Long-term neuroprotective effects of allopurinol after moderate perinatal asphyxia: Follow-up of two randomised controlled trials

Archives of Disease in Childhood: Fetal and Neonatal Edition

Volumn 97, Issue 3, 2012, Pages

  Kaandorp, Joepe J ^a   Van Bel, Frank ^a   Veen, Sylvia ^b   Derks, Jan B ^a   Groenendaal, Floris ^a   Rijken, Monique ^b   Roze, Elise ^c   Uniken Venema, Monica M A ^a   Rademaker, Carin M A ^a   Bos, Arend F ^c   Benders, Manon J N L ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOPURINOL;

ARTICLE; CHILD; CONTROLLED STUDY; DISEASE SEVERITY; ELECTROENCEPHALOGRAPHY; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; NEUROLOGIC EXAMINATION; NEUROPROTECTION; PERINATAL ASPHYXIA; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; TREATMENT OUTCOME;

ALLOPURINOL; ASPHYXIA NEONATORUM; BIRTH WEIGHT; DEVELOPMENTAL DISABILITIES; FEMALE; FOLLOW-UP STUDIES; FREE RADICAL SCAVENGERS; GESTATIONAL AGE; HUMANS; HYPOXIA-ISCHEMIA, BRAIN; INFANT, NEWBORN; INTELLIGENCE; MALE; NEUROPROTECTIVE AGENTS; NEUROPSYCHOLOGICAL TESTS; REPERFUSION INJURY; TREATMENT OUTCOME;

EID: 84860837341     PISSN: 13592998     EISSN: 14682052     Source Type: Journal    
DOI: 10.1136/archdischild-2011-300356     Document Type: Article

References (27)

1. Ferriero DM. Neonatal brain injury. N Engl J Med 2004;351:1985-95.
2. McCord JM. Oxygen-derived free radicals in postischemic tissue injury. N Engl J Med 1985;312:159-63. (Pubitemid 15192863)
3. van Bel F, Groenendaal F. Long-term pharmacologic neuroprotection after birth asphyxia: where do we stand? Neonatology 2008; 94:203-10.
4. Palmer C, Towfighi J, Roberts RL, et al. Allopurinol administered after inducing hypoxia-ischemia reduces brain injury in 7-day-old rats. Pediatr Res 1993;33:405-11. (Pubitemid 23095775)
5. Fan X, van Bel F. Pharmacological neuroprotection after perinatal asphyxia. J Matern Fetal Neonatal Med 2010;23 Suppl 3:17-19.
6. Chaudhari T, McGuire W. Allopurinol for preventing mortality and morbidity in newborn infants with suspected hypoxic-ischaemic encephalopathy. Cochrane Database Syst Rev 2008;2:CD006817.
7. Gluckman PD, Wyatt JS, Azzopardi D, et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial. Lancet 2005;365:663-70. (Pubitemid 40260887)
8. Shankaran S, Laptook AR. Hypothermia as a treatment for birth asphyxia. Clin Obstet Gynecol 2007;50:624-35. (Pubitemid 47357239)
9. Edwards AD, Brocklehurst P, Gunn AJ, et al. Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: synthesis and meta-analysis of trial data. BMJ 2010;340:c363.
10. Jacobs S, Hunt R, Tarnow-Mordi W, et al. Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane Database Syst Rev 2007;4:CD003311.
11. Van Bel F, Shadid M, Moison RM, et al. Effect of allopurinol on postasphyxial free radical formation, cerebral hemodynamics, and electrical brain activity. Pediatrics 1998;101:185-93. (Pubitemid 28076649)
12. Benders MJ, Bos AF, Rademaker CM, et al. Early postnatal allopurinol does not improve short term outcome after severe birth asphyxia. Arch Dis Child Fetal Neonatal Ed 2006;91:F163-5. (Pubitemid 43667611)
13. Peeters-Scholte C, van den Tweel E, Groenendaal F, et al. Redox state of near infrared spectroscopy-measured cytochrome aa(3) correlates with delayed cerebral energy failure following perinatal hypoxia-ischaemia in the newborn pig. Exp Brain Res 2004;156:20-6. (Pubitemid 38680139)
14. Russell GA, Cooke RW. Randomised controlled trial of allopurinol prophylaxis in very preterm infants. Arch Dis Child Fetal Neonatal Ed 1995;73:F27-31.
15. Gunes T, Ozturk MA, Koklu E, et al. Effect of allopurinol supplementation on nitric oxide levels in asphyxiated newborns. Pediatr Neurol 2007;36:17-24. (Pubitemid 46437231)
16. Toet MC, Hellström-Westas L, Groenendaal F, et al. Amplitude integrated EEG 3 and 6 hours after birth in full term neonates with hypoxic-ischaemic encephalopathy. Arch Dis Child Fetal Neonatal Ed 1999;81:F19-23.
17. Toet MC, Lemmers PM, van Schelven LJ, et al. Cerebral oxygenation and electrical activity after birth asphyxia: their relation to outcome. Pediatrics 2006;117:333-9 (Pubitemid 46071596)
18. Wechsler D. Wechsler Preschool and Primary Scale of Intelligence. Third edition (WPPSI-III). San Antonio, TX: PsychCorp 2002.
19. van Iterson L, Kaufman AS. Intra-individual subtest variability on the Dutch Wechsler Intelligence Scales for Children-Revised (WISC-R(NL)) for children with learning disabilities, psychiatric disorders, and epilepsy. Psychol Rep 2009;105:995-1008.
20. Resing W, Blok J. De classificatie van intelligentiescores: voorstel voor een eenduidig systeem. De Psycholoog 2002;37:244-8.
21. van Haastert IC, de Vries LS, Eijsermans MJ, et al. Gross motor functional abilities in preterm-born children with cerebral palsy due to periventricular leukomalacia. Dev Med Child Neurol 2008;50:684-9.
22. Palisano R, Rosenbaum P, Walter S, et al. Development and reliability of a system to classify gross motor function in children with cerebral palsy. Dev Med Child Neurol 1997;39:214-23. (Pubitemid 27226331)
23. Cito. Mission and Core values. http://www.cito.com/about-cito/mission- and-core-values.aspx (accessed September 2011).
24. de Vries LS, Hellström-Westas L. Role of cerebral function monitoring in the newborn. Arch Dis Child Fetal Neonatal Ed 2005;90:F201-7.
25. Boda D, Németh P, Kiss P, et al. Treatment of mothers with allopurinol to produce therapeutic blood levels in newborns. Prenat Neonat Med 1999;4:130-4.
26. Torrance HL, Benders MJ, Derks JB, et al. Maternal allopurinol during fetal hypoxia lowers cord blood levels of the brain injury marker S-100B. Pediatrics 2009;124:350-7.
27. Kaandorp JJ, Benders MJ, Rademaker CM, et al. Antenatal allopurinol for reduction of birth asphyxia induced brain damage (ALLO-Trial); a randomized double blind placebo controlled multicenter study. BMC Pregnancy Childbirth 2010;10:8.