Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis

Journal of Experimental Medicine

Volumn 198, Issue 6, 2003, Pages 971-975

  Villa, Pia ^a,b   Bigini, Paolo ^a   Mennini, Tiziana ^a   Agnello, Davide ^a   Laragione, Teresa ^a   Cagnotto, Alfredo ^a   Viviani, Barbara ^a   Marinovich, Marina ^c   Cerami, Anthony ^d   Coleman, Thomas R ^d   Brines, Michael ^d   Ghezzi, Pietro ^a,d  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b CNR   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

^d Kenneth S Warren Institute   (United States)

Author keywords

Apoptosis; Erythropoietin; Inflammation; Ischemia; Stroke

Indexed keywords

CYTOKINE; ERYTHROPOIETIN RECEPTOR; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MONOCYTE CHEMOTACTIC PROTEIN 1; RECOMBINANT ERYTHROPOIETIN; TIN DERIVATIVE; TRIMETHYLTIN CHLORIDE; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASTROCYTE; BRAIN ISCHEMIA; CELL ACTIVATION; CELL LOSS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG RECEPTOR BINDING; GLIA; HORMONE ACTION; HUMAN; HUMAN CELL; IMMUNOPHARMACOLOGY; INFLAMMATION; INFLAMMATORY CELL; LEUKOCYTE ACTIVATION; LEUKOCYTE MIGRATION; MALE; MICROGLIA; MIDDLE CEREBRAL ARTERY OCCLUSION; MONONUCLEAR CELL; MOUSE; NERVE CELL NECROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STROKE;

ANIMALS; APOPTOSIS; BRAIN ISCHEMIA; CELLS, CULTURED; COCULTURE TECHNIQUES; CYTOKINES; ERYTHROPOIETIN; HUMANS; INFARCTION, MIDDLE CEREBRAL ARTERY; INFLAMMATION; LIPOPOLYSACCHARIDES; MALE; NEUROGLIA; NEURONS; NEUROPROTECTIVE AGENTS; RATS; RECEPTORS, ERYTHROPOIETIN; RECOMBINANT PROTEINS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0141784841     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20021067     Document Type: Article

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