Dual beneficial effect of interloop disulfide bond for single domain antibody fragments

Journal of Biological Chemistry

Volumn 287, Issue 3, 2012, Pages 1970-1979

  Govaert, Jochen ^a,b   Pellis, Mireille ^a,b   Deschacht, Nick ^a,b   Vincke, Cécile ^a,b   Conrath, Katja ^a,b,c   Muyldermans, Serge ^a,b   Saerens, Dirk ^a,b  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^b DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^c GALAPAGOS NV   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID SUBSTITUTION; ANTIBODY FRAGMENT; ANTIBODY MATURATION; ANTIGEN BINDING CAPACITY; ANTIGEN-BINDING; BENEFICIAL EFFECTS; DISULFIDE BONDS; HEAVY CHAIN; HEAVY-CHAIN ANTIBODIES; IN-VIVO; INTRINSIC STABILITY; LIGHT CHAIN; SINGLE DOMAINS; VARIABLE DOMAIN;

AMINO ACIDS; ANTIGENS; COVALENT BONDS;

ANTIBODIES;

AMINO ACID; CYSTINE; DISULFIDE;

AMINO ACID SUBSTITUTION; ANTIGEN BINDING; ANTIGEN PURIFICATION; ANTIGEN RECOGNITION; ANTIGEN SPECIFICITY; ARTICLE; CONTROLLED STUDY; DISULFIDE BOND; HEAVY CHAIN; HYDROPHILICITY; IN VIVO STUDY; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN STABILITY;

ANIMALS; CAMELS; CYSTEINE; DISULFIDES; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; SINGLE-CHAIN ANTIBODIES;

CAMELIDAE; CAMELUS DROMEDARIUS;

EID: 84855849845     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.242818     Document Type: Article

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