Glucose-induced beta cell dysfunction in vivo in rats: Link between oxidative stress and endoplasmic reticulum stress

Diabetologia

Volumn 55, Issue 5, 2012, Pages 1366-1379

  Tang, C ^a   Koulajian, K ^a   Schuiki, I ^b   Zhang, L ^b   Desai, T ^a   Ivovic, A ^a   Wang, P ^c   Robson Doucette, C ^a   Wheeler, M B ^a   Minassian, B ^c   Volchuk, A ^b   Giacca, A ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY HEALTH NETWORK   (Canada)

^c HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Beta cell dysfunction; Endoplasmic reticulum stress; Glucotoxicity; In vivo; Oxidative stress

Indexed keywords

4 PHENYLBUTYRIC ACID; GLUCOSE; SUPEROXIDE; TAUROURSODEOXYCHOLIC ACID; TEMPOL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ENDOPLASMIC RETICULUM STRESS; FEMALE; GLUCOSE CLAMP TECHNIQUE; HYPERGLYCEMIA; IN VIVO STUDY; MITOCHONDRION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL DYSFUNCTION; PANCREAS ISLET CELL FUNCTION; PANCREAS ISLET DISEASE; PATHOGENESIS; POSITIVE FEEDBACK; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIOXIDANTS; CYCLIC N-OXIDES; ENDOPLASMIC RETICULUM STRESS; FEMALE; GLUCOSE; HYPERGLYCEMIA; INSULIN-SECRETING CELLS; MITOCHONDRIA; OXIDATIVE STRESS; PHENYLBUTYRATES; RATS; RATS, WISTAR; SPIN LABELS; SUPEROXIDES; TAUROCHENODEOXYCHOLIC ACID;

EID: 84862797520     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-012-2474-8     Document Type: Article

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