Reduced endoplasmic reticulum (ER)-to-Golgi protein trafficking contributes to ER stress in lipotoxic mouse beta cells by promoting protein overload

Diabetologia

Volumn 52, Issue 11, 2009, Pages 2369-2373

  Preston, A M ^a,b,c   Gurisik, E ^a,b   Bartley, C ^a   Laybutt, D R ^a,b   Biden, T J ^a,b  

^a GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

Apoptosis; Endoplasmic reticulum stress; Lipotoxicity; Pancreatic beta cell; Protein trafficking; Type 2 diabetes; Vesicular stomatitis virus G protein

Indexed keywords

ANTIBODY; BIOLOGICAL MARKER; BREFELDIN A; CALCIUM; CHAPERONE; GREEN FLUORESCENT PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; OLEIC ACID; PALMITIC ACID; SATURATED FATTY ACID; THAPSIGARGIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; GENETIC TRANSFECTION; GOLGI COMPLEX; INSULINOMA; MOLECULAR PROBE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN TRANSPORT; QUANTITATIVE ANALYSIS; TUMOR CELL LINE; VESICULAR STOMATITIS VIRUS; WESTERN BLOTTING;

ANIMALS; CELL LINE, TUMOR; CYCLOHEXIMIDE; ENDOPLASMIC RETICULUM; GENES, REPORTER; INSULIN-SECRETING CELLS; INSULINOMA; MEMBRANE GLYCOPROTEINS; MICE; PALMITIC ACID; PROTEIN TRANSPORT; PROTEINS; STRESS, PHYSIOLOGICAL; TRANSFECTION; VIRAL ENVELOPE PROTEINS;

EID: 70349871409     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-009-1506-5     Document Type: Article

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