-
1
-
-
0032543307
-
-
P. D. Kwong et al., Nature 393, 648 (1998).
-
(1998)
Nature
, vol.393
, pp. 648
-
-
Kwong, P.D.1
-
4
-
-
12444291017
-
-
D. A. Calarese et al., Science 300, 2065 (2003).
-
(2003)
Science
, vol.300
, pp. 2065
-
-
Calarese, D.A.1
-
5
-
-
80053132436
-
-
L. M. Walker et al., Nature 477, 466 (2011).
-
(2011)
Nature
, vol.477
, pp. 466
-
-
Walker, L.M.1
-
6
-
-
70349887757
-
-
L. M. Walker et al., Science 326, 285 (2009).
-
(2009)
Science
, vol.326
, pp. 285
-
-
Walker, L.M.1
-
7
-
-
77954920017
-
-
X. Wu et al., Science 329, 856 (2010).
-
(2010)
Science
, vol.329
, pp. 856
-
-
Wu, X.1
-
8
-
-
80052942203
-
-
X. Wu et al., Science 333, 1593 (2011).
-
(2011)
Science
, vol.333
, pp. 1593
-
-
Wu, X.1
-
9
-
-
8644251891
-
-
J. M. Binley et al., J. Virol. 78, 13232 (2004).
-
(2004)
J. Virol.
, vol.78
, pp. 13232
-
-
Binley, J.M.1
-
13
-
-
84922752561
-
-
note
-
It has been shown that a three-amino acid insertion in the heavy-chain CDR H2 of the influenza virus-specific mAb 2D1 rearranges the antibody-combining site and enhances neutralization potency (12), demonstrating that somatically introduced amino acid insertions may be a conserved molecular mechanism for increasing antibody potency against viral pathogens.
-
-
-
-
14
-
-
84922703910
-
-
note
-
-/- HEK 293S cells to mimic the oligomannose-type glycosylation of that domain within intact gp120.
-
-
-
-
15
-
-
84922700927
-
-
note
-
325 peptide bond. Also, similar to many other bnmAbs to HIV, the PGT 128 CDR H3 loop is relatively long (19 amino acids), although not the longest seen to date for human Abs [31 or 32 residues for the PGT 140 series (5)].
-
-
-
-
16
-
-
1242351232
-
-
R. L. Stanfield, M. K. Gorny, C. Williams, S. Zolla-Pazner, I. A. Wilson, Structure 12, 193 (2004).
-
(2004)
Structure
, vol.12
, pp. 193
-
-
Stanfield, R.L.1
Gorny, M.K.2
Williams, C.3
Zolla-Pazner, S.4
Wilson, I.A.5
-
17
-
-
77954943648
-
-
T. Zhou et al., Science 329, 811 (2010).
-
(2010)
Science
, vol.329
, pp. 811
-
-
Zhou, T.1
-
23
-
-
84922734661
-
-
note
-
The HIV-1 664G trimer is based on the clade A strain KNH1144 and incorporates stabilizing mutations A501C, T605C, and I559P. We have previously shown that trimers incorporating these stabilizing mutations are competent to undergo CD4-induced conformational changes akin to those observed in the native trimer (22).
-
-
-
-
26
-
-
0028291731
-
-
P. Roben et al., J. Virol. 68, 4821 (1994).
-
(1994)
J. Virol.
, vol.68
, pp. 4821
-
-
Roben, P.1
-
29
-
-
84922744588
-
-
note
-
JR-FL is the only HIV isolate that has been shown to express a high proportion of fully cleaved Env trimers on the surface of transfected cells and was, therefore, selected for binding studies.
-
-
-
-
30
-
-
51349162563
-
-
J. Liu, A. Bartesaghi, M. J. Borgnia, G. Sapiro, S. Subramaniam, Nature 455, 109 (2008).
-
(2008)
Nature
, vol.455
, pp. 109
-
-
Liu, J.1
Bartesaghi, A.2
Borgnia, M.J.3
Sapiro, G.4
Subramaniam, S.5
-
34
-
-
54049109927
-
-
C. Ansarah-Sobrinho, S. Nelson, C. A. Jost, S. S. Whitehead, T. C. Pierson, Virology 381, 67 (2008).
-
(2008)
Virology
, vol.381
, pp. 67
-
-
Ansarah-Sobrinho, C.1
Nelson, S.2
Jost, C.A.3
Whitehead, S.S.4
Pierson, T.C.5
-
35
-
-
0026755629
-
-
S. P. Layne et al., Virology 189, 695 (1992).
-
(1992)
Virology
, vol.189
, pp. 695
-
-
Layne, S.P.1
-
36
-
-
0033587377
-
-
J. M. Le Doux, H. E. Davis, J. R. Morgan, M. L. Yarmush, Biotechnol. Bioeng. 63, 654 (1999).
-
(1999)
Biotechnol. Bioeng.
, vol.63
, pp. 654
-
-
Le Doux, J.M.1
Davis, H.E.2
Morgan, J.R.3
Yarmush, M.L.4
-
37
-
-
79959812241
-
-
K. A. Dowd, C. A. Jost, A. P. Durbin, S. S. Whitehead, T. C. Pierson, PLoS Pathog. 7, e1002111 (2011).
-
(2011)
PLoS Pathog.
, vol.7
-
-
Dowd, K.A.1
Jost, C.A.2
Durbin, A.P.3
Whitehead, S.S.4
Pierson, T.C.5
-
40
-
-
79955389756
-
-
and the CAPRISA002 Study Team
-
E. S. Gray et al.; and the CAPRISA002 Study Team, J. Virol. 85, 4828 (2011).
-
(2011)
J. Virol.
, vol.85
, pp. 4828
-
-
Gray, E.S.1
-
42
-
-
80052502584
-
-
H. Tang et al., J. Virol., 85, 9286 (2011).
-
(2011)
J. Virol.
, vol.85
, pp. 9286
-
-
Tang, H.1
-
43
-
-
84922710734
-
NIAID Center for HIV/AIDS Vaccine Immunology
-
A. Nandi et al.; NIAID Center for HIV/AIDS Vaccine Immunology, Virology 396, 339 (2010).
-
(2010)
Virology
, vol.396
, pp. 339
-
-
Nandi, A.1
|