhibition by interferonbeta-1b
    • Chabot, S.; Williams, G.; Yong, V.W. Microglial production of tnf-alpha is induced by activated T lymphocytes. Involvement of vla-4 and inhibition by interferonbeta-1b. J. Clin. Investig. 1997, 100, 604-612.
    • (1997) J. Clin. Investig. , vol.100 , pp. 604-612
    • Chabot, S.1    Williams, G.2    Yong, V.W.3
  • 97
    • 54249119561 scopus 로고    scopus 로고
    • Jnk signaling in apoptosis
    • Dhanasekaran, D.N.; Reddy, E.P. Jnk signaling in apoptosis. Oncogene 2008, 27, 6245-6251.
    • (2008) Oncogene , vol.27 , pp. 6245-6251
    • Dhanasekaran, D.N.1    Reddy, E.P.2
  • 98
    • 70349658528 scopus 로고    scopus 로고
    • Alternate pathways preserve tumor necrosis factor-alpha production after nuclear factor-kappab inhibition in neonatal cerebral hypoxia-ischemia
    • Nijboer, C.H.; Heijnen, C.J.; Groenendaal, F.; van Bel, F.; Kavelaars, A. Alternate pathways preserve tumor necrosis factor-alpha production after nuclear factor-kappab inhibition in neonatal cerebral hypoxia-ischemia. Stroke 2009, 40, 3362-3368.
    • (2009) Stroke , vol.40 , pp. 3362-3368
    • Nijboer, C.H.1    Heijnen, C.J.2    Groenendaal, F.3    Van Bel, F.4    Kavelaars, A.5
  • 99
    • 84876301610 scopus 로고    scopus 로고
    • Mitochondrial jnk phosphorylation as a novel therapeutic target to inhibit neuroinflammation and apoptosis after neonatal ischemic brain damage
    • Nijboer, C.H.; Bonestroo, H.J.; Zijlstra, J.; Kavelaars, A.; Heijnen, C.J. Mitochondrial jnk phosphorylation as a novel therapeutic target to inhibit neuroinflammation and apoptosis after neonatal ischemic brain damage. Neurobiol. Dis. 2013, 54, 432-444.
    • (2013) Neurobiol. Dis , vol.54 , pp. 432-444
    • Nijboer, C.H.1    Bonestroo, H.J.2    Zijlstra, J.3    Kavelaars, A.4    Heijnen, C.J.5
  • 100
    • 77955294343 scopus 로고    scopus 로고
    • Prophylactic phenobarbital and whole-body cooling for neonatal hypoxic-ischemic encephalopathy
    • Meyn, D.F., Jr.; Ness, J.; Ambalavanan, N.; Carlo, W.A. Prophylactic phenobarbital and whole-body cooling for neonatal hypoxic-ischemic encephalopathy. J. Pediatr. 2010, 157, 334-336.
    • (2010) J. Pediatr , vol.157 , pp. 334-336
    • Meyn, D.F.1    Ness, J.2    Ambalavanan, N.3    Carlo, W.A.4
  • 102
    • 39149129341 scopus 로고    scopus 로고
    • Melatonin protects from the long-term consequences of a neonatal hypoxic-ischemic brain injury in rats
    • Carloni, S.; Perrone, S.; Buonocore, G.; Longini, M.; Proietti, F.; Balduini, W. Melatonin protects from the long-term consequences of a neonatal hypoxic-ischemic brain injury in rats. J. Pineal. Res. 2008, 44, 157-164.
    • (2008) J. Pineal. Res , vol.44 , pp. 157-164
    • Carloni, S.1    Perrone, S.2    Buonocore, G.3    Longini, M.4    Proietti, F.5    Balduini, W.6
  • 105
    • 67049159768 scopus 로고    scopus 로고
    • Edaravone inhibits DNA peroxidation and neuronal cell death in neonatal hypoxic-ischemic encephalopathy model rat
    • Takizawa, Y.; Miyazawa, T.; Nonoyama, S.; Goto, Y.; Itoh, M. Edaravone inhibits DNA peroxidation and neuronal cell death in neonatal hypoxic-ischemic encephalopathy model rat. Pediatr. Res. 2009, 65, 636-641.
    • (2009) Pediatr. Res , vol.65 , pp. 636-641
    • Takizawa, Y.1    Miyazawa, T.2    Nonoyama, S.3    Goto, Y.4    Itoh, M.5
  • 107
    • 80255133262 scopus 로고    scopus 로고
    • Striatal neuroprotection from neonatal hypoxia-ischemia in piglets by antioxidant treatment with euk-134 or edaravone. Dev
    • Ni, X.; Yang, Z.J.; Carter, E.L.; Martin, L.J.; Koehler, R.C. Striatal neuroprotection from neonatal hypoxia-ischemia in piglets by antioxidant treatment with euk-134 or edaravone. Dev. Neurosci. 2011, 33, 299-311.
    • (2011) Neurosci , vol.33 , pp. 299-311
    • Ni, X.1    Yang, Z.J.2    Carter, E.L.3    Martin, L.J.4    Koehler, R.C.5
  • 109
    • 3042688444 scopus 로고    scopus 로고
    • Treatment of stroke with erythropoietin enhances neurogenesis and angiogenesis and improves neurological function in rats
    • Wang, L.; Zhang, Z.; Wang, Y.; Zhang, R.; Chopp, M. Treatment of stroke with erythropoietin enhances neurogenesis and angiogenesis and improves neurological function in rats. Stroke 2004, 35, 1732-1737.
    • (2004) Stroke , vol.35 , pp. 1732-1737
    • Wang, L.1    Zhang, Z.2    Wang, Y.3    Zhang, R.4    Chopp, M.5
  • 110
    • 84872055651 scopus 로고    scopus 로고
    • Hypothermia plus erythropoietin for neonatal neuroprotection? Commentary on Fan et al. and Fang et al
    • Juul, S.E. Hypothermia plus erythropoietin for neonatal neuroprotection? Commentary on Fan et al. and Fang et al. Pediatr. Res. 2013, 73, 10-11.
    • (2013) Pediatr. Res , vol.73 , pp. 10-11
    • Juul, S.E.1
  • 112
    • 24744444711 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1alpha and erythropoietin upregulation with deferoxamine salvage after neonatal stroke
    • Mu, D.; Chang, Y.S.; Vexler, Z.S.; Ferriero, D.M. Hypoxia-inducible factor 1alpha and erythropoietin upregulation with deferoxamine salvage after neonatal stroke. Exp. Neurol. 2005, 195, 407-415.
    • (2005) Exp. Neurol , vol.195 , pp. 407-415
    • Mu, D.1    Chang, Y.S.2    Vexler, Z.S.3    Ferriero, D.M.4
  • 113
    • 0027499214 scopus 로고
    • Allopurinol administered after inducing hypoxia-ischemia reduces brain injury in 7-day-old rats
    • Palmer, C.; Towfighi, J.; Roberts, R.L.; Heitjan, D.F. Allopurinol administered after inducing hypoxia-ischemia reduces brain injury in 7-day-old rats. Pediatr. Res. 1993, 33, 405-411.
    • (1993) Pediatr. Res , vol.33 , pp. 405-411
    • Palmer, C.1    Towfighi, J.2    Roberts, R.L.3    Heitjan, D.F.4
  • 115
    • 42049086535 scopus 로고    scopus 로고
    • Neuroprotective effects of xenon: A therapeutic window of opportunity in rats subjected to transient cerebral ischemia
    • David, H.N.; Haelewyn, B.; Rouillon, C.; Lecoq, M.; Chazalviel, L.; Apiou, G.; Risso, J.J.; Lemaire, M.; Abraini, J.H. Neuroprotective effects of xenon: A therapeutic window of opportunity in rats subjected to transient cerebral ischemia. FASEB J. 2008, 22, 1275-1286.
    • (2008) FASEB J , vol.22 , pp. 1275-1286
    • David, H.N.1    Haelewyn, B.2    Rouillon, C.3    Lecoq, M.4    Chazalviel, L.5    Apiou, G.6    Risso, J.J.7    Lemaire, M.8    Abraini, J.H.9
  • 117
    • 2342662620 scopus 로고    scopus 로고
    • Glutamate receptor-mediated oligodendrocyte toxicity in periventricular leukomalacia: A protective role for topiramate
    • Follett, P.L.; Deng, W.; Dai, W.; Talos, D.M.; Massillon, L.J.; Rosenberg, P.A.; Volpe, J.J.; Jensen, F.E. Glutamate receptor-mediated oligodendrocyte toxicity in periventricular leukomalacia: A protective role for topiramate. J. Neurosci. 2004, 24, 4412-4420.
    • (2004) J. Neurosci , vol.24 , pp. 4412-4420
    • Follett, P.L.1    Deng, W.2    Dai, W.3    Talos, D.M.4    Massillon, L.J.5    Rosenberg, P.A.6    Volpe, J.J.7    Jensen, F.E.8
  • 118
    • 1942436861 scopus 로고    scopus 로고
    • Topiramate selectively protects against seizures induced by atpa, a glur5 kainate receptor agonist
    • Kaminski, R.M.; Banerjee, M.; Rogawski, M.A. Topiramate selectively protects against seizures induced by atpa, a glur5 kainate receptor agonist. Neuropharmacology 2004, 46, 1097-1104.
    • (2004) Neuropharmacology , vol.46 , pp. 1097-1104
    • Kaminski, R.M.1    Banerjee, M.2    Rogawski, M.A.3
  • 119
    • 3042692042 scopus 로고    scopus 로고
    • Nbqx or topiramate treatment after perinatal hypoxia-induced seizures prevents later increases in seizure-induced neuronal injury
    • Koh, S.; Tibayan, F.D.; Simpson, J.N.; Jensen, F.E. Nbqx or topiramate treatment after perinatal hypoxia-induced seizures prevents later increases in seizure-induced neuronal injury. Epilepsia 2004, 45, 569-575.
    • (2004) Epilepsia , vol.45 , pp. 569-575
    • Koh, S.1    Tibayan, F.D.2    Simpson, J.N.3    Jensen, F.E.4
  • 120
    • 0030867764 scopus 로고    scopus 로고
    • Topiramate attenuates voltage-gated sodium currents in rat cerebellar granule cells
    • Zona, C.; Ciotti, M.T.; Avoli, M. Topiramate attenuates voltage-gated sodium currents in rat cerebellar granule cells. Neurosci. Lett. 1997, 231, 123-126.
    • (1997) Neurosci. Lett , vol.231 , pp. 123-126
    • Zona, C.1    Ciotti, M.T.2    Avoli, M.3
  • 122
    • 0034115766 scopus 로고    scopus 로고
    • Topiramate as an inhibitor of carbonic anhydrase isoenzymes
    • Dodgson, S.J.; Shank, R.P.; Maryanoff, B.E. Topiramate as an inhibitor of carbonic anhydrase isoenzymes. Epilepsia 2000, 41, 35-39.
    • (2000) Epilepsia , vol.41 , pp. 35-39
    • Dodgson, S.J.1    Shank, R.P.2    Maryanoff, B.E.3
  • 123
    • 10644267593 scopus 로고    scopus 로고
    • The mechanism of neuroprotection by topiramate in an animal model of epilepsy
    • Kudin, A.P.; Debska-Vielhaber, G.; Vielhaber, S.; Elger, C.E.; Kunz, W.S. The mechanism of neuroprotection by topiramate in an animal model of epilepsy. Epilepsia 2004, 45, 1478-1487.
    • (2004) Epilepsia , vol.45 , pp. 1478-1487
    • Kudin, A.P.1    Debska-Vielhaber, G.2    Vielhaber, S.3    Elger, C.E.4    Kunz, W.S.5
  • 124
    • 84866878763 scopus 로고    scopus 로고
    • Neuroprotective effects of melatonin administered alone or in combination with topiramate in neonatal hypoxic-ischemic rat model
    • Ozyener, F.; Cetinkaya, M.; Alkan, T.; Goren, B.; Kafa, I.M.; Kurt, M.A.; Koksal, N. Neuroprotective effects of melatonin administered alone or in combination with topiramate in neonatal hypoxic-ischemic rat model. Restor. Neurol. Neurosci. 2012, 30, 435-444.
    • (2012) Restor. Neurol. Neurosci , vol.30 , pp. 435-444
    • Ozyener, F.1    Cetinkaya, M.2    Alkan, T.3    Goren, B.4    Kafa, I.M.5    Kurt, M.A.6    Koksal, N.7
  • 127
    • 84883447310 scopus 로고    scopus 로고
    • Magnesium for newborns with hypoxic-ischemic encephalopathy: A systematic review and meta-analysis
    • Tagin, M.; Shah, P.S.; Lee, K.S. Magnesium for newborns with hypoxic-ischemic encephalopathy: A systematic review and meta-analysis. J. Perinatol. 2013, 33, 663-669.
    • (2013) J. Perinatol , vol.33 , pp. 663-669
    • Tagin, M.1    Shah, P.S.2    Lee, K.S.3
  • 128
    • 84922336600 scopus 로고    scopus 로고
    • One, two, three steps toward cell therapy for stroke
    • Diamandis, T.; Borlongan, C.V. One, two, three steps toward cell therapy for stroke. Stroke 2015, 46, 588-591.
    • (2015) Stroke , vol.46 , pp. 588-591
    • Diamandis, T.1    Borlongan, C.V.2
  • 131
    • 33750706917 scopus 로고    scopus 로고
    • Functional engraftment of human es cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes
    • Roy, N.S.; Cleren, C.; Singh, S.K.; Yang, L.; Beal, M.F.; Goldman, S.A. Functional engraftment of human es cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes. Nat. Med. 2006, 12, 1259-1268.
    • (2006) Nat. Med , vol.12 , pp. 1259-1268
    • Roy, N.S.1    Cleren, C.2    Singh, S.K.3    Yang, L.4    Beal, M.F.5    Goldman, S.A.6
  • 132
    • 33846705350 scopus 로고    scopus 로고
    • Cell transplantation therapy for stroke
    • Bliss, T.; Guzman, R.; Daadi, M.; Steinberg, G.K. Cell transplantation therapy for stroke. Stroke 2007, 38, 817-826.
    • (2007) Stroke , vol.38 , pp. 817-826
    • Bliss, T.1    Guzman, R.2    Daadi, M.3    Steinberg, G.K.4
  • 133
    • 84880201289 scopus 로고    scopus 로고
    • Rescuing the neonatal brain from hypoxic injury with autologous cord blood
    • Liao, Y.; Cotten, M.; Tan, S.; Kurtzberg, J.; Cairo, M.S. Rescuing the neonatal brain from hypoxic injury with autologous cord blood. Bone Marrow Transplant. 2013, 48, 890-900.
    • (2013) Bone Marrow Transplant , vol.48 , pp. 890-900
    • Liao, Y.1    Cotten, M.2    Tan, S.3    Kurtzberg, J.4    Cairo, M.S.5
  • 134
    • 0035021027 scopus 로고    scopus 로고
    • Osteopontin as a means to cope with environmental insults: Regulation of inflammation, tissue remodeling, and cell survival
    • Denhardt, D.T.; Noda, M.; O'Regan, A.W.; Pavlin, D.; Berman, J.S. Osteopontin as a means to cope with environmental insults: Regulation of inflammation, tissue remodeling, and cell survival. J. Clin. Investig. 2001, 107, 1055-1061.
    • (2001) J. Clin. Investig , vol.107 , pp. 1055-1061
    • Denhardt, D.T.1    Noda, M.2    O'regan, A.W.3    Pavlin, D.4    Berman, J.S.5
  • 136
    • 79961207409 scopus 로고    scopus 로고
    • Osteopontin enhances endogenous repair after neonatal hypoxic-ischemic brain injury
    • van Velthoven, C.T.; Heijnen, C.J.; van Bel, F.; Kavelaars, A. Osteopontin enhances endogenous repair after neonatal hypoxic-ischemic brain injury. Stroke 2011, 42, 2294-2301.
    • (2011) Stroke , vol.42 , pp. 2294-2301
    • Van Velthoven, C.T.1    Heijnen, C.J.2    Van Bel, F.3    Kavelaars, A.4
  • 137
    • 79952072254 scopus 로고    scopus 로고
    • Osteopontin reduced hypoxia-ischemia neonatal brain injury by suppression of apoptosis in a rat pup model
    • Chen, W.; Ma, Q.; Suzuki, H.; Hartman, R.; Tang, J.; Zhang, J.H. Osteopontin reduced hypoxia-ischemia neonatal brain injury by suppression of apoptosis in a rat pup model. Stroke 2011, 42, 764-769.
    • (2011) Stroke , vol.42 , pp. 764-769
    • Chen, W.1    Ma, Q.2    Suzuki, H.3    Hartman, R.4    Tang, J.5    Zhang, J.H.6
  • 138
    • 84928611414 scopus 로고    scopus 로고
    • The neonatal brain is not protected by osteopontin peptide treatment after hypoxia-ischemia. Dev
    • Bonestroo, H.J.; Nijboer, C.H.; van Velthoven, C.T.; van Bel, F.; Heijnen, C.J. The neonatal brain is not protected by osteopontin peptide treatment after hypoxia-ischemia. Dev. Neurosci. 2015, 37, 142-152.
    • (2015) Neurosci , vol.37 , pp. 142-152
    • Bonestroo, H.J.1    Nijboer, C.H.2    Van Velthoven, C.T.3    Van Bel, F.4    Heijnen, C.J.5
  • 140
    • 33645825163 scopus 로고    scopus 로고
    • Interferon-beta fails to protect in a model of transient focal stroke
    • Maier, C.M.; Yu, F.; Nishi, T.; Lathrop, S.J.; Chan, P.H. Interferon-beta fails to protect in a model of transient focal stroke. Stroke 2006, 37, 1116-1119.
    • (2006) Stroke , vol.37 , pp. 1116-1119
    • Maier, C.M.1    Yu, F.2    Nishi, T.3    Lathrop, S.J.4    Chan, P.H.5
  • 141
    • 1542269020 scopus 로고    scopus 로고
    • Targeting the jnk mapk cascade for inhibition: Basic science and therapeutic potential. Biochim. Biophys
    • Bogoyevitch, M.A.; Boehm, I.; Oakley, A.; Ketterman, A.J.; Barr, R.K. Targeting the jnk mapk cascade for inhibition: Basic science and therapeutic potential. Biochim. Biophys. Acta Prot. Proteom. 2004, 1697, 89-101.
    • (2004) Acta Prot. Proteom. , vol.1697 , pp. 89-101
    • Bogoyevitch, M.A.1    Boehm, I.2    Oakley, A.3    Ketterman, A.J.4    Barr, R.K.5
  • 142
    • 21344474327 scopus 로고    scopus 로고
    • From jnk to pay dirt: Jun kinases, their biochemistry, physiology and clinical importance
    • Karin, M.; Gallagher, E. From jnk to pay dirt: Jun kinases, their biochemistry, physiology and clinical importance. IUBMB Life 2005, 57, 283-295.
    • (2005) IUBMB Life , vol.57 , pp. 283-295
    • Karin, M.1    Gallagher, E.2
  • 143
    • 77953615910 scopus 로고    scopus 로고
    • Kavelaars, A. Inhibition of the jnk/ap-1 pathway reduces neuronal death and improves behavioral outcome after neonatal hypoxic-ischemic brain injury
    • Nijboer, C.H.; van der Kooij, M.A.; van Bel, F.; Ohl, F.; Heijnen, C.J.; Kavelaars, A. Inhibition of the jnk/ap-1 pathway reduces neuronal death and improves behavioral outcome after neonatal hypoxic-ischemic brain injury. Brain Behav. Immun. 2010, 24, 812-821.
    • (2010) Brain Behav. Immun , vol.24 , pp. 812-821
    • Nijboer, C.H.1    Van Der Kooij, M.A.2    Van Bel, F.3    Ohl, F.4    Heijnen, C.J.5
  • 146
    • 84929994405 scopus 로고    scopus 로고
    • What can you do to protect the newborn brain
    • Shea, K.L.; Palanisamy, A. What can you do to protect the newborn brain? Curr. Opin. Anaesthesiol. 2015, 28, 261-266.
    • (2015) Curr. Opin. Anaesthesiol , vol.28 , pp. 261-266
    • Shea, K.L.1    Palanisamy, A.2
  • 147
    • 27644520933 scopus 로고    scopus 로고
    • Short-term administration of a new free radical scavenger, edaravone, is more effective than its long-term administration for the treatment of neonatal hypoxic-ischemic encephalopathy
    • Noor, J.I.; Ikeda, T.; Mishima, K.; Aoo, N.; Ohta, S.; Egashira, N.; Iwasaki, K.; Fujiwara, M.; Ikenoue, T. Short-term administration of a new free radical scavenger, edaravone, is more effective than its long-term administration for the treatment of neonatal hypoxic-ischemic encephalopathy. Stroke 2005, 36, 2468-2474.
    • (2005) Stroke , vol.36 , pp. 2468-2474
    • Noor, J.I.1    Ikeda, T.2    Mishima, K.3    Aoo, N.4    Ohta, S.5    Egashira, N.6    Iwasaki, K.7    Fujiwara, M.8    Ikenoue, T.9
  • 148
    • 0032995001 scopus 로고    scopus 로고
    • Immunohistochemical localization of erythropoietin and its receptor in the developing human brain. Pediatr. Dev
    • Juul, S.E.; Yachnis, A.T.; Rojiani, A.M.; Christensen, R.D. Immunohistochemical localization of erythropoietin and its receptor in the developing human brain. Pediatr. Dev. Pathol. 1999, 2, 148-158.
    • (1999) Pathol , vol.2 , pp. 148-158
    • Juul, S.E.1    Yachnis, A.T.2    Rojiani, A.M.3    Christensen, R.D.4
  • 149
    • 1842613593 scopus 로고    scopus 로고
    • Erytropoietin concentrations in cerebrospinal fluid of nonhuman primates and fetal sheep following high-dose recombinant erythropoietin
    • Juul, S.E.; McPherson, R.J.; Farrell, F.X.; Jolliffe, L.; Ness, D.J.; Gleason, C.A. Erytropoietin concentrations in cerebrospinal fluid of nonhuman primates and fetal sheep following high-dose recombinant erythropoietin. Neonatology 2004, 85, 138-144.
    • (2004) Neonatology , vol.85 , pp. 138-144
    • Juul, S.E.1    McPherson, R.J.2    Farrell, F.X.3    Jolliffe, L.4    Ness, D.J.5    Gleason, C.A.6
  • 150
    • 67749137294 scopus 로고    scopus 로고
    • Erythropoietin improved neurologic outcomes in newborns with hypoxic-ischemic encephalopathy
    • Zhu, C.; Kang, W.; Xu, F.; Cheng, X.; Zhang, Z.; Jia, L.; Ji, L.; Guo, X.; Xiong, H.; Simbruner, G.; et al. Erythropoietin improved neurologic outcomes in newborns with hypoxic-ischemic encephalopathy. Pediatrics 2009, 124, 218-226.
    • (2009) Pediatrics , vol.124 , pp. 218-226
    • Zhu, C.1    Kang, W.2    Xu, F.3    Cheng, X.4    Zhang, Z.5    Jia, L.6    Ji, L.7    Guo, X.8    Xiong, H.9    Simbruner, G.10
  • 151
    • 0031012857 scopus 로고    scopus 로고
    • Hypoxia dramatically increases the nonspecific transport of blood-borne proteins to the brain
    • Plateel, M.; Teissier, E.; Cecchelli, R. Hypoxia dramatically increases the nonspecific transport of blood-borne proteins to the brain. J. Neurochem. 1997, 68, 874-877.
    • (1997) J. Neurochem , vol.68 , pp. 874-877
    • Plateel, M.1    Teissier, E.2    Cecchelli, R.3
  • 152
    • 34249048850 scopus 로고    scopus 로고
    • Pharmacokinetics of high-dose recombinant erythropoietin in plasma and brain of neonatal rats
    • Statler, P.A.; McPherson, R.J.; Bauer, L.A.; Kellert, B.A.; Juul, S.E. Pharmacokinetics of high-dose recombinant erythropoietin in plasma and brain of neonatal rats. Pediatr. Res. 2007, 61, 671-675.
    • (2007) Pediatr. Res. , vol.61 , pp. 671-675
    • Statler, P.A.1    McPherson, R.J.2    Bauer, L.A.3    Kellert, B.A.4    Juul, S.E.5
  • 155
    • 3042638808 scopus 로고    scopus 로고
    • Erythropoietin improves long-term spatial memory deficits and brain injury following neonatal hypoxia-ischemia in rats. Behav
    • Kumral, A.; Uysal, N.; Tugyan, K.; Sonmez, A.; Yilmaz, O.; Gokmen, N.; Kiray, M.; Genc, S.; Duman, N.; Koroglu, T.F. et al. Erythropoietin improves long-term spatial memory deficits and brain injury following neonatal hypoxia-ischemia in rats. Behav. Brain Res. 2004, 153, 77-86.
    • (2004) Brain Res , vol.153 , pp. 77-86
    • Kumral, A.1    Uysal, N.2    Tugyan, K.3    Sonmez, A.4    Yilmaz, O.5    Gokmen, N.6    Kiray, M.7    Genc, S.8    Duman, N.9    Koroglu, T.F.10
  • 156
    • 68349103103 scopus 로고    scopus 로고
    • Erythropoietin sustains cognitive function and brain volume after neonatal stroke
    • Gonzalez, F.F.; Abel, R.; Almli, C.R.; Mu, D.; Wendland, M.; Ferriero, D.M. Erythropoietin sustains cognitive function and brain volume after neonatal stroke. Dev. Neurosci. 2009, 31, 403-411.
    • (2009) Dev. Neurosci , vol.31 , pp. 403-411
    • Gonzalez, F.F.1    Abel, R.2    Almli, C.R.3    Mu, D.4    Wendland, M.5    Ferriero, D.M.6
  • 158
    • 84893714139 scopus 로고    scopus 로고
    • Outcomes of hypoxic-ischemic encephalopathy in neonates treated with hypothermia
    • Shankaran, S. Outcomes of hypoxic-ischemic encephalopathy in neonates treated with hypothermia. Clin. Perinatol. 2014, 41, 149-159.
    • (2014) Clin. Perinatol , vol.41 , pp. 149-159
    • Shankaran, S.1
  • 160
    • 38449110473 scopus 로고    scopus 로고
    • Glioblastoma multiforme cells: Expression of erythropoietin receptor and response to erythropoietin
    • Yin, D.; Kawabata, H.; Tcherniamtchouk, O.; Huynh, T.; Black, K.L.; Koeffler, H.P. Glioblastoma multiforme cells: Expression of erythropoietin receptor and response to erythropoietin. Int. J. Oncol. 2007, 31, 1193-1198.
    • (2007) Int. J. Oncol , vol.31 , pp. 1193-1198
    • Yin, D.1    Kawabata, H.2    Tcherniamtchouk, O.3    Huynh, T.4    Black, K.L.5    Koeffler, H.P.6
  • 161
    • 0035833541 scopus 로고    scopus 로고
    • Erythropoietin-mediated neuroprotection involves cross-talk between jak2 and nf-kappab signalling cascades
    • Digicaylioglu, M.; Lipton, S.A. Erythropoietin-mediated neuroprotection involves cross-talk between jak2 and nf-kappab signalling cascades. Nature 2001, 412, 641-647.
    • (2001) Nature , vol.412 , pp. 641-647
    • Digicaylioglu, M.1    Lipton, S.A.2
  • 162
    • 33644791801 scopus 로고    scopus 로고
    • Erythropoietin reduces perihematomal inflammation and cell death with enos and stat3 activations in experimental intracerebral hemorrhage
    • Lee, S.T.; Chu, K.; Sinn, D.I.; Jung, K.H.; Kim, E.H.; Kim, S.J.; Kim, J.M.; Ko, S.Y.; Kim, M.; Roh, J.K. Erythropoietin reduces perihematomal inflammation and cell death with enos and stat3 activations in experimental intracerebral hemorrhage. J. Neurochem. 2006, 96, 1728-1739.
    • (2006) J. Neurochem , vol.96 , pp. 1728-1739
    • Lee, S.T.1    Chu, K.2    Sinn, D.I.3    Jung, K.H.4    Kim, E.H.5    Kim, S.J.6    Kim, J.M.7    Ko, S.Y.8    Kim, M.9    Roh, J.K.10
  • 163
    • 29044435401 scopus 로고    scopus 로고
    • Erk-mediated production of neurotrophic factors by astrocytes promotes neuronal stem cell differentiation by erythropoietin
    • Park, M.H.; Lee, S.M.; Lee, J.W.; Son, D.J.; Moon, D.C.; Yoon, D.Y.; Hong, J.T. Erk-mediated production of neurotrophic factors by astrocytes promotes neuronal stem cell differentiation by erythropoietin. Biochem. Biophys. Res. Commun. 2006, 339, 1021-1028.
    • (2006) Biochem. Biophys. Res. Commun , vol.339 , pp. 1021-1028
    • Park, M.H.1    Lee, S.M.2    Lee, J.W.3    Son, D.J.4    Moon, D.C.5    Yoon, D.Y.6    Hong, J.T.7
  • 166
    • 84860837341 scopus 로고    scopus 로고
    • Long-term neuroprotective effects of allopurinol after moderate perinatal asphyxia: Follow-up of two randomised controlled trials. Arch. Dis. Child
    • Kaandorp, J.J.; van Bel, F.; Veen, S.; Derks, J.B.; Groenendaal, F.; Rijken, M.; Roze, E.; Venema, M.M.; Rademaker, C.M.; Bos, A.F. et al. Long-term neuroprotective effects of allopurinol after moderate perinatal asphyxia: Follow-up of two randomised controlled trials. Arch. Dis. Child. Fetal Neonatal Ed. 2012, 97, 162-166.
    • (2012) Fetal Neonatal Ed , vol.97 , pp. 162-166
    • Kaandorp, J.J.1    Van Bel, F.2    Veen, S.3    Derks, J.B.4    Groenendaal, F.5    Rijken, M.6    Roze, E.7    Venema, M.M.8    Rademaker, C.M.9    Bos, A.F.10
  • 167
    • 49949090854 scopus 로고    scopus 로고
    • Pharmacologic neuroprotection-is xenon the light at the end of the tunnel? Crit
    • Dworschak, M. Pharmacologic neuroprotection-is xenon the light at the end of the tunnel? Crit. Care Med. 2008, 36, 2477-2479.
    • (2008) Care Med , vol.36 , pp. 2477-2479
    • Dworschak, M.1
  • 169
    • 41149176603 scopus 로고    scopus 로고
    • Xenon and hypothermia combine additively, offering long-term functional and histopathologic neuroprotection after neonatal hypoxia/ischemia
    • Hobbs, C.; Thoresen, M.; Tucker, A.; Aquilina, K.; Chakkarapani, E.; Dingley, J. Xenon and hypothermia combine additively, offering long-term functional and histopathologic neuroprotection after neonatal hypoxia/ischemia. Stroke 2008, 39, 1307-1313.
    • (2008) Stroke , vol.39 , pp. 1307-1313
    • Hobbs, C.1    Thoresen, M.2    Tucker, A.3    Aquilina, K.4    Chakkarapani, E.5    Dingley, J.6
  • 170
    • 63949083970 scopus 로고    scopus 로고
    • Cooling combined with immediate or delayed xenon inhalation provides equivalent long-term neuroprotection after neonatal hypoxia-ischemia
    • Thoresen, M.; Hobbs, C.E.; Wood, T.; Chakkarapani, E.; Dingley, J. Cooling combined with immediate or delayed xenon inhalation provides equivalent long-term neuroprotection after neonatal hypoxia-ischemia. J. Cereb. Blood Flow Metab. 2009, 29, 707-714.
    • (2009) J. Cereb. Blood Flow Metab , vol.29 , pp. 707-714
    • Thoresen, M.1    Hobbs, C.E.2    Wood, T.3    Chakkarapani, E.4    Dingley, J.5
  • 173
    • 77955982977 scopus 로고    scopus 로고
    • Synergistic neuroprotective therapies with hypothermia. Semin
    • Cilio, M.R.; Ferriero, D.M. Synergistic neuroprotective therapies with hypothermia. Semin. Fetal Neonatal Med. 2010, 15, 293-298.
    • (2010) Fetal Neonatal Med , vol.15 , pp. 293-298
    • Cilio, M.R.1    Ferriero, D.M.2
  • 174
    • 33645828611 scopus 로고    scopus 로고
    • Topiramate and its clinical applications in epilepsy
    • Guerrini, R.; Parmeggiani, L. Topiramate and its clinical applications in epilepsy. Expert Opin. Pharmacother. 2006, 7, 811-823.
    • (2006) Expert Opin. Pharmacother , vol.7 , pp. 811-823
    • Guerrini, R.1    Parmeggiani, L.2
  • 176
    • 23844547177 scopus 로고    scopus 로고
    • Topiramate reduces ampa-induced Ca2+ transients and inhibits glur1 subunit phosphorylation in astrocytes from primary cultures
    • Angehagen, M.; Ronnback, L.; Hansson, E.; Ben-Menachem, E. Topiramate reduces ampa-induced Ca2+ transients and inhibits glur1 subunit phosphorylation in astrocytes from primary cultures. J. Neurochem. 2005, 94, 1124-1130.
    • (2005) J. Neurochem , vol.94 , pp. 1124-1130
    • Angehagen, M.1    Ronnback, L.2    Hansson, E.3    Ben-Menachem, E.4
  • 177
    • 27744597909 scopus 로고    scopus 로고
    • Topiramate prevents excitotoxic damage in the newborn rodent brain
    • Sfaello, I.; Baud, O.; Arzimanoglou, A.; Gressens, P. Topiramate prevents excitotoxic damage in the newborn rodent brain. Neurobiol. Dis. 2005, 20, 837-848.
    • (2005) Neurobiol. Dis , vol.20 , pp. 837-848
    • Sfaello, I.1    Baud, O.2    Arzimanoglou, A.3    Gressens, P.4
  • 178
    • 0026782947 scopus 로고
    • Evidence that the loss of the voltage-dependent Mg2+ block at the n-methyl-d-aspartate receptor underlies receptor activation during inhibition of neuronal metabolism
    • Zeevalk, G.D.; Nicklas, W.J. Evidence that the loss of the voltage-dependent Mg2+ block at the n-methyl-d-aspartate receptor underlies receptor activation during inhibition of neuronal metabolism. J. Neurochem. 1992, 59, 1211-1220.
    • (1992) J. Neurochem , vol.59 , pp. 1211-1220
    • Zeevalk, G.D.1    Nicklas, W.J.2
  • 180
    • 0028180241 scopus 로고
    • Protective effect of mgso4 infusion on nmda receptor binding characteristics during cerebral cortical hypoxia in the newborn piglet
    • Hoffman, D.J.; Marro, P.J.; McGowan, J.E.; Mishra, O.P.; Delivoria-Papadopoulos, M. Protective effect of mgso4 infusion on nmda receptor binding characteristics during cerebral cortical hypoxia in the newborn piglet. Brain Res. 1994, 644, 144-149.
    • (1994) Brain Res , vol.644 , pp. 144-149
    • Hoffman, D.J.1    Marro, P.J.2    McGowan, J.E.3    Mishra, O.P.4    Delivoria-Papadopoulos, M.5
  • 181
    • 77952932174 scopus 로고    scopus 로고
    • Effects of antenatal magnesium sulfate therapy on cerebral and systemic hemodynamics in preterm newborns
    • Shokry, M.; Elsedfy, G.O.; Bassiouny, M.M.; Anmin, M.; Abozid, H. Effects of antenatal magnesium sulfate therapy on cerebral and systemic hemodynamics in preterm newborns. Acta Obstet. Gynecol. Scand. 2010, 89, 801-806
    • (2010) Acta Obstet. Gynecol. Scand. , vol.89 , pp. 801-806
    • Shokry, M.1    Elsedfy, G.O.2    Bassiouny, M.M.3    Anmin, M.4    Abozid, H.5
  • 182
    • 0030638156 scopus 로고    scopus 로고
    • Magnesium sulfate therapy during asphyxia in near-term fetal lambs does not compromise the fetus but does not reduce cerebral injury
    • de Haan, H.H.; Gunn, A.J.; Williams, C.E.; Heymann, M.A.; Gluckman, P.D. Magnesium sulfate therapy during asphyxia in near-term fetal lambs does not compromise the fetus but does not reduce cerebral injury. Am. J. Obstet. Gynecol. 1997, 176, 18-27.
    • (1997) Am. J. Obstet. Gynecol. , vol.176 , pp. 18-27
    • De Haan, H.H.1    Gunn, A.J.2    Williams, C.E.3    Heymann, M.A.4    Gluckman, P.D.5
  • 184
    • 0033875197 scopus 로고    scopus 로고
    • Magnesium sulfate treatment after transient hypoxia-ischemia in the newborn piglet does not protect against cerebral damage
    • Greenwood, K.; Cox, P.; Mehmet, H.; Penrice, J.; Amess, P.N.; Cady, E.B.; Wyatt, J.S.; Edwards, A.D. Magnesium sulfate treatment after transient hypoxia-ischemia in the newborn piglet does not protect against cerebral damage. Pediatr. Res. 2000, 48, 346-350.
    • (2000) Pediatr. Res , vol.48 , pp. 346-350
    • Greenwood, K.1    Cox, P.2    Mehmet, H.3    Penrice, J.4    Amess, P.N.5    Cady, E.B.6    Wyatt, J.S.7    Edwards, A.D.8
  • 185
    • 84857228824 scopus 로고    scopus 로고
    • Significant clinical, neuropathological and behavioural recovery from acute spinal cord trauma by transplantation of a well-defined somatic stem cell from human umbilical cord blood
    • Schira, J.; Gasis, M.; Estrada, V.; Hendricks, M.; Schmitz, C.; Trapp, T.; Kruse, F.; Kogler, G.; Wernet, P.; Hartung, H.P.; et al. Significant clinical, neuropathological and behavioural recovery from acute spinal cord trauma by transplantation of a well-defined somatic stem cell from human umbilical cord blood. Brain 2012, 135, 431-446.
    • (2012) Brain , vol.135 , pp. 431-446
    • Schira, J.1    Gasis, M.2    Estrada, V.3    Hendricks, M.4    Schmitz, C.5    Trapp, T.6    Kruse, F.7    Kogler, G.8    Wernet, P.9    Hartung, H.P.10
  • 187
    • 77956333060 scopus 로고    scopus 로고
    • Differences in quality between privately and publicly banked umbilical cord blood units: A pilot study of autologous cord blood infusion in children with acquired neurologic disorders
    • Sun, J.; Allison, J.; McLaughlin, C.; Sledge, L.; Waters-Pick, B.; Wease, S.; Kurtzberg, J. Differences in quality between privately and publicly banked umbilical cord blood units: A pilot study of autologous cord blood infusion in children with acquired neurologic disorders. Transfusion 2010, 50, 1980-1987.
    • (2010) Transfusion , vol.50 , pp. 1980-1987
    • Sun, J.1    Allison, J.2    McLaughlin, C.3    Sledge, L.4    Waters-Pick, B.5    Wease, S.6    Kurtzberg, J.7
  • 189
    • 79960278364 scopus 로고    scopus 로고
    • Baby steps: A giant leap for cell therapy in neonatal brain injury
    • Borlongan, C.V.; Weiss, M.D. Baby steps: A giant leap for cell therapy in neonatal brain injury. Pediatr. Res. 2011, 70, 3-9.
    • (2011) Pediatr. Res , vol.70 , pp. 3-9
    • Borlongan, C.V.1    Weiss, M.D.2
  • 191
    • 20144386976 scopus 로고    scopus 로고
    • Implantation of encapsulated glial cell line-derived neurotrophic factor-secreting cells prevents long-lasting learning impairment following neonatal hypoxic-ischemic brain insult in rats
    • Katsuragi, S.; Ikeda, T.; Date, I.; Shingo, T.; Yasuhara, T.; Mishima, K.; Aoo, N.; Harada, K.; Egashira, N.; Iwasaki, K. et al. Implantation of encapsulated glial cell line-derived neurotrophic factor-secreting cells prevents long-lasting learning impairment following neonatal hypoxic-ischemic brain insult in rats. Am. J. Obstet. Gynecol. 2005, 192, 1028-1037.
    • (2005) Am. J. Obstet. Gynecol. , vol.192 , pp. 1028-1037
    • Katsuragi, S.1    Ikeda, T.2    Date, I.3    Shingo, T.4    Yasuhara, T.5    Mishima, K.6    Aoo, N.7    Harada, K.8    Egashira, N.9    Iwasaki, K.10
  • 192
    • 84930995293 scopus 로고    scopus 로고
    • Current and experimental pharmacological approaches in neonatal hypoxic-ischemic encephalopathy
    • Zalewska, T.; Jaworska, J.; Ziemka-Nalecz, M. Current and experimental pharmacological approaches in neonatal hypoxic-ischemic encephalopathy. Curr. Pharm. Des. 2015, 21, 1433-1439.
    • (2015) Curr. Pharm. Des , vol.21 , pp. 1433-1439
    • Zalewska, T.1    Jaworska, J.2    Ziemka-Nalecz, M.3
  • 193
    • 84870947198 scopus 로고    scopus 로고
    • Biomarkers of hypoxic-ischemic encephalopathy in newborns
    • Douglas-Escobar, M.; Weiss, M.D. Biomarkers of hypoxic-ischemic encephalopathy in newborns. Front. Neurol. 2012, 3, 144.
    • (2012) Front. Neurol , vol.3 , pp. 144
    • Douglas-Escobar, M.1    Weiss, M.D.2
  • 194
    • 77956058640 scopus 로고    scopus 로고
    • Potential biomarkers for hypoxic-ischemic encephalopathy
    • Bennet, L.; Booth, L.; Gunn, A.J. Potential biomarkers for hypoxic-ischemic encephalopathy. Semin. Fetal Neonatal Med. 2010, 15, 253-260.
    • (2010) Semin. Fetal Neonatal Med , vol.15 , pp. 253-260
    • Bennet, L.1    Booth, L.2    Gunn, A.J.3
  • 196
    • 79957818809 scopus 로고    scopus 로고
    • Human umbilical cord blood cells restore brain damage induced changes in rat somatosensory cortex
    • Geissler, M.; Dinse, H.R.; Neuhoff, S.; Kreikemeier, K.; Meier, C. Human umbilical cord blood cells restore brain damage induced changes in rat somatosensory cortex. PLoS ONE 2011, 6, 20194.
    • (2011) Plos ONE , vol.6 , pp. 20194
    • Geissler, M.1    Dinse, H.R.2    Neuhoff, S.3    Kreikemeier, K.4    Meier, C.5
  • 197
    • 77949617579 scopus 로고    scopus 로고
    • Human cord blood transplantation in a neonatal rat model of hypoxic-ischemic brain damage: Functional outcome related to neuroprotection in the striatum
    • Pimentel-Coelho, P.M.; Magalhães, E.S.; Lopes, L.M.; deAzevedo, L.C.; Santiago, M.F.; Mendez-Otero, R. Human cord blood transplantation in a neonatal rat model of hypoxic-ischemic brain damage: Functional outcome related to neuroprotection in the striatum. Stem Cells Dev. 2010, 19, 351-358.
    • (2010) Stem Cells Dev , vol.19 , pp. 351-358
    • Pimentel-Coelho, P.M.1    Magalhães, E.S.2    Lopes, L.M.3    Deazevedo, L.C.4    Santiago, M.F.5    Mendez-Otero, R.6
  • 198
    • 77953932135 scopus 로고    scopus 로고
    • Mannitol facilitates neurotrophic factor up-regulation and behavioural recovery in neonatal hypoxic-ischaemic rats with human umbilical cord blood grafts
    • Yasuhara, T.; Hara, K.; Maki, M.; Xu, L.; Yu, G.; Ali, M.M.; Masuda, T.; Yu, S.J.; Bae, E.K.; Hayashi, T. et al. Mannitol facilitates neurotrophic factor up-regulation and behavioural recovery in neonatal hypoxic-ischaemic rats with human umbilical cord blood grafts. J. Cell. Mol. Med. 2010, 14, 914-921.
    • (2010) J. Cell. Mol. Med. , vol.14 , pp. 914-921
    • Yasuhara, T.1    Hara, K.2    Maki, M.3    Xu, L.4    Yu, G.5    Ali, M.M.6    Masuda, T.7    Yu, S.J.8    Bae, E.K.9    Hayashi, T.10
  • 199
    • 67049155611 scopus 로고    scopus 로고
    • Hemispheric brain injury and behavioral deficits induced by severe neonatal hypoxia-ischemia in rats are not attenuated by intravenous administration of human umbilical cord blood cells
    • De Paula, S.; Vitola, A.S.; Greggio, S.; de Paula, D.; Mello, P.B.; Lubianca, J.M.; Xavier, L.L.; Fiori, H.H.; Dacosta, J.C. Hemispheric brain injury and behavioral deficits induced by severe neonatal hypoxia-ischemia in rats are not attenuated by intravenous administration of human umbilical cord blood cells. Pediatr. Res. 2009, 65, 631-635.
    • (2009) Pediatr. Res , vol.65 , pp. 631-635
    • De Paula, S.1    Vitola, A.S.2    Greggio, S.3    De Paula, D.4    Mello, P.B.5    Lubianca, J.M.6    Xavier, L.L.7    Fiori, H.H.8    Dacosta, J.C.9
  • 200
    • 84892764005 scopus 로고    scopus 로고
    • Intra-arterial transplantation of human umbilical cord blood mononuclear cells in neonatal hypoxic-ischemic rats
    • Greggio, S.; de Paula, S.; Azevedo, P.N.; Venturin, G.T.; Dacosta, J.C. Intra-arterial transplantation of human umbilical cord blood mononuclear cells in neonatal hypoxic-ischemic rats. Life Sci. 2014, 96, 33-39.
    • (2014) Life Sci , vol.96 , pp. 33-39
    • Greggio, S.1    De Paula, S.2    Azevedo, P.N.3    Venturin, G.T.4    Dacosta, J.C.5
  • 201
    • 84898022255 scopus 로고    scopus 로고
    • Umbilical cord blood cells regulate the differentiation of endogenous neural stem cells in hypoxic ischemic neonatal rats via the hedgehog signaling pathway
    • Wang, X.; Zhao, Y.; Wang, X. Umbilical cord blood cells regulate the differentiation of endogenous neural stem cells in hypoxic ischemic neonatal rats via the hedgehog signaling pathway. Brain Res. 2014, 1560, 18-26.
    • (2014) Brain Res , vol.1560 , pp. 18-26
    • Wang, X.1    Zhao, Y.2    Wang, X.3
  • 202
    • 33646572210 scopus 로고    scopus 로고
    • Behavioral and histological characterization of intrahippocampal grafts of human bone marrow-derived multipotent progenitor cells in neonatal rats with hypoxic-ischemic injury
    • Yasuhara, T.; Matsukawa, N.; Yu, G.; Xu, L.; Mays, R.W.; Kovach, J.; Deans, R.J.; Hess, D.C.; Carroll, J.E.; Borlongan, C.V. Behavioral and histological characterization of intrahippocampal grafts of human bone marrow-derived multipotent progenitor cells in neonatal rats with hypoxic-ischemic injury. Cell. Transplant. 2006, 15, 231-238.
    • (2006) Cell. Transplant , vol.15 , pp. 231-238
    • Yasuhara, T.1    Matsukawa, N.2    Yu, G.3    Xu, L.4    Mays, R.W.5    Kovach, J.6    Deans, R.J.7    Hess, D.C.8    Carroll, J.E.9    Borlongan, C.V.10
  • 203
    • 54949145003 scopus 로고    scopus 로고
    • Intravenous grafts recapitulate the neurorestoration afforded by intracerebrally delivered multipotent adult progenitor cells in neonatal hypoxic-ischemic rats
    • Yasuhara, T.; Hara, K.; Maki, M.; Mays, R.W.; Deans, R.J.; Hess, D.C.; Carroll, J.E.; Borlongan, C.V. Intravenous grafts recapitulate the neurorestoration afforded by intracerebrally delivered multipotent adult progenitor cells in neonatal hypoxic-ischemic rats. J. Cereb. Blood Flow Metab. 2008, 28, 1804-1810.
    • (2008) J. Cereb. Blood Flow Metab , vol.28 , pp. 1804-1810
    • Yasuhara, T.1    Hara, K.2    Maki, M.3    Mays, R.W.4    Deans, R.J.5    Hess, D.C.6    Carroll, J.E.7    Borlongan, C.V.8
  • 204
    • 77954736319 scopus 로고    scopus 로고
    • Repeated mesenchymal stem cell treatment after neonatal hypoxia-ischemia has distinct effects on formation and maturation of new neurons and oligodendrocytes leading to restoration of damage, corticospinal motor tract activity, and sensorimotor function
    • Van Velthoven, C.T.J.; Kavelaars, A.; van Bel, F.; Heijnen, C.J. Repeated mesenchymal stem cell treatment after neonatal hypoxia-ischemia has distinct effects on formation and maturation of new neurons and oligodendrocytes leading to restoration of damage, corticospinal motor tract activity, and sensorimotor function. J. Neurosci. 2010, 30, 9603-9611.
    • (2010) J. Neurosci , vol.30 , pp. 9603-9611
    • Van Velthoven, C.1    Kavelaars, A.2    Van Bel, F.3    Heijnen, C.J.4
  • 205
    • 77958450795 scopus 로고    scopus 로고
    • Nasal administration of stem cells: A promising novel route to treat neonatal ischemic brain damage. Pediatr
    • Van Velthoven, C.T.J.; Kavelaars, A.; van Bel, F.; Heijnen, C.J. Nasal administration of stem cells: A promising novel route to treat neonatal ischemic brain damage. Pediatr. Res. 2010, 68, 419-422.
    • (2010) Res , vol.68 , pp. 419-422
    • Van Velthoven, C.1    Kavelaars, A.2    Van Bel, F.3    Heijnen, C.J.4
  • 206
    • 84905252459 scopus 로고    scopus 로고
    • Intranasally administered mesenchymal stem cells promote a regenerative niche for repair of neonatal ischemic brain injury
    • Donega, V.; Nijboer, C.H.; van Tilborg, G.; Dijkhuizen, R.M.; Kavelaars, A.; Heijnen, C.J. Intranasally administered mesenchymal stem cells promote a regenerative niche for repair of neonatal ischemic brain injury. Exp. Neurol. 2014, 261, 53-64.
    • (2014) Exp. Neurol , vol.261 , pp. 53-64
    • Donega, V.1    Nijboer, C.H.2    Van Tilborg, G.3    Dijkhuizen, R.M.4    Kavelaars, A.5    Heijnen, C.J.6
  • 207
    • 84895431932 scopus 로고    scopus 로고
    • Therapeutic potential of genetically modified mesenchymal stem cells after neonatal hypoxic-ischemic brain damage
    • Van Velthoven, C.T.; Braccioli, L.; Willemen, H.L.; Kavelaars, A.; Heijnen, C.J. Therapeutic potential of genetically modified mesenchymal stem cells after neonatal hypoxic-ischemic brain damage. Mol. Ther. 2014, 22, 645-654.
    • (2014) Mol. Ther , vol.22 , pp. 645-654
    • Van Velthoven, C.T.1    Braccioli, L.2    Willemen, H.L.3    Kavelaars, A.4    Heijnen, C.J.5
  • 208
    • 81855194776 scopus 로고    scopus 로고
    • Dedifferentiation-reprogrammed mesenchymal stem cells with improved therapeutic potential
    • Liu, Y.; Jiang, X.; Zhang, X.; Chen, R.; Sun, T.; Fok, K.L.; Dong, J.; Tsang, L.L.; Yi, S.; Ruan, Y. et al. Dedifferentiation-reprogrammed mesenchymal stem cells with improved therapeutic potential. Stem Cells 2011, 29, 2077-2089.
    • (2011) Stem Cells , vol.29 , pp. 2077-2089
    • Liu, Y.1    Jiang, X.2    Zhang, X.3    Chen, R.4    Sun, T.5    Fok, K.L.6    Dong, J.7    Tsang, L.L.8    Yi, S.9    Ruan, Y.10
  • 209
    • 84865327142 scopus 로고    scopus 로고
    • Human umbilical cord blood-derived mesenchymal stem cell transplantation attenuates severe brain injury by permanent middle cerebral artery occlusion in newborn rats
    • Kim, E.S.; Ahn, S.Y.; Im, G.H.; Sung, D.K.; Park, Y.R.; Choi, S.H.; Choi, S.J.; Chang, Y.S.; Oh, W.; Lee, J.H. et al. Human umbilical cord blood-derived mesenchymal stem cell transplantation attenuates severe brain injury by permanent middle cerebral artery occlusion in newborn rats. Pediatr. Res. 2012, 72, 277-284.
    • (2012) Pediatr. Res , vol.72 , pp. 277-284
    • Kim, E.S.1    Ahn, S.Y.2    Im, G.H.3    Sung, D.K.4    Park, Y.R.5    Choi, S.H.6    Choi, S.J.7    Chang, Y.S.8    Oh, W.9    Lee, J.H.10
  • 210
    • 84929484644 scopus 로고    scopus 로고
    • Hypothermia augments neuroprotective activity of mesenchymal stem cells for neonatal hypoxic-ischemic encephalopathy
    • Park, W.S.; Sung, S.I.; Ahn, S.Y.; Yoo, H.S.; Sung, D.K.; Im, G.H.; Choi, S.J.; Chang, Y.S. Hypothermia augments neuroprotective activity of mesenchymal stem cells for neonatal hypoxic-ischemic encephalopathy. PLoS ONE 2015, 10, 120893.
    • (2015) Plos ONE , vol.10
    • Park, W.S.1    Sung, S.I.2    Ahn, S.Y.3    Yoo, H.S.4    Sung, D.K.5    Im, G.H.6    Choi, S.J.7    Chang, Y.S.8
  • 211
    • 77749267604 scopus 로고    scopus 로고
    • Intracerebral transplantation of mesenchymal stem cells derived from human umbilical cord blood alleviates hypoxic ischemic brain injury in rat neonates
    • Xia, G.; Hong, X.; Chen, X.; Lan, F.; Zhang, G.; Liao, L. Intracerebral transplantation of mesenchymal stem cells derived from human umbilical cord blood alleviates hypoxic ischemic brain injury in rat neonates. J. Perinat. Med. 2010, 38, 215-221.
    • (2010) J. Perinat. Med , vol.38 , pp. 215-221
    • Xia, G.1    Hong, X.2    Chen, X.3    Lan, F.4    Zhang, G.5    Liao, L.6
  • 212
    • 84888035155 scopus 로고    scopus 로고
    • Therapeutic effect of human umbilical cord mesenchymal stem cells on neonatal rat hypoxic-ischemic encephalopathy
    • Zhang, X.; Zhang, Q.; Li, W.; Nie, D.; Chen, W.; Xu, C.; Yi, X.; Shi, J.; Tian, M.; Qin, J. et al. Therapeutic effect of human umbilical cord mesenchymal stem cells on neonatal rat hypoxic-ischemic encephalopathy. J. Neurosci. Res. 2014, 92, 35-45.
    • (2014) J. Neurosci. Res. , vol.92 , pp. 35-45
    • Zhang, X.1    Zhang, Q.2    Li, W.3    Nie, D.4    Chen, W.5    Xu, C.6    Yi, X.7    Shi, J.8    Tian, M.9    Qin, J.10
  • 213
    • 73449112945 scopus 로고    scopus 로고
    • Mesenchymal stem-cell transplantation for hypoxic-ischemic brain injury in neonatal rat model
    • Lee, J.A.; Kim, B.I.; Jo, C.H.; Choi, C.W.; Kim, E.-K.; Kim, H.-S.; Yoon, K.-S.; Choi, J.-H. Mesenchymal stem-cell transplantation for hypoxic-ischemic brain injury in neonatal rat model. Pediatr. Res. 2010, 67, 42-46.
    • (2010) Pediatr. Res , vol.67 , pp. 42-46
    • Lee, J.A.1    Kim, B.I.2    Jo, C.H.3    Choi, C.W.4    Kim, E.-K.5    Kim, H.-S.6    Yoon, K.-S.7    Choi, J.-H.8
  • 214
    • 84872977245 scopus 로고    scopus 로고
    • Human dental pulp-derived stem cells protect against hypoxic-ischemic brain injury in neonatal mice
    • Yamagata, M.; Yamamoto, A.; Kako, E.; Kaneko, N.; Matsubara, K.; Sakai, K.; Sawamoto, K.; Ueda, M. Human dental pulp-derived stem cells protect against hypoxic-ischemic brain injury in neonatal mice. Stroke 2013, 44, 551-554.
    • (2013) Stroke , vol.44 , pp. 551-554
    • Yamagata, M.1    Yamamoto, A.2    Kako, E.3    Kaneko, N.4    Matsubara, K.5    Sakai, K.6    Sawamoto, K.7    Ueda, M.8
  • 215
    • 84879134488 scopus 로고    scopus 로고
    • Intraventricular injection of human dental pulp stem cells improves hypoxic-ischemic brain damage in neonatal rats
    • Fang, C.; Yang, Y.; Wang, Q.; Yao, Y.; Zhang, X.; He, X. Intraventricular injection of human dental pulp stem cells improves hypoxic-ischemic brain damage in neonatal rats. PLoS ONE 2013, 8, 66748.
    • (2013) Plos ONE , vol.8 , pp. 66748
    • Fang, C.1    Yang, Y.2    Wang, Q.3    Yao, Y.4    Zhang, X.5    He, X.6
  • 216
    • 0036842501 scopus 로고    scopus 로고
    • The injured brain interacts reciprocally with neural stem cells supported by scaffolds to reconstitute lost tissue
    • Park, K.I.; Teng, Y.D.; Snyder, E.Y. The injured brain interacts reciprocally with neural stem cells supported by scaffolds to reconstitute lost tissue. Nat. Biotechnol. 2002, 20, 1111-1117.
    • (2002) Nat. Biotechnol , vol.20 , pp. 1111-1117
    • Park, K.I.1    Teng, Y.D.2    Snyder, E.Y.3
  • 217
    • 33745018941 scopus 로고    scopus 로고
    • Neural stem cells may be uniquely suited for combined gene therapy and cell replacement: Evidence from engraftment of Neurotrophin-3-expressing stem cells in hypoxic-ischemic brain injury
    • Park, K.I.; Himes, B.T.; Stieg, P.E.; Tessler, A.; Fischer, I.; Snyder, E.Y. Neural stem cells may be uniquely suited for combined gene therapy and cell replacement: Evidence from engraftment of Neurotrophin-3-expressing stem cells in hypoxic-ischemic brain injury. Exp. Neurol. 2006, 199, 179-190.
    • (2006) Exp. Neurol , vol.199 , pp. 179-190
    • Park, K.I.1    Himes, B.T.2    Stieg, P.E.3    Tessler, A.4    Fischer, I.5    Snyder, E.Y.6
  • 218
    • 77649120565 scopus 로고    scopus 로고
    • Human neural stem cell grafts modify microglial response and enhance axonal sprouting in neonatal hypoxic-ischemic brain injury
    • Daadi, M.M.; Davis, A.S.; Arac, A.; Li, Z.; Maag, A.-L.; Bhatnagar, R.; Jiang, K.; Sun, G.; Wu, J.C.; Steinberg, G.K. Human neural stem cell grafts modify microglial response and enhance axonal sprouting in neonatal hypoxic-ischemic brain injury. Stroke 2010, 41, 516-523.
    • (2010) Stroke , vol.41 , pp. 516-523
    • Daadi, M.M.1    Davis, A.S.2    Arac, A.3    Li, Z.4    Maag, A.-L.5    Bhatnagar, R.6    Jiang, K.7    Sun, G.8    Wu, J.C.9    Steinberg, G.K.10
  • 219
  • 220
    • 84925874741 scopus 로고    scopus 로고
    • Neuroprotective effects of oligodendrocyte progenitor cell transplantation in premature rat brain following hypoxic-ischemic injury
    • Chen, L.-X.; Ma, S.-M.; Zhang, P.; Fan, Z.-C.; Xiong, M.; Cheng, G.-Q.; Yang, Y.; Qiu, Z.-L.; Zhou, W.-H.; Li, J. Neuroprotective effects of oligodendrocyte progenitor cell transplantation in premature rat brain following hypoxic-ischemic injury. PLoS ONE 2015, 10, 115997.
    • (2015) Plos ONE , vol.10
    • Chen, L.-X.1    Ma, S.-M.2    Zhang, P.3    Fan, Z.-C.4    Xiong, M.5    Cheng, G.-Q.6    Yang, Y.7    Qiu, Z.-L.8    Zhou, W.-H.9    Li, J.10


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