The pros and cons of vertebrate animal models for functional and therapeutic research on inherited retinal dystrophies

Progress in Retinal and Eye Research

Volumn 48, Issue , 2015, Pages 137-159

  Slijkerman, Ralph W N ^a,b   Song, Fei ^c   Astuti, Galuh D N ^a,b,d   Huynen, Martijn A ^a,b   van Wijk, Erwin ^a,b   Stieger, Knut ^c   Collin, Rob W J ^a,b  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c JUSTUS LIEBIG UNIVERSITY GIESSEN   (Germany)

^d DIPONEGORO UNIVERSITY   (Indonesia)

Author keywords

Animal models; Gene therapy; Inherited retinal dystrophies; Photoreceptors; Retina

Indexed keywords

CAS9 PROTEIN; CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN; ENDONUCLEASE; HEMAGGLUTININ; MESSENGER RNA PRECURSOR; RETINOID; RHODOPSIN; TRANSCRIPTION ACTIVATOR LIKE EFFECTOR NUCLEASE; TYROSINE; UNCLASSIFIED DRUG; VIRUS DNA; VIRUS VECTOR; ZINC FINGER NUCLEASE;

CAT; CHICKEN; CLINICAL RESEARCH; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; CRISPR CAS SYSTEM; DNA MODIFICATION; DOG; GENE CONSTRUCT; GENE EXPRESSION; GENE INSERTION; GENE MUTATION; GENE SILENCING; GENE TRANSFER; GENETIC ANALYSIS; GENETIC PROCEDURES; GENETIC REDUNDANCY; GENOME; GENOMICS; HOMOLOGOUS RECOMBINATION; HUMAN; INHERITANCE; INHERITED RETINAL DYSTROPHY; LETHALITY; MUTAGENESIS; NONHUMAN; PHENOTYPE; PHOTORECEPTOR CELL; PHOTORECEPTOR OUTER SEGMENT; PHOTOTRANSDUCTION; PIG; PIGMENT EPITHELIUM; PRIMATE; PRIORITY JOURNAL; RETINA; RETINA CONE; RETINA DEGENERATION; RETINA DYSTROPHY; RETINA GANGLION CELL; RETINA ROD; REVERSE GENETICS; REVIEW; RNA SPLICING; RODENT; SHEEP; STARGARDT DISEASE; TRANSPOSON; TROPISM; USHER SYNDROME; VERTEBRATE; VISION; ZEBRA FISH; ANATOMY AND HISTOLOGY; ANIMAL; DISEASE MODEL; GENETICS; PATHOPHYSIOLOGY; RETINAL DYSTROPHIES; TRANSGENIC ANIMAL;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; DISEASE MODELS, ANIMAL; HUMANS; PHENOTYPE; RETINA; RETINAL DYSTROPHIES;

EID: 84939257485     PISSN: 13509462     EISSN: 18731635     Source Type: Journal    
DOI: 10.1016/j.preteyeres.2015.04.004     Document Type: Review

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