The structural analysis of shark IgNAR antibodies reveals evolutionary principles of immunoglobulins

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 22, 2014, Pages 8155-8160

  Feige, Matthias J ^a   Gräwert, Melissa A ^b,e   Marcinowski, Moritz ^b   Hennig, Janosch ^b   Behnke, Julia ^a   Auslan̈der, David ^f   Heroldb, Eva M ^b   Peschek, Jirka ^b,g   Castrod, Caitlin D ^d   Flajnik, Martin ^d   Hendershot, Linda M ^a   Sattler, Michael ^b,c   Grollb, Michael ^b   Buchner, Johannes ^b  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b Munich Center for Integrated Protein Science   (Germany)

^c INSTITUTE OF EPIDEMIOLOGY   (Germany)

^d UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^e EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^f ETH ZURICH   (Switzerland)

^g UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Antibody structure; Protein engineering; Protein evolution; Protein folding

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN NEW ANTIGEN RECEPTOR; LYMPHOCYTE ANTIGEN RECEPTOR; UNCLASSIFIED DRUG;

ADAPTATION; AMINO TERMINAL SEQUENCE; ANTIBODY ENGINEERING; ANTIBODY PRODUCTION; ANTIBODY STRUCTURE; ANTIGEN BINDING; ARTICLE; DIMERIZATION; HINGE REGION; HUMAN; IGNAR C1 DOMAIN; IGNAR C2 DOMAIN; IGNAR C3 DOMAIN; IGNAR C4 DOMAIN; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN DOMAIN; SHARK; SPECIES DIFFERENCE; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

ANTIBODY STRUCTURE; PROTEIN ENGINEERING; PROTEIN EVOLUTION; PROTEIN FOLDING;

ADAPTIVE IMMUNITY; AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES; CELLS, CULTURED; EVOLUTION, MOLECULAR; HUMANS; IMMUNOGLOBULIN CONSTANT REGIONS; IMMUNOGLOBULIN HEAVY CHAINS; INSECTS; MOLECULAR SEQUENCE DATA; OSMOREGULATION; PROTEIN ENGINEERING; PROTEIN FOLDING; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, ANTIGEN; SHARKS; UREA;

EID: 84901820594     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1321502111     Document Type: Article

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