Feasibility of autologous cord blood cells for infants with hypoxic-ischemic encephalopathy

Journal of Pediatrics

Volumn 164, Issue 5, 2014, Pages

  Cotten, C Michael ^a   Murtha, Amy P ^b   Goldberg, Ronald N ^a   Grotegut, Chad A ^b   Smith, P Brian ^a   Goldstein, Ricki F ^a   Fisher, Kimberley A ^a   Gustafson, Kathryn E ^b   Waters Pick, Barbara ^c   Swamy, Geeta K ^b   Rattray, Benjamin ^a   Tan, Siddhartha ^d   Kurtzberg, Joanne ^b  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c DUKE UNIVERSITY HOSPITAL   (United States)

^d NORTHSHORE UNIVERSITY HEALTHSYSTEM   (United States)

Author keywords

Bayley III; Bayley Scales of Infant and Toddler Development, III edition; Carolinas Cord Blood Bank; CCBB; Cerebral palsy; CP; Dimethyl sulfoxide; DMSO; DUH; DUHS; Duke University Health System; Duke University hospital; Eunice Kennedy Shriver National Institute of Child Health and Human Development; FDA; Food and Drug Administration; HIE; Hypoxic ischemic encephalopathy; ICN; IND; Intensive care nursery; Investigational new drug; Maternal fetal medicine; MFM; NICHD; RBC; Red blood cell; SCL; Stem Cell Laboratory; UCB; Umbilical cord blood

Indexed keywords

ARTICLE; AUTOLOGOUS STEM CELL TRANSPLANTATION; BAYLEY SCALES OF INFANT DEVELOPMENT; CLINICAL ARTICLE; COGNITIVE DEVELOPMENT; COOLING; CORD BLOOD STEM CELL TRANSPLANTATION; ERYTHROCYTE; FEMALE; HOSPITAL DISCHARGE; HUMAN; HYPOXIC ISCHEMIC ENCEPHALOPATHY; INFANT; INTENSIVE CARE; LANGUAGE DEVELOPMENT; MALE; MOTOR DEVELOPMENT; NEWBORN; OPEN STUDY; OXYGEN SATURATION; POSTNATAL CARE; PRIORITY JOURNAL; SURVIVAL RATE; UMBILICAL CORD BLOOD; VITAL SIGN;

CHILD, PRESCHOOL; COMBINED MODALITY THERAPY; CORD BLOOD STEM CELL TRANSPLANTATION; DEVELOPMENTAL DISABILITIES; FEASIBILITY STUDIES; FEMALE; FOLLOW-UP STUDIES; HUMANS; HYPOTHERMIA, INDUCED; HYPOXIA-ISCHEMIA, BRAIN; INFANT; INFANT, NEWBORN; INFANT, PREMATURE; INFANT, PREMATURE, DISEASES; MALE; PILOT PROJECTS; SEVERITY OF ILLNESS INDEX; TRANSPLANTATION, AUTOLOGOUS; TREATMENT OUTCOME;

EID: 84899065815     PISSN: 00223476     EISSN: 10976833     Source Type: Journal    
DOI: 10.1016/j.jpeds.2013.11.036     Document Type: Article

References (37)

1. P.D. Gluckman, J.S. Wyatt, D. Azzopardi, D. Ballard, A.D. Edwards, and D.M. Ferriero Selective head cooling with mild systemic hypothermia to improve neurodevelopmental outcome following neonatal encephalopathy Lancet 365 2005 663 670
2. S. Shankaran, A.R. Laptook, R.A. Ehrenkranz, J.E. Tyson, S.A. McDonald, and E.F. Donovan et al. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy N Engl J Med 35 2005 1574 1584
3. D.V. Azzopardi, B. Strohm, A.D. Edwards, L. Dyet, H.L. Halliday, and E. Juszczak et al. Moderate hypothermia to treat perinatal asphyxial encephalopathy N Engl J Med 361 2009 1349 1358
4. S.E. Jacobs, C.J. Morley, T.E. Inder, M.J. Stewart, K.R. Smith, and P.J. McNamara et al. Whole-body hypothermia for term and near-term newborns with hypoxic-ischemic encephalopathy: a randomized controlled trial Arch Pediatr Adolesc Med 165 2011 692 700
5. S.L. Bonifacio, H.C. Glass, S. Peloquin, and D.M. Ferriero A new neurological focus in neonatal intensive care Nat Rev Neurol 7 2011 485 494
6. A.J. Gunn, and T.R. Gunn The pharmacology of neuronal rescue with cerebral hypothermia Early Hum Dev 53 1998 19 35
7. F.J. Northington, M.E. Zelaya, D.P. O'Riordan, K. Blomgren, D.L. Flock, and H. Hagberg et al. Failure to complete apoptosis following neonatal hypoxia-ischemia manifests as "continuum" phenotype of cell death and occurs with multiple manifestations of mitochondrial dysfunction in rodent forebrain Neuroscience 149 2007 822 833
8. S.P. Miller, and D.M. Ferriero From selective vulnerability to connectivity: insights from newborn brain imaging Trends Neurosci 32 2009 496 505
9. J.R. Sanchez-Ramos, S. Song, S.G. Kamath, T. Zigova, A. Willing, and F. Cardozo-Pelaez et al. Expression of neural markers in human umbilical cord blood Exp Neurol 171 2001 109 115
10. L. Buzańska, E.K. Machaj, B. Zabłocka, Z. Pojda, and K. Domańska-Janik Human cord blood-derived cells attain neuronal and glial features in vitro J Cell Sci 115 2002 2131 2138
11. E. Tracy, J. Aldrink, J. Panosian, D. Beam, J. Thacker, and M. Reese et al. Isolation of oligodendrocyte-like cells from human umbilical cord blood Cytotherapy 10 2008 518 525
12. S.L. Staba, M.L. Escolar, M. Poe, Y. Kim, P.L. Martin, and P. Szabolcs et al. Cord-blood transplants from unrelated donors in patients with Hurler's syndrome N Engl J Med 350 2004 1960 1969
13. M.L. Escolar, M.D. Poe, J.M. Provenzale, K.C. Richards, J. Allison, and S. Wood et al. Transplantation of umbilical-cord blood in babies with infantile Krabbe's disease N Engl J Med 352 2005 2069 2081
14. C. Meier, J. Middelanis, B. Wasielewski, S. Neuhoff, A. Roth-Haerer, and M. Gantert et al. Spastic paresis after perinatal brain damage in rats is reduced by human cord blood mononuclear cells Pediatr Res 59 2006 244 249
15. P.M. Pimentel-Coelho, E.S. Magalhaes, L.M. Lopes, L.C. deAzevedo, M.F. Santiago, and R. Mendez-Otero Human cord blood transplantation in a neonatal rat model of hypoxic-ischemic brain damage: functional outcome related to neuroprotection in the striatum Stem Cells Dev 19 2010 351 358
16. T. Yasuhara, K. Hara, M. Maki, L. Xu, G. Yu, and M.M. Ali et al. Mannitol facilitates neurotrophic factor up-regulation and behavioral recovery in neonatal hypoxic-ischemic rats with human umbilical cord blood grafts J Cell Mol Med 14 2010 914 921
17. M. Geissler, H.R. Dinse, S. Neuhoff, K. Kreikemeier, and C. Meier Human umbilical cord blood cells restore brain damage induced changes in rat somatosensory cortex PLoS One 6 2011 e20194
18. K. Rosenkranz, and C. Meier Umbilical cord blood cell transplantation after brain ischemia - from recovery of function to cellular mechanisms Ann Anat 193 2011 371 379
19. L. Bennet, S. Tan, L. Van den Heuij, M. Derrick, F. Groenendaal, and F. van Bel et al. Cell therapy for neonatal hypoxia-ischemia and cerebral palsy Ann Neurol 71 2012 589 600
20. Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network website: Available at: https://neonatal.rti.org/pdf/StudySummary/Hypothermia/Manual.pdf. Accessed December 17, 2013.
21. J. Kurtzberg, A.D. Lyerly, and J. Sugarman Untying the Gordian knot: policies, practices, and ethical issues related to banking of umbilical cord blood J Clin Invest 115 2005 2592 2597
22. N. Bayley Bayley Scales of Infant and Toddler Development III ed. 2006 The Psychological Corporation San Antonio, TX
23. N. Ambalavanan, W.A. Carlo, S. Shankaran, C.M. Bann, S.L. Emrich, and R.D. Higgins et al. Predicting outcomes of neonates diagnosed with hypoxemic-ischemic encephalopathy Pediatrics 118 2006 2084 2093
24. I.E. Olsen, S.A. Groveman, M.L. Lawson, R.H. Clark, and B. Zemel New intrauterine growth curves based on united states data Pediatrics 125 2010 e214 e224
25. C.T. van Velthoven, A. Kavelaars, F. van Bel, and C.J. Heijnen Mesenchymal stem cell treatment after neonatal hypoxic-ischemic brain injury improves behavioral outcome and induces neuronal and oligodendrocyte regeneration Brain Behav Immun 24 2010 387 393
26. S. de Paula, A.S. Vitola, S. Greggio, D. de Paula, P.B. Mello, and J.M. Lubianca et al. Hemispheric brain injury and behavioral deficits induced by severe neonatal hypoxia-ischemia in rats are not attenuated by intravenous administration of human umbilical cord blood cells Pediatr Res 65 2009 631 635
27. S. de Paula, S. Greggio, D.R. Marinowic, D.C. Machado, and J.C. DaCosta The dose-response effect of acute intravenous transplantation of human umbilical cord blood cells on brain damage and spatial memory deficits in neonatal hypoxia-ischemia Neuroscience 210 2012 431 441
28. B. Wasielewski, A. Jensen, A. Roth-Härer, R. Dermietzel, and C. Meier Neuroglial activation and Cx43 expression are reduced upon transplantation of human umbilical cord blood cells after perinatal hypoxic-ischemic injury Brain Res 1487 2012 39 53
29. K. Rosenkranz, S. Kumbruch, M. Tenbusch, K. Marcus, K. Marschner, and R. Dermietzel et al. Transplantation of human umbilical cord blood cells mediated beneficial effects on apoptosis, angiogenesis, and neuronal survival after hypoxic-ischemic brain injury in rats Cell Tissue Res 348 2012 429 438
30. J. Sun, J. Allison, C. McLaughlin, L. Sledge, B. Waters-Pick, and S. Wease et al. Differences in quality between privately and publicly banked umbilical cord blood units: a pilot study of autologous cord blood infusion in children with acquired neurologic disorders Transfusion 50 2010 1980 1987
31. K.I. Papadopoulos, S.S. Low, T.C. Aw, and T. Chantarojanasiri Safety and feasibility of autologous umbilical cord blood transfusion in 2 toddlers with cerebral palsy and the role of low dose granulocyte colony stimulating factor injections Restor Neurol Neurosci 29 2011 17 22
32. K. Min, J. Song, J.Y. Kang, J. Ko, J.S. Ryu, and M.S. Kang et al. Umbilical cord blood therapy potentiated with erythropoietin for children with cerebral palsy: a double-blind, randomized, placebo-controlled trial Stem Cells 31 2013 581 591
33. V. Donega, C.T. van Velthoven, C.H. Nijboer, F. van Bel, M.J. Kas, and A. Kavelaars et al. Intranasal mesenchymal stem cell treatment for neonatal brain damage: long-term cognitive and sensorimotor improvement PLoS One 8 2013 e51253
34. R.H. Lee, A.A. Pulin, M.J. Seo, D.J. Kota, J. Ylostalo, and B.L. Larson et al. Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6 Cell Stem Cell 5 2009 54 63
35. L. Wang, H. Ji, J. Zhou, J. Xie, Z. Zhong, and M. Li et al. Therapeutic potential of umbilical cord mesenchymal stromal cells transplantation for cerebral palsy: a case report Case Rep Transplant 2013 2013 146347
36. C. Purandare, D.G. Shitole, V. Belle, A. Kedari, N. Bora, and M. Joshi Therapeutic potential of autologous stem cell transplantation for cerebral palsy Case Rep Transplant 2012 2012 825289 10.1155/2012/825289
37. A.D. Edwards, P. Brocklehurst, A.J. Gunn, H. Halliday, E. Juszczak, and M. Levene et al. Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic-ischemic encephalopathy: synthesis and meta-analysis of trial data BMJ 340 2010 c363