-
1
-
-
0034705228
-
Highly reduced protection against streptococcus pneumoniae after deletion of a single heavy chain gene in mouse
-
Mi Q.S., Zhou L., Schulze D.H., Fischer R.T., Lustig A., Rezanka L.J., Donovan D.M., Longo D.L., Kenny J.J. Highly reduced protection against streptococcus pneumoniae after deletion of a single heavy chain gene in mouse. Proc Natl Acad Sci U S A 2000, 97:6031-6036.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 6031-6036
-
-
Mi, Q.S.1
Zhou, L.2
Schulze, D.H.3
Fischer, R.T.4
Lustig, A.5
Rezanka, L.J.6
Donovan, D.M.7
Longo, D.L.8
Kenny, J.J.9
-
2
-
-
29344475707
-
Diversity and function of adaptive immune receptors in a jawless vertebrate
-
Alder M.N., Rogozin I.B., Iyer L.M., Glazko G.V., Cooper M.D., Pancer Z. Diversity and function of adaptive immune receptors in a jawless vertebrate. Science 2005, 310:1970-1973.
-
(2005)
Science
, vol.310
, pp. 1970-1973
-
-
Alder, M.N.1
Rogozin, I.B.2
Iyer, L.M.3
Glazko, G.V.4
Cooper, M.D.5
Pancer, Z.6
-
3
-
-
0023969216
-
Chicken immunoglobulin gamma-heavy chains: limited VH gene repertoire, combinatorial diversification by D gene segments and evolution of the heavy chain locus
-
Parvari R., Avivi A., Lentner F., Ziv E., Tel-Or S., Burstein Y., Schechter I. Chicken immunoglobulin gamma-heavy chains: limited VH gene repertoire, combinatorial diversification by D gene segments and evolution of the heavy chain locus. EMBO J 1988, 7:739-744.
-
(1988)
EMBO J
, vol.7
, pp. 739-744
-
-
Parvari, R.1
Avivi, A.2
Lentner, F.3
Ziv, E.4
Tel-Or, S.5
Burstein, Y.6
Schechter, I.7
-
4
-
-
0020534965
-
Somatic generation of antibody diversity
-
Tonegawa S. Somatic generation of antibody diversity. Nature 1983, 302:575-581.
-
(1983)
Nature
, vol.302
, pp. 575-581
-
-
Tonegawa, S.1
-
5
-
-
84878821153
-
Reshaping antibody diversity
-
Wang F., Ekiert D.C., Ahmad I., Yu W., Zhang Y., Bazirgan O., Torkamani A., Raudsepp T., Mwangi W., Criscitiello M.F., Wilson I.A., et al. Reshaping antibody diversity. Cell 2013, 153:1379-1393.
-
(2013)
Cell
, vol.153
, pp. 1379-1393
-
-
Wang, F.1
Ekiert, D.C.2
Ahmad, I.3
Yu, W.4
Zhang, Y.5
Bazirgan, O.6
Torkamani, A.7
Raudsepp, T.8
Mwangi, W.9
Criscitiello, M.F.10
Wilson, I.A.11
-
6
-
-
3142616423
-
Somatic diversification of variable lymphocyte receptors in the agnathan sea lamprey
-
Pancer Z., Amemiya C.T., Ehrhardt G.R., Ceitlin J., Gartland G.L., Cooper M.D. Somatic diversification of variable lymphocyte receptors in the agnathan sea lamprey. Nature 2004, 430:174-180.
-
(2004)
Nature
, vol.430
, pp. 174-180
-
-
Pancer, Z.1
Amemiya, C.T.2
Ehrhardt, G.R.3
Ceitlin, J.4
Gartland, G.L.5
Cooper, M.D.6
-
7
-
-
0034094425
-
The rag proteins and V(D)J recombination: complexes, ends, and transposition
-
Fugmann S.D., Lee A.I., Shockett P.E., Villey I.J., Schatz D.G. The rag proteins and V(D)J recombination: complexes, ends, and transposition. Annu Rev Immunol 2000, 18:495-527.
-
(2000)
Annu Rev Immunol
, vol.18
, pp. 495-527
-
-
Fugmann, S.D.1
Lee, A.I.2
Shockett, P.E.3
Villey, I.J.4
Schatz, D.G.5
-
8
-
-
0031171708
-
The end-joining reaction in V(D)J recombination
-
Smider V., Chu G. The end-joining reaction in V(D)J recombination. Semin Immunol 1997, 9:189-197.
-
(1997)
Semin Immunol
, vol.9
, pp. 189-197
-
-
Smider, V.1
Chu, G.2
-
9
-
-
77957361348
-
Development trends for human monoclonal antibody therapeutics
-
Nelson A.L., Dhimolea E., Reichert J.M. Development trends for human monoclonal antibody therapeutics. Nat Rev Drug Discov 2010, 9:767-774.
-
(2010)
Nat Rev Drug Discov
, vol.9
, pp. 767-774
-
-
Nelson, A.L.1
Dhimolea, E.2
Reichert, J.M.3
-
10
-
-
27144457667
-
Monoclonal antibody successes in the clinic
-
Reichert J.M., Rosensweig C.J., Faden L.B., Dewitz M.C. Monoclonal antibody successes in the clinic. Nat Biotechnol 2005, 23:1073-1078.
-
(2005)
Nat Biotechnol
, vol.23
, pp. 1073-1078
-
-
Reichert, J.M.1
Rosensweig, C.J.2
Faden, L.B.3
Dewitz, M.C.4
-
11
-
-
0016756272
-
Continuous cultures of fused cells secreting antibody of predefined specificity
-
Kohler G., Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 1975, 256:495-497.
-
(1975)
Nature
, vol.256
, pp. 495-497
-
-
Kohler, G.1
Milstein, C.2
-
12
-
-
84900873687
-
Antibody discovery: sourcing of monoclonal antibody variable domains
-
Strohl W.R. Antibody discovery: sourcing of monoclonal antibody variable domains. Curr Drug Discov Technol 2014, 11:3-19.
-
(2014)
Curr Drug Discov Technol
, vol.11
, pp. 3-19
-
-
Strohl, W.R.1
-
13
-
-
78149322603
-
Spatially addressed combinatorial protein libraries for recombinant antibody discovery and optimization
-
Mao H., Graziano J.J., Chase T.M., Bentley C.A., Bazirgan O.A., Reddy N.P., Song B.D., Smider V.V. Spatially addressed combinatorial protein libraries for recombinant antibody discovery and optimization. Nat Biotechnol 2010, 28:1195-1202.
-
(2010)
Nat Biotechnol
, vol.28
, pp. 1195-1202
-
-
Mao, H.1
Graziano, J.J.2
Chase, T.M.3
Bentley, C.A.4
Bazirgan, O.A.5
Reddy, N.P.6
Song, B.D.7
Smider, V.V.8
-
14
-
-
78649681781
-
Therapeutic antibodies directed at G protein-coupled receptors
-
Hutchings C.J., Koglin M., Marshall F.H. Therapeutic antibodies directed at G protein-coupled receptors. MAbs 2010, 2:594-606.
-
(2010)
MAbs
, vol.2
, pp. 594-606
-
-
Hutchings, C.J.1
Koglin, M.2
Marshall, F.H.3
-
15
-
-
84902215464
-
A monoclonal antibody that targets a NaV1.7 channel voltage sensor for pain and itch relief
-
Lee J.-H., Park C.-K., Chen G., Han Q., Xie R.-G., Liu T., Ji R.-R., Lee S.-Y. A monoclonal antibody that targets a NaV1.7 channel voltage sensor for pain and itch relief. Cell 2014, 157:1393-1404.
-
(2014)
Cell
, vol.157
, pp. 1393-1404
-
-
Lee, J.-H.1
Park, C.-K.2
Chen, G.3
Han, Q.4
Xie, R.-G.5
Liu, T.6
Ji, R.-R.7
Lee, S.-Y.8
-
16
-
-
65749107719
-
HIV-1 and influenza antibodies: seeing antigens in new ways
-
Kwong P.D., Wilson I.A. HIV-1 and influenza antibodies: seeing antigens in new ways. Nat Immunol 2009, 10:573-578.
-
(2009)
Nat Immunol
, vol.10
, pp. 573-578
-
-
Kwong, P.D.1
Wilson, I.A.2
-
17
-
-
82255179322
-
A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield
-
Pejchal R., Doores K.J., Walker L.M., Khayat R., Huang P.S., Wang S.K., Stanfield R.L., Julien J.P., Ramos A., Crispin M., Depetris R., et al. A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield. Science 2011, 334:1097-1103.
-
(2011)
Science
, vol.334
, pp. 1097-1103
-
-
Pejchal, R.1
Doores, K.J.2
Walker, L.M.3
Khayat, R.4
Huang, P.S.5
Wang, S.K.6
Stanfield, R.L.7
Julien, J.P.8
Ramos, A.9
Crispin, M.10
Depetris, R.11
-
18
-
-
0013870005
-
The functions of the thymus system and the bursa system in the chicken
-
Cooper M.D., Peterson R.D.A., South M.A., Good R.A. The functions of the thymus system and the bursa system in the chicken. J Exp Med 1966, 123:75-102.
-
(1966)
J Exp Med
, vol.123
, pp. 75-102
-
-
Cooper, M.D.1
Peterson, R.D.A.2
South, M.A.3
Good, R.A.4
-
19
-
-
0001303269
-
The bursa of fabricius and antibody production
-
Glick B., Chang T.S., Jaap R.G. The bursa of fabricius and antibody production. Poultry Sci 1956, 35:224-225.
-
(1956)
Poultry Sci
, vol.35
, pp. 224-225
-
-
Glick, B.1
Chang, T.S.2
Jaap, R.G.3
-
20
-
-
26044467886
-
Antibodies, immunoglobulin genes and the bursa of fabricius in chicken B cell development
-
Ratcliffe M.J. Antibodies, immunoglobulin genes and the bursa of fabricius in chicken B cell development. Dev Comp Immunol 2006, 30:101-118.
-
(2006)
Dev Comp Immunol
, vol.30
, pp. 101-118
-
-
Ratcliffe, M.J.1
-
21
-
-
0029155781
-
IgY: clues to the origins of modern antibodies
-
Warr G.W., Magor K.E., Higgins D.A. IgY: clues to the origins of modern antibodies. Immunol Today 1995, 16:392-398.
-
(1995)
Immunol Today
, vol.16
, pp. 392-398
-
-
Warr, G.W.1
Magor, K.E.2
Higgins, D.A.3
-
22
-
-
0037083364
-
Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversion
-
Arakawa H., Hauschild J., Buerstedde J.M. Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversion. Science 2002, 295:1301-1306.
-
(2002)
Science
, vol.295
, pp. 1301-1306
-
-
Arakawa, H.1
Hauschild, J.2
Buerstedde, J.M.3
-
23
-
-
0037083562
-
One aid to unite them all
-
Fugmann S.D., Schatz D.G. One aid to unite them all. Science 2002, 295:1244-1245.
-
(2002)
Science
, vol.295
, pp. 1244-1245
-
-
Fugmann, S.D.1
Schatz, D.G.2
-
24
-
-
84855361545
-
Fundamental characteristics of the immunoglobulin VH repertoire of chickens in comparison with those of humans, mice, and camelids
-
Wu L., Oficjalska K., Lambert M., Fennell B.J., Darmanin-Sheehan A., Ní Shúilleabháin D., Autin B., Cummins E., Tchistiakova L., Bloom L., Paulsen J., et al. Fundamental characteristics of the immunoglobulin VH repertoire of chickens in comparison with those of humans, mice, and camelids. J Immunol 2012, 188:322-333.
-
(2012)
J Immunol
, vol.188
, pp. 322-333
-
-
Wu, L.1
Oficjalska, K.2
Lambert, M.3
Fennell, B.J.4
Darmanin-Sheehan, A.5
Ní Shúilleabháin, D.6
Autin, B.7
Cummins, E.8
Tchistiakova, L.9
Bloom, L.10
Paulsen, J.11
-
25
-
-
0025676044
-
Somatic diversification of immunoglobulin heavy chain VDJ genes: evidence for somatic gene conversion in rabbits
-
Becker R.S., Knight K.L. Somatic diversification of immunoglobulin heavy chain VDJ genes: evidence for somatic gene conversion in rabbits. Cell 1990, 63:987-997.
-
(1990)
Cell
, vol.63
, pp. 987-997
-
-
Becker, R.S.1
Knight, K.L.2
-
26
-
-
4344714933
-
Synthetic antibodies from a four-amino-acid code: a dominant role for tyrosine in antigen recognition
-
Fellouse F.A., Wiesmann C., Sidhu S.S. Synthetic antibodies from a four-amino-acid code: a dominant role for tyrosine in antigen recognition. Proc Natl Acad Sci U S A 2004, 101:12467-12472.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 12467-12472
-
-
Fellouse, F.A.1
Wiesmann, C.2
Sidhu, S.S.3
-
27
-
-
20444394778
-
Development of the expressed ig CDR-H3 repertoire is marked by focusing of constraints in length, amino acid use, and charge that are first established in early B cell progenitors
-
Ivanov I.I., Schelonka R.L., Zhuang Y., Gartland G.L., Zemlin M., Schroeder H.W. Development of the expressed ig CDR-H3 repertoire is marked by focusing of constraints in length, amino acid use, and charge that are first established in early B cell progenitors. J Immunol 2005, 174:7773-7780.
-
(2005)
J Immunol
, vol.174
, pp. 7773-7780
-
-
Ivanov, I.I.1
Schelonka, R.L.2
Zhuang, Y.3
Gartland, G.L.4
Zemlin, M.5
Schroeder, H.W.6
-
28
-
-
0029146320
-
Impact of the high tyrosine fraction in complementarity determining regions: measured and predicted effects of radioiodination on IgG immunoreactivity
-
Nikula T.K., Bocchia M., Curcio M.J., Sgouros G., Ma Y., Finn R.D., Scheinberg D.A. Impact of the high tyrosine fraction in complementarity determining regions: measured and predicted effects of radioiodination on IgG immunoreactivity. Mol Immunol 1995, 32:865-872.
-
(1995)
Mol Immunol
, vol.32
, pp. 865-872
-
-
Nikula, T.K.1
Bocchia, M.2
Curcio, M.J.3
Sgouros, G.4
Ma, Y.5
Finn, R.D.6
Scheinberg, D.A.7
-
29
-
-
84901718095
-
Reconciling the structural attributes of avian antibodies
-
Conroy P.J., Law R.H.P., Gilgunn S., Hearty S., Caradoc-Davies T.T., Lloyd G., O'Kennedy R.J., Whisstock J.C. Reconciling the structural attributes of avian antibodies. J Biol Chem 2014, 289:15384-15392.
-
(2014)
J Biol Chem
, vol.289
, pp. 15384-15392
-
-
Conroy, P.J.1
Law, R.H.P.2
Gilgunn, S.3
Hearty, S.4
Caradoc-Davies, T.T.5
Lloyd, G.6
O'Kennedy, R.J.7
Whisstock, J.C.8
-
30
-
-
84865647723
-
Avian IgY antibodies and their recombinant equivalents in research, diagnostics and therapy
-
Spillner E., Braren I., Greunke K., Seismann H., Blank S., du Plessis D. Avian IgY antibodies and their recombinant equivalents in research, diagnostics and therapy. Biologicals 2012, 40:313-322.
-
(2012)
Biologicals
, vol.40
, pp. 313-322
-
-
Spillner, E.1
Braren, I.2
Greunke, K.3
Seismann, H.4
Blank, S.5
du Plessis, D.6
-
31
-
-
0028825910
-
Selection of specific phage-display antibodies using libraries derived from chicken immunoglobulin genes
-
Davies E.L., Smith J.S., Birkett C.R., Manser J.M., Anderson-Dear D.V., Young J.R. Selection of specific phage-display antibodies using libraries derived from chicken immunoglobulin genes. J Immunol Methods 1995, 186:125-135.
-
(1995)
J Immunol Methods
, vol.186
, pp. 125-135
-
-
Davies, E.L.1
Smith, J.S.2
Birkett, C.R.3
Manser, J.M.4
Anderson-Dear, D.V.5
Young, J.R.6
-
32
-
-
3042615154
-
A large semi-synthetic single-chain Fv phage display library based on chicken immunoglobulin genes
-
van Wyngaardt W., Malatji T., Mashau C., Fehrsen J., Jordaan F., Miltiadou D., du Plessis D.H. A large semi-synthetic single-chain Fv phage display library based on chicken immunoglobulin genes. BMC Biotechnol 2004, 4:6.
-
(2004)
BMC Biotechnol
, vol.4
, pp. 6
-
-
van Wyngaardt, W.1
Malatji, T.2
Mashau, C.3
Fehrsen, J.4
Jordaan, F.5
Miltiadou, D.6
du Plessis, D.H.7
-
33
-
-
0030210311
-
Chicken monoclonal antibody isolated by a phage display system
-
Yamanaka H.I., Inoue T., Ikeda-Tanaka O. Chicken monoclonal antibody isolated by a phage display system. J Immunol 1996, 157:1156-1162.
-
(1996)
J Immunol
, vol.157
, pp. 1156-1162
-
-
Yamanaka, H.I.1
Inoue, T.2
Ikeda-Tanaka, O.3
-
34
-
-
77952741054
-
Enhancement of hypermutation frequency in the chicken B cell line DT40 for efficient diversification of the antibody repertoire
-
Magari M., Kanehiro Y., Todo K., Ikeda M., Kanayama N., Ohmori H. Enhancement of hypermutation frequency in the chicken B cell line DT40 for efficient diversification of the antibody repertoire. Biochem Biophys Res Commun 2010, 396:353-358.
-
(2010)
Biochem Biophys Res Commun
, vol.396
, pp. 353-358
-
-
Magari, M.1
Kanehiro, Y.2
Todo, K.3
Ikeda, M.4
Kanayama, N.5
Ohmori, H.6
-
35
-
-
84894276781
-
Harnessing gene conversion in chicken B cells to create a human antibody sequence repertoire
-
Schusser B., Yi H., Collarini E.J., Izquierdo S.M., Harriman W.D., Etches R.J., Leighton P.A. Harnessing gene conversion in chicken B cells to create a human antibody sequence repertoire. PLoS One 2013, 8:e80108.
-
(2013)
PLoS One
, vol.8
-
-
Schusser, B.1
Yi, H.2
Collarini, E.J.3
Izquierdo, S.M.4
Harriman, W.D.5
Etches, R.J.6
Leighton, P.A.7
-
36
-
-
84890290471
-
Immunoglobulin knockout chickens via efficient homologous recombination in primordial germ cells
-
Schusser B., Collarini E.J., Yi H., Izquierdo S.M., Fesler J., Pedersen D., Klasing K.C., Kaspers B., Harriman W.D., van de Lavoir M.-C., Etches R.J., et al. Immunoglobulin knockout chickens via efficient homologous recombination in primordial germ cells. Proc Natl Acad Sci U S A 2013, 110:20170-20175.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 20170-20175
-
-
Schusser, B.1
Collarini, E.J.2
Yi, H.3
Izquierdo, S.M.4
Fesler, J.5
Pedersen, D.6
Klasing, K.C.7
Kaspers, B.8
Harriman, W.D.9
van de Lavoir, M.-C.10
Etches, R.J.11
-
37
-
-
84897116795
-
Analysis of heavy and light chain sequences of conventional camelid antibodies from camelus dromedarius and camelus bactrianus species
-
Griffin L.M., Snowden J.R., Lawson A.D., Wernery U., Kinne J., Baker T.S. Analysis of heavy and light chain sequences of conventional camelid antibodies from camelus dromedarius and camelus bactrianus species. J Immunol Methods 2014, 405:35-46.
-
(2014)
J Immunol Methods
, vol.405
, pp. 35-46
-
-
Griffin, L.M.1
Snowden, J.R.2
Lawson, A.D.3
Wernery, U.4
Kinne, J.5
Baker, T.S.6
-
38
-
-
0027310612
-
Naturally occurring antibodies devoid of light chains
-
Hamers-Casterman C., Atarhouch T., Muyldermans S., Robinson G., Hamers C., Songa E.B., Bendahman N., Hamers R. Naturally occurring antibodies devoid of light chains. Nature 1993, 363:446-448.
-
(1993)
Nature
, vol.363
, pp. 446-448
-
-
Hamers-Casterman, C.1
Atarhouch, T.2
Muyldermans, S.3
Robinson, G.4
Hamers, C.5
Songa, E.B.6
Bendahman, N.7
Hamers, R.8
-
39
-
-
0033544535
-
Single domain antibodies: comparison of camel VH and camelised human VH domains
-
Riechmann L., Muyldermans S. Single domain antibodies: comparison of camel VH and camelised human VH domains. J Immunol Methods 1999, 231:25-38.
-
(1999)
J Immunol Methods
, vol.231
, pp. 25-38
-
-
Riechmann, L.1
Muyldermans, S.2
-
40
-
-
0034524838
-
Llama heavy-chain V regions consist of at least four distinct subfamilies revealing novel sequence features
-
Harmsen M.M., Ruuls R.C., Nijman I.J., Niewold T.A., Frenken L.G., de Geus B. Llama heavy-chain V regions consist of at least four distinct subfamilies revealing novel sequence features. Mol Immunol 2000, 37:579-590.
-
(2000)
Mol Immunol
, vol.37
, pp. 579-590
-
-
Harmsen, M.M.1
Ruuls, R.C.2
Nijman, I.J.3
Niewold, T.A.4
Frenken, L.G.5
de Geus, B.6
-
41
-
-
49649115313
-
Tetrameric and homodimeric camelid IgGs originate from the same IgH locus
-
Achour I., Cavelier P., Tichit M., Bouchier C., Lafaye P., Rougeon F. Tetrameric and homodimeric camelid IgGs originate from the same IgH locus. J Immunol 2008, 181:2001-2009.
-
(2008)
J Immunol
, vol.181
, pp. 2001-2009
-
-
Achour, I.1
Cavelier, P.2
Tichit, M.3
Bouchier, C.4
Lafaye, P.5
Rougeon, F.6
-
42
-
-
0034161488
-
Camel heavy-chain antibodies: diverse germline V(H)H and specific mechanisms enlarge the antigen-binding repertoire
-
Nguyen V.K., Hamers R., Wyns L., Muyldermans S. Camel heavy-chain antibodies: diverse germline V(H)H and specific mechanisms enlarge the antigen-binding repertoire. EMBO J 2000, 19:921-930.
-
(2000)
EMBO J
, vol.19
, pp. 921-930
-
-
Nguyen, V.K.1
Hamers, R.2
Wyns, L.3
Muyldermans, S.4
-
43
-
-
0032559379
-
The specific variable domain of camel heavy-chain antibodies is encoded in the germline
-
Nguyen V.K., Muyldermans S., Hamers R. The specific variable domain of camel heavy-chain antibodies is encoded in the germline. J Mol Biol 1998, 275:413-418.
-
(1998)
J Mol Biol
, vol.275
, pp. 413-418
-
-
Nguyen, V.K.1
Muyldermans, S.2
Hamers, R.3
-
44
-
-
77954739350
-
A novel promiscuous class of camelid single-domain antibody contributes to the antigen-binding repertoire
-
Deschacht N., De Groeve K., Vincke C., Raes G., De Baetselier P., Muyldermans S. A novel promiscuous class of camelid single-domain antibody contributes to the antigen-binding repertoire. J Immunol 2010, 184:5696-5704.
-
(2010)
J Immunol
, vol.184
, pp. 5696-5704
-
-
Deschacht, N.1
De Groeve, K.2
Vincke, C.3
Raes, G.4
De Baetselier, P.5
Muyldermans, S.6
-
45
-
-
0345425685
-
Loss of splice consensus signal is responsible for the removal of the entire C(H)1 domain of the functional camel IGG2A heavy-chain antibodies
-
Nguyen V.K., Hamers R., Wyns L., Muyldermans S. Loss of splice consensus signal is responsible for the removal of the entire C(H)1 domain of the functional camel IGG2A heavy-chain antibodies. Mol Immunol 1999, 36:515-524.
-
(1999)
Mol Immunol
, vol.36
, pp. 515-524
-
-
Nguyen, V.K.1
Hamers, R.2
Wyns, L.3
Muyldermans, S.4
-
46
-
-
0028168145
-
Sequence and structure of VH domain from naturally occurring camel heavy chain immunoglobulins lacking light chains
-
Muyldermans S., Atarhouch T., Saldanha J., Barbosa J.A., Hamers R. Sequence and structure of VH domain from naturally occurring camel heavy chain immunoglobulins lacking light chains. Protein Eng 1994, 7:1129-1135.
-
(1994)
Protein Eng
, vol.7
, pp. 1129-1135
-
-
Muyldermans, S.1
Atarhouch, T.2
Saldanha, J.3
Barbosa, J.A.4
Hamers, R.5
-
47
-
-
0022339938
-
Domain association in immunoglobulin molecules. The packing of variable domains
-
Chothia C., Novotny J., Bruccoleri R., Karplus M. Domain association in immunoglobulin molecules. The packing of variable domains. J Mol Biol 1985, 186:651-663.
-
(1985)
J Mol Biol
, vol.186
, pp. 651-663
-
-
Chothia, C.1
Novotny, J.2
Bruccoleri, R.3
Karplus, M.4
-
48
-
-
33645241975
-
Molecular basis for the preferential cleft recognition by dromedary heavy-chain antibodies
-
De Genst E., Silence K., Decanniere K., Conrath K., Loris R., Kinne J., Muyldermans S., Wyns L. Molecular basis for the preferential cleft recognition by dromedary heavy-chain antibodies. Proc Natl Acad Sci U S A 2006, 103:4586-4591.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 4586-4591
-
-
De Genst, E.1
Silence, K.2
Decanniere, K.3
Conrath, K.4
Loris, R.5
Kinne, J.6
Muyldermans, S.7
Wyns, L.8
-
49
-
-
35348819390
-
Properties, production, and applications of camelid single-domain antibody fragments
-
Harmsen M.M., De Haard H.J. Properties, production, and applications of camelid single-domain antibody fragments. Appl Microbiol Biotechnol 2007, 77:13-22.
-
(2007)
Appl Microbiol Biotechnol
, vol.77
, pp. 13-22
-
-
Harmsen, M.M.1
De Haard, H.J.2
-
50
-
-
79958056394
-
Analysis and modeling of the variable region of camelid single-domain antibodies
-
Sircar A., Sanni K.A., Shi J., Gray J.J. Analysis and modeling of the variable region of camelid single-domain antibodies. J Immunol 2011, 186:6357-6367.
-
(2011)
J Immunol
, vol.186
, pp. 6357-6367
-
-
Sircar, A.1
Sanni, K.A.2
Shi, J.3
Gray, J.J.4
-
51
-
-
0037303456
-
Emergence and evolution of functional heavy-chain antibodies in camelidae
-
Conrath K.E., Wernery U., Muyldermans S., Nguyen V.K. Emergence and evolution of functional heavy-chain antibodies in camelidae. Dev Comp Immunol 2003, 27:87-103.
-
(2003)
Dev Comp Immunol
, vol.27
, pp. 87-103
-
-
Conrath, K.E.1
Wernery, U.2
Muyldermans, S.3
Nguyen, V.K.4
-
52
-
-
84855849845
-
Dual beneficial effect of interloop disulfide bond for single domain antibody fragments
-
Govaert J., Pellis M., Deschacht N., Vincke C., Conrath K., Muyldermans S., Saerens D. Dual beneficial effect of interloop disulfide bond for single domain antibody fragments. J Biol Chem 2012, 287:1970-1979.
-
(2012)
J Biol Chem
, vol.287
, pp. 1970-1979
-
-
Govaert, J.1
Pellis, M.2
Deschacht, N.3
Vincke, C.4
Conrath, K.5
Muyldermans, S.6
Saerens, D.7
-
53
-
-
0025823716
-
Identical V region amino acid sequences and segments of sequences in antibodies of different specificities. Relative contributions of VH and VL genes, minigenes, and complementarity-determining regions to binding of antibody-combining sites
-
Kabat E.A., Wu T.T. Identical V region amino acid sequences and segments of sequences in antibodies of different specificities. Relative contributions of VH and VL genes, minigenes, and complementarity-determining regions to binding of antibody-combining sites. J Immunol 1991, 147:1709-1719.
-
(1991)
J Immunol
, vol.147
, pp. 1709-1719
-
-
Kabat, E.A.1
Wu, T.T.2
-
54
-
-
0037133506
-
Biophysical properties of camelid V(HH) domains compared to those of human V(H)3 domains
-
Ewert S., Cambillau C., Conrath K., Pluckthun A. Biophysical properties of camelid V(HH) domains compared to those of human V(H)3 domains. Biochemistry 2002, 41:3628-3636.
-
(2002)
Biochemistry
, vol.41
, pp. 3628-3636
-
-
Ewert, S.1
Cambillau, C.2
Conrath, K.3
Pluckthun, A.4
-
55
-
-
59149104037
-
General strategy to humanize a camelid single-domain antibody and identification of a universal humanized nanobody scaffold
-
Vincke C., Loris R., Saerens D., Martinez-Rodriguez S., Muyldermans S., Conrath K. General strategy to humanize a camelid single-domain antibody and identification of a universal humanized nanobody scaffold. J Biol Chem 2009, 284:3273-3284.
-
(2009)
J Biol Chem
, vol.284
, pp. 3273-3284
-
-
Vincke, C.1
Loris, R.2
Saerens, D.3
Martinez-Rodriguez, S.4
Muyldermans, S.5
Conrath, K.6
-
56
-
-
84875971358
-
The global sequence signature algorithm unveils a structural network surrounding heavy chain CDR3 loop in camelidae variable domains
-
Kastelic D., Soler N., Komel R., Pompon D. The global sequence signature algorithm unveils a structural network surrounding heavy chain CDR3 loop in camelidae variable domains. Biochim Biophys Acta 2013, 1830:3373-3381.
-
(2013)
Biochim Biophys Acta
, vol.1830
, pp. 3373-3381
-
-
Kastelic, D.1
Soler, N.2
Komel, R.3
Pompon, D.4
-
57
-
-
84921418700
-
Camelid nanobodies: killing two birds with one stone
-
Desmyter A., Spinelli S., Roussel A., Cambillau C. Camelid nanobodies: killing two birds with one stone. Curr Opin Struct Biol 2015, 32:1-8.
-
(2015)
Curr Opin Struct Biol
, vol.32
, pp. 1-8
-
-
Desmyter, A.1
Spinelli, S.2
Roussel, A.3
Cambillau, C.4
-
58
-
-
78651411166
-
Structure of a nanobody-stabilized active state of the beta(2) adrenoceptor
-
Rasmussen S.G., Choi H.J., Fung J.J., Pardon E., Casarosa P., Chae P.S., Devree B.T., Rosenbaum D.M., Thian F.S., Kobilka T.S., Schnapp A., et al. Structure of a nanobody-stabilized active state of the beta(2) adrenoceptor. Nature 2011, 469:175-180.
-
(2011)
Nature
, vol.469
, pp. 175-180
-
-
Rasmussen, S.G.1
Choi, H.J.2
Fung, J.J.3
Pardon, E.4
Casarosa, P.5
Chae, P.S.6
Devree, B.T.7
Rosenbaum, D.M.8
Thian, F.S.9
Kobilka, T.S.10
Schnapp, A.11
-
59
-
-
79957937913
-
Evaluation of a nanobody phage display library constructed from a brucella-immunised camel
-
Abbady A.Q., Al-Mariri A., Zarkawi M., Al-Assad A., Muyldermans S. Evaluation of a nanobody phage display library constructed from a brucella-immunised camel. Vet Immunol Immunopathol 2011, 142:49-56.
-
(2011)
Vet Immunol Immunopathol
, vol.142
, pp. 49-56
-
-
Abbady, A.Q.1
Al-Mariri, A.2
Zarkawi, M.3
Al-Assad, A.4
Muyldermans, S.5
-
60
-
-
65349172055
-
Immunological applications of single-domain llama recombinant antibodies isolated from a naive library
-
Monegal A., Ami D., Martinelli C., Huang H., Aliprandi M., Capasso P., Francavilla C., Ossolengo G., de Marco A. Immunological applications of single-domain llama recombinant antibodies isolated from a naive library. Protein Eng Des Sel 2009, 22:273-280.
-
(2009)
Protein Eng Des Sel
, vol.22
, pp. 273-280
-
-
Monegal, A.1
Ami, D.2
Martinelli, C.3
Huang, H.4
Aliprandi, M.5
Capasso, P.6
Francavilla, C.7
Ossolengo, G.8
de Marco, A.9
-
61
-
-
84923633871
-
Construction of a synthetic phage-displayed nanobody library with CDR3 regions randomized by trinucleotide cassettes for diagnostic applications
-
Yan J., Li G., Hu Y., Ou W., Wan Y. Construction of a synthetic phage-displayed nanobody library with CDR3 regions randomized by trinucleotide cassettes for diagnostic applications. J Translat Med 2014, 12:343.
-
(2014)
J Translat Med
, vol.12
, pp. 343
-
-
Yan, J.1
Li, G.2
Hu, Y.3
Ou, W.4
Wan, Y.5
-
62
-
-
84884523021
-
Selection of single domain antibodies from immune libraries displayed on the surface of E. Coli cells with two beta-domains of opposite topologies
-
Salema V., Marin E., Martinez-Arteaga R., Ruano-Gallego D., Fraile S., Margolles Y., Teira X., Gutierrez C., Bodelon G., Fernandez L.A. Selection of single domain antibodies from immune libraries displayed on the surface of E. Coli cells with two beta-domains of opposite topologies. PLoS One 2013, 8:e75126.
-
(2013)
PLoS One
, vol.8
-
-
Salema, V.1
Marin, E.2
Martinez-Arteaga, R.3
Ruano-Gallego, D.4
Fraile, S.5
Margolles, Y.6
Teira, X.7
Gutierrez, C.8
Bodelon, G.9
Fernandez, L.A.10
-
63
-
-
82555187501
-
Potent neutralization of influenza A virus by a single-domain antibody blocking M2 ion channel protein
-
Wei G., Meng W., Guo H., Pan W., Liu J., Peng T., Chen L., Chen C.Y. Potent neutralization of influenza A virus by a single-domain antibody blocking M2 ion channel protein. PLoS One 2011, 6:e28309.
-
(2011)
PLoS One
, vol.6
-
-
Wei, G.1
Meng, W.2
Guo, H.3
Pan, W.4
Liu, J.5
Peng, T.6
Chen, L.7
Chen, C.Y.8
-
64
-
-
84888156575
-
In vivo neutralization of botulinum neurotoxins serotype e with heavy-chain camelid antibodies (VHH)
-
Bakherad H., Mousavi Gargari S.L., Rasooli I., Rajabibazl M., Mohammadi M., Ebrahimizadeh W., Safaee Ardakani L., Zare H. In vivo neutralization of botulinum neurotoxins serotype e with heavy-chain camelid antibodies (VHH). Mol Biotechnol 2013, 55:159-167.
-
(2013)
Mol Biotechnol
, vol.55
, pp. 159-167
-
-
Bakherad, H.1
Mousavi Gargari, S.L.2
Rasooli, I.3
Rajabibazl, M.4
Mohammadi, M.5
Ebrahimizadeh, W.6
Safaee Ardakani, L.7
Zare, H.8
-
66
-
-
84876271982
-
The African coelacanth genome provides insights into tetrapod evolution
-
Amemiya C.T., Alfoldi J., Lee A.P., Fan S., Philippe H., Maccallum I., Braasch I., Manousaki T., Schneider I., Rohner N., Organ C., et al. The African coelacanth genome provides insights into tetrapod evolution. Nature 2013, 496:311-316.
-
(2013)
Nature
, vol.496
, pp. 311-316
-
-
Amemiya, C.T.1
Alfoldi, J.2
Lee, A.P.3
Fan, S.4
Philippe, H.5
Maccallum, I.6
Braasch, I.7
Manousaki, T.8
Schneider, I.9
Rohner, N.10
Organ, C.11
-
67
-
-
84861528891
-
Origin of immunoglobulin isotype switching
-
Zhu C., Lee V., Finn A., Senger K., Zarrin A.A., Du Pasquier L., Hsu E. Origin of immunoglobulin isotype switching. Curr Biol 2012, 22:872-880.
-
(2012)
Curr Biol
, vol.22
, pp. 872-880
-
-
Zhu, C.1
Lee, V.2
Finn, A.3
Senger, K.4
Zarrin, A.A.5
Du Pasquier, L.6
Hsu, E.7
-
68
-
-
0028962371
-
A new antigen receptor gene family that undergoes rearrangement and extensive somatic diversification in sharks
-
Greenberg A.S., Avila D., Hughes M., Hughes A., McKinney E.C., Flajnik M.F. A new antigen receptor gene family that undergoes rearrangement and extensive somatic diversification in sharks. Nature 1995, 374:168-173.
-
(1995)
Nature
, vol.374
, pp. 168-173
-
-
Greenberg, A.S.1
Avila, D.2
Hughes, M.3
Hughes, A.4
McKinney, E.C.5
Flajnik, M.F.6
-
69
-
-
35348880944
-
Four primordial immunoglobulin light chain isotypes, including lambda and kappa, identified in the most primitive living jawed vertebrates
-
Criscitiello M.F., Flajnik M.F. Four primordial immunoglobulin light chain isotypes, including lambda and kappa, identified in the most primitive living jawed vertebrates. Eur J Immunol 2007, 37:2683-2694.
-
(2007)
Eur J Immunol
, vol.37
, pp. 2683-2694
-
-
Criscitiello, M.F.1
Flajnik, M.F.2
-
70
-
-
77953646925
-
Evolutionarily conserved tcr binding sites, identification of T cells in primary lymphoid tissues, and surprising trans-rearrangements in nurse shark
-
Criscitiello M.F., Ohta Y., Saltis M., McKinney E.C., Flajnik M.F. Evolutionarily conserved tcr binding sites, identification of T cells in primary lymphoid tissues, and surprising trans-rearrangements in nurse shark. J Immunol 2010, 184:6950-6960.
-
(2010)
J Immunol
, vol.184
, pp. 6950-6960
-
-
Criscitiello, M.F.1
Ohta, Y.2
Saltis, M.3
McKinney, E.C.4
Flajnik, M.F.5
-
71
-
-
33645503864
-
An evolutionarily mobile antigen receptor variable region gene: doubly rearranging NAR-TcR genes in sharks
-
Criscitiello M.F., Saltis M., Flajnik M.F. An evolutionarily mobile antigen receptor variable region gene: doubly rearranging NAR-TcR genes in sharks. Proc Natl Acad Sci U S A 2006, 103:5036-5041.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 5036-5041
-
-
Criscitiello, M.F.1
Saltis, M.2
Flajnik, M.F.3
-
73
-
-
66649097841
-
Characterization of arrangement and expression of the T cell receptor gamma locus in the sandbar shark
-
Chen H., Kshirsagar S., Jensen I., Lau K., Covarrubias R., Schluter S.F., Marchalonis J.J. Characterization of arrangement and expression of the T cell receptor gamma locus in the sandbar shark. Proc Natl Acad Sci U S A 2009, 106:8591-8596.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 8591-8596
-
-
Chen, H.1
Kshirsagar, S.2
Jensen, I.3
Lau, K.4
Covarrubias, R.5
Schluter, S.F.6
Marchalonis, J.J.7
-
74
-
-
0022518316
-
Major reorganization of immunoglobulin VH segmental elements during vertebrate evolution
-
Hinds K.R., Litman G.W. Major reorganization of immunoglobulin VH segmental elements during vertebrate evolution. Nature 1986, 320:546-549.
-
(1986)
Nature
, vol.320
, pp. 546-549
-
-
Hinds, K.R.1
Litman, G.W.2
-
75
-
-
45849107256
-
Immunoglobulin heavy chain exclusion in the shark
-
Malecek K., Lee V., Feng W., Huang J.L., Flajnik M.F., Ohta Y., Hsu E. Immunoglobulin heavy chain exclusion in the shark. PLoS Biol 2008, 6:e157.
-
(2008)
PLoS Biol
, vol.6
-
-
Malecek, K.1
Lee, V.2
Feng, W.3
Huang, J.L.4
Flajnik, M.F.5
Ohta, Y.6
Hsu, E.7
-
76
-
-
0024114932
-
Diverse organization of immunoglobulin VH gene loci in a primitive vertebrate
-
Kokubu F., Litman R., Shamblott M.J., Hinds K., Litman G.W. Diverse organization of immunoglobulin VH gene loci in a primitive vertebrate. EMBO J 1988, 7:3413-3422.
-
(1988)
EMBO J
, vol.7
, pp. 3413-3422
-
-
Kokubu, F.1
Litman, R.2
Shamblott, M.J.3
Hinds, K.4
Litman, G.W.5
-
77
-
-
0034658657
-
Rearrangement of immunoglobulin genes in shark germ cells
-
Lee S.S., Fitch D., Flajnik M.F., Hsu E. Rearrangement of immunoglobulin genes in shark germ cells. J Exp Med 2000, 191:1637-1648.
-
(2000)
J Exp Med
, vol.191
, pp. 1637-1648
-
-
Lee, S.S.1
Fitch, D.2
Flajnik, M.F.3
Hsu, E.4
-
78
-
-
0035852647
-
A shark antibody heavy chain encoded by a nonsomatically rearranged VDJ is preferentially expressed in early development and is convergent with mammalian IgG
-
Rumfelt L.L., Avila D., Diaz M., Bartl S., McKinney E.C., Flajnik M.F. A shark antibody heavy chain encoded by a nonsomatically rearranged VDJ is preferentially expressed in early development and is convergent with mammalian IgG. Proc Natl Acad Sci U S A 2001, 98:1775-1780.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 1775-1780
-
-
Rumfelt, L.L.1
Avila, D.2
Diaz, M.3
Bartl, S.4
McKinney, E.C.5
Flajnik, M.F.6
-
79
-
-
0023389682
-
Extensive families of constant region genes in a phylogenetically primitive vertebrate indicate an additional level of immunoglobulin complexity
-
Kokubu F., Hinds K., Litman R., Shamblott M.J., Litman G.W. Extensive families of constant region genes in a phylogenetically primitive vertebrate indicate an additional level of immunoglobulin complexity. Proc Natl Acad Sci U S A 1987, 84:5868-5872.
-
(1987)
Proc Natl Acad Sci U S A
, vol.84
, pp. 5868-5872
-
-
Kokubu, F.1
Hinds, K.2
Litman, R.3
Shamblott, M.J.4
Litman, G.W.5
-
80
-
-
0024040672
-
Complete structure and organization of immunoglobulin heavy chain constant region genes in a phylogenetically primitive vertebrate
-
Kokubu F., Hinds K., Litman R., Shamblott M.J., Litman G.W. Complete structure and organization of immunoglobulin heavy chain constant region genes in a phylogenetically primitive vertebrate. EMBO J 1988, 7:1979-1988.
-
(1988)
EMBO J
, vol.7
, pp. 1979-1988
-
-
Kokubu, F.1
Hinds, K.2
Litman, R.3
Shamblott, M.J.4
Litman, G.W.5
-
81
-
-
84964312932
-
The immunoglobulins of cold-blooded vertebrates
-
Pettinello R., Dooley H. The immunoglobulins of cold-blooded vertebrates. Biomolecules 2014, 4:1045-1069.
-
(2014)
Biomolecules
, vol.4
, pp. 1045-1069
-
-
Pettinello, R.1
Dooley, H.2
-
82
-
-
0031894290
-
Evolution of somatic hypermutation and gene conversion in adaptive immunity
-
Diaz M., Flajnik M.F. Evolution of somatic hypermutation and gene conversion in adaptive immunity. Immunol Rev 1998, 162:13-24.
-
(1998)
Immunol Rev
, vol.162
, pp. 13-24
-
-
Diaz, M.1
Flajnik, M.F.2
-
83
-
-
84888032786
-
Noncoordinate expression of J-chain and Blimp-1 define nurse shark plasma cell populations during ontogeny
-
Castro C.D., Ohta Y., Dooley H., Flajnik M.F. Noncoordinate expression of J-chain and Blimp-1 define nurse shark plasma cell populations during ontogeny. Eur J Immunol 2013, 43:3061-3075.
-
(2013)
Eur J Immunol
, vol.43
, pp. 3061-3075
-
-
Castro, C.D.1
Ohta, Y.2
Dooley, H.3
Flajnik, M.F.4
-
84
-
-
0036063457
-
The development of primary and secondary lymphoid tissues in the nurse shark ginglymostoma cirratum: B-cell zones precede dendritic cell immigration and T-cell zone formation during ontogeny of the spleen
-
Rumfelt L.L., McKinney E.C., Taylor E., Flajnik M.F. The development of primary and secondary lymphoid tissues in the nurse shark ginglymostoma cirratum: B-cell zones precede dendritic cell immigration and T-cell zone formation during ontogeny of the spleen. Scand J Immunol 2002, 56:130-148.
-
(2002)
Scand J Immunol
, vol.56
, pp. 130-148
-
-
Rumfelt, L.L.1
McKinney, E.C.2
Taylor, E.3
Flajnik, M.F.4
-
85
-
-
15844403109
-
Shark immunity bites back: affinity maturation and memory response in the nurse shark, ginglymostoma cirratum
-
Dooley H., Flajnik M.F. Shark immunity bites back: affinity maturation and memory response in the nurse shark, ginglymostoma cirratum. Eur J Immunol 2005, 35:936-945.
-
(2005)
Eur J Immunol
, vol.35
, pp. 936-945
-
-
Dooley, H.1
Flajnik, M.F.2
-
86
-
-
0032911308
-
Mutational pattern of the nurse shark antigen receptor gene (NAR) is similar to that of mammalian ig genes and to spontaneous mutations in evolution: the translesion synthesis model of somatic hypermutation
-
Diaz M., Velez J., Singh M., Cerny J., Flajnik M.F. Mutational pattern of the nurse shark antigen receptor gene (NAR) is similar to that of mammalian ig genes and to spontaneous mutations in evolution: the translesion synthesis model of somatic hypermutation. Int Immunol 1999, 11:825-833.
-
(1999)
Int Immunol
, vol.11
, pp. 825-833
-
-
Diaz, M.1
Velez, J.2
Singh, M.3
Cerny, J.4
Flajnik, M.F.5
-
87
-
-
0036224829
-
Hypermutation in shark immunoglobulin light chain genes results in contiguous substitutions
-
Lee S.S., Tranchina D., Ohta Y., Flajnik M.F., Hsu E. Hypermutation in shark immunoglobulin light chain genes results in contiguous substitutions. Immunity 2002, 16:571-582.
-
(2002)
Immunity
, vol.16
, pp. 571-582
-
-
Lee, S.S.1
Tranchina, D.2
Ohta, Y.3
Flajnik, M.F.4
Hsu, E.5
-
88
-
-
84901820594
-
The structural analysis of shark ignar antibodies reveals evolutionary principles of immunoglobulins
-
Feige M.J., Grawert M.A., Marcinowski M., Hennig J., Behnke J., Auslander D., Herold E.M., Peschek J., Castro C.D., Flajnik M., Hendershot L.M., et al. The structural analysis of shark ignar antibodies reveals evolutionary principles of immunoglobulins. Proc Natl Acad Sci U S A 2014, 111:8155-8160.
-
(2014)
Proc Natl Acad Sci U S A
, vol.111
, pp. 8155-8160
-
-
Feige, M.J.1
Grawert, M.A.2
Marcinowski, M.3
Hennig, J.4
Behnke, J.5
Auslander, D.6
Herold, E.M.7
Peschek, J.8
Castro, C.D.9
Flajnik, M.10
Hendershot, L.M.11
-
89
-
-
84856420721
-
Characterization of the immunoglobulin repertoire of the spiny dogfish (Squalus acanthias)
-
Smith L.E., Crouch K., Cao W., Muller M.R., Wu L., Steven J., Lee M., Liang M., Flajnik M.F., Shih H.H., Barelle C.J., et al. Characterization of the immunoglobulin repertoire of the spiny dogfish (Squalus acanthias). Dev Comp Immunol 2012, 36:665-679.
-
(2012)
Dev Comp Immunol
, vol.36
, pp. 665-679
-
-
Smith, L.E.1
Crouch, K.2
Cao, W.3
Muller, M.R.4
Wu, L.5
Steven, J.6
Lee, M.7
Liang, M.8
Flajnik, M.F.9
Shih, H.H.10
Barelle, C.J.11
-
90
-
-
32444436434
-
First molecular and biochemical analysis of in vivo affinity maturation in an ectothermic vertebrate
-
Dooley H., Stanfield R.L., Brady R.A., Flajnik M.F. First molecular and biochemical analysis of in vivo affinity maturation in an ectothermic vertebrate. Proc Natl Acad Sci U S A 2006, 103:1846-1851.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 1846-1851
-
-
Dooley, H.1
Stanfield, R.L.2
Brady, R.A.3
Flajnik, M.F.4
-
91
-
-
84879040923
-
Atypical antigen recognition mode of a shark immunoglobulin new antigen receptor (IgNAR) variable domain characterized by humanization and structural analysis
-
Kovalenko O.V., Olland A., Piche-Nicholas N., Godbole A., King D., Svenson K., Calabro V., Muller M.R., Barelle C.J., Somers W., Gill D.S., et al. Atypical antigen recognition mode of a shark immunoglobulin new antigen receptor (IgNAR) variable domain characterized by humanization and structural analysis. J Biol Chem 2013, 288:17408-17419.
-
(2013)
J Biol Chem
, vol.288
, pp. 17408-17419
-
-
Kovalenko, O.V.1
Olland, A.2
Piche-Nicholas, N.3
Godbole, A.4
King, D.5
Svenson, K.6
Calabro, V.7
Muller, M.R.8
Barelle, C.J.9
Somers, W.10
Gill, D.S.11
-
92
-
-
80052341911
-
A case of convergence: why did a simple alternative to canonical antibodies arise in sharks and camels?
-
Flajnik M.F., Deschacht N., Muyldermans S. A case of convergence: why did a simple alternative to canonical antibodies arise in sharks and camels?. PLoS Biol 2011, 9:e1001120.
-
(2011)
PLoS Biol
, vol.9
-
-
Flajnik, M.F.1
Deschacht, N.2
Muyldermans, S.3
-
93
-
-
84903164466
-
What the shark immune system can and cannot provide for the expanding design landscape of immunotherapy
-
Criscitiello M.F. What the shark immune system can and cannot provide for the expanding design landscape of immunotherapy. Expert Opin Drug Dis 2014, 9:725-739.
-
(2014)
Expert Opin Drug Dis
, vol.9
, pp. 725-739
-
-
Criscitiello, M.F.1
-
94
-
-
84921385703
-
Structural insights and biomedical potential of IgNAR scaffolds from sharks
-
Zielonka S., Empting M., Grzeschik J., Konning D., Barelle C.J., Kolmar H. Structural insights and biomedical potential of IgNAR scaffolds from sharks. mAbs 2015, 7:15-25.
-
(2015)
mAbs
, vol.7
, pp. 15-25
-
-
Zielonka, S.1
Empting, M.2
Grzeschik, J.3
Konning, D.4
Barelle, C.J.5
Kolmar, H.6
-
95
-
-
70350051125
-
The generation and selection of single-domain, V region libraries from nurse sharks
-
Flajnik M.F., Dooley H. The generation and selection of single-domain, V region libraries from nurse sharks. Methods Mol Biol 2009, 562:71-82.
-
(2009)
Methods Mol Biol
, vol.562
, pp. 71-82
-
-
Flajnik, M.F.1
Dooley, H.2
-
96
-
-
0042195979
-
Selection and characterization of naturally occurring single-domain (IgNAR) antibody fragments from immunized sharks by phage display
-
Dooley H., Flajnik M.F., Porter A.J. Selection and characterization of naturally occurring single-domain (IgNAR) antibody fragments from immunized sharks by phage display. Mol Immunol 2003, 40:25-33.
-
(2003)
Mol Immunol
, vol.40
, pp. 25-33
-
-
Dooley, H.1
Flajnik, M.F.2
Porter, A.J.3
-
97
-
-
80051927541
-
Isolation and characterisation of ebolavirus-specific recombinant antibody fragments from murine and shark immune libraries
-
Goodchild S.A., Dooley H., Schoepp R.J., Flajnik M., Lonsdale S.G. Isolation and characterisation of ebolavirus-specific recombinant antibody fragments from murine and shark immune libraries. Mol Immunol 2011, 48:2027-2037.
-
(2011)
Mol Immunol
, vol.48
, pp. 2027-2037
-
-
Goodchild, S.A.1
Dooley, H.2
Schoepp, R.J.3
Flajnik, M.4
Lonsdale, S.G.5
-
98
-
-
84867806992
-
Generation and isolation of target-specific single-domain antibodies from shark immune repertoires
-
Muller M.R., O'Dwyer R., Kovaleva M., Rudkin F., Dooley H., Barelle C.J. Generation and isolation of target-specific single-domain antibodies from shark immune repertoires. Methods Mol Biol 2012, 907:177-194.
-
(2012)
Methods Mol Biol
, vol.907
, pp. 177-194
-
-
Muller, M.R.1
O'Dwyer, R.2
Kovaleva, M.3
Rudkin, F.4
Dooley, H.5
Barelle, C.J.6
-
99
-
-
4544250973
-
Crystal structure of a shark single-domain antibody V region in complex with lysozyme
-
Stanfield R.L., Dooley H., Flajnik M.F., Wilson I.A. Crystal structure of a shark single-domain antibody V region in complex with lysozyme. Science 2004, 305:1770-1773.
-
(2004)
Science
, vol.305
, pp. 1770-1773
-
-
Stanfield, R.L.1
Dooley, H.2
Flajnik, M.F.3
Wilson, I.A.4
-
100
-
-
4344565797
-
Structural evidence for evolution of shark Ig new antigen receptor variable domain antibodies from a cell-surface receptor
-
Streltsov V.A., Varghese J.N., Carmichael J.A., Irving R.A., Hudson P.J., Nuttall S.D. Structural evidence for evolution of shark Ig new antigen receptor variable domain antibodies from a cell-surface receptor. Proc Natl Acad Sci U S A 2004, 101:12444-12449.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 12444-12449
-
-
Streltsov, V.A.1
Varghese, J.N.2
Carmichael, J.A.3
Irving, R.A.4
Hudson, P.J.5
Nuttall, S.D.6
-
101
-
-
0034830063
-
Isolation of the new antigen receptor from wobbegong sharks, and use as a scaffold for the display of protein loop libraries
-
Nuttall S.D., Krishnan U.V., Hattarki M., De Gori R., Irving R.A., Hudson P.J. Isolation of the new antigen receptor from wobbegong sharks, and use as a scaffold for the display of protein loop libraries. Mol Immunol 2001, 38:313-326.
-
(2001)
Mol Immunol
, vol.38
, pp. 313-326
-
-
Nuttall, S.D.1
Krishnan, U.V.2
Hattarki, M.3
De Gori, R.4
Irving, R.A.5
Hudson, P.J.6
-
102
-
-
33751164807
-
In vitro improvement of a shark IgNAR antibody by qbeta replicase mutation and ribosome display mimics in vivo affinity maturation
-
Kopsidas G., Roberts A.S., Coia G., Streltsov V.A., Nuttall S.D. In vitro improvement of a shark IgNAR antibody by qbeta replicase mutation and ribosome display mimics in vivo affinity maturation. Immunol Lett 2006, 107:163-168.
-
(2006)
Immunol Lett
, vol.107
, pp. 163-168
-
-
Kopsidas, G.1
Roberts, A.S.2
Coia, G.3
Streltsov, V.A.4
Nuttall, S.D.5
-
103
-
-
84911899117
-
Shark attack: high affinity binding proteins derived from shark vNAR domains by stepwise in vitro affinity maturation
-
Zielonka S., Weber N., Becker S., Doerner A., Christmann A., Christmann C., Uth C., Fritz J., Schafer E., Steinmann B., Empting M., et al. Shark attack: high affinity binding proteins derived from shark vNAR domains by stepwise in vitro affinity maturation. J Biotechnol 2014, 191:236-245.
-
(2014)
J Biotechnol
, vol.191
, pp. 236-245
-
-
Zielonka, S.1
Weber, N.2
Becker, S.3
Doerner, A.4
Christmann, A.5
Christmann, C.6
Uth, C.7
Fritz, J.8
Schafer, E.9
Steinmann, B.10
Empting, M.11
-
104
-
-
84907056407
-
Shark variable new antigen receptor biologics-a novel technology platform for therapeutic drug development
-
Kovaleva M., Ferguson L., Steven J., Porter A., Barelle C. Shark variable new antigen receptor biologics-a novel technology platform for therapeutic drug development. Expert Opin Biol Ther 2014, 14:1527-1539.
-
(2014)
Expert Opin Biol Ther
, vol.14
, pp. 1527-1539
-
-
Kovaleva, M.1
Ferguson, L.2
Steven, J.3
Porter, A.4
Barelle, C.5
-
105
-
-
39049132442
-
Selection of cholera toxin specific IgNAR single-domain antibodies from a naive shark library
-
Liu J.L., Anderson G.P., Delehanty J.B., Baumann R., Hayhurst A., Goldman E.R. Selection of cholera toxin specific IgNAR single-domain antibodies from a naive shark library. Mol Immunol 2007, 44:1775-1783.
-
(2007)
Mol Immunol
, vol.44
, pp. 1775-1783
-
-
Liu, J.L.1
Anderson, G.P.2
Delehanty, J.B.3
Baumann, R.4
Hayhurst, A.5
Goldman, E.R.6
-
106
-
-
79551685528
-
Targeting the hepatitis B virus precore antigen with a novel IgNAR single variable domain intrabody
-
Walsh R., Nuttall S., Revill P., Colledge D., Cabuang L., Soppe S., Dolezal O., Griffiths K., Bartholomeusz A., Locarnini S. Targeting the hepatitis B virus precore antigen with a novel IgNAR single variable domain intrabody. Virology 2011, 411:132-141.
-
(2011)
Virology
, vol.411
, pp. 132-141
-
-
Walsh, R.1
Nuttall, S.2
Revill, P.3
Colledge, D.4
Cabuang, L.5
Soppe, S.6
Dolezal, O.7
Griffiths, K.8
Bartholomeusz, A.9
Locarnini, S.10
-
107
-
-
57749192917
-
Somatic hypermutations and isotype restricted exceptionally long CDR3H contribute to antibody diversification in cattle
-
Kaushik A.K., Kehrli M.E., Kurtz A., Ng S., Koti M., Shojaei F., Saini S.S. Somatic hypermutations and isotype restricted exceptionally long CDR3H contribute to antibody diversification in cattle. Vet Immunol Immunopathol 2009, 127:106-113.
-
(2009)
Vet Immunol Immunopathol
, vol.127
, pp. 106-113
-
-
Kaushik, A.K.1
Kehrli, M.E.2
Kurtz, A.3
Ng, S.4
Koti, M.5
Shojaei, F.6
Saini, S.S.7
-
108
-
-
50249180171
-
Organization of DH-gene locus is distinct in cattle
-
Koti M., Kataeva G., Kaushik A. Organization of DH-gene locus is distinct in cattle. Dev Biol 2008, 132:307-313.
-
(2008)
Dev Biol
, vol.132
, pp. 307-313
-
-
Koti, M.1
Kataeva, G.2
Kaushik, A.3
-
109
-
-
0035724803
-
Incorporation of long CDR3S into V domains: implications for the structural evolution of the antibody-combining site
-
Ramsland P.A., Kaushik A., Marchalonis J.J., Edmundson A.B. Incorporation of long CDR3S into V domains: implications for the structural evolution of the antibody-combining site. Exp Clin Immunogenet 2001, 18:176-198.
-
(2001)
Exp Clin Immunogenet
, vol.18
, pp. 176-198
-
-
Ramsland, P.A.1
Kaushik, A.2
Marchalonis, J.J.3
Edmundson, A.B.4
-
110
-
-
0032766502
-
Exceptionally long CDR3H region with multiple cysteine residues in functional bovine igm antibodies
-
Saini S.S., Allore B., Jacobs R.M., Kaushik A. Exceptionally long CDR3H region with multiple cysteine residues in functional bovine igm antibodies. Eur J Immunol 1999, 29:2420-2426.
-
(1999)
Eur J Immunol
, vol.29
, pp. 2420-2426
-
-
Saini, S.S.1
Allore, B.2
Jacobs, R.M.3
Kaushik, A.4
-
111
-
-
0038350861
-
Bovine igm antibodies with exceptionally long complementarity-determining region 3 of the heavy chain share unique structural properties conferring restricted VH+Vlambda pairings
-
Saini S.S., Farrugia W., Ramsland P.A., Kaushik A.K. Bovine igm antibodies with exceptionally long complementarity-determining region 3 of the heavy chain share unique structural properties conferring restricted VH+Vlambda pairings. Int Immunol 2003, 15:845-853.
-
(2003)
Int Immunol
, vol.15
, pp. 845-853
-
-
Saini, S.S.1
Farrugia, W.2
Ramsland, P.A.3
Kaushik, A.K.4
-
112
-
-
0036227682
-
Extensive CDR3H length heterogeneity exists in bovine foetal VDJ rearrangements
-
Saini S.S., Kaushik A. Extensive CDR3H length heterogeneity exists in bovine foetal VDJ rearrangements. Scand J Immunol 2002, 55:140-148.
-
(2002)
Scand J Immunol
, vol.55
, pp. 140-148
-
-
Saini, S.S.1
Kaushik, A.2
-
113
-
-
0043198208
-
Unusually long germline DH genes contribute to large sized CDR3H in bovine antibodies
-
Shojaei F., Saini S.S., Kaushik A.K. Unusually long germline DH genes contribute to large sized CDR3H in bovine antibodies. Mol Immunol 2003, 40:61-67.
-
(2003)
Mol Immunol
, vol.40
, pp. 61-67
-
-
Shojaei, F.1
Saini, S.S.2
Kaushik, A.K.3
-
114
-
-
0030614749
-
Use of a single VH family and long CDR3S in the variable region of cattle Ig heavy chains
-
Berens S.J., Wylie D.E., Lopez O.J. Use of a single VH family and long CDR3S in the variable region of cattle Ig heavy chains. Int Immunol 1997, 9:189-199.
-
(1997)
Int Immunol
, vol.9
, pp. 189-199
-
-
Berens, S.J.1
Wylie, D.E.2
Lopez, O.J.3
-
115
-
-
2942722301
-
Duplicated copies of the bovine JH locus contribute to the Ig repertoire
-
Hosseini A., Campbell G., Prorocic M., Aitken R. Duplicated copies of the bovine JH locus contribute to the Ig repertoire. Int Immunol 2004, 16:843-852.
-
(2004)
Int Immunol
, vol.16
, pp. 843-852
-
-
Hosseini, A.1
Campbell, G.2
Prorocic, M.3
Aitken, R.4
-
116
-
-
0031596845
-
A single VH family and long CDR3S are the targets for hypermutation in bovine immunoglobulin heavy chains
-
Lopez O., Perez C., Wylie D. A single VH family and long CDR3S are the targets for hypermutation in bovine immunoglobulin heavy chains. Immunol Rev 1998, 162:55-66.
-
(1998)
Immunol Rev
, vol.162
, pp. 55-66
-
-
Lopez, O.1
Perez, C.2
Wylie, D.3
-
118
-
-
77951621301
-
The genome sequence of taurine cattle: a window to ruminant biology and evolution
-
Consortium TBGSA, Elsik C.G., Tellam R.L., Worley K.C. The genome sequence of taurine cattle: a window to ruminant biology and evolution. Science 2009, 324:522-528.
-
(2009)
Science
, vol.324
, pp. 522-528
-
-
Elsik, C.G.1
Tellam, R.L.2
Worley, K.C.3
-
119
-
-
84883191974
-
Activation-induced cytidine deaminase (AID) is strongly expressed in the fetal bovine ileal peyer's patch and spleen and is associated with expansion of the primary antibody repertoire in the absence of exogenous antigens
-
Liljavirta J., Ekman A., Knight J.S., Pernthaner A., Iivanainen A., Niku M. Activation-induced cytidine deaminase (AID) is strongly expressed in the fetal bovine ileal peyer's patch and spleen and is associated with expansion of the primary antibody repertoire in the absence of exogenous antigens. Mucosal Immunol 2013, 6:942-949.
-
(2013)
Mucosal Immunol
, vol.6
, pp. 942-949
-
-
Liljavirta, J.1
Ekman, A.2
Knight, J.S.3
Pernthaner, A.4
Iivanainen, A.5
Niku, M.6
-
120
-
-
84902777243
-
Expansion of the preimmune antibody repertoire by junctional diversity in Bos taurus
-
Liljavirta J., Niku M., Pessa-Morikawa T., Ekman A., Iivanainen A. Expansion of the preimmune antibody repertoire by junctional diversity in Bos taurus. PLoS One 2014, 9:e99808.
-
(2014)
PLoS One
, vol.9
-
-
Liljavirta, J.1
Niku, M.2
Pessa-Morikawa, T.3
Ekman, A.4
Iivanainen, A.5
-
121
-
-
0033582221
-
Generation of native bovine mabs by phage display
-
O'Brien P.M., Aitken R., O'Neil B.W., Campo M.S. Generation of native bovine mabs by phage display. Proc Natl Acad Sci U S A 1999, 96:640-645.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 640-645
-
-
O'Brien, P.M.1
Aitken, R.2
O'Neil, B.W.3
Campo, M.S.4
-
122
-
-
84882255351
-
Functional antibody CDR3 fusion proteins with enhanced pharmacological properties
-
Zhang Y., Wang D., de Lichtervelde L., Sun S.B., Smider V.V., Schultz P.G., Wang F. Functional antibody CDR3 fusion proteins with enhanced pharmacological properties. Angew Chem Int Ed 2013, 52:8295-8298.
-
(2013)
Angew Chem Int Ed
, vol.52
, pp. 8295-8298
-
-
Zhang, Y.1
Wang, D.2
de Lichtervelde, L.3
Sun, S.B.4
Smider, V.V.5
Schultz, P.G.6
Wang, F.7
-
123
-
-
84886454533
-
An antibody CDR3-erythropoietin fusion protein
-
Zhang Y., Wang D., Welzel G., Wang Y., Schultz P.G., Wang F. An antibody CDR3-erythropoietin fusion protein. ACS Chem Biol 2013, 8:2117-2121.
-
(2013)
ACS Chem Biol
, vol.8
, pp. 2117-2121
-
-
Zhang, Y.1
Wang, D.2
Welzel, G.3
Wang, Y.4
Schultz, P.G.5
Wang, F.6
-
124
-
-
84905216248
-
Rational design of CXCR4 specific antibodies with elongated CDRS
-
Liu T., Liu Y., Wang Y., Hull M., Schultz P.G., Wang F. Rational design of CXCR4 specific antibodies with elongated CDRS. J Am Chem Soc 2014, 136:10557-10560.
-
(2014)
J Am Chem Soc
, vol.136
, pp. 10557-10560
-
-
Liu, T.1
Liu, Y.2
Wang, Y.3
Hull, M.4
Schultz, P.G.5
Wang, F.6
-
125
-
-
0002242319
-
The rumen microbial ecosystem
-
Hungate R.E. The rumen microbial ecosystem. Annu Rev Ecol Syst 1975, 6:39-66.
-
(1975)
Annu Rev Ecol Syst
, vol.6
, pp. 39-66
-
-
Hungate, R.E.1
-
127
-
-
0035843960
-
Factors that alter rumen microbial ecology
-
Russell J.B., Rychlik J.L. Factors that alter rumen microbial ecology. Science 2001, 292:1119-1122.
-
(2001)
Science
, vol.292
, pp. 1119-1122
-
-
Russell, J.B.1
Rychlik, J.L.2
-
128
-
-
0014525175
-
The occurrence of natural antibodies to rumen bacteria
-
Sharpe M.E., Latham M.J., Reiter B. The occurrence of natural antibodies to rumen bacteria. J Gen Microbiol 1969, 56:353-364.
-
(1969)
J Gen Microbiol
, vol.56
, pp. 353-364
-
-
Sharpe, M.E.1
Latham, M.J.2
Reiter, B.3
-
129
-
-
84893831480
-
The promise and challenge of high-throughput sequencing of the antibody repertoire
-
Georgiou G., Ippolito G.C., Beausang J., Busse C.E., Wardemann H., Quake S.R. The promise and challenge of high-throughput sequencing of the antibody repertoire. Nat Biotechnol 2014, 32:158-168.
-
(2014)
Nat Biotechnol
, vol.32
, pp. 158-168
-
-
Georgiou, G.1
Ippolito, G.C.2
Beausang, J.3
Busse, C.E.4
Wardemann, H.5
Quake, S.R.6
-
130
-
-
84903648345
-
Systematic characterization and comparative analysis of the rabbit immunoglobulin repertoire
-
Lavinder J.J., Hoi K.H., Reddy S.T., Wine Y., Georgiou G. Systematic characterization and comparative analysis of the rabbit immunoglobulin repertoire. PLoS One 2014, 9:e101322.
-
(2014)
PLoS One
, vol.9
-
-
Lavinder, J.J.1
Hoi, K.H.2
Reddy, S.T.3
Wine, Y.4
Georgiou, G.5
|