The severe autosomal dominant retinitis pigmentosa rhodopsin mutant Ter349Glu mislocalizes and induces rapid rod cell death

Journal of Biological Chemistry

Volumn 288, Issue 40, 2013, Pages 29047-29055

  Hollingsworth, T J ^a   Gross, Alecia K ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOSOMAL DOMINANT RETINITIS PIGMENTOSA; OUTER SEGMENTS; PATHOGENIC MECHANISMS; RETINAL DEGENERATIONS; SUBCELLULAR LOCALIZATIONS;

AMINO ACIDS;

CELL DEATH;

AMINO ACID; GLUTAMIC ACID; GUANINE NUCLEOTIDE BINDING PROTEIN; MUTANT PROTEIN; RHODOPSIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOSOMAL DOMINANT DISORDER; CARBOXY TERMINAL SEQUENCE; CELL ULTRASTRUCTURE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; DISEASE ACTIVITY; DISEASE COURSE; DISEASE SEVERITY; FEMALE; GENE MUTATION; GENETIC TRANSFECTION; IN VITRO STUDY; IN VIVO STUDY; LIGAND BINDING; MALE; MOLECULAR PATHOLOGY; MOUSE; NERVE CELL NECROSIS; NONHUMAN; PHOTORECEPTOR; PHOTOTRANSDUCTION; PRIORITY JOURNAL; PROTEIN DEFECT; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RETINA DEVELOPMENT; RETINA NERVE CELL; RETINA ROD; RETINA ROD OUTER SEGMENT; RETINITIS PIGMENTOSA; XENOPUS LAEVIS;

CILIA; G PROTEIN-COUPLED RECEPTORS (GPCRS); NEURODEGENERATION; NEURODEGENERATIVE DISEASES; PHOTORECEPTORS; PHOTOTRANSDUCTION; RETINAL DEGENERATION; RHODOPSIN; TER349GLU; VISION;

AMINO ACID SEQUENCE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; CATTLE; CELL DEATH; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; COS CELLS; GENES, DOMINANT; GTP-BINDING PROTEINS; HUMANS; LIGANDS; MICE; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; MUTATION; PROTEIN FOLDING; PROTEIN TRANSPORT; RETINAL ROD PHOTORECEPTOR CELLS; RETINITIS PIGMENTOSA; RHODOPSIN; XENOPUS LAEVIS;

EID: 84885088231     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.495184     Document Type: Article

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