Three gene-targeted mouse models of RNA splicing factor RP show late-onset RPE and retinal degeneration

Investigative Ophthalmology and Visual Science

Volumn 52, Issue 1, 2011, Pages 190-198

  Graziotto, John J ^a,b   Farkas, Michael H ^a   Bujakowska, Kinga ^c   Deramaudt, Bertrand M ^a   Zhang, Qi ^a   Nandrot, Emeline F ^c   Inglehearn, Chris F ^d   Bhattacharya, Shomi S ^c,e   Pierce, Eric A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c INSTITUT DE LA VISION   (France)

^d UNIVERSITY OF LEEDS   (United Kingdom)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; PRE MESSENGER RNA PROCESSING FACTOR 3; PRE MESSENGER RNA PROCESSING FACTOR 31; PRE MESSENGER RNA PROCESSING FACTOR 8; UNCLASSIFIED DRUG; EYE PROTEIN; PRP8 PROTEIN, MOUSE; PRPF3 PROTEIN, MOUSE; PRPF31 PROTEIN, MOUSE; RNA BINDING PROTEIN; SMALL NUCLEAR RIBONUCLEOPROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRUCH MEMBRANE; CONTROLLED STUDY; ELECTRON MICROSCOPY; ELECTRORETINOGRAM; EMBRYO; EMBRYONIC STEM CELL; GENE; GENE MUTATION; GENE TARGETING; HETEROZYGOTE; HISTOPATHOLOGY; HOMOZYGOTE; KNOCKOUT MOUSE; MOLECULAR PATHOLOGY; MOUSE; NONHUMAN; PHENOTYPE; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PRPF3 GENE; PRPF31 GENE; PRPF8 GENE; RETINA DEGENERATION; RETINA PIGMENT DEGENERATION; RETINITIS PIGMENTOSA; RNA SPLICING; ANIMAL; C57BL MOUSE; DISEASE MODEL; ELECTRORETINOGRAPHY; GENETIC TRANSFECTION; GENETICS; GENOTYPE; MOUSE MUTANT; NORTHERN BLOTTING; PATHOLOGY; POLYMERASE CHAIN REACTION; ULTRASTRUCTURE; WESTERN BLOTTING;

ANIMALS; BLOTTING, NORTHERN; BLOTTING, WESTERN; DISEASE MODELS, ANIMAL; ELECTRORETINOGRAPHY; EYE PROTEINS; GENE KNOCK-IN TECHNIQUES; GENOTYPE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; POLYMERASE CHAIN REACTION; RETINAL PIGMENT EPITHELIUM; RETINITIS PIGMENTOSA; RIBONUCLEOPROTEIN, U4-U6 SMALL NUCLEAR; RNA SPLICING; RNA-BINDING PROTEINS; TRANSFECTION;

EID: 79952239508     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.10-5194     Document Type: Article

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