Effects of allopurinol and deferoxamine on reperfusion injury of the brain in newborn piglets after neonatal hypoxia-ischemia

Pediatric Research

Volumn 54, Issue 4, 2003, Pages 516-522

  Peeters Scholte, Cacha ^a   Braun, Kees ^c   Koster, Johanna ^a   Kops, Nicole ^a,b   Blomgren, Klas ^c   Buonocore, Giuseppe ^d   Van Buul Offers, Sylvia ^a   Hagberg, Henrik ^c   Nicolay, Klaas ^b   Van Bel, Frank ^a   Groenendaal, Floris ^a,e  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c UNIVERSITY OF GOTHENBURG   (Sweden)

^d UNIVERSITY OF SIENA   (Italy)

^e UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOPURINOL; CASPASE 3; CREATINE PHOSPHATE; DEFEROXAMINE; IRON CHELATE; PHOSPHATE; XANTHINE OXIDASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN EDEMA; BRAIN METABOLISM; CAROTID ARTERY OBSTRUCTION; CONTROLLED STUDY; DISEASE MODEL; DRUG EFFECT; ENERGY METABOLISM; ENZYME ACTIVITY; HISTOLOGY; HYPOTHERMIA; ISCHEMIA; NERVE CELL LESION; NEUROPROTECTION; NEWBORN; NEWBORN HYPOXIA; NICK END LABELING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; REOXYGENATION; REPERFUSION INJURY; SWINE; THALAMUS;

ALLOPURINOL; ANIMALS; ANIMALS, NEWBORN; BRAIN; CASPASE 3; CASPASES; DEFEROXAMINE; ENZYME INHIBITORS; HYPOXIA-ISCHEMIA, BRAIN; IN SITU NICK-END LABELING; IRON; IRON CHELATING AGENTS; MAGNETIC RESONANCE IMAGING; REPERFUSION INJURY; SWINE;

EID: 12444257000     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/01.PDR.0000081297.53793.C6     Document Type: Article

References (36)

1. Ferriero DM 2001 Oxidant mechanisms in neonatal hypoxia-ischemia. Dev Neurosci 23:198-202
2. Delivoria-Papadopoulos M, Mishra OP 1998 Mechanisms of cerebral injury in perinatal asphyxia and strategies for prevention. J Pediatr 132:S30-S34
3. Fellman V, Raivio KO 1997 Reperfusion injury as the mechanism of brain damage after perinatal asphyxia. Pediatr Res 41:599-606
4. Halliwell B 1989 Protection against tissue damage in vivo by desferrioxamine: what is its mechanism of action? Free Radic Biol Med 7:645-651
5. Gluckman PD, Williams CE 1992 When and why do brain cells die? Dev Med Child Neurol 34:1010-1014
6. Lorek A, Takei Y, Cady EB, Wyatt JS, Penrice J, Edwards AD, Peebles D, Wylezinska M, Owen Reece H, Kirkbride V, et al 1994 Delayed (" secondary") cerebral energy failure after acute hypoxia-ischemia in the newborn piglet: continuous 48-hour studies by phosphorus magnetic resonance spectroscopy. Pediatr Res 36:699-706
7. Shadid M, Moison R, Steendijk P, Hiltermann L, Berger HM, Van Bel F 1998 The effect of antioxidative combination therapy on post hypoxic-ischemic perfusion, metabolism, and electrical activity of the newborn brain. Pediatr Res 44:119-124
8. Van Bel F, Shadid M, Moison RMW, Dorrepaal CA, Fontijn J, Monteiro L, Van de Bor M, Berger HM 1998 Effect of allopurinol on postasphyxial free radical formation, cerebral hemodynamics, and electrical brain activity. Pediatrics 101:185-193
9. Marro PJ, McGowan JE, Razdan B, Mishra OP, Delivoria-Papadopoulos M 1994 Effect of allopurinol on uric acid levels and brain cell membrane Na+,K(+)-ATPase activity during hypoxia in newborn piglets. Brain Res 650:9-15
10. Palmer C, Towfighi J, Roberts RL, Heitjan DF 1993 Allopurinol administered after inducing hypoxia-ischemia reduces brain injury in 7-day-old rats. Pediatr Res 33:405-411
11. Hurn PD, Koehler RC, Blizzard KK, Traystman RJ 1995 Deferoxamine reduces early metabolic failure associated with severe cerebral ischemic acidosis in dogs. Stroke 26:688-694
12. Peeters-Scholte C, Koster JG, Veldhuis W, van den Tweel E, Zhu C, Kops N, Blomgren K, Bär D, van Buul-Offers SC, Hagberg H, Nicolay K, Van Bel F, Groenendaal F 2002 Neuroprotection by selective nitric oxide synthase inhibition at 24 hours after perinatal hypoxia-ischemia. Stroke 33:2304-2310
13. Naressi A, Couturier C, Devos JM, Janssen M, Mangeat C, de Beer R, Graveron-Demilly D 2001 Java-based graphical user interface for the MRUI quantitation package. MAGMA 12:141-152
14. Wung WE, Howell SB 1980 Simultaneous liquid chromatography of 5-fluorouracil, uridine, hypoxanthine, xanthine, uric acid, allopurinol, and oxipurinol in plasma. Clin Chem 26:1704-1708
15. Whitaker JR, Granum PE 1980 An absolute method for protein determination based on difference in absorbance at 235 and 280 nm. Anal Biochem 109:156-159
16. Kime R, Gibson A, Yong W, Hider R, Powers H 1996 Chromatographic method for the determination of non-transferrin-bound iron suitable for use on the plasma and bronchoalveolar lavage fluid of preterm babies. Clin Sci (Lond) 91:633-638
17. Felix B, Leger ME, Albe-Fessard D, Marcilloux JC, Rampin O, Laplace JP 1999 Stereotaxic atlas of the pig brain. Brain Res Bull 49:1-137
18. Peeters-Scholte C, van den Tweel E, Ioroi T, Post I, Braun K, Veldhuis W, Nicolay K, Groenendaal F, Van Bel F 2002 Pharmacological interventions in the newborn piglet in the first 24h after hypoxia-ischaemia: a haemodynamic and electrophysiological perspective. Exp Brain Res 147:200-208
19. Williams GD, Palmer C, Heitjan DF, Smith MB 1992 Allopurinol preserves cerebral energy metabolism during perinatal hypoxia-ischemia: a 31P NMR study in unanesthetized immature rats. Neurosci Lett 144:103-106
20. Palmer C, Vannucci RC, Towfighi J 1990 Reduction of perinatal hypoxic-ischemic brain damage with allopurinol. Pediatr Res 27:332-336.
21. Betz AL 1985 Identification of hypoxanthine transport and xanthine oxidase activity in brain capillaries. J Neurochem 44:574-579
22. Phillis JW, Sen S 1993 Oxypurinol attenuates hydroxyl radical production during ischemia/reperfusion injury of the rat cerebral cortex: an ESR study. Brain Res 628:309-312
23. Moorhouse PC, Grootveld M, Halliwell B, Quinlan JG, Gutteridge JM 1987 Allopurinol and oxypurinol are hydroxyl radical scavengers. FEBS Lett 213:23-28
24. Hudome S, Palmer C, Roberts RL, Mauger D, Housman C, Towfighi J 1997 The role of neutrophils in the production of hypoxic-ischemic brain injury in the neonatal rat. Pediatr Res 41:607-616
25. Ko KM, Godin DV 1990 Inhibition of transition metal ion-catalysed ascorbate oxidation and lipid peroxidation by allopurinol and oxypurinol. Biochem Pharmacol 40:803-809
26. Peterson DA, Kelly B, Gerrard JM 1986 Allopurinol can act as an electron transfer agent. Is this relevant during reperfusion injury? Biochem Biophys Res Commun 137:76-79
27. Lebon V, Petersen KF, Cline GW, Shen J, Mason GF, Dufour S, Behar KL, Shulman GI, Rothman DL 2002 Astroglial contribution to brain energy metabolism in humans revealed by 13C nuclear magnetic resonance spectroscopy: elucidation of the dominant pathway for neurotransmitter glutamate repletion and measurement of astrocytic oxidative metabolism. J Neurosci 22:1523-1531
28. Palmer C, Roberts RL, Bero C 1994 Deferoxamine posttreatment reduces ischemic brain injury in neonatal rats. Stroke 25:1039-1045
29. Feng Y, LeBlanc MH, LeBlanc EB, Parker CC, Fratkin JD, Qian XB, Patel DM, Huang M, Smith EE, Vig PJ 2000 Desmethyl tirilazad improves neurologic function after hypoxic ischemic brain injury in piglets. Crit Care Med 28:1431-1438
30. Cable H, Lloyd JB 1999 Cellular uptake and release of two contrasting iron chelators. J Pharm Pharmacol 51:131-134
31. Shadid M, Buonocore. G, Groenendaal F, Moison R, Ferrali M, Berger HM, Van Bel F 1998 Effect of deferoxamine and allopurinol on non-protein-bound iron concentrations in plasma and cortical brain tissue of newborn lambs following hypoxiaischemia. Neurosci Lett 248:5-8
32. deLemos RA, Roberts RJ, Coalson JJ, deLemos JA, Null Jr DM, Gerstmann DR 1990 Toxic effects associated with the administration of deferoxamine in the premature baboon with hyaline membrane disease. Am J Dis Child 144:915-919
33. Varani J, Dame MK, Diaz M, Stoolman L 1996 Deferoxamine interferes with adhesive functions of activated human neutrophils. Shock 5:395-401
34. Groenendaal F, Shadid M, McGowan JE, Mishra OP, Van Bel F 2000 Effects of deferoxamine, a chelator of free iron, on Na+,K+-ATPase activity of cortical brain cell membrane during early reperfusion after hypoxia-ischemia in newborn lambs. Pediatr Res 48:560-564
35. Dorrepaal CA, Berger HM, Benders MJ, Zoeren-Grobben D, Van deBor M, Van Bel F 1996 Nonprotein-bound iron in postasphyxial reperfusion injury of the newborn. Pediatrics 98:883-889
36. Weber E, Allegrini PR, Sauer D 1993 Assessment of infarct volume in the mouse brain: correlation of magnetic resonance imaging with morphometry. In Vivo 7:335-338