메뉴 건너뛰기




Volumn 41, Issue SUPPL. 1, 2000, Pages 3-9

An overview of the preclinical aspects of topiramate: Pharmacology, pharmacokinetics, and mechanism of action

Author keywords

AMPA kainate receptors; Anticonvulsant; Epilepsy; GABAA receptors; Na+ channels; Topiramate

Indexed keywords


EID: 0003150278     PISSN: 00139580     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1528-1157.2000.tb02163.x     Document Type: Article
Times cited : (483)

References (10)
  • 1
    • 0011143923 scopus 로고
    • Anticonvulsant activity of McN-4853 (M) 2,3:4,5-bis-O-[1-methylethylidene]-β-D-fructopyranose sulfamate in mice and rats
    • Gardocki JF, Labinsky LS, Brown GL, Maryanoff BE. Anticonvulsant activity of McN-4853 (M) (2,3:4,5-bis-O-[1-methylethylidene]-β-D-fructopyranose sulfamate in mice and rats. Epilepsia 1986;27:648-9.
    • (1986) Epilepsia , vol.27 , pp. 648-649
    • Gardocki, J.F.1    Labinsky, L.S.2    Brown, G.L.3    Maryanoff, B.E.4
  • 2
    • 0023253518 scopus 로고
    • Anticonvulsant O-alkyl sulfamates: 2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate and related compounds
    • Maryanoff BE, Nortey SO, Gardocki JF, Shank RP, Dodgson SP. Anticonvulsant O-alkyl sulfamates: 2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate and related compounds. J Med Chem 1987;30:880-7.
    • (1987) J Med Chem , vol.30 , pp. 880-887
    • Maryanoff, B.E.1    Nortey, S.O.2    Gardocki, J.F.3    Shank, R.P.4    Dodgson, S.P.5
  • 3
    • 0028221989 scopus 로고
    • Topiramate: Preclinical evaluation of a structurally novel anticonvulsant
    • Shank RP, Gardocki JF, Vaught JL, et al. Topiramate: preclinical evaluation of a structurally novel anticonvulsant. Epilepsia 1994; 35:450-60.
    • (1994) Epilepsia , vol.35 , pp. 450-460
    • Shank, R.P.1    Gardocki, J.F.2    Vaught, J.L.3
  • 4
    • 0034115766 scopus 로고    scopus 로고
    • Topiramate as an inhibitor of carbonic anhydrase isozymes
    • Dodgson SJ, Shank RP, Maryanoff, BE. Topiramate as an inhibitor of carbonic anhydrase isozymes. Epilepsia 2000;41(suppl 1):S35-9.
    • (2000) Epilepsia , vol.41 , Issue.1 SUPPL.
    • Dodgson, S.J.1    Shank, R.P.2    Maryanoff, B.E.3
  • 5
    • 0034074118 scopus 로고    scopus 로고
    • Topiramate modulates GABA-evoked currents in murine cortical neurons by a nonbenzodiazepine mechanism
    • White HS, Brown SD, Woodhead JH, Skeen GA, Wolf HH. Topiramate modulates GABA-evoked currents in murine cortical neurons by a nonbenzodiazepine mechanism. Epilepsia 2000;41(suppl 1):S17-20.
    • (2000) Epilepsia , vol.41 , Issue.1 SUPPL.
    • White, H.S.1    Brown, S.D.2    Woodhead, J.H.3    Skeen, G.A.4    Wolf, H.H.5
  • 7
    • 0344625216 scopus 로고    scopus 로고
    • Anticonvulsant activity of topiramate and phenytoin in a rat model of ischemia-induced epilepsy
    • Edmonds HL Jr., Jiang YD, Zhang PY, Shank RP. Anticonvulsant activity of topiramate and phenytoin in a rat model of ischemia-induced epilepsy. Life Sci 1996;59:PL127-31.
    • (1996) Life Sci , vol.59
    • Edmonds Jr., H.L.1    Jiang, Y.D.2    Zhang, P.Y.3    Shank, R.P.4
  • 8
    • 0029899076 scopus 로고    scopus 로고
    • Topiramate: A potent anticonvulsant in the amygdala-kindled rat
    • Wauquier A, Zhou S. Topiramate: a potent anticonvulsant in the amygdala-kindled rat. Epilepsy Res 1996;24:73-7.
    • (1996) Epilepsy Res , vol.24 , pp. 73-77
    • Wauquier, A.1    Zhou, S.2
  • 9
    • 0038417652 scopus 로고
    • Pharmacokinetics of topiramate in the rat
    • Streeter AJ, Stahle PL, Hills JF, et al. Pharmacokinetics of topiramate in the rat. Pharm Res 1994;11(suppl):S372.
    • (1994) Pharm Res , vol.11 , Issue.SUPPL.
    • Streeter, A.J.1    Stahle, P.L.2    Hills, J.F.3
  • 10
    • 0001052465 scopus 로고
    • Plasma pharmacokinetics of topiramate, a new anticonvulsant, in humans
    • Easterling DE, Zakszewski T, Moyer MD, et al. Plasma pharmacokinetics of topiramate, a new anticonvulsant, in humans. Epilepsia 1988;29(suppl):662.
    • (1988) Epilepsia , vol.29 , Issue.SUPPL. , pp. 662
    • Easterling, D.E.1    Zakszewski, T.2    Moyer, M.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.