Exceptionally long CDR3H region with multiple cysteine residues in functional bovine IgM antibodies

European Journal of Immunology

Volumn 29, Issue 8, 1999, Pages 2420-2426

  Saini, Surinder S ^a   Allore, Brian ^b   Jacobs, Robert M ^a   Kaushik, Azad ^a  

^a UNIVERSITY OF GUELPH   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

Antibody; Complementarity determining region 3; V( ) gene; V(H) gene; VDJ rearrangement

Indexed keywords

CD5 ANTIGEN; CYSTEINE; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN M ANTIBODY;

ANIMAL CELL; ANTIBODY COMBINING SITE; ANTIGEN ANTIBODY REACTION; ANTIGEN SPECIFICITY; ARTICLE; B LYMPHOCYTE; CATTLE; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; DISULFIDE BOND; GENE MUTATION; GENE REARRANGEMENT; IMMUNOGLOBULIN VARIABLE REGION; NONHUMAN; NUCLEOTIDE SEQUENCE; POINT MUTATION; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODY DIVERSITY; BASE SEQUENCE; CATTLE; CYSTEINE; DNA PRIMERS; ENZOOTIC BOVINE LEUKOSIS; GENE REARRANGEMENT, B-LYMPHOCYTE; GENES, ENV; GENES, IMMUNOGLOBULIN; HYBRIDOMAS; IMMUNOGLOBULIN M; IMMUNOGLOBULIN VARIABLE REGION; LEUKEMIA VIRUS, BOVINE; MOLECULAR SEQUENCE DATA; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0032766502     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199908)29:08<2420::AID-IMMU2420>3.0.CO;2-A     Document Type: Article

References (19)

1. Tonegawa, S., Somatic generation of antibody diversity. Nature 1983. 302: 575-581.
2. Wagner, S. D. and Neuberger, M. S., Somatic hypermutation of immunoglobulin genes. Annu. Rev. Immunol. 1996. 14: 441-457.
3. Kabat, E. A., Wu, T. T., Perry, H. M., Gottesman, K. S. and Foeller, C., (Eds.) Sequences of Proteins of Immunological Interest. U.S. Department of Health and Human Services, NIH, Bethesda.
4. H gene of the chicken with a high incidence in the D region. Cell 1989. 59: 171-183.
5. H diversification by gene conversion-like and hypermutation mechanisms. Immunity 1994. 1: 647-659.
6. Reynaud, C. A., Garcia, C., Hein, W. R. and Weill, J. C., Hypermutations generating the sheep immunoglobulin repertoire is an antigen-independent process. Cell 1995. 80: 115-125.
7. H gene family, related to mammalian group I, clan II, is identified in cattle. Mol. Immunol. 1997. 34: 641-651.
8. H family and long CDR3s in the variable region of cattle Ig heavy chains. Int. Immunol. 1997. 9: 189-199.
9. H gene family. J. Immunol. 1997. 159: 3883-3889.
10. Sinclair, M. C., Gilchrist, J. and Aitken, R., Molecular characterization of bovine Vλ regions. J. Immunol. 1995. 155: 3068-3078.
11. Meirom, R., Brenner, J. and Trainin, Z., BLV-infected lymphocytes exhibit two patterns of expression as determined by Ig and CD5 markers. Vet. Immunol. Immunopathol. 1993. 36: 179-186.
12. Vandyk, L. and Meek, K., Assembly of IgH CDR3: Mechanism, regulation, and influence on antibody diversity. Int. Rev. Immunol. 1992. 8: 123-133.
13. Reynaud, C. A., Anquez, V. and Weill, J. C., The chicken D locus and its contribution to the immunoglobulin heavy chain repertoire. Eur. J. Immunol. 1991. 21: 2661-2670.
14. H1 genes expressed in B cell chronic lymphocytic leukemia exhibit distinctive molecular features. J. Immunol. 1997. 158: 235-246.
15. Piper, C. E., Ferrer, J. F., Abt, D. D. and Marshala, R. A., Postnatal and prenatal transmission of the bovine leukemia virus under natural conditions. J. Natl. Cancer Inst. 1979. 62: 165-168.
16. Jackson, T., Morris, B. A. and Sanders, P. G., Nucleotide sequences and expression of cDNAs for a bovine anti-testosterone monoclonal IgG1 antibody. Mol. Immunol. 1992. 29: 667-676.
17. Altschul, S. F., Gish, W., Miller, W., Myers, E. W. and Lipman, D. J., Basic local alignment search tool. J. Mol. Biol. 1990. 215: 403-410.
18. Kyte, J. and Doolittle, R. F., A simple method for displaying the hydropathic character of a protein. J. Mol. Biol. 1982. 157: 105-132.
19. Murtaugh, M. P., Lin, G. F., Haggard, D. L., Weber, A. F. and Meiske, J. C., Detection of bovine leukemia virus in cattle by the polymerase chain reaction. J. Virol. Methods 1991. 33: 73-85.