Inhibition of the JNK/AP-1 pathway reduces neuronal death and improves behavioral outcome after neonatal hypoxic-ischemic brain injury

Brain, Behavior, and Immunity

Volumn 24, Issue 5, 2010, Pages 812-821

  Nijboer, Cora H ^a   van der Kooij, Michael A ^a   van Bel, Frank ^a   Ohl, Frauke ^b,c   Heijnen, Cobi J ^a   Kavelaars, Annemieke ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

AP 1; Apoptosis; Behavior; Calpain; Inflammation; JNK MAP kinase; Neonatal hypoxia ischemia; Neuroprotection; Smac DIABLO; Transduction peptide

Indexed keywords

CALPAIN; CASPASE 3; CASPASE 8; CASPASE 9; CHEMOKINE; CYTOCHROME C; CYTOKINE; FODRIN; PROTEIN BID; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; TAT JBD; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN HYPOXIA; BRAIN INJURY; BRAIN ISCHEMIA; CAROTID ARTERY OBSTRUCTION; CELL SURVIVAL; COGNITION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME RELEASE; GRAY MATTER; NERVE CELL NECROSIS; NEUROPROTECTION; NEWBORN; NEWBORN HYPOXIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; RAT; SENSORIMOTOR FUNCTION; SIGNAL TRANSDUCTION; TREATMENT OUTCOME; WHITE MATTER;

ANALYSIS OF VARIANCE; ANIMALS; APOPTOSIS; BEHAVIOR, ANIMAL; BLOTTING, WESTERN; BRAIN; CASPASE 3; CASPASE 9; ELECTROPHORETIC MOBILITY SHIFT ASSAY; HYPOXIA-ISCHEMIA, BRAIN; JNK MITOGEN-ACTIVATED PROTEIN KINASES; NEURONS; PEPTIDES; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; ROTAROD PERFORMANCE TEST; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1;

EID: 77953615910     PISSN: 08891591     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbi.2009.09.008     Document Type: Article

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