The balance between adaptive and apoptotic unfolded protein responses regulates β-cell death under ER stress conditions through XBP1, CHOP and JNK

Molecular and Cellular Endocrinology

Volumn 413, Issue , 2015, Pages 189-201

  Chan, Jeng Yie ^a   Luzuriaga, Jude ^a   Maxwell, Emma L ^a   West, Phillip K ^a   Bensellam, Mohammed ^a   Laybutt, D Ross ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

Diabetes; Endoplasmic reticulum stress; Islets; Unfolded protein response; Cell

Indexed keywords

GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; PALMITIC ACID; STRESS ACTIVATED PROTEIN KINASE; X BOX BINDING PROTEIN 1; DDIT3 PROTEIN, MOUSE; DNA BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; REGULATORY FACTOR X TRANSCRIPTION FACTORS; TRANSCRIPTION FACTOR;

ADAPTIVE IMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DEATH; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION; IN VITRO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN SYNTHESIS REGULATION; PROTEIN TARGETING; REGULATORY MECHANISM; UNFOLDED PROTEIN RESPONSE; ANIMAL; BAGG ALBINO MOUSE; CELL LINE; GENETICS; METABOLISM; NONOBESE DIABETIC MOUSE; PATHOLOGY;

ANIMALS; APOPTOSIS; CELL LINE; DNA-BINDING PROTEINS; ENDOPLASMIC RETICULUM STRESS; INSULIN-SECRETING CELLS; MAP KINASE KINASE 4; MICE; MICE, INBRED BALB C; MICE, INBRED NOD; TRANSCRIPTION FACTOR CHOP; TRANSCRIPTION FACTORS; UNFOLDED PROTEIN RESPONSE;

EID: 84938284738     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2015.06.025     Document Type: Article

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