Rational design of CXCR4 specific antibodies with elongated CDRs

Journal of the American Chemical Society

Volumn 136, Issue 30, 2014, Pages 10557-10560

  Liu, Tao ^a   Liu, Yan ^b   Wang, Ying ^b   Hull, Mitchell ^b   Schultz, Peter G ^a,b   Wang, Feng ^b  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b California Institute for Biomedical Research   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; PEPTIDES; SIGNAL TRANSDUCTION;

ANTIBODY ENGINEERING; BINDING AFFINITIES; BINDING PEPTIDE; COMPLEMENTARITY-DETERMINING REGION 3; HAIRPIN CONFORMATION; NANOMOLAR RANGE; PEPTIDE FUSION; RATIONAL DESIGN;

ANTIBODIES;

ANTIBODY; CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR4 ANTIBODY; STROMAL CELL DERIVED FACTOR 1; UNCLASSIFIED DRUG; COMPLEMENTARITY DETERMINING REGION; HYBRID PROTEIN; PEPTIDE;

ANIMAL CELL; ANTIBODY ENGINEERING; ARTICLE; BINDING AFFINITY; CELL MIGRATION; COMPLEMENTARITY DETERMINING REGION; HEAVY CHAIN; INTRACELLULAR SIGNALING; LIGAND BINDING; NONHUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; ANIMAL; ANTIBODY SPECIFICITY; BOVINE; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; HUMAN; IMMUNOLOGY; MOLECULAR GENETICS; PROTEIN ENGINEERING; PROTEIN SECONDARY STRUCTURE;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES; ANTIBODY SPECIFICITY; CATTLE; CELL LINE; CHEMOKINE CXCL12; COMPLEMENTARITY DETERMINING REGIONS; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN ENGINEERING; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, CXCR4; RECOMBINANT FUSION PROTEINS;

EID: 84905216248     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja5042447     Document Type: Article

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