Generation of rat mutants using a coat color-tagged Sleeping Beauty transposon system

Mammalian Genome

Volumn 18, Issue 5, 2007, Pages 338-346

  Lu, Baisong ^a,b   Geurts, Aron M ^c   Poirier, Christophe ^a,d   Petit, Deborah C ^a,e   Harrison, Wilbur ^a   Overbeek, Paul A ^a   Bishop, Colin E ^a,b  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b WAKE FOREST UNIVERSITY HEALTH SCIENCES   (United States)

^c MEDICAL COLLEGE OF WISCONSIN   (United States)

^d UNIVERSITY OF CHICAGO   (United States)

^e UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSPOSASE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; EYE DISEASE; FEMALE; GAMETE; GERM CELL; IN VIVO STUDY; MALE; MUTAGENESIS; MUTANT; NONHUMAN; NUCLEOTIDE SEQUENCE; PROGENY; RAT; TRANSGENIC RAT; TRANSPOSON;

AMINO ACID SEQUENCE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; DNA TRANSPOSABLE ELEMENTS; MONOPHENOL MONOOXYGENASE; MUTAGENESIS, INSERTIONAL; PHENOTYPE; RATS;

RATTUS;

EID: 34547102476     PISSN: 09388990     EISSN: 14321777     Source Type: Journal    
DOI: 10.1007/s00335-007-9025-5     Document Type: Article

References (33)

1. Beermann F, Ruppert S, Hummler E, Bosch FX, Muller G, et al. (1990) Rescue of the albino phenotype by introduction of a functional tyrosinase gene into mice. EMBO J 9:2819-2826
2. Carlson CM, Dupuy AJ, Fritz S, Roberg-Perez KJ, Fletcher CF, et al. (2003) Transposon mutagenesis of the mouse germline. Genetics 165:243-256
3. Dupuy AJ, Clark K, Carlson CM, Fritz S, Davidson AE, et al. (2002) Mammalian germ-line transgenesis by transposition. Proc Natl Acad Sci U S A 99:4495-4499
4. Dupuy AJ, Akagi K, Largaespada DA, Copeland NG, Jenkins NA (2005) Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system. Nature 436:221-226
5. Geurts AM, Yang Y, Clark KJ, Liu G, Cui Z, et al. (2003) Gene transfer into genomes of human cells by the sleeping beauty transposon system. Mol Ther 8:108-117
6. Geurts AM, Collier LS, Geurts JL, Oseth LL, Bell ML, et al. (2006) Gene mutations and genomic rearrangements in the mouse as a result of transposon mobilization from chromosomal concatemers. PLoS Genet 2:e156
7. Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, et al. (2004) Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature 428:493-521
8. Gossler A, Joyner AL, Rossant J, Skarnes WC (1989) Mouse embryonic stem cells and reporter constructs to detect developmentally regulated genes. Science 244:463-465
9. Hamra FK, Chapman KM, Nguyen DM, Williams-Stephens AA, Hammer RE, et al. (2005) Self renewal, expansion, and transfection of rat spermatogonial stem cells in culture. Proc Natl Acad Sci U S A 102:17430-17435
10. Horie K, Kuroiwa A, Ikawa M, Okabe M, Kondoh G, et al. (2001) Efficient chromosomal transposition of a Tc1/mariner- like transposon Sleeping Beauty in mice. Proc Natl Acad Sci U S A 98:9191-9196
11. Horie K, Yusa K, Yae K, Odajima J, Fischer SE, et al. (2003) Characterization of Sleeping Beauty transposition and its application to genetic screening in mice. Mol Cell Biol 23:9189-9207
12. Ivics Z, Izsvak Z (2006) Transposons for gene therapy! Curr Gene Ther 6:593-607
13. Ivics Z, Hackett PB, Plasterk RH, Izsvak Z (1997) Molecular reconstruction of Sleeping Beauty, a Tc1-like transposon from fish, and its transposition in human cells. Cell 91:501-510
14. Keng VW, Yae K, Hayakawa T, Mizuno S, Uno Y, et al. (2005) Region-specific saturation germline mutagenesis in mice using the Sleeping Beauty transposon system. Nat Methods 2:763-769
15. Kitada K, Ishishita S, Tosaka K, Takahashi R, Ueda M, et al. (2007) Transposon-tagged mutagenesis in the rat. Nat Methods 4:131-133
16. Kubota H, Avarbock MR, Brinster RL (2004) Growth factors essential for self-renewal and expansion of mouse spermatogonial stem cells. Proc Natl Acad Sci U S A 101:16489-16494
17. Laurent T, Jean C, Severine M, Severine R, Claire U, et al. (2005) Transgenic modifications of the rat genome. Transgenic Res 14:531-546
18. Mulle C, Sailer A, Perez-Otano I, Dickinson-Anson H, Castillo PE, et al. (1998) Altered synaptic physiology and reduced susceptibility to kainate-induced seizures in GluR6-deficient mice. Nature 392:601-605
19. Mullins JJ, Peters J, Ganten D (1990) Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 gene. Nature 344:541-544
20. Nolan PM, Peters J, Strivens M, Rogers D, Hagan J, et al. (2000) A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse. Nat Genet 25:440-443
21. Noveroske JK, Weber JS, Justice MJ (2000) The mutagenic action of N-ethyl-N-nitrosourea in the mouse. Mamm Genome 11:478-483
22. Reid W, Sadowska M, Denaro F, Rao S, Foulke J Jr, et al. (2001) An HIV-1 transgenic rat that develops HIV-related pathology and immunologic dysfunction. Proc Natl Acad Sci U S A 98:9271-9276
23. Robinson MO, McCarrey JR, Simon MI (1989) Transcriptional regulatory regions of testis-specific PGK2 defined in transgenic mice. Proc Natl Acad Sci U S A 86:8437-8441
24. Ruhnke M, Ungefroren H, Zehle G, Bader M, Kremer B, et al. (2003) Long-term culture and differentiation of rat embryonic stem cell-like cells into neuronal, glial, endothelial, and hepatic lineages. Stem Cells 21:428-436
25. Ryu BY, Orwig KE, Kubota H, Avarbock MR, Brinster RL (2004) Phenotypic and functional characteristics of spermatogonial stem cells in rats. Dev Biol 274:158-170
26. Sambrook J, Fritsch EF, Maniatis T (1989) Molecular Cloning: A Laboratory Manual. Sambrook J, Fritsch EF, Maniatis T, eds. (Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press)
27. Schulze M, Ungefroren H, Bader M, Fandrich F (2006) Derivation, maintenance, and characterization of rat embryonic stem cells in vitro. Methods Mol Biol 329:45-58
28. Tanaka S, Yamamoto H, Takeuchi S, Takeuchi T (1990) Melanization in albino mice transformed by introducing cloned mouse tyrosinase gene. Development 108:223-227
29. von Horsten S, Schmitt I, Nguyen HP, Holzmann C, Schmidt T, et al. (2003) Transgenic rat model of Huntington's disease. Hum Mol Genet 12:617-624
30. Yokoyama T, Silversides DW, Waymire KG, Kwon BS, Takeuchi T, et al. (1990) Conserved cysteine to serine mutation in tyrosinase is responsible for the classical albino mutation in laboratory mice. Nucleic Acids Res 18:7293-7298
31. Zan Y, Haag JD, Chen KS, Shepel LA, Wigington D, et al. (2003) Production of knockout rats using ENU mutagenesis and a yeast-based screening assay. Nat Biotechnol 21:645-651
32. Zheng B, Mills AA, Bradley A (2001) Introducing defined chromosomal rearrangements into the mouse genome. Methods 24:81-94
33. Zhou Q, Renard JP, Le Friec G, Brochard V, Beaujean N, et al. (2003) Generation of fertile cloned rats by regulating oocyte activation. Science 302:1179