Neonatal seizures in hypoxic-ischaemic encephalopathy - risks and benefits of anticonvulsant therapy

Developmental Medicine and Child Neurology

Volumn 57, Issue S3, 2015, Pages 40-43

  Shetty, Jayakara ^a  

^a ROYAL HOSPITAL FOR SICK CHILDREN   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; AMPA RECEPTOR; ANTICONVULSIVE AGENT; BUMETANIDE; GLUTAMATE RECEPTOR; KAINIC ACID RECEPTOR; MIDAZOLAM; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PHENOBARBITAL; PHENYTOIN; TOPIRAMATE;

ADVERSE OUTCOME; AGE; ANTICONVULSANT THERAPY; APNEA; APOPTOSIS; ARTICLE; BRAIN DEVELOPMENT; BRAIN ELECTROPHYSIOLOGY; CELL MIGRATION; CELL PROLIFERATION; CLINICAL PRACTICE; DRUG BLOOD LEVEL; DRUG INDUCED DISEASE; EEG ABNORMALITY; FOLLOW UP; HUMAN; HYPOXIC ISCHEMIC ENCEPHALOPATHY; INDUCED HYPOTHERMIA; INFANTILE SPASM; LONG TERM CARE; MYELINATION; NERVE CELL DIFFERENTIATION; NERVE CELL PLASTICITY; NERVOUS SYSTEM DEVELOPMENT; NEUROTOXICITY; NEUROTRANSMISSION; NEWBORN PERIOD; NONHUMAN; PATHOPHYSIOLOGY; PHARMACOKINETICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL (TOPIC); RISK BENEFIT ANALYSIS; RISK FACTOR; SEIZURE; SYNAPTOGENESIS; ANIMAL; COMPLICATION; ELECTROENCEPHALOGRAPHY; NEWBORN; SEIZURES;

ANIMALS; ANTICONVULSANTS; ELECTROENCEPHALOGRAPHY; HUMANS; HYPOXIA-ISCHEMIA, BRAIN; INFANT, NEWBORN; RISK FACTORS; SEIZURES;

EID: 84925275079     PISSN: 00121622     EISSN: 14698749     Source Type: Journal    
DOI: 10.1111/dmcn.12724     Document Type: Article

References (43)

1. Volpe JJ. Neonatal seizures: current concepts and revised classification. Pediatrics 1989; 84: 422-8.
2. Lanska MJ, Lanska DJ, Baumann RJ, et al. A population-based study of neonatal seizures in Fayette County, Kentucky. Neurology 1995; 45: 724-32.
3. Ronen GM, Penney S, Andrews W. The epidemiology of clinical neonatal seizures in Newfoundland: a population-based study. J Pediatr 1999; 134: 71-5.
4. Saliba RM, Annegers JF, Waller DK, Tyson JE, Mizrahi EM. Incidence of neonatal seizures in Harris County, Texas, 1992-1994. Am J Epidemiol 1999; 150: 763-9.
5. Tekgul H, Gauvreau K, Soul J, et al. The current etoliologic profile and neurodevelopmental outcome of seizures in term newborn infants. Pediatrics 2006; 117: 1270-80.
6. Ronen GM, Buckley D, Penney S, et al. Long-term prognosis in children with neonatal seizures: a population-based study. Neurology 2007; 69: 1816-22.
7. Ben-Ari Y, Holmes GL. Effects of seizures on developmental processes in the immature brain. Lancet Neurol 2006; 5: 1055-63.
8. Holmes GL, Ben-Ari Y. The neurobiology and consequences of epilepsy in the developing brain. Pediatr Res 2001; 49: 320-5.
9. Jensen FE. Neonatal seizures: an update on mechanisms and management. Clin Perinatol 2009; 36: 881-900.
10. Rakhade SN, Jensen FE. Epileptogenesis in the immature brain: emerging mechanisms. Nat Rev Neurol 2009; 5: 380-91.
11. Sanchez RM, Jensen FE. Maturational aspects of epilepsy mechanisms and consequences for the immature brain. Epilepsia 2001; 42: 577-85.
12. Huang LT, Tain YL, Lai MC, Yang SN. Neonatal seizures: dialogues between clinic and bench. J Formos Med Assoc 2012; 111: 239-44.
13. Murray DM, Boylan GB, Ali I, Ryan CA, Murphy BP, Connolly S. Defining the gap between electrographic seizure burden, clinical expression and staff recognition of neonatal seizures. Arch Dis Child Fetal Neonatal Ed 2008; 93: F187-91.
14. Clancy RR. Prolonged electroencephalogram monitoring for seizures and their treatment. Clin Perinatol 2006; 33: 649-65.
15. El-Dib M, Chang T, Tsuchida TN, Clancy RR. Amplitude-integrated electroencephalography in neonates. Pediatr Neurol 2009; 41: 315-26.
16. Rennie JM, Chorley G, Boylan GB, et al. Non-expert use of the cerebral function monitor for neonatal seizure detection. Arch Dis Child Fetal Neonatal Ed 2004; 89: F37-40.
17. Shah DK, de Vries LS, Hellström-Westas L, Toet MC, Inder TE. Amplitude-integrated electroencephalography in the newborn: a valuable tool. Pediatrics 2008; 122: 863-5.
18. Scher MS. Controversies regarding neonatal seizure recognition. Epileptic Disord 2002; 4: 139-58.
19. Slaughter LA, Patel AD, Slaughter JL. Pharmacological treatment of neonatal seizures: a systematic review. J Child Neurol 2013; 28: 351-64.
20. van Rooij LG, Hellstrom-Westas L, de Vries LS. Treatment of neonatal seizures. Semin Fetal Neonatal Med 2013; 18: 209-15.
21. Painter MJ, Scher MS, Stein AD, et al. Phenobarbital compared with phenytoin for the treatment of neonatal seizures. N Engl J Med 1999; 341: 485-9.
22. Sarkar S, Barks JD, Bapuraj JR, et al. Does phenobarbital improve the effectiveness of therapeutic hypothermia in infants with hypoxic-ischemic encephalopathy? J Perinatol 2012; 32: 15-20.
23. Furwentsches A, Bussmann C, Ramantani G, et al. Levetiracetam in the treatment of neonatal seizures: a pilot study. Seizure 2010; 19: 185-9.
24. Boylan G, Rennie J, Chorley G, et al. Second-line anticonvulsant treatment of neonatal seizures. Neurology 2004; 62: 486-8.
25. Castro-Conde JR, Borges AAH, Martinez ED, et al. Midazolam in neonatal seizures with no response to phenobarbital. Neurology 2005; 64: 876-9.
26. Abend NS, Gutierrez-Colina AM, Monk HM, et al. Levetiracetam for treatment of neonatal seizures. J Child Neurol 2011; 26: 465-70.
27. Blume HK, Garrison MM, Christakis DA. Neonatal seizures: treatment and treatment variability in 31 United States pediatric hospitals. J Child Neurol 2009; 24: 148-54.
28. Carmo KB, Barr P. Drug treatment of neonatal seizures by neonatologists and paediatric neurologists. J Paediatr Child Health 2005; 41: 313-6.
29. Levene M. The clinical conundrum of neonatal seizures. Arch Dis Child Fetal Neonatal Ed 2002; 86: F75-7.
30. Glass HC, Poulin C, Shevell MI. Topiramate for the treatment of neonatal seizures. Pediatr Neurol 2011; 44: 439-42.
31. Kahle KT, Staley KJ. The bumetanide-sensitive Na-K-2Cl cotransporter NKCC1 as a potential target of a novel mechanism-based treatment strategy for neonatal seizures. Neurosurg Focus 2008; 25: E22.
32. Vanhatalo S, Hellstrom-Westas L, De Vries LS. Bumetanide for neonatal seizures: based on evidence or enthusiasm? Epilepsia 2009; 50: 1292-3.
33. NEMO Project. Treatment of Neonatal Seizures with Medication Off-patent: Evaluation of Efficacy and Safety of Bumetanide. http://www.nemo-europe.com (accessed 05 March 2013).
34. Evans DJ, Levene MI, Tsakmakis M. Anticonvulsants for preventing mortality and morbidity in full term newborns with perinatal asphyxia. Cochrane Database Syst Rev 2007; 18: CD001240.
35. Wirrell EC. Neonatal seizures: to treat or not to treat? Semin Pediatr Neurol 2005; 12: 97-105.
36. Wirrell EC, Armstrong EA, Osman LD, Yager JY. Prolonged seizures exacerbate perinatal hypoxic-ischemic brain damage. Pediatr Res 2001; 50: 445-54.
37. Yager JY, Armstrong EA, Miyashita H, Wirrell EC. Prolonged neonatal seizures exacerbate hypoxic-ischemic brain damage: correlation with cerebral energy metabolism and excitatory amino acid release. Dev Neurosci 2002; 24: 367-81.
38. Glass HC, Glidden D, Jeremy RJ, Barkovich AJ, Ferriero DM, Miller SP. Clinical neonatal seizures are independently associated with outcome in infants at risk for hypoxic-ischemic brain injury. J Pediatr 2009; 155: 318-23.
39. Sankar R, Shin DH, Liu H, Mazarati A, Pereira de Vasconcelos A, Wasterlain CG. Patterns of status epilepticus-induced neuronal injury during development and long-term consequences. J Neurosci 1998; 18: 8382-93.
40. Filippi L, la Marca G, Cavallaro G, et al. Phenobarbital for neonatal seizures in hypoxic ischemic encephalopathy: a pharmacokinetic study during whole body hypothermia. Epilepsia 2011; 52: 794-801.
41. Bittigau P, Sifringer M, Genz K, et al. Antiepileptic drugs and apoptotic neurodegeneration in the developing brain. Proc Natl Acad Sci USA 2002; 99: 15089-94.
42. Ikonomidou C, Turski L. Antiepileptic drugs and brain development. Epilepsy Res 2010; 88: 11-22.
43. Forcelli PA, Kim J, Kondratyev A, Gale K. Pattern of antiepileptic drug-induced cell death in limbic regions of the neonatal rat brain. Epilepsia 2011; 52: e207-11.