Topiramate attenuates voltage-gated sodium currents in rat cerebellar granule cells

Neuroscience Letters

Volumn 231, Issue 3, 1997, Pages 123-126

  Zona, Cristina ^a   Ciotti, Maria Teresa ^b   Avoli, Massimo ^c,d  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b CNR   (Italy)

^c MCGILL UNIVERSITY   (Canada)

^d MCGILL UNIVERSITY   (Canada)

Author keywords

Anticonvulsant drug; Cerebellum; Excitability; Na+ currents; Rat; Topiramate

Indexed keywords

TOPIRAMATE;

ANIMAL CELL; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; DRUG MECHANISM; GRANULE CELL; NERVE CELL EXCITABILITY; NERVE CELL MEMBRANE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; RAT; SEIZURE;

ANIMALS; ANIMALS, NEWBORN; ANTICONVULSANTS; CEREBELLUM; DOSE-RESPONSE RELATIONSHIP, DRUG; FRUCTOSE; ION CHANNEL GATING; MEMBRANE POTENTIALS; PATCH-CLAMP TECHNIQUES; RATS; RATS, WISTAR; SODIUM; SODIUM CHANNELS; TETRODOTOXIN;

EID: 0030867764     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(97)00543-0     Document Type: Article

References (19)

1. +-dependent theta-like rhythmicity in stellate cells of entorhinal cortex layer II, Nature (Lond.), 342 (1989) 175-177.
2. Biton, V., Reife, R., Kamin, M. and Bobrosky, K., Topiramate (Topamax) as add-on therapy for patients with primary generalized epilepsy, Neurology, 46 (1996) 176.
3. Brown, S.D., Wolf, H.H., Swinyard, E.A., Twyman, R.E. and White, H.S., The novel anticonvulsant topiramate enhances GABA-mediated chloride flux, Epilepsia, 34 (1993) 123-124.
4. Coulter, D.A., Sombati, S. and DeLorenzo, R.J., Selective effects of topiramate on sustained repetitive firing and spontaneous bursting in cultured hippocampal neurons, Epilepsia, 34 (1993) 123.
5. Coulter, D.A., Sombati, S. and DeLorenzo, R.J., Topiramate effects on excitatory amino acid mediated responses in cultured hippocampal neurons: selective blockade of kainate currents, Epilepsia, 36 (1995) 40.
6. Crill, W.E., Schwindt, P.C. and Spain, W.J., Membrane properties of cat Betz cells studied in vitro. In M. Avoli, P. Gloor, G. Kostopoulos and R. Naquet (Eds.), Generalized Epilepsy: Neurobiological Approaches, Birkhäuser, Boston, 1990, pp. 51-60.
7. Edmonds, Jr., H.L., Jiang, Y.D., Zhang, P.Y. and Shank, R.P., Anticonvulsant activity of topiramate and phenytoin in a rat model of ischemia-induced epilepsy, Life Sci., 59 (1996) 127-131.
8. Levi, G., Aloisi, F., Ciotti, M.T. and Gallo, V., Autoradiographic localization and depolarization-induced release of amino acids in differentiating cerebellar granule cell cultures, Brain Res., 290 (1984) 77-86.
9. Macdonald, R.L. and McLean, M.J., Anticonvulsant drugs: mechanisms of action. In A.V. Delgado-Escueta, A.A. Ward, Jr., D.M. Woodbury and R.J. Porter (Eds.), Advances in Neurology, Raven Press, New York, 1986, pp. 713-736.
10. Nakamura, J., Tamura, S., Kanda, T., Ishii, A., Ishihara, K., Serikawa, T., Yamada, J. and Sasa, M., Inhibition by topiramate of seizures in spontaneously epileptic rats and DBA/2 mice, Eur. J. Pharmacol., 254 (1994) 83-89.
11. Prince, D.A. and Connors, B.W., Mechanisms of interictal epileptogenesis. In A.V. Delgado-Escueta, A.A. Ward, Jr., D.M. Woodbury and R.J. Porter (Eds.), Advances in Neurology, Raven Press, New York, 1986, pp. 275-299.
12. + channels, expressed in a mammalian cell line, by local anesthetic, antiarrhythmic, and anticonvulsant drugs, Mol. Pharmacol., 40 (1991) 756-765.
13. Sachdeo, R.C., Sachdeo, S.K., Walker, S.A., Kramer, L.D., Nayak, R.K. and Doose, D.R., Steady-state pharmacokinetics of topiramate and carbamazepine in patients with epilepsy during monotherapy and concomitant therapy, Epilepsia, 37 (1996) 774-780.
14. Shank, R.P., Gardocki, J.F., Vaught, J.L., Davis, C.B., Schupsky, J.J., Raffa, R.B., Dodgson, S.J., Nortey, S.O. and Maryanoff, B.E., Topiramate: preclinical evaluation of a structurally novel anticonvulsant, Epilepsia, 35 (1994) 450-460.
15. Tassinari, C.A., Michelucci, R., Chauvel, P., Chodkiewicz, J.P., Shorvon, S.D., Henriksen, O., Dam, M., Reife, R., Pledger, G. and Karim, R., Double-blind, placebo-controlled trial of topiramate (600 mg daily) for the treatment of refractory partial epilepsy, Epilepsia, 37 (1996) 763-768.
16. Wauquier, A. and Zhou, S., Topiramate: a potent anticonvulsant in the amygdala-kindled rat, Epilepsy Res., 24 (1996) 73-77.
17. + channels in rat hippocampal neurones, Pflügers Arch. Eur. J. Physiol., 430 (1995) 437-446.
18. Zona, C. and Avoli, M., Effects induced by the antiepileptic drug valproic acid upon the ionic currents recorded in rat neocortical neurons in cell culture, Exp. Brain Res., 81 (1990) 313-317.
19. Zona, C., Ragozino, D., Ciotti, M.T., Mercanti, D., Avoli, M., Brancati, A. and Calissano, P., Sodium, calcium and late potassium currents are reduced in cerebellar granule cells cultured in the presence of a protein complex conferring resistance to excitatory amino acids, Eur. J. Neurosci., 5 (1993) 1479-1484.