Biomarkers of hypoxic-ischemic encephalopathy in newborns

Frontiers in Neurology

Volumn NOV, Issue , 2012, Pages

  Douglas Escobar, Martha ^a,b   Weiss, Michael D ^a,b  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

Author keywords

Biomarkers; Brain injury; Hypoxic ischemic encephalopathy

Indexed keywords

EID: 84870947198     PISSN: None     EISSN: 16642295     Source Type: Journal    
DOI: 10.3389/fneur.2012.00144     Document Type: Article

References (44)

1. Azzopardi, D. V., Strohm, B., Edwards, A. D., Dyet, L., Halliday, H. L., Juszczak, E., et al. (2009). TOBY study group. Moderate hypothermia to treat perinatal asphyxial encephalopathy. N. Engl. J. Med. 361, 1349-1358.
2. Bejot, Y., Mossiat, C., Giroud, M., Prigent-Tessier, A., and Marie, C. (2011). Circulating and brain BDNF levels in stroke rats. Relevance to clinical studies. PLoS ONE 6,e29405. doi:10.1371/journal.pone.0029405
3. Bembea, M. M., Savage,W., Strouse, J. J., Schwartz,J. M.,Graham,E.,Thompson, C. B., et al. (2010). Glial fibrillary acidic protein as a brain injury biomarker in children undergoing extracorporeal membrane oxygenation. Pediatr. Crit. Care Med. 11, 723-730.
4. Berger, R. P., Adelson, P. D., Pierce, M. C., Dulani, T., Cassidy, L. D., and Kochanek, P. M. (2005). Serum neuron-specific enolase, S100B, and myelin basic protein concentrations after inflicted and non inflicted traumatic brain injury in children. J. Neurosurg. 103, 61-68.
5. Berger, R. P., Bazaco, M. C., Wagner, A. K., Kochanek, P. M., and Fabio, A. (2010). Trajectory analysis of serum biomarker concentrations facilitates outcome prediction after pediatric traumatic and hypoxemic brain injury. Dev. Neurosci. 32, 5-6.
6. Borghesani, P. R., Peyrin, J. M., Klein, R., Rubin, J., Carter, A. R., and Schwartz, P. M. (2002). BDNF stimulates migration of cerebellar granule cells. Development 129, 1435-1442.
7. Bouvier, D., Castellani, C., Fournier, M., Dauphin, J. B., Ughetto, S., Breton, M., et al. (2011). Reference ranges for serum S100B protein during the first three years of life. Clin. Biochem. 44, 927-929.
8. Celtik, C., Acunas, B., Oner, N., and Pala, O. (2004). Neuron-specific enolase as a marker of the severity and outcome of hypoxic ischemic encephalopathy. Brain Dev. 26, 398-402.
9. Chiesa, C., Pellegrini, G., Panero, A., De Luca, T., Assumma, M., Signore, F., et al. (2003). Umbilical cord interleukin-6 levels are elevated in term neonates with perinatal asphyxia. Eur. J. Clin. Invest. 33, 352-358.
10. Costine, B. A., Quebeda-Clerkin, P. B., Dodge, C. P., Harris, B. T., Hillier, S. C., and Duhaime, A. C. (2012). Neuron-specific enolase, but not S100B or myelin basic protein, increases in peripheral blood corresponding to lesion volume after cortical impact in piglets. J. Neurotrauma. PMID: 22867012. [Epub ahead of print].
11. Douglas-Escobar, M., Yang, C., Bennett, J., Shuster, J., Theriaque, D., Leibovici, A., et al. (2010). A pilot study of novel biomarkers in neonates with hypoxic-ischemic encephalopathy. Pediatr. Res. 68, 531-536.
12. Ennen, C. S., Huisman, T. A., Savage, W. J., Northington, F. J., Jennings, J. M., Everett, A. D., et al. (2011). Glial fibrillary acidic protein as a biomarker for neonatal hypoxic-ischemic encephalopathy treated with whole-body cooling. Am. J. Obstet. Gynecol. 205, e1-e7.
13. Finer,N. N.,Robertson,C. M.,Richards, R. T., Pinnell, L. E., and Peters, K. L. (1981). Hypoxic-ischemic encephalopathy in term neonates: perinatal factors and outcome. J. Pediatr. 98, 112-117.
14. Gazzolo, D., Abella, R., Frigiola, A., Giamberti, A., Tina, G., Nigro, F., et al. (2010). Neuromarkers and unconventional biological fluids. J. Matern. Fetal. Neonatal. Med. 23(Suppl. 3), 66-69.
15. Gazzolo, D., Frigiola, A., Bashir, M., Iskander, I., Mufeed, H., Aboulgar, H., et al. (2009). Diagnostic accuracy of S100B urinary testing at birth in full-term asphyxiated newborns to predict neonatal death. PLoS ONE 4, e4298. doi:10.1371/journal.pone.0004298
16. Gazzolo, D., Frulio, R., Roletti, A., Bruschettini, P., Lituania, M., and Michetti, F. (2007). S100A1B and S100BB urine levels in preterm and term healthy newborns. Clin. Chim. Acta 384, 186-187.
17. Gazzolo, D., Marinoni, E., Di Iorio, R., Bruschettini, M., Kornacka, M., Lituania, M., et al. (2004). Urinary S100B protein measurements: a tool for the early identification of hypoxic-ischemic encephalopathy in asphyxiated full-term infants. Crit. Care Med. 32, 131-136.
18. Gazzolo, D., and Michetti, F. (2010). Perinatal S100B protein assessment in human unconventional biological fluids: a minireview and new perspectives. Cardiovasc. Psychiatry Neurol. PMID: 20634930. [Epub ahead of print].
19. Giffard, R. G., Monyer, H., and Choi, D. W. (1990). Selective vulnerability of cultured cortical glia to injury by extracellular acidosis. Brain Res. 530, 138-141.
20. Gluckman, P. D., Wyatt, J. S., Azzopardi, D., Ballard, R., Edwards, A. D., Ferriero, D. M., et al. (2005). Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomized trial. Lancet 365, 663-670.
21. Hay, E., Royds, J. A., Davies-Jones, G. A., Lewtas, N. A., Timperley, W. R., and Taylor, C. B. (1984). Cerebrospinal fluid enolase in stroke. J. Neurol. Neurosurg. Psychiatr. 47, 724-729.
22. Hellstrom-Westas, L., Rosén, I., and Svenningsen, N. W. (1995). Predictive value of early continuous amplitude integrated EEG recordings on outcome after severe birth asphyxia in full term infants. Arch. Dis. Child. Fetal Neonatal Ed. 72, F34-F38.
23. Imam, S. S., Gad, G. I., Atef, S. H., and Shawky, M. A. (2009). Cord blood brain derived neurotrophic factor: diagnostic and prognostic marker in full term newborns with perinatal asphyxia. Pak. J. Biol. Sci. 12, 1498-1504.
24. Kaneko, T., Kasaoka, S., Miyauchi, T., Fujita, M., Oda, Y., Tsuruta, R., et al. (2009). Serum glial fibrillary acidic protein as a predictive biomarker of neurological outcome after cardiac arrest. Resuscitation 80, 790-794.
25. Ling, X., and Sylvester, K. (2011). Proteomics and biomarkers in neonatology. Neoreviews 12, 585-591.
26. Low, J. A., Lindsay, B. G., and Derrick, E. J. (1997). Threshold of metabolic acidosis associated with newborn complications. Am. J. Obstet. Gynecol. 177, 1391-1394.
27. Lumpkins, K. M., Bochicchio, G. V., Keledjian, K., Simard, J. M., McCunn, M., and Scalea, T. (2008). Glial fibrillary acidic protein is highly correlated with brain injury. J. Trauma. 65, 778-782; discussion 782-784.
28. MacDonald, H. M., Mulligan, J. C., Allen,A. C., and Taylor, P. M. (1980). Neonatal asphyxia. I. Relationship of obstetric and neonatal complications to neonatal mortality in 38,405 consecutive deliveries. J. Pediatr. 96, 898-902.
29. Marangos, P. J., Schmechel, D. E., Parma, A. M., and Goodwin, F. K. (1980). Developmental profile of neuron-specific (NSE) and nonneuronal (NNE) enolase. Brain Res. 190, 185-193.
30. Marangos, P. J., Campbell, I. C., Schmechel, D. E., Murphy, D. L., and Goodwin, F. K. (1980). Blood platelets contain a neuron-specific enolase subunit. J. Neurochem. 34, 1254-1258.
31. Mulligan, J. C., Painter, M. J., O'Donoghue, P. A., MacDonald, H. M., Allan, A. C., and Taylor, P. M. (1980). Neonatal asphyxia. II. Neonatal mortality and long-term sequelae. J. Pediatr. 96, 903-907.
32. Pelinka, L. E., Kroepfl, A., Leixnering, M., Buchinger, W., Raabe, A., and Redl, H. (2004). GFAP versus S100Binserumaftertraumaticbrain injury: relationship to brain damage and outcome. J. Neurotrauma 21, 1553-1561.
33. Pelinka, L. E., Kroepfl, A., Schmidhammer, R., Krenn, M., Buchinger, W., Redl, H., et al. (2004). Glial fibrillary acidic protein in serum after traumatic brain injury and multiple trauma. J. Trauma. 57, 1006-1012.
34. Qian, J., Zhou, D., and Wang, Y. W. (2009). Umbilical artery blood S100beta protein: a tool for the early identification of neonatal hypoxicischemic encephalopathy. Eur. J. Pediatr. 168, 71-77.
35. Ramaswamy, V., Horton, J., Vandermeer, B., Buscemi, N., Miller, S., and Yager, J. (2009). Systematic review of biomarkers of brain injury in term neonatal encephalopathy. Pediatr. Neurol. 40, 215-226.
36. Risso, F. M., Serpero, L. D., Zimmermann, L. J., Gavilanes, A. W., Frulio, R., Michetti, F., et al. (2011). Perinatal asphyxia: kidney failure does not affect S100B urine concentrations. Clin. Chim. Acta 18, 150-153.
37. Robertson, C. M., Finer, N. N., and Grace, M. G. (1989). School performance of survivors of neonatal encephalopathy associated with birth asphyxia at term. J. Pediatr. 114, 753-760.
38. Roine, R. O., Somer, H., Kaste, M., Viinikka, L., and Karonen, S. L. (1989). "Neurological outcome after out-of-hospital cardiac arrest. Prediction by cerebrospinal fluid enzyme analysis." Arch. Neurol. 46, 753-756.
39. Rundgren, M., Karlsson, T., Nielsen, N., Cronberg, T., Johnsson, P., and Friberg, H. (2009). Neuron specific enolase and S-100B as predictors of outcome after cardiac arrest and induced hypothermia. Resuscitation 80, 784-789.
40. Sarnat, H. B., and Sarnat, M. S. (1976). Neonatal encephalopathy following fetal distress. A clinical and electroencephalo graphic study. Arch. Neurol. 33, 696-705.
41. Schmitt, B., Bauersfeld, U., Schmid, E. R.,Tuchschmid,P.,Molinari,L.,Fanconi, S., et al. (1998). Serum and CSF levels of neuron-specific enolase (NSE) in cardiac surgery with cardiopulmonary bypass: a marker of brain injury? Brain Dev. 20,536-539.
42. Thoresen, M., Hellström-Westas, L., Liu, X., and de Vries, L. S. (2010). Effect of hypothermia on amplitude-integrated elec-troencephalogram in infants with asphyxia. Pediatrics 126, e131-e139.
43. Vannucci, R. (1997). "Hypoxia ischemia: pathogenesis and neuropathology," in NeonatalPerinatal Medicine: Diseases of the Fetus and Infant, 6th Edn, ed. A. Fanaroff (St. Louis, MO: Mosby), 856-891.
44. Vos, P. E., Lamers, K. J., Hendriks, J. C., van Haaren, M., Beems, T., Zimmerman, C., et al. (2004). Glial and neuronal proteins in serum predict outcome after severe traumatic brain injury. Neurology 62, 1303-1310.