Immunoglobulin knockout chickens via efficient homologous recombination in primordial germ cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 50, 2013, Pages 20170-20175

  Schusser, Benjamin ^a,b   Collarini, Ellen J ^a   Yi, Henry ^a   Izquierdo, Shelley Mettler ^a   Fesler, Jeffrey ^a   Pedersen, Darlene ^a   Klasing, Kirk C ^b   Kaspers, Bernd ^c   Harriman, William D ^a   Van De Lavoir, Marie Cecile ^a   Etches, Robert J ^a   Leighton, Philip A ^a  

^a Crystal Bioscience Inc   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF MUNICH   (Germany)

Author keywords

Avian immunology; B cell development; Genome editing

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BURSA FABRICII; CELL MUTANT; CELL TYPE; CHICKEN MODEL; CONTROLLED STUDY; FEMALE; GENE INACTIVATION; GENE TARGETING; HOMOLOGOUS RECOMBINATION; HOMOZYGOTE; IMMUNE SYSTEM; IMMUNIZATION; IMMUNOGLOBULIN HEAVY CHAIN GENE; IMMUNOGLOBULIN PRODUCTION; INFECTION; LYMPHOCYTE MIGRATION; LYMPHOCYTE SUBPOPULATION; MALE; NONHUMAN; PRE B LYMPHOCYTE; PRIMORDIAL GERM CELL; PRIORITY JOURNAL; TRANSGENIC ANIMAL;

EID: 84890290471     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1317106110     Document Type: Article

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