Edaravone inhibits lipid peroxidation in neonatal hypoxic-ischemic rats: An in vivo microdialysis study

Neuroscience Letters

Volumn 414, Issue 1, 2007, Pages 5-9

  Noor, Jesmin I ^a   Ueda, Yuto ^a   Ikeda, Tomoaki ^a   Ikenoue, Tsuyomu ^a  

^a UNIVERSITY OF MIYAZAKI   (Japan)

Author keywords

Edaravone; Lipid free radicals; Microdialysis; Neonatal hypoxic ischemic brain damage; POBN

Indexed keywords

N TERT BUTYL ALPHA (4 PYRIDYL 1 OXIDE) NITRONE; NORPHENAZONE; OXYGEN; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN ISCHEMIA; BRAIN PROTECTION; CAROTID ARTERY LIGATION; COMMON CAROTID ARTERY; CONTROLLED STUDY; DNA ADDUCT; DOSE RESPONSE; DRUG EFFECT; DRUG INHIBITION; ELECTRON SPIN RESONANCE; FEMALE; HIPPOCAMPUS; IN VIVO STUDY; LIPID PEROXIDATION; MICRODIALYSIS; MOLECULAR PROBE; NEWBORN; NEWBORN HYPOXIA; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL NOISE RATIO; SIGNAL PROCESSING; THERAPY EFFECT; TREATMENT OUTCOME; TREATMENT RESPONSE;

ANIMALS; ANIMALS, NEWBORN; ANTIPYRINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRON SPIN RESONANCE SPECTROSCOPY; EXTRACELLULAR FLUID; FREE RADICAL SCAVENGERS; FREE RADICALS; HIPPOCAMPUS; HYPOXIA-ISCHEMIA, BRAIN; LIPID PEROXIDATION; MICRODIALYSIS; NERVE DEGENERATION; OXIDATIVE STRESS; PYRIDINES; RATS; RATS, WISTAR; TREATMENT OUTCOME;

EID: 33846940208     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2006.10.024     Document Type: Article

References (24)

1. Connor H.D., Fischer V., and Mason R.P. A search for oxygen-centered free radicals in the lipoxygenase/linoleic acid system. Biochem. Biophys. Res. Commun. 141 (1986) 614-621
2. Giuseppe B., Serefina P., and Radolfo B. Free radicals and brain damage in the newborn. Biol. Neonate 79 (2001) 180-186
3. Goda Y., and Marnett L.J. High-performance liquid chromatography with electrochemical detection for determination of the major malonaldehyde-guanine adduct. Chem. Res. Toxicol. 4 (1991) 520-524
4. Halliwell B., and Gutteridge J.M. Oxygen free radicals and iron in relation to biology and medicine: some problems and concepts. Arch. Biochem. Biophys. 246 (1986) 501-514
5. Ikeda T., Xia Y.X., Kaneko M., Sameshima H., and Ikenoue T. Effect of the free radical scavenger, 3-methyl-1phenyl-2pyrazolin-5-one (MCI-186), on hypoxia-ischemia-induced brain injury in neonatal rats. Neurosci. Lett. 329 (2002) 33-36
6. Knight J.A., Pieper R.K., and McClellan L. Specificity of the thiobarbituric acid reaction: its use in studies of lipid peroxidation. Clin. Chem. 34 (1998) 2433-2438
7. Kosugi H., and Kikugwa K. Potential thiobarbituric acid-reactive substances in peroxidized lipids. Free Radic. Biol. Ad. Med. 7 (1989) 205-207
8. Kusaka T., Matsuura S., Fujikawa Y., Okubo K., Kawada K., Namba M., Okada H., Imai T., Isobe K., and Itoh S. Relationship between cerebral interstitial levels of amino acids and phosphorylation potential during secondary energy failure in hypoxic-ischemic newborn piglets. Pediatr. Res. 55 (2004) 273-279
9. Mishra O.P., and Delivoria-Papadopoulos M. Cellular mechanism of hypoxic injury in the developing brain. Brain Res. Bull. 48 (1998) 233-238
10. Monje M.L., Chatten-Brown J., Hye S.E., and Raley-Susman K.M. Free radicals are involved in the damage to protein synthesis after anoxia/aglycemia and NMDA exposure. Brain Res. 857 (2000) 172-182
11. Mortola J.P., and Dotta A. Effects of hypoxia and ambient temperature on gaseous metabolism of newborn rats. Am. J. Physio. 263 (1992) R267-R272
12. Nakahara D., Ozaki N., Miura Y., Miura H., and Nagatsu T. Increased dopamine and serotonin metabolism in rat nucleus accumbens produced by intracranial self-stimulation of medial forebrain bundle as measured by in vivo microdialysis. Brain Res. 495 (1989) 178-181
13. Noor J.I., Ikeda T., Mishima K., Aoo N., Ohta S., Egashira N., Iwasaki K., Fujiwara M., and Ikenoue T. Short-term administration of a new free radical scavenger, edaravone, is more effective than its long-term administration for the treatment of neonatal hypoxic-ischemic encephalopathy. Stroke 36 (2005) 2468-2474
14. Noor J.I., Ikeda T., Ueda Y., and Ikenoue T. A free radical scavenger, edaravone, inhibits lipid peroxidation and the production of nitric oxide in hypoxic-ischemic brain damage of neonatal rats. Am. J. Obstet. Gynecol. 193 (2005) 1703-1708
15. Onitsuka M., Mihara S., Yamamoto S., Shigemori M., and Higashi H. Nitric oxide contributes to irreversible membrane dysfunction caused by experimental ischemia in rat hippocampal CA1 neurons. Neurosci. Res. 30 (1998) 7-12
16. Rawal A.K., Muddeshwar M.G., and Biswas S.K. Rubia cordifolia, Fagonia cretica linn and Tinospora cordifolia exert neuroprotection by modulating the antioxidant system in rat hippocampal slices subjected to oxygen glucose deprivation. B.M.C. Complement Altern. Med. 4 (2004) 11
17. Tanaka E., Niiyama S., Sato S., Yamada A., and Higashi H. Arachidonic acid metabolites contribute to the irreversible depolarization induced by in vitro ischemia. J. Neurophysiol. 90 (2000) 3213-3223
18. Ueda Y., Yokoyama H., Nakajima A., Tokumaru J., Doi T., and Mitsuyama Y. Glutamate excess and free radical formation during and following kainic acid-induced status epilepticus. Exp. Brain Res. 147 (2002) 219-226
19. Ueda Y., Yokoyama H., Ohya-Nishiguchi H., and Kamada H. Generation of lipid radicals in the hippocampal extracellular space during kainic acid-induced seizures in rats. Epilepsy Res. 26 (1997) 329-333
20. Ueda Y., Noor J.I., Nagatomo K., Taku D., Ikeda T., Nakajima A., and Ikenoue T. Generation of lipid radicals in the hippocampus of neonatal rats after acute hypoxic-ischemic brain damage. Exp. Brain Res. 147 (2006) 219-226
21. Watanabe T., and Egawa M. Effects of an antistroke agent MCI-186 on cerebral arachidonate cascade. J. Pharmacol. Exp. Ther. 271 (1994) 1624-1629
22. Yamamoto Y., Kuwahara T., and Watanabe K. Antioxidant activity of 3-methyl-1phenyl-2pyrazolin-5-one. Redox. Rep. 5 (1996) 333-338
23. Yasuoka N., Nakajima W., Ishida A., and Takada G. Neuroprotection of edaravone on hypoxic-ischemic brain injury in neonatal rats. Dev. Brain Res. 151 (2004) 129-139
24. Yokoyama H., Ueda Y., Itoh O., Ikeda T., Noor J.I., and Ikenoue T. EPR imaging to estimate the in vivo intracerebral reducing ability of mature rats after neonatal hypoxic-ischemic brain injury. Magn. Reson. Imaging 22 (2004) 1305-1309