Relationship between β-cell mass and diabetes onset

Diabetes, Obesity and Metabolism

Volumn 10, Issue SUPPL. 4, 2008, Pages 23-31

  Matveyenko, Aleksey V ^a   Butler, P C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Pulsatile insulin secretion; Type 1 diabetes; Type 2 diabetes; cell apoptosis; cell mass

Indexed keywords

GLUCOSE; INSULIN; NICOTINAMIDE; STREPTOZOCIN;

APOPTOSIS; AUTOPSY; CONFERENCE PAPER; CYTOTOXICITY; DISEASE COURSE; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HUMAN; HYPERGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS INSUFFICIENCY; PANCREAS ISLET BETA CELL; PANCREAS ISLET BETA CELL MASS; PANCREAS ISLET CELL FUNCTION; PANCREAS RESECTION;

EID: 53549094111     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/j.1463-1326.2008.00939.x     Document Type: Conference Paper

References (73)

1. Meier JJ, Butler PC. Insulin secretion. In: DeGroot LJ JJ. ed. Endocrinology, 5 edn. Philadelphia: Elsevier Saunders; 2005; 961-973.
2. DeFronzo RA. Lilly lecture 1987. The triumvirate: Beta-cell, muscle, liver. A collusion responsible for NIDDM. Diabetes 1988; 37: 667-687.
3. Kloppel G, Lohr M, Habich K, Oberholzer M, Heitz PU. Islet pathology and the pathogenesis of type 1 and type 2 diabetes mellitus revisited. Surv Synth Pathol Res 1985; 4: 110-125.
4. Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 2003; 52: 102-110.
5. Yoon KH, Ko SH, Cho JH et al. Selective beta-cell loss and alpha-cell expansion in patients with type 2 diabetes mellitus in Korea. J Clin Endocrinol Metab 2003; 88: 2300-2308.
6. Meier JJ, Bhushan A, Butler AE, Rizza RA, Butler PC. Sustained b-cell apoptosis in patients with long-standing type 1 diabetes: Indirect evidence for islet regeneration? Diabetologia 2005; 48: 2221-2228.
7. Rahier J, Goebbels RM, Henquin JC. Cellular composition of the human diabetic pancreas. Diabetologia 1983; 24: 366-371.
8. Pipeleers D, Ling Z. Pancreatic b-cells in insulin-dependent diabetes. Diabetes Metab Rev 1992; 8: 209-227.
9. Kloppel G, Drenck CR, Oberholzer M, Heitz PU. Morphometric evidence for a striking B-cell reduction at the clinical onset of type 1 diabetes. Virchows Arch A Pathol Anat Histopathol 1984; 403: 441-452.
10. Lernmark A, Kloppel G, Stenger D et al. Heterogeneity of islet pathology in two infants with recent onset diabetes mellitus. Virchows Arch 1995; 425: 631-640.
11. Junker K, Egeberg J, Kromann H, Nerup J. An autopsy study of the islets of Langerhans in acute-onset juvenile diabetes mellitus. Acta Pathol Microbiol Scand A 1977; 85: 699-706.
12. Gepts W. Pathologic anatomy of the pancreas in juvenile diabetes mellitus. Diabetes 1965; 14: 619-633.
13. Gepts W, De Mey J. Islet cell survival determined by morphology. An immunocytochemical study of the islets of Langerhans in juvenile diabetes mellitus. Diabetes 1978; 27 (Suppl. 1): 251-261.
14. Clark A, Wells CA, Buley ID et al. Islet amyloid, increased A-cells, reduced B-cells and exocrine fibrosis: Quantitative changes in the pancreas in type 2 diabetes. Diabetes Res 1988; 9: 151-159.
15. Butler AE, Galasso R, Meier JJ, Basu R, Rizza RA, Butler PC. Modestly increased b-cell apoptosis but no increased b-cell replication in recent-onset type 1 diabetic patients who died of diabetic ketoacidosis. Diabetologia 2007; 50: 2323-2331.
16. Shimizu M, Hayashi T, Saitoh Y, Ohta K, Itoh H. Postmortem autolysis in the pancreas: Multivariate statistical study. The influence of clinicopathological conditions. Pancreas 1990; 5: 91-94.
17. Fogar P, Pasquali C, Basso D et al. Diabetes mellitus in pancreatic cancer follow-up. Anticancer Res 1994; 14: 2827-2830.
18. Chari ST, Zapiach M, Yadav D, Rizza RA. Beta-cell function and insulin resistance evaluated by HOMA in pancreatic cancer subjects with varying degrees of glucose intolerance. Pancreatology 2005; 5: 229-233.
19. Levetan CS, Passaro M, Jablonski K, Kass M, Ratner RE. Unrecognized diabetes among hospitalized patients. Diabetes Care 1998;21: 246-249.
20. Saisho Y, Butler AE, Meier JJ et al. Pancreas volumes in humans from birth to age one hundred taking into account sex, obesity, and presence of type-2 diabetes. Clin Anat 2007; 20: 933-942.
21. Sakuraba H, Mizukami H, Yagihashi N, Wada R, Hanyu C, Yagihashi S. Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients. Diabetologia 2002; 45: 85-96.
22. Meier JJ, Butler AE, Saisho Y et al. Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans. Diabetes 2008; 57: 1584-1594.
23. Dabelea D, Hanson RL, Bennett PH, Roumain J, Knowler WC, Pettitt DJ. Increasing prevalence of Type II diabetes in American Indian children. Diabetologia 1998; 41: 904-910.
24. Pundziute-Lycka A, Dahlquist G, Nystrom L et al. The incidence of Type I diabetes has not increased but shifted to a younger age at diagnosis in the 0-34 years group in Sweden 1983-1998. Diabetologia 2002; 45: 783-791.
25. Stanger BZ, Tanaka AJ, Melton DA. Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver. Nature 2007; 445: 886-891.
26. Zeggini E, Weedon MN, Lindgren CM et al. Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 2007; 316: 1336-1341.
27. Atkinson MA, Eisenbarth GS. Type 1 diabetes: New perspectives on disease pathogenesis and treatment. Lancet 2001; 358: 221-229.
28. Ziegler AG, Ziegler R, Vardi P, Jackson RA, Soeldner JS, Eisenbarth GS. Life-table analysis of progression to diabetes of anti-insulin autoantibody-positive relatives of individuals with type I diabetes. Diabetes 1989; 38: 1320-1325.
29. Heinze E, Thon A. Honeymoon period in insulin-dependent diabetes mellitus. Pediatrician 1983; 12: 208-212.
30. Sherry NA, Tsai EB, Herold KC. Natural history of beta-cell function in type 1 diabetes. Diabetes 2005; 54 (Suppl. 2): S32-S39.
31. Karjalainen J, Salmela P, Ilonen J, Surcel HM, Knip M. A comparison of childhood and adult type I diabetes mellitus. N Engl J Med 1989; 320: 881-886.
32. Bonfanti R, Bazzigaluppi E, Calori G et al. Parameters associated with residual insulin secretion during the first year of disease in children and adolescents with Type 1 diabetes mellitus. Diabet Med 1998; 15: 844-850.
33. Snorgaard O, Lassen LH, Binder C. Homogeneity in pattern of decline of beta-cell function in IDDM. Prospective study of 204 consecutive cases followed for 7.4 yr. Diabetes Care 1992; 15: 1009-1013.
34. Steele C, Hagopian WA, Gitelman S et al. Insulin secretion in type 1 diabetes. Diabetes 2004; 53: 426-433.
35. Harris MI. Epidemiologic studies on the pathogenesis of non-insulin-dependent diabetes mellitus (NIDDM). Clin Invest Med 1995; 18: 231-239.
36. Gerich JE. The genetic basis of type 2 diabetes mellitus: Impaired insulin secretion versus impaired insulin sensitivity. Endocr Rev 1998; 19: 491-503.
37. Mason CC, Hanson RL, Knowler WC. Progression to type 2 diabetes characterized by moderate then rapid glucose increases. Diabetes 2007; 56: 2054-2061.
38. Xiang AH, Wang C, Peters RK, Trigo E, Kjos SL, Buchanan TA. Coordinate changes in plasma glucose and pancreatic beta-cell function in Latino women at high risk for type 2 diabetes. Diabetes 2006; 55: 1074-1079.
39. Marchetti P, Del Guerra S, Marselli L et al. Pancreatic islets from type 2 diabetic patients have functional defects and increased apoptosis that are ameliorated by metformin. J Clin Endocrinol Metab 2004; 89: 5535-5541.
40. Huang CJ, Lin CY, Haataja L et al. High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated beta-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes. Diabetes 2007; 56: 2016-2027.
41. Laybutt DR, Preston AM, Akerfeldt MC et al. Endoplasmic reticulum stress contributes to b-cell apoptosis in type 2 diabetes. Diabetologia 2007; 50: 752-763.
42. Schroder M, Kaufman RJ. ER stress and the unfolded protein response. Mutat Res 2005; 569: 29-63.
43. Robertson RP, Zhang HJ, Pyzdrowski KL, Walseth TF. Preservation of insulin mRNA levels and insulin secretion in HIT cells by avoidance of chronic exposure to high glucose concentrations. J Clin Invest 1992; 90: 320-325.
44. Tanaka Y, Gleason CE, Tran PO, Harmon JS, Robertson RP. Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants. Proc Natl Acad Sci USA 1999; 96: 10857-10862.
45. Poitout V, Robertson RP. Glucolipotoxicity: Fuel excess and {beta}-cell dysfunction. Endocr Rev 2008; 29: 351-366.
46. Ritzel RA, Butler AE, Rizza RA, Veldhuis JD, Butler PC. Relationship between beta-cell mass and fasting blood glucose concentration in humans. Diabetes Care 2006; 29: 717-718.
47. Robertson RP, Lanz KJ, Sutherland DE, Seaquist ER. Relationship between diabetes and obesity 9 to 18 years after hemipancreatectomy and transplantation in donors and recipients. Transplantation 2002; 73: 736-741.
48. Seaquist ER, Robertson RP. Effects of hemipancreatectomy on pancreatic alpha and b-cell function in healthy human donors. J Clin Invest 1992; 89: 1761-1766.
49. Kendall DM, Sutherland DE, Najarian JS, Goetz FC, Robertson RP. Effects of hemipancreatectomy on insulin secretion and glucose tolerance in healthy humans. N Engl J Med 1990; 322: 898-903.
50. Slezak LA, Andersen DK. Pancreatic resection: Effects on glucose metabolism. World J Surg 2001; 25: 452-460.
51. Portha B, Giroix MH, Serradas P et al. beta-cell function and viability in the spontaneously diabetic GK rat: Information from the GK/Par colony. Diabetes 2001; 50 (Suppl. 1): S89-S93.
52. Lee Y, Hirose H, Ohneda M, Johnson JH, McGarry JD, Unger RH. Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: Impairment in adipocyte-beta-cell relationships. Proc Natl Acad Sci USA 1994; 91: 10878-10882.
53. Shafrir E, Ziv E, Mosthaf L. Nutritionally induced insulin resistance and receptor defect leading to beta-cell failure in animal models. Ann N Y Acad Sci 1999; 892: 223-246.
54. Tomita T, Doull V, Pollock HG, Krizsan D. Pancreatic islets of obese hyperglycemic mice (ob/ob). Pancreas 1992; 7: 367-375.
55. Lee HC, Bonner-Weir S, Weir GC, Leahy JL. Compensatory adaption to partial pancreatectomy in the rat. Endocrinology 1989; 124: 1571-1575.
56. Peshavaria M, Larmie BL, Lausier J et al. Regulation of pancreatic beta-cell regeneration in the normoglycemic 60% partial-pancreatectomy mouse. Diabetes 2006; 55: 3289-3298.
57. Pearson KW, Scott D, Torrance B. Effects of partial surgical pancreatectomy in rats. I. Pancreatic regeneration. Gastroenterology 1977; 72: 469-473.
58. Goodner CJ, Koerker DJ, Weigle DS, McCulloch DK. Decreased insulin- and glucagon-pulse amplitude accompanying beta-cell deficiency induced by streptozocin in baboons. Diabetes 1989; 38: 925-931.
59. Gotoh M, Monden M, Okamura J, Mori T, Shima K. Insulin and glucagon secretion after pancreatectomies. Correlation of secretion and hormonal contents of remaining pancreas. Diabetes 1989; 38: 861-867.
60. Marincola F, Cobb LF, Horaguchi A, Maeda M, Merrell R. Accommodation to a reduced islet cell mass in dogs. Am J Physiol 1984; 247: E456-E461.
61. Stagner JI, Samols E. Deterioration of islet beta-cell function after hemipancreatectomy in dogs. Diabetes 1991; 40: 1472-1479.
62. Matveyenko AV, Veldhuis JD, Butler PC. Mechanisms of impaired fasting glucose and glucose intolerance induced by ∼50% pancreatectomy. Diabetes 2006; 55: 2347-2356.
63. Kjems LL, Kirby BM, Welsh EM et al. Decrease in beta-cell mass leads to impaired pulsatile insulin secretion, reduced postprandial hepatic insulin clearance, and relative hyperglucagonemia in the minipig. Diabetes 2001; 50: 2001-2012.
64. Larsen MO, Rolin B, Wilken M, Carr RD, Gotfredsen CF. Measurements of insulin secretory capacity and glucose tolerance to predict pancreatic beta-cell mass in vivo in the nicotinamide/streptozotocin Gottingen minipig, a model of moderate insulin deficiency and diabetes. Diabetes 2003; 52: 118-123.
65. Larsen MO, Gotfredsen CF, Wilken M, Carr RD, Porksen N, Rolin B. Loss of beta-cell mass leads to a reduction of pulse mass with normal periodicity, regularity and entrainment of pulsatile insulin secretion in Gottingen minipigs. Diabetologia 2003; 46: 195-202.
66. Meier JJ, Veldhuis JD, Butler PC. Pulsatile insulin secretion dictates systemic insulin delivery by regulating hepatic insulin extraction in humans. Diabetes 2005; 54: 1649-1656.
67. Porksen N, Munn SR, Steers JL, Veldhuis JD, Butler PC. Effects of somatostatin on pulsatile insulin secretion: Elective inhibition of insulin burst mass. Am J Physiol 1996; 270: E1043-E1049.
68. Matveyenko AV, Butler PC. Beta-cell deficit due to increased apoptosis in the human islet amyloid polypeptide transgenic (HIP) rat recapitulates the metabolic defects present in type 2 diabetes. Diabetes 2006; 55: 2106-2114.
69. Matthews DR, Naylor BA, Jones RG, Ward GM, Turner RC. Pulsatile insulin has greater hypoglycemic effect than continuous delivery. Diabetes 1983; 32: 617-621.
70. Schmitz O, Arnfred J, Nielsen OH, Beck-Nielsen H, Orskov H. Glucose uptake and pulsatile insulin infusion: Euglycaemic clamp and [3-3H]glucose studies in healthy subjects. Acta Endocrinol (Copenh) 1986; 113: 559-563.
71. Ward GM, Walters JM, Aitken PM, Best JD, Alford FP. Effects of prolonged pulsatile hyperinsulinemia in humans. Enhancement of insulin sensitivity. Diabetes 1990; 39: 501-507.
72. Paolisso G, Sgambato S, Gentile S et al. Advantageous metabolic effects of pulsatile insulin delivery in noninsulin-dependent diabetic patients. J Clin Endocrinol Metab 1988; 67: 1005-1010.
73. DeFronzo RA, Simonson D, Ferrannini E. Hepatic and peripheral insulin resistance: A common feature of type 2 (non-insulin-dependent) and type 1 (insulin-dependent) diabetes mellitus. Diabetologia 1982; 23: 313-319.